×
About 1,375 results

ALLMedicine™ Torsade De Pointes Center

Research & Reviews  321 results

Linezolid and the risk of QT interval prolongation: A pharmacovigilance study of the Fo...
https://doi.org/10.1111/bcp.15587
British Journal of Clinical Pharmacology; Shao H, Shi D et. al.

Nov 9th, 2022 - Few studies have investigated linezolid (LZD)-associated cardiotoxicity. This study explored the potential association between LZD and QT interval prolongation. Adverse event reports of QT interval prolongation associated with LZD from the Food an...

Determination of five positive control drugs in hERG external solution (buffer) by LC-M...
https://doi.org/10.1016/j.vascn.2022.107229
Journal of Pharmacological and Toxicological Methods; King TI, Indapurkar A et. al.

Nov 6th, 2022 - ICH S7B recommends screening for hERG channel block using patch clamp recordings to assess a drug's proarrhythmic risk. Block of the hERG channel has been associated with clinical QTC prolongation as well as the rare, but potentially fatal ventric...

Vernakalant for Cardioversion of Recent-Onset Atrial Fibrillation in the Emergency Depa...
https://doi.org/10.1159/000526831
Cardiology Bager JE, Martín A et. al.

Oct 26th, 2022 - Intravenous vernakalant is a therapeutic option for symptomatic, recent-onset atrial fibrillation (AF). This secondary analysis from the large SPECTRUM study assessed the safety and effectiveness of vernakalant when used in the emergency departmen...

Hypokalemia in Emergency Medicine
https://emedicine.medscape.com/article/767448-overview

Oct 10th, 2022 - Practice Essentials Hypokalemia is defined as a potassium level of less than 3.5 mEq/L, while moderate hypokalemia is a serum level of 2.5-3 mEq/L. Severe hypokalemia is defined as a level of less than 2.5 mEq/L. Potassium is one of the body's maj...

Hypokalemia in Emergency Medicine
https://emedicine.medscape.com/article/767448-print

Oct 10th, 2022 - Practice Essentials Hypokalemia is defined as a potassium level of less than 3.5 mEq/L, while moderate hypokalemia is a serum level of 2.5-3 mEq/L. Severe hypokalemia is defined as a level of less than 2.5 mEq/L. Potassium is one of the body's maj...

see more →

Guidelines  2 results

Guidelines for reporting case studies and series on drug-induced QT interval prolongati...
https://doi.org/10.1080/15563650.2019.1605077
Clinical Toxicology (Philadelphia, Pa.); Berling I, Hatten BW et. al.

Apr 26th, 2019 - Background: The assessment and management of patients with QT interval prolongation in poisoning requires an appropriate method of measuring and adjusting the QT interval for the heart rate (HR) in order to decide if the patient is at risk of life...

Prevention of torsade de pointes in hospital settings: a scientific statement from the ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3056123
Circulation Drew BJ, Ackerman MJ et. al.

Feb 10th, 2010 - Prevention of torsade de pointes in hospital settings: a scientific statement from the American Heart Association and the American College of Cardiology Foundation.|2010|Drew BJ,Ackerman MJ,Funk M,Gibler WB,Kligfield P,|physiology,epidemiology,phy...

see more →

Drugs  175 results see all →

Clinicaltrials.gov  14 results

RiLuzole to Reduce Atrial FIb A Prospective, Double-Blind, Randomized, Placebo-Controlled Study Using Holter Monitoring
https://clinicaltrials.gov/ct2/show/NCT05292209

Sep 2nd, 2022 - HYPOTHESIS: Riluzole will statistically reduce the number of AF episodes compared to placebo over a one-month follow-up period in patients with permanent AF (PAF). A prospective, double-blind, randomized, placebo-controlled, two-arm study design i...

Long-term Efficacy Study of Sodium Channel Blocker in LQT3 Patients
https://clinicaltrials.gov/ct2/show/NCT01648205

Apr 7th, 2022 - Long QT syndrome (LQTS) is a genetic disorder characterized by prolongation of the QT interval in the electrocardiogram (ECG) and a propensity to torsade de pointes ventricular tachycardia frequently leading to syncope, cardiac arrest, or sudden d...

Thorough QT/QTc Study of Multiple Oral Doses of NOMAC-E2 (Org 10486 0 + Org 2317) in Healthy Women (Study 292011)(P05802)
https://clinicaltrials.gov/ct2/show/NCT00779532

Feb 16th, 2022 - The trial is a single-center randomized, double-blind, double-dummy, placebo and positive controlled, parallel group clinical trial. This trial investigated whether NOMAC-E2 (Org 10486 -0 + Org 2317), a new combined hormonal contraceptive, has pot...

Genetics of QT Response to Moxifloxacin
https://clinicaltrials.gov/ct2/show/NCT01936480

Jan 12th, 2022 - I. Background and Significance A. Historical Background and Scientific Basis The most common cause of withdrawal or restriction of drugs that are already on the market is prolongation of the QT interval, and the consequent, potentially fatal, arrh...

A Registry to Determine the Clinical and Genetic Risk Factors for Torsade De Pointes
https://clinicaltrials.gov/ct2/show/NCT02439645

Dec 3rd, 2021 - BACKGROUND AND SIGNIFICANCE Drug-induced long QT syndrome (LQTS), and the subsequent fatal arrhythmia torsade de pointes (TdP), is an important side effect associated with the use of a number of medications. Prolongation of the QT interval is the ...

see more →

News  37 results

Antibiotics Used in Dialysis Patients Linked With Sudden Cardiac Death
https://www.medpagetoday.com/nephrology/esrd/95143

Oct 20th, 2021 - Fluoroquinolones were associated with a modest uptick in sudden cardiac death (SCD) among people getting hemodialysis, though the benefits of these antibiotics may still outweigh their risks in this group, according to a study. SCD rates within 5 ...

Common Antibiotics Spell Trouble in Existing Aortopathy
https://www.medpagetoday.com/infectiousdisease/generalinfectiousdisease/92048

Apr 12th, 2021 - For the first time, fluoroquinolone exposure was tied to aortic complications in patients with established aortic disease in a large study. In the cohort study from Taiwan, people with an existing aortic dissection (AD) or aortic aneurysm (AA) wer...

FDA Grants Fast Track Designation to Devimistat for AML
https://www.onclive.com/view/fda-grants-fast-track-designation-to-devimistat-for-aml

Dec 15th, 2020 - The FDA has granted a fast track designation to devimistat (CPI-613) for the treatment of patients with acute myeloid leukemia (AML).1 Receiving fast track designation, especially during a pandemic that has created significant challenges for ma...

Do You Believe in HCQ for COVID-19? It Will Break Your Heart
https://www.medpagetoday.com/infectiousdisease/covid19/86318

May 6th, 2020 - Chloroquine and hydroxychloroquine (HCQ) have been touted as promising and effective treatments for patients with COVID-19 infection. The drugs are often recommended to be used together with azithromycin, an antibiotic. On March 21, 2020, Presiden...

High-Dose CQ Tied to Death, Cardiac Events in COVID-19 Patients
https://www.medpagetoday.com/infectiousdisease/covid19/86151

Apr 24th, 2020 - Hospitalized patients with COVID-19 coronavirus infection treated with high-dose chloroquine diphosphate (CQ) in conjunction with azithromycin or oseltamivir experienced higher rates of death and adverse cardiac events compared with a low-dose gro...

see more →

Patient Education  1 results see all →