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About 2,270 results

ALLMedicine™ Long QT Syndrome Center

Research & Reviews  829 results

Role of Chronic, Long Term Intravenous Lidocaine in the Clinical Management of Patients...
https://doi.org/10.1016/j.hrthm.2021.09.016
Heart Rhythm; Bains S, Lador A et. al.

Sep 20th, 2021 - Type 3 long QT syndrome (LQT3) is caused by pathogenic, gain-of-function variants in SCN5A leading to a prolonged action potential, ventricular ectopy, and torsades de pointes. Treatment options include pharmacotherapy, cardiac denervation, and/or...

Mutation location and IKs regulation in the arrhythmic risk of long QT syndrome type 1:...
https://doi.org/10.1093/eurheartj/ehab582
European Heart Journal; Schwartz PJ, Moreno C et. al.

Sep 11th, 2021 - Mutation type, location, dominant-negative IKs reduction, and possibly loss of cyclic adenosine monophosphate (cAMP)-dependent IKs stimulation via protein kinase A (PKA) influence the clinical severity of long QT syndrome type 1 (LQT1). Given the ...

Long QT syndrome with potassium voltage-gated channel subfamily H member 2 gene mutatio...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8418736
BMC Neurology; Kang H, Lan L et. al.

Sep 6th, 2021 - Epileptic seizures can be difficult to distinguish from other etiologies that cause cerebral hypoxia, especially cardiac diseases. Long QT syndrome (LQTS), especially LQTS type 2 (LQT2), frequently masquerades as seizures because of the transient ...

Phosphodiesterase 5: A Novel Therapeutic Target in Long QT Syndrome.
https://doi.org/10.1161/CIRCRESAHA.121.319851
Circulation Research; Zaza A, Lodola F

Sep 3rd, 2021 - Phosphodiesterase 5: A Novel Therapeutic Target in Long QT Syndrome.|2021|Zaza A,Lodola F,|

Mechanisms of gefitinib-induced QT prolongation.
https://doi.org/10.1016/j.ejphar.2021.174441
European Journal of Pharmacology; Jie LJ, Li YD et. al.

Sep 3rd, 2021 - Gefitinib, a tyrosine kinase inhibitor, was the first targeted therapy for non-small cell lung cancer (NSCLC). Gefitinib could block human Ether-à-go-go-Related Gene (hERG) channel, an important target in drug-induced long QT syndrome. However, it...

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Drugs  20 results see all →

News  55 results

Pathogenic Variants Tied to Unexplained Sudden Cardiac Death in US Adults
https://www.medscape.com/viewarticle/952606

Jun 8th, 2021 - NEW YORK (Reuters Health) - Close to 20% of U.S. adults dying from unexplained sudden cardiac death (SCD) carried pathogenic or likely pathogenic (P/LP) variants of inherited cardiomyopathies (CMs) and arrhythmia syndromes in a large genetic assoc...

Genetic Variant Might Contribute to Racial Disparity in COVID-19 Cardiac Mortality
https://www.medscape.com/viewarticle/930642

May 18th, 2020 - NEW YORK (Reuters Health) — A genetic variant that increases the risk of drug-induced long QT syndrome (LQTS) and sudden cardiac death (SCD) could contribute to the higher COVID-19-related mortality seen in African Americans, researchers report. I...

Genomic Experts Throw Cold Water on Most Long QT Genes
https://www.medscape.com/viewarticle/924411

Jan 28th, 2020 - Genomics experts say evidence falls short for more than half the genes published and anointed as causing long QT syndrome (LQTS) and assessed routinely on commercial genetic test panels. Of the 17 genes previously reported in the literature to cau...

Genomic Experts Throw Cold Water on Most Long QT Genes
https://www.staging.medscape.com/viewarticle/924411

Jan 28th, 2020 - Genomics experts say evidence falls short for more than half the genes published and anointed as causing long QT syndrome (LQTS) and assessed routinely on commercial genetic test panels. Of the 17 genes previously reported in the literature to cau...

ECG Challenge: Teen With His First Seizure
https://www.medscape.com/viewarticle/920545_2

Nov 6th, 2019 - The correct diagnosis is long QT, torsade de pointes (Figure 2). Figure 2. Courtesy of Dr Podrid. Discussion The first QRS complex is narrow and supraventricular (*). It is followed by a rapid and irregular rhythm with a rate of up to 300 beats/mi...

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Patient Education  4 results see all →