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About 1,745 results

ALLMedicine Malignant Hyperthermia Center

Research & Reviews  835 results

Trihexyphenidyl induced malignant hyperthermia in a patient with Parkinson's disease co...
https://doi.org/10.1097/MD.0000000000020129
Medicine Zhao J, Xu G et. al.

May 23rd, 2020 - Drug-induced fever is easy to overlook in respiratory departments. High fever is a rare side effect of trihexyphenidyl, which can be used clinically to treat Parkinson's disease. Syndrome of inappropriate antidiuretic hormone secretion (SIADH) is ...

Approaches To Optimizing Dantrolene Neuroprotection For The Treatment Of Alzheimer's Di...
https://doi.org/10.2174/1567205017666200522204722
Current Alzheimer Research; Abou MB, Sun L et. al.

May 22nd, 2020 - Alzheimer's Disease (AD), a neurodegenerative disorder with high incidence and mortality, is leading its way to the top of the list of the deadliest diseases [1], without an effective disease-modifying drug. Ca2+ dysregulation, specifically abnorm...

A "crush" course on rhabdomyolysis: risk stratification and clinical management update ...
https://doi.org/10.1007/s00540-020-02792-w
Journal of Anesthesia; Cote DR, Fuentes E et. al.

May 17th, 2020 - Rhabdomyolysis, the release of myoglobin and other cellular breakdown products from necrotic muscle tissue, is seen in patients with crush injuries, drug overdose, malignant hyperthermia, muscular dystrophy, and with increasing frequency in obese ...

Preclinical model systems of ryanodine receptor 1-related myopathies and malignant hype...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204063
Orphanet Journal of Rare Diseases; Lawal TA, Wires ES et. al.

May 9th, 2020 - Pathogenic variations in the gene encoding the skeletal muscle ryanodine receptor (RyR1) are associated with malignant hyperthermia (MH) susceptibility, a life-threatening hypermetabolic condition and RYR1-related myopathies (RYR1-RM), a spectrum ...

Hypermetabolic Syndrome and Dyskinesia After Neurologic Surgery for Labrune Syndrome: A...
https://doi.org/10.1213/XAA.0000000000001212
A&A Practice; Holland EL, Saneto RP et. al.

May 5th, 2020 - A 20-year-old man with a rare neurodegenerative disease developed hypermetabolic symptoms with dyskinesia after a third ventriculostomy for hydrocephalus. The initial presentation was concerning for an acute dystonic reaction after metoclopramide ...

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Guidelines  5 results

Malignant Hyperthermia-Susceptible Adult Patient and Ambulatory Surgery Center: Society...
https://doi.org/10.1213/ANE.0000000000004257
Anesthesia and Analgesia; Urman RD, Rajan N et. al.

Jun 5th, 2019 - This document represents a joint effort of the Society for Ambulatory Anesthesia (SAMBA) and the Ambulatory Surgical Care Committee of the American Society of Anesthesiologists (ASA) concerning the safe anesthetic care of adult malignant hyperther...

JSA guideline for the management of malignant hyperthermia crisis 2016.
https://doi.org/10.1007/s00540-016-2305-z
Journal of Anesthesia;

Mar 1st, 2017 - Malignant hyperthermia (MH) can be fatal if the crisis is not appropriately treated. It is an inherited disease usually triggered by the administration of volatile inhalational anesthetics and/or succinylcholine, a muscle relaxant. In a patient wi...

European Malignant Hyperthermia Group guidelines for investigation of malignant hyperth...
https://doi.org/10.1093/bja/aev225
British Journal of Anaesthesia; Hopkins PM, Rüffert H et. al.

Jul 18th, 2015 - It is 30 yr since the British Journal of Anaesthesia published the first consensus protocol for the laboratory diagnosis of malignant hyperthermia susceptibility from the European Malignant Hyperthermia Group. This has subsequently been used in mo...

Special article: Creation of a guide for the transfer of care of the malignant hyperthe...
https://doi.org/10.1213/ANE.0b013e3182373b4a
Anesthesia and Analgesia; Larach MG, Dirksen SJ et. al.

Nov 4th, 2011 - Volatile anesthetics and/or succinylcholine may trigger a potentially lethal malignant hyperthermia (MH) event requiring critical care crisis management. If the MH triggering anesthetic is given in an ambulatory surgical center (ASC), then the pat...

Recognizing and managing a malignant hyperthermia crisis: guidelines from the European ...
https://doi.org/10.1093/bja/aeq243
British Journal of Anaesthesia; Glahn KP, Ellis FR et. al.

Sep 14th, 2010 - Survival from a malignant hyperthermia (MH) crisis is highly dependent on early recognition and prompt action. MH crises are very rare and an increasing use of total i.v. anaesthesia is likely to make it even rarer, leading to the potential risk o...

