ALLMedicine™ Long QT Syndrome Center

May 17th, 2022 - Congenital Long QT Syndrome (CLQTS) is the most common inherited arrhythmia. The QT interval, which marks the duration of ventricular depolarization and repolarization in the myocardium, can be prolonged due to mutations in genes coding for the io...

May 12th, 2022 - Accurately determining variant pathogenicity is critical in the diagnosis of cardiac channelopathies; however, it remains unknown how variant pathogenicity status changes over time. Our aim is to use a comprehensive analysis of ClinVar to understa...

May 11th, 2022 - Current exercise recommendations make it difficult for long QT syndrome (LQTS) patients to adopt a physically active and/or athletic lifestyle. The purpose of this review is to summarize the current evidence, identify knowledge gaps, and discuss r...

May 11th, 2022 - Application of next-generation sequencing may lead to the detection of secondary findings (SF) not related to the initially analyzed disease but to other severe medically actionable diseases. However, the analysis of SFs is not yet routinely perfo...

May 11th, 2022 - This study will address the hypothesis that re-phenotyping patients with AF and pathogenic arrhythmia/CM variants will identify unrecognized underlying genetic disease. The investigators will recruit from participants sequenced as part of our pros...

May 11th, 2022 - This study will address the hypothesis that re-phenotyping patients with AF and pathogenic arrhythmia/CM variants will identify unrecognized underlying genetic disease. The investigators will recruit from participants sequenced as part of our pros...

May 6th, 2022 - Pressure wire-based Fractional Flow Reserve (FFR) has become the reference standard index of haemodynamic significance to guide revascularisation of intermediate coronary artery lesions. The FFR measurement determines the ratio of the maximum bloo...

Feb 22nd, 2022 - Congenital long QT syndrome (LQTS) is a rare genetic disorder characterized by prolongation of the corrected QT interval (QTc) on the electrocardiogram. LQTS is associated with a risk of syncope or sudden death from ventricular arrhythmia. The inc...

Feb 21st, 2022 - Ascertainment of LQTS, an inherited arrhythmia disorder in a group of conditions known as the channelopathies, is challenging before birth. Recently, in a retrospective study it was reported that a gestational age dependent bradycardia allows a mu...

Dec 3rd, 2021 - BACKGROUND AND SIGNIFICANCE Drug-induced long QT syndrome (LQTS), and the subsequent fatal arrhythmia torsade de pointes (TdP), is an important side effect associated with the use of a number of medications. Prolongation of the QT interval is the ...

Apr 12th, 2022 - Physicians doing a diagnostic workup for nocturnal enuresis, or bedwetting, appear to rarely consider cardiac arrhythmia as a differential diagnosis, new research suggests. Researchers surveyed doctors about how they would approach assessment of a...

Aug 19th, 2021 - (Reuters Health) - Women with long QT syndrome who use progestin-only oral contraceptives without concomitant beta-blockers are at increased risk for cardiac events, a new study suggests. Researchers examined data on 1,659 women with long QT syndr...

Aug 17th, 2021 - The story of interventional cardiologist Sherman Sorensen, MD, and his numerous patent foramen ovale closures, fraudulent billing, and pending malpractice lawsuits. (The Atlantic) A cardiologist in Australia caught with "deviant, distressing and d...

Jul 30th, 2021 - NEW YORK (Reuters Health) - New data from the Mayo Clinic challenges the automatic benching of all athletes found to have a genetic heart disease (GHD) predisposing to sudden cardiac death, such as long QT syndrome (LQTS), in favor of the more con...

Jun 8th, 2021 - NEW YORK (Reuters Health) - Close to 20% of U.S. adults dying from unexplained sudden cardiac death (SCD) carried pathogenic or likely pathogenic (P/LP) variants of inherited cardiomyopathies (CMs) and arrhythmia syndromes in a large genetic assoc...