Circulation Adam J. Nelson et al
Nov 30th, 2019 - Antithrombotic therapy for cardiovascular disease revolves around balancing 2 key outcomes—reducing ischemic events without increasing bleeding. There has been a subtle but progressive shift away from a dominant focus on reducing ischemic events to a more balanced and explicit interest in avoiding bleeding. Bleeding is common and, in part, an expected result of the increased use of anticoagulan...
Journal of the American Heart Association; Caraballo C, et al
Nov 26th, 2019 - The New York Heart Association (NYHA) classification has served as a fundamental tool for risk stratification of heart failure (HF) and determines clinical trial eligibility and candidacy for drugs and devices. However, its ability to adequately stratify risk is unclear.
Circulation Schnabel RB, et al
Nov 25th, 2019 - Cardiac thromboembolism attributed to atrial fibrillation (AF) is responsible for up to one-third of ischemic strokes. Stroke may be the first manifestation of previously undetected AF. Given the efficacy of oral anticoagulants in preventing AF-related ischemic strokes, strategies of searching for AF after a stroke using ECG monitoring followed by oral anticoagulation (OAC) treatment have been ...
European Heart Journal; Sturgeon KM, et al
Nov 24th, 2019 - This observational study characterized cardiovascular disease (CVD) mortality risk for multiple cancer sites, with respect to the following: (i) continuous calendar year, (ii) age at diagnosis, and (iii) follow-up time after diagnosis.
Annals of Internal Medicine; James Sall, et al
Nov 20th, 2019 - In June 2019, the U.S. Department of Veterans Affairs (VA) and U.S. Department of Defense (DoD) approved an update of the joint clinical practice guideline for rehabilitation after stroke. This synopsis summarizes the key recommendations from this guideline.
New England Journal of Medicine; Tardif JC et al
Nov 16th, 2019 - Experimental and clinical evidence support the role of inflammation in atherosclerosis and its complications. Colchicine is an orally administered, potent antiinflammatory medication that is indicated for the treatment of gout and pericarditis.
Circulation Peter A. Noseworthy, et al.
Nov 14th, 2019 - The widespread use of cardiac implantable electronic devices and wearable monitors has led to the detection of subclinical atrial fibrillation in a substantial proportion of patients. There is evidence that these asymptomatic arrhythmias are associated with increased risk of stroke. Thus, detection of subclinical atrial fibrillation may offer an opportunity to reduce stroke risk by initiating a...
HIV Medicine; Brusca RM, et al
Nov 13th, 2019 - Elite controllers (ECs), viraemic controllers (VCs), and long‐term nonprogressors (LTNPs) control HIV viral replication or maintain CD4 T‐cell counts without antiretroviral therapy, but may have increased cardiovascular disease (CVD) risk compared to HIV‐uninfected persons. We evaluated subclinical carotid and coronary atherosclerosis and inflammatory biomarker levels among HIV controllers, LTN...
Circulation: Cardiovascular Quality and Outcomes; Casey E, et al.
Nov 12th, 2019 - In 2018, the Task Force convened the writing committee to begin the process of revising the existing performance measures set for hypertension that had been released in 2011.3 The writing committee also was charged with the task of developing new measures to evaluate the care of patients in accordance with the 2017 Hypertension Clinical Practice Guidelines.4 The writing committee developed a...
Nephrology Dialysis Transplantation; Kalantar-Zadeh K, et al
Nov 6th, 2019 - How often have you been told to eat more protein and less carbohydrates to stay healthy? This is not an emerging food culture but rather a prevailing dogma in our society. Physicians, dietitians and other health care professionals tell us constantly about the advantages of a high-protein diet (HPD), such as losing weight rapidly, burning calories, diminishing appetite, preventing obesity, manag...
American Family Physician; JEFFREY C. LEGGIT, MD
Nov 5th, 2019 - RAS inhibitors have been widely prescribed to treat hypertension; however, it remains unclear whether they are superior to other antihypertensive drugs in terms of clinically relevant outcomes for primary hypertension.
Oct 23rd, 2019 - Uncertainty remains about the optimal monotherapy for hypertension, with current guidelines recommending any primary agent among the first-line drug classes thiazide or thiazide-like diuretics, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, dihydropyridine calcium channel blockers, and non-dihydropyridine calcium channel blockers, in the absence of comorbid indications...
Circulation Drazner, M. et. al.
Oct 20th, 2019 - This article is a commentary on the following Prognostic Implications of Congestion on Physical Examination Among Contemporary Patients With Heart Failure and Reduced Ejection Fraction
Oct 20th, 2019 - AstraZeneca today announced that the US Food and Drug Administration (FDA) has approved Farxiga (dapagliflozin) to reduce the risk of hospitalisation for heart failure (hHF) in adults with type-2 diabetes (T2D) and established cardiovascular disease (CVD) or multiple cardiovascular (CV) risk factors.
Oct 17th, 2019 - TCT 2019 in San Francisco has left us with a few trials that potentially may change our interventional practice. The COMPLETE study is now complete! To refresh your memory, the COMPLETE trial was presented at ESC Congress 2019, one month before TCT, and studied patients presented with STEMI and multivessel disease. At a median of three-years follow-up, complete revascularization was superior to...
JAMA Cardiology; Chen, Y. et. al.
Oct 15th, 2019 - Question How have the trends in premature mortality from cardiovascular disease (CVD) changed in the United States during 2000 to 2015 by demographics and county-level factors, including education, rurality, and the prevalence of smoking, obesity, and diabetes? Findings In this study, CVD mortality rates increased significantly among American Indian/Alaska Native individuals age 25 to 49 y...
BMJ Byrne, P. et. al.
Oct 15th, 2019 - Statins are now the most commonly used drug in the UK and one of the most commonly used medicines in the world.12 Although prices have fallen since their patents expired, statins account for substantial drug expenditure in a context of often overstretched healthcare budgets, with estimated global sales approaching $1tn by 2020.3 Use of statins in people with established cardiovascular disease i...
European Heart Journal; Grant, P. et. al.
Oct 13th, 2019 - The prevalence of diabetes continues to increase, with 60 million thought to have diabetes in Europe in 2017 and predictions of more than 600 million individuals with diabetes worldwide by 2045. These numbers carry a huge burden of morbidity and mortality with a high prevalence of microvascular disease affecting the eyes, nerves, and kidneys and macrovascular disease leading to CV, cerebrovascu...
JAMA Cardiology; Wang, S. et. al.
Oct 8th, 2019 - Question What is the association between bidirectional income change and cardiovascular disease? Findings In this cohort study of middle-aged, community-dwelling adults, a more than 50% income drop was significantly associated with higher risk of incident cardiovascular disease, while a more than 50% income rise was significantly associated with lower risk of incident cardiovascular diseas...
Circulation Kramer, C. et. al.
Oct 7th, 2019 - Dog ownership has been associated with decreased cardiovascular risk. Recent reports have suggested an association of dog companionship with lower blood pressure levels, improved lipid profile, and diminished sympathetic responses to stress. However, it is unclear if dog ownership is associated with improved survival as previous studies have yielded inconsistent results. Thus, we performed a sy...