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Drugs  7 results see all →

Clinicaltrials.gov  875 results

Trihexyphenidyl induced malignant hyperthermia in a patient with Parkinson's disease co...
https://doi.org/10.1097/MD.0000000000020129
Medicine Zhao J, Xu G et. al.

May 23rd, 2020 - Drug-induced fever is easy to overlook in respiratory departments. High fever is a rare side effect of trihexyphenidyl, which can be used clinically to treat Parkinson's disease. Syndrome of inappropriate antidiuretic hormone secretion (SIADH) is ...

Approaches To Optimizing Dantrolene Neuroprotection For The Treatment Of Alzheimer's Di...
https://doi.org/10.2174/1567205017666200522204722
Current Alzheimer Research; Abou MB, Sun L et. al.

May 22nd, 2020 - Alzheimer's Disease (AD), a neurodegenerative disorder with high incidence and mortality, is leading its way to the top of the list of the deadliest diseases [1], without an effective disease-modifying drug. Ca2+ dysregulation, specifically abnorm...

A "crush" course on rhabdomyolysis: risk stratification and clinical management update ...
https://doi.org/10.1007/s00540-020-02792-w
Journal of Anesthesia; Cote DR, Fuentes E et. al.

May 17th, 2020 - Rhabdomyolysis, the release of myoglobin and other cellular breakdown products from necrotic muscle tissue, is seen in patients with crush injuries, drug overdose, malignant hyperthermia, muscular dystrophy, and with increasing frequency in obese ...

Preclinical model systems of ryanodine receptor 1-related myopathies and malignant hype...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204063
Orphanet Journal of Rare Diseases; Lawal TA, Wires ES et. al.

May 9th, 2020 - Pathogenic variations in the gene encoding the skeletal muscle ryanodine receptor (RyR1) are associated with malignant hyperthermia (MH) susceptibility, a life-threatening hypermetabolic condition and RYR1-related myopathies (RYR1-RM), a spectrum ...

Hypermetabolic Syndrome and Dyskinesia After Neurologic Surgery for Labrune Syndrome: A...
https://doi.org/10.1213/XAA.0000000000001212
A&A Practice; Holland EL, Saneto RP et. al.

May 5th, 2020 - A 20-year-old man with a rare neurodegenerative disease developed hypermetabolic symptoms with dyskinesia after a third ventriculostomy for hydrocephalus. The initial presentation was concerning for an acute dystonic reaction after metoclopramide ...

see more →

News  19 results

FDA rejects Eagle Pharmaceuticals' heat stroke treatment
https://www.reuters.com/article/us-eagle-pharms-fda/fda-rejects-eagle-pharmaceuticals-heat-stroke-treatment-idUSKBN1AB2D8

Jul 26th, 2017 - (Reuters) - Eagle Pharmaceuticals Inc said on Wednesday the U.S. Food and Drug Administration declined to approve its drug Ryanodex to treat heat stroke and requested an additional clinical trial, sending its shares down 20 percent. The drug, whic...

Coronavirus (COVID-19) Update: Daily Roundup May 19, 2020
http://www.fda.gov/news-events/press-announcements/coronavirus-covid-19-update-daily-roundup-may-19-2020

For Immediate Release: May 19, 2020 The U.S. Food and Drug Administration today announced the following actions taken in its ongoing response effort to the COVID-19 pandemic: Today, the FDA approved succinylcholine chloride injection USP 200 mg/10...

Study explains link between malignant hyperthermia and bleeding abnormalities
https://www.mdedge.com/hematology-oncology/article/187232/thrombosis/study-explains-link-between-malignant-hyperthermia-and-bleeding
HT Staff

Jul 6th, 2016 - Lab mouse A new study helps explain why some patients with malignant hyperthermia may suffer from excessive bleeding. The findings suggest a mutation that causes malignant hyperthermia can disrupt calcium signaling in vascular smooth muscle cells,.

FDA OKs Injectable Dantrolene for Malignant Hyperthermia
https://www.medscape.com/viewarticle/828813

Jul 22nd, 2014 - The US Food and Drug Administration (FDA) has approved an injectable form of dantrolene sodium (Ryanodex, Eagle Pharmaceuticals) for rapid treatment of malignant hyperthermia (MH), along with the appropriate supportive measures, the company announ...

Surgicenters Need Plans for Malignant Hyperthermia
https://www.medpagetoday.com/surgery/anesthesiology/30430

Dec 29th, 2011 - Action Points Explain that ambulatory surgical centers need to have policies and equipment in place to handle malignant hyperthermia, a rare but potentially lethal complication of anesthesia. Point out that facilities must have the muscle relaxant...

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Patient Education  4 results see all →