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About 1,058 results

ALLMedicine™ Torsade De Pointes Center

Research & Reviews  271 results

Electrophysiologic effects of sacubitril in different arrhythmia models.
https://doi.org/10.1016/j.ejphar.2022.174747
European Journal of Pharmacology; Ellermann C, Dimanski D et. al.

Jan 14th, 2022 - Previous studies report conflicting data regarding anti- or proarrhythmic effects of sacubitril. Aim of this study was to assess the impact of acute sacubitril treatment in different arrhythmia models. Sacubitril was administered (3, 5, 10 μM) in ...

Open-access database of literature derived drug-related Torsade de Pointes cases.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8750847
BMC Pharmacology & Toxicology; Laura K, Barbara W et. al.

Jan 12th, 2022 - Since an introduction of an ICH guidance in 2005, no new drugs were withdrawn from the market because of the causation of Torsade de Pointes (TdP). However, the risk of TdP is still a concern for marketed drugs. TdP is a type of polymorphic ventri...

Genetics of QT Response to Moxifloxacin
https://clinicaltrials.gov/ct2/show/NCT01936480

Jan 12th, 2022 - I. Background and Significance A. Historical Background and Scientific Basis The most common cause of withdrawal or restriction of drugs that are already on the market is prolongation of the QT interval, and the consequent, potentially fatal, arrh...

Prevalence and Risk Factors of QTc Prolongation in Prostate Cancer Patients Undergoing ...
https://doi.org/10.1080/07357907.2022.2027435
Cancer Investigation; Saad S, Delouya G et. al.

Jan 11th, 2022 - QTc prolongation is linked to Torsade de Pointes, sudden cardiac death, and overall cardiovascular mortality. 754 prostate cancer patients undergoing brachytherapy were analyzed, prolonged QTc was defined as ≥450ms. A prolonged QTc was more freque...

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Guidelines  2 results

Guidelines for reporting case studies and series on drug-induced QT interval prolongati...
https://doi.org/10.1080/15563650.2019.1605077
Clinical Toxicology (Philadelphia, Pa.); Berling I, Hatten BW et. al.

Apr 26th, 2019 - Background: The assessment and management of patients with QT interval prolongation in poisoning requires an appropriate method of measuring and adjusting the QT interval for the heart rate (HR) in order to decide if the patient is at risk of life...

Prevention of torsade de pointes in hospital settings: a scientific statement from the ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3056123
Circulation Drew BJ, Ackerman MJ et. al.

Feb 10th, 2010 - Prevention of torsade de pointes in hospital settings: a scientific statement from the American Heart Association and the American College of Cardiology Foundation.|2010|Drew BJ,Ackerman MJ,Funk M,Gibler WB,Kligfield P,|physiology,epidemiology,phy...

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Drugs  114 results see all →

Clinicaltrials.gov  6 results

Genetics of QT Response to Moxifloxacin
https://clinicaltrials.gov/ct2/show/NCT01936480

Jan 12th, 2022 - I. Background and Significance A. Historical Background and Scientific Basis The most common cause of withdrawal or restriction of drugs that are already on the market is prolongation of the QT interval, and the consequent, potentially fatal, arrh...

A Registry to Determine the Clinical and Genetic Risk Factors for Torsade De Pointes
https://clinicaltrials.gov/ct2/show/NCT02439645

Dec 3rd, 2021 - BACKGROUND AND SIGNIFICANCE Drug-induced long QT syndrome (LQTS), and the subsequent fatal arrhythmia torsade de pointes (TdP), is an important side effect associated with the use of a number of medications. Prolongation of the QT interval is the ...

The Comparison of Changes of QTc, Tp-e Interval, and Tp-e/QT Ratio, Tp-e/QTc Ratio on the ECG During Living Donor Liver Transplantation Under Desflurane and Total Intravenous Anesthesia -Randomized...
https://clinicaltrials.gov/ct2/show/NCT03864276

Oct 15th, 2021 - Prolonged corrected QT interval (QTc) has been observed in about half of patients with liver cirrhosis. Marked prolongation of QTc (ie, 500 msec) has been considered to be a risk factor for fatal ventricular arrhythmia, such as torsade de pointes,...

Safety of Short-term Hydroxychloroquine Plus Azithromycin Treatment in Critically Ill Patients With Severe COVID-19
https://clinicaltrials.gov/ct2/show/NCT04452617

Sep 1st, 2020 - Hydroxychloroquine and azithromycin have been proposed as treatment of COVID-19 patients, but few reports have assessed this combination therapy in critically ill COVID-19 patients. Many raised concerns regarding the potential cardiac toxicity of ...

Effect of Methadone and Hydromorphone on the QT Interval After Anesthesia and Surgery
https://clinicaltrials.gov/ct2/show/NCT03893734

Sep 13th, 2019 - In the past decade, the single most common cause of withdrawal of the use of drugs that have already been marketed has been the prolongation of the QT interval on the electrocardiogram associated with polymorphic ventricular tachycardia, or torsad...

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News  29 results

Do You Believe in HCQ for COVID-19? It Will Break Your Heart
https://www.medpagetoday.com/infectiousdisease/covid19/86318

May 6th, 2020 - Chloroquine and hydroxychloroquine (HCQ) have been touted as promising and effective treatments for patients with COVID-19 infection. The drugs are often recommended to be used together with azithromycin, an antibiotic. On March 21, 2020, Presiden...

Cardiology Groups Push Back on Hydroxychloroquine, Azithromycin for COVID-19
https://www.staging.medscape.com/viewarticle/928456

Apr 9th, 2020 - Editor's note: Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center. The nation's leading cardiology associations urged caution with hydroxychloroquine and azithromycin for COVID-19 in patients with cardiovascular d...

Cardiology groups push back on hydroxychloroquine, azithromycin for COVID-19
https://www.mdedge.com/cardiology/article/220492/arrhythmias-ep/cardiology-groups-push-back-hydroxychloroquine-azithromycin
M. Alexander Otto

Apr 8th, 2020 - The nation’s leading cardiology associations urged caution with hydroxychloroquine and azithromycin for COVID-19 in patients with cardiovascular disease. Thinkstock “Hydroxychloroquine and azithromycin have been touted for potential prophylaxis or.

ECG Challenge: Teen With His First Seizure
https://www.medscape.com/viewarticle/920545_2

Nov 6th, 2019 - The correct diagnosis is long QT, torsade de pointes (Figure 2). Figure 2. Courtesy of Dr Podrid. Discussion The first QRS complex is narrow and supraventricular (*). It is followed by a rapid and irregular rhythm with a rate of up to 300 beats/mi...

Is Prucalopride the Gastroparesis Treatment We've Been Waiting For?
https://www.staging.medscape.com/viewarticle/916387

Aug 20th, 2019 - This transcript has been edited for clarity. Hello. I'm Dr David Johnson, professor of medicine and chief of gastroenterology at Eastern Virginia Medical School in Norfolk, Virginia. If you've been taking care of patients in a practice, you'll rec...

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Patient Education  1 results see all →