ALLMedicine™ Long QT Syndrome Center

Sep 20th, 2021 - Type 3 long QT syndrome (LQT3) is caused by pathogenic, gain-of-function variants in SCN5A leading to a prolonged action potential, ventricular ectopy, and torsades de pointes. Treatment options include pharmacotherapy, cardiac denervation, and/or...

Sep 11th, 2021 - Mutation type, location, dominant-negative IKs reduction, and possibly loss of cyclic adenosine monophosphate (cAMP)-dependent IKs stimulation via protein kinase A (PKA) influence the clinical severity of long QT syndrome type 1 (LQT1). Given the ...

Sep 6th, 2021 - Epileptic seizures can be difficult to distinguish from other etiologies that cause cerebral hypoxia, especially cardiac diseases. Long QT syndrome (LQTS), especially LQTS type 2 (LQT2), frequently masquerades as seizures because of the transient ...

Sep 3rd, 2021 - Phosphodiesterase 5: A Novel Therapeutic Target in Long QT Syndrome.|2021|Zaza A,Lodola F,|

Sep 3rd, 2021 - Gefitinib, a tyrosine kinase inhibitor, was the first targeted therapy for non-small cell lung cancer (NSCLC). Gefitinib could block human Ether-à-go-go-Related Gene (hERG) channel, an important target in drug-induced long QT syndrome. However, it...

Jun 8th, 2021 - NEW YORK (Reuters Health) - Close to 20% of U.S. adults dying from unexplained sudden cardiac death (SCD) carried pathogenic or likely pathogenic (P/LP) variants of inherited cardiomyopathies (CMs) and arrhythmia syndromes in a large genetic assoc...

May 18th, 2020 - NEW YORK (Reuters Health) — A genetic variant that increases the risk of drug-induced long QT syndrome (LQTS) and sudden cardiac death (SCD) could contribute to the higher COVID-19-related mortality seen in African Americans, researchers report. I...

Jan 28th, 2020 - Genomics experts say evidence falls short for more than half the genes published and anointed as causing long QT syndrome (LQTS) and assessed routinely on commercial genetic test panels. Of the 17 genes previously reported in the literature to cau...

Jan 28th, 2020 - Genomics experts say evidence falls short for more than half the genes published and anointed as causing long QT syndrome (LQTS) and assessed routinely on commercial genetic test panels. Of the 17 genes previously reported in the literature to cau...

Nov 6th, 2019 - The correct diagnosis is long QT, torsade de pointes (Figure 2). Figure 2. Courtesy of Dr Podrid. Discussion The first QRS complex is narrow and supraventricular (*). It is followed by a rapid and irregular rhythm with a rate of up to 300 beats/mi...