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About 908 results

ALLMedicine™ Malignant Hyperthermia Center

Research & Reviews  324 results

Malignant Hyperthermia-A Case From Camp Humphreys, South Korea, and Lessons for the Mil...
https://doi.org/10.1093/milmed/usab281
Military Medicine; Wren P, Chun SM et. al.

Jul 18th, 2021 - Although malignant hyperthermia (MH) is a well-known complication of anesthesia, it presents unique considerations in the military health system. In this case report, the authors present a 26-year-old male active duty service member who experience...

A novel RyR1-selective inhibitor prevents and rescues sudden death in mouse models of m...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8277899
Nature Communications; Yamazawa T, Kobayashi T et. al.

Jul 15th, 2021 - Mutations in the type 1 ryanodine receptor (RyR1), a Ca2+ release channel in skeletal muscle, hyperactivate the channel to cause malignant hyperthermia (MH) and are implicated in severe heat stroke. Dantrolene, the only approved drug for MH, has t...

Functional Characterization of Endogenously Expressed Human RYR1 Variants.
https://doi.org/10.3791/62196
Journal of Visualized Experiments : JoVE; Treves S, Girard T et. al.

Jun 29th, 2021 - More than 700 variants in the RYR1 gene have been identified in patients with different neuromuscular disorders including malignant hyperthermia susceptibility, core myopathies and centronuclear myopathy. Because of the diverse phenotypes linked t...

Functional Calsequestrin-1 Is Expressed in the Heart and Its Deficiency Is Causally Rel...
https://doi.org/10.1161/CIRCULATIONAHA.121.053255
Circulation Sun Z, Wang L et. al.

Jun 25th, 2021 - Background: Calsequestrins (Casqs), comprising the Casq1 and Casq2 isoforms, buffer Ca2+ and regulate its release in the sarcoplasmic reticulum (SR) of skeletal and cardiac muscle, respectively. Human inherited diseases associated with mutations i...

Comments on: "Postoperative Hyperthermia and Hemodynamic Instability in a Suspected Mal...
https://doi.org/10.1213/XAA.0000000000001471
A&A Practice; Kaplan RF

Jun 24th, 2021 - Comments on: "Postoperative Hyperthermia and Hemodynamic Instability in a Suspected Malignant Hyperthermia Susceptible Patient: A Case Report".|2021|Kaplan RF,|

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Guidelines  4 results

Consensus guidelines on perioperative management of malignant hyperthermia suspected or...
https://doi.org/10.1016/j.bja.2020.09.029
British Journal of Anaesthesia; Rüffert H, Bastian B et. al.

Nov 3rd, 2020 - Malignant hyperthermia is a potentially fatal condition, in which genetically predisposed individuals develop a hypermetabolic reaction to potent inhalation anaesthetics or succinylcholine. Because of the rarity of malignant hyperthermia and ethic...

Availability of dantrolene for the management of malignant hyperthermia crises: Europea...
https://doi.org/10.1016/j.bja.2020.04.089
British Journal of Anaesthesia; Glahn KPE, Bendixen D et. al.

Jun 28th, 2020 - Faced with a malignant hyperthermia crisis, the immediate access to sufficient dantrolene is essential to achieve the best possible outcome for the patient. However, malignant hyperthermia crises are rare, and there may be administrative pressures...

Malignant Hyperthermia-Susceptible Adult Patient and Ambulatory Surgery Center: Society...
https://doi.org/10.1213/ANE.0000000000004257
Anesthesia and Analgesia; Urman RD, Rajan N et. al.

Jun 6th, 2019 - This document represents a joint effort of the Society for Ambulatory Anesthesia (SAMBA) and the Ambulatory Surgical Care Committee of the American Society of Anesthesiologists (ASA) concerning the safe anesthetic care of adult malignant hyperther...

Special article: Creation of a guide for the transfer of care of the malignant hyperthe...
https://doi.org/10.1213/ANE.0b013e3182373b4a
Anesthesia and Analgesia; Larach MG, Dirksen SJ et. al.

Nov 5th, 2011 - Volatile anesthetics and/or succinylcholine may trigger a potentially lethal malignant hyperthermia (MH) event requiring critical care crisis management. If the MH triggering anesthetic is given in an ambulatory surgical center (ASC), then the pat...

