About 3,115 results

ALLMedicine™ Long QT Syndrome Center

Research & Reviews  1,069 results

CRISPR-Cas9-mediated Precise Knock-in Edits in Zebrafish Hearts.
Journal of Visualized Experiments : JoVE; Simpson KE, Faizi S et. al.

Oct 4th, 2022 - Clustered regularly interspaced short palindromic repeats (CRISPR) in animal models enable precise genetic manipulation for the study of physiological phenomena. Zebrafish have been used as an effective genetic model to study numerous questions re...

Safety of COVID-19 vaccines in children with inborn errors of metabolism in terms of de...
Journal of Paediatrics and Child Health; Zubarioglu T, Oral-Cebeci S et. al.

Sep 30th, 2022 - There are no recommended guidelines or clinical studies on safety of COVID-19 vaccines in patients with inborn errors of metabolism (IEMs). Here, we aimed to examine the relationship between COVID-19 vaccination and metabolic outcome in paediatric...

Cardiogenetics: the role of genetic testing for inherited arrhythmia syndromes and sudd...
Heart (British Cardiac Society); Specterman MJ, Behr ER

Sep 28th, 2022 - There have been remarkable advances in our knowledge of the underlying heritability of cardiac arrhythmias. Long QT syndrome, Brugada syndrome, catecholaminergic polymorphic ventricular tachycardia, progressive cardiac conduction disease and the s...

Subcutaneous Implantable Cardioverter Defibrillators for the Prevention of Sudden Cardi...
International Journal of Environmental Research and Publi... Wieniawski P, Buczyński M et. al.

Sep 24th, 2022 - The subcutaneous implantable cardioverter defibrillator (S-ICD) was developed as an alternative to the transvenous ICD, to prevent lead-related complications associated with the latter. The absence of intravascular or intracardiac components offer...

Prevalence and Phenotypic Burden of Monogenic Arrhythmias Using Integration of Electron...
Circulation. Genomic and Precision Medicine; Nafissi NA, Abdulrahim JW et. al.

Sep 23rd, 2022 - Inherited primary arrhythmia syndromes and arrhythmogenic cardiomyopathies can lead to sudden cardiac arrest in otherwise healthy individuals. The burden and expression of these diseases in a real-world, well-phenotyped cardiovascular population i...

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Drugs  30 results see all →

Clinicaltrials.gov  53 results

Assessment of Mortality Rates in COVID-19 Infected Populations Treated With Repurposed Medications

Sep 2nd, 2022 - There is a deficit in literature assessing the risk associated with these repurposed medications in COVID-19 patients. The investigators propose to evaluate if the use of repurposed drugs including hydroxychloroquine and chloroquine is associated ...

Prospective Phenotyping for Genetic Subtypes of Early-onset Atrial Fibrillation

Aug 24th, 2022 - This study will address the hypothesis that re-phenotyping patients with AF and pathogenic arrhythmia/CM variants will identify unrecognized underlying genetic disease. The investigators will recruit from participants sequenced as part of our pros...

Feasibility of Improving Risk Stratification in Brugada Syndrome

Aug 17th, 2022 - It is estimated that approximately 600 apparently fit and healthy individuals aged under 35 years die suddenly in the UK every year Many of these sudden cardiac deaths (SCD) in the young are the result of inherited cardiac conditions (ICC), the ma...

A Study to Evaluate Direct Wire Pacing (DWP) for Measuring Fractional Flow Reserve (FFR)

Jun 14th, 2022 - Pressure wire-based Fractional Flow Reserve (FFR) has become the reference standard index of haemodynamic significance to guide revascularisation of intermediate coronary artery lesions. The FFR measurement determines the ratio of the maximum bloo...

Low Cost QTc Meter for Long QT Syndrome Screening in Primary Care

Apr 27th, 2022 - The study will involve acquiring ECG data in a cohort of up to 1,000 newborns and infants (500 controls (non-LQTS) and 500 LQTS newborns and infants) that are being seen in the Gonda SL ECG Lab (or Baldwin Building)and enrolled during their appoin...

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News  87 results

Ventricular Arrhythmia Clinical Practice Guidelines (ESC, 2022)

Sep 30th, 2022 - Updated clinical guidelines for managing patients with ventricular arrhythmias and preventing sudden cardiac death were published in August 2022 by the European Society of Cardiology (ESC), in the European Heart Journal.[1] In patients presenting ...

Cardiac Arrhythmia Should Be Considered With Nocturnal Enuresis

Apr 12th, 2022 - Physicians doing a diagnostic workup for nocturnal enuresis, or bedwetting, appear to rarely consider cardiac arrhythmia as a differential diagnosis, new research suggests. Researchers surveyed doctors about how they would approach assessment of a...

NSCLC therapies associated with cardiac events
Walter Alexander

Jan 4th, 2022 - A new analysis of cardiovascular adverse drug reactions for non–small cell lung cancer (NCSLC)–targeted therapies finds that ALK and ROS1 inhibitors are associated with higher odds of conduction disease and QT prolongation than BRAF and EGFR inhib.

Progestin-Only Oral Contraceptives Tied to Cardiac Events in Long QT Syndrome

Aug 19th, 2021 - (Reuters Health) - Women with long QT syndrome who use progestin-only oral contraceptives without concomitant beta-blockers are at increased risk for cardiac events, a new study suggests. Researchers examined data on 1,659 women with long QT syndr...

Sorensen's PFO Closure Saga; Long QT and Pregnancy Loss; Another LAA Occluder OK'd

Aug 17th, 2021 - The story of interventional cardiologist Sherman Sorensen, MD, and his numerous patent foramen ovale closures, fraudulent billing, and pending malpractice lawsuits. (The Atlantic) A cardiologist in Australia caught with "deviant, distressing and d...

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Patient Education  7 results see all →