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Drugs  14 results see all →

Clinicaltrials.gov  7 results

Effect of an Electronic Cognitive Aid Versus Static Cognitive Aid on the Management of a Simulated Crisis
https://clinicaltrials.gov/ct2/show/NCT02440607

Sep 11th, 2019 - Clinical decision support tools with in the electronic medical record can improve clinical care processes. To date, there is little evidence evaluating crisis management with such decision support tools. The investigators aim to create an electron...

A Case Control Study of Patients With Diagnosis of Malignant Hyperthermia
https://clinicaltrials.gov/ct2/show/NCT02561598

Feb 1st, 2019 - The current study will use the combination of electronic medical records and genomic information in samples of persons who have exhibited signs of Malignant Hyperthermia (MH) or have family history or high risk of MH to see if risk factors can be ...

Use of a Hand-held Digital Cognitive Aid in the Early Management of Simulated War Wounds.
https://clinicaltrials.gov/ct2/show/NCT03483727

Mar 30th, 2018 - In a first study (MAX, BJA 2017, Lelaidier et al) the investigators designed a digital cognitive aid (MAX for Medical Assistant eXpert) under the form of a smartphone application including 5 scenarios of anaesthesia and intensive care crises (mali...

Pharmacokinetic/Pharmacodynamic Model of Propofol in Children
https://clinicaltrials.gov/ct2/show/NCT02544854

Oct 12th, 2016 - Propofol is an intravenous anesthetic capable of providing a safe general anesthesia, free from many of the adverse effects associated with inhalation anesthetics (postoperative nausea and vomiting, agitation on awakening, seizures and trigger mal...

Use of a Wearable Digital Cognitive Aid in Simulated Anesthesia and Intensive Care Crises.
https://clinicaltrials.gov/ct2/show/NCT02678819

Jul 26th, 2016 - " Errare humanum est ", to err is human. This Latin saying attributed to Seneca shows that since the dawn of time, human beings are aware that managing complex situations will always be an inexhaustible source of mistakes. This is particularly tru...

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News  11 results

Coronavirus (COVID-19) Update: Daily Roundup May 26, 2020
http://www.fda.gov/news-events/press-announcements/coronavirus-covid-19-update-daily-roundup-may-26-2020

For Immediate Release: May 26, 2020 The U.S. Food and Drug Administration today announced the following actions taken in its ongoing response effort to the COVID-19 pandemic: The FDA issued an Emergency Use Authorization (EUA) in response to conce...

Coronavirus (COVID-19) Update: December 22, 2020
http://www.fda.gov/news-events/press-announcements/coronavirus-covid-19-update-december-22-2020

For Immediate Release: December 22, 2020 The U.S. Food and Drug Administration today announced the following actions taken in its ongoing response effort to the COVID-19 pandemic: The FDA has posted translations of the Moderna COVID-19 Vaccine fac...

Coronavirus (COVID-19) Update: Daily Roundup June 17, 2020
http://www.fda.gov/news-events/press-announcements/coronavirus-covid-19-update-daily-roundup-june-17-2020

For Immediate Release: June 17, 2020 The U.S. Food and Drug Administration today announced the following actions taken in its ongoing response effort to the COVID-19 pandemic: On June 16, 2020, the FDA approved an abbreviated new drug application ...

Coronavirus (COVID-19) Update: Daily Roundup May 19, 2020
http://www.fda.gov/news-events/press-announcements/coronavirus-covid-19-update-daily-roundup-may-19-2020

For Immediate Release: May 19, 2020 The U.S. Food and Drug Administration today announced the following actions taken in its ongoing response effort to the COVID-19 pandemic: Today, the FDA approved succinylcholine chloride injection USP 200 mg/10...

A 26-Year-Old Woman With Confusion and Hyperthermia
https://reference.medscape.com/viewarticle/876162_4

Feb 24th, 2017 - Besides serotonin syndrome, other differential diagnoses were considered but excluded in this case. Neuroleptic malignant syndrome (NMS) is an idiopathic drug reaction to antipsychotics that has a presentation similar to that of serotonin syndrome...

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Patient Education  3 results see all →