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About 1,762 results

ALLMedicine™ Malignant Hyperthermia Center

Research & Reviews  853 results

Impact of statin intake on malignant hyperthermia: an in vitro and in vivo swine study.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7585199
BMC Anesthesiology; Gonzalez A, Iles TL et. al.

Oct 24th, 2020 - Statin intake is associated with muscular side effects, among which the unmasking of latent myopathies and of malignant hyperthermia (MH) susceptibility have been reported. These findings, together with experimental data in small animals, prompt s...

Adaptive thermogenesis enhances the life-threatening response to heat in mice with an R...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7547078
Nature Communications; Wang HJ, Lee CS et. al.

Oct 10th, 2020 - Mutations in the skeletal muscle Ca2+ release channel, the type 1 ryanodine receptor (RYR1), cause malignant hyperthermia susceptibility (MHS) and a life-threatening sensitivity to heat, which is most severe in children. Mice with an MHS-associate...

Genomic Screening for Malignant Hyperthermia Susceptibility.
https://doi.org/10.1097/ALN.0000000000003547
Anesthesiology Biesecker LG, Dirksen RT et. al.

Sep 8th, 2020 - Malignant hyperthermia (MH) was described 60 yr ago and understanding of the clinical and pathophysiologic features of this syndrome continue to advance. MH is attributed to a genetically determined susceptibility to an abnormal skeletal muscle ce...

Malignant Hyperthermia.
https://doi.org/10.1002/aorn.13167
AORN Journal REFERENCES; Spruce L

Aug 28th, 2020 - Malignant Hyperthermia.|2020|Spruce L,|

A multi-dimensional analysis of genotype-phenotype discordance in malignant hyperthermi...
https://doi.org/10.1016/j.bja.2020.07.042
British Journal of Anaesthesia; Ibarra Moreno CA, Kraeva N et. al.

Aug 25th, 2020 - Malignant hyperthermia (MH) susceptibility is an inherited condition, diagnosed either by the presence of a pathogenic genetic variant or by in vitro caffeine-halothane contracture testing. Through a multi-dimensional approach, we describe the imp...

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Guidelines  7 results

Availability of dantrolene for the management of malignant hyperthermia crises: Europea...
https://doi.org/10.1016/j.bja.2020.04.089
British Journal of Anaesthesia; Glahn KPE, Bendixen D et. al.

Jun 27th, 2020 - Faced with a malignant hyperthermia crisis, the immediate access to sufficient dantrolene is essential to achieve the best possible outcome for the patient. However, malignant hyperthermia crises are rare, and there may be administrative pressures...

Malignant Hyperthermia-Susceptible Adult Patient and Ambulatory Surgery Center: Society...
https://doi.org/10.1213/ANE.0000000000004257
Anesthesia and Analgesia; Urman RD, Rajan N et. al.

Jun 5th, 2019 - This document represents a joint effort of the Society for Ambulatory Anesthesia (SAMBA) and the Ambulatory Surgical Care Committee of the American Society of Anesthesiologists (ASA) concerning the safe anesthetic care of adult malignant hyperther...

JSA guideline for the management of malignant hyperthermia crisis 2016.
https://doi.org/10.1007/s00540-016-2305-z
Journal of Anesthesia;

Mar 1st, 2017 - Malignant hyperthermia (MH) can be fatal if the crisis is not appropriately treated. It is an inherited disease usually triggered by the administration of volatile inhalational anesthetics and/or succinylcholine, a muscle relaxant. In a patient wi...

European Malignant Hyperthermia Group guidelines for investigation of malignant hyperth...
https://doi.org/10.1093/bja/aev225
British Journal of Anaesthesia; Hopkins PM, Rüffert H et. al.

Jul 18th, 2015 - It is 30 yr since the British Journal of Anaesthesia published the first consensus protocol for the laboratory diagnosis of malignant hyperthermia susceptibility from the European Malignant Hyperthermia Group. This has subsequently been used in mo...

Special article: Creation of a guide for the transfer of care of the malignant hyperthe...
https://doi.org/10.1213/ANE.0b013e3182373b4a
Anesthesia and Analgesia; Larach MG, Dirksen SJ et. al.

Nov 4th, 2011 - Volatile anesthetics and/or succinylcholine may trigger a potentially lethal malignant hyperthermia (MH) event requiring critical care crisis management. If the MH triggering anesthetic is given in an ambulatory surgical center (ASC), then the pat...

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Drugs  7 results see all →

Clinicaltrials.gov  883 results

Impact of statin intake on malignant hyperthermia: an in vitro and in vivo swine study.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7585199
BMC Anesthesiology; Gonzalez A, Iles TL et. al.

Oct 24th, 2020 - Statin intake is associated with muscular side effects, among which the unmasking of latent myopathies and of malignant hyperthermia (MH) susceptibility have been reported. These findings, together with experimental data in small animals, prompt s...

Adaptive thermogenesis enhances the life-threatening response to heat in mice with an R...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7547078
Nature Communications; Wang HJ, Lee CS et. al.

Oct 10th, 2020 - Mutations in the skeletal muscle Ca2+ release channel, the type 1 ryanodine receptor (RYR1), cause malignant hyperthermia susceptibility (MHS) and a life-threatening sensitivity to heat, which is most severe in children. Mice with an MHS-associate...

Genomic Screening for Malignant Hyperthermia Susceptibility.
https://doi.org/10.1097/ALN.0000000000003547
Anesthesiology Biesecker LG, Dirksen RT et. al.

Sep 8th, 2020 - Malignant hyperthermia (MH) was described 60 yr ago and understanding of the clinical and pathophysiologic features of this syndrome continue to advance. MH is attributed to a genetically determined susceptibility to an abnormal skeletal muscle ce...

Ryanodex dantrolene sodium - dantrolene sodium injection, suspension-Eagle Pharmaceuticals, Inc.
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=8f7b3ac0-604d-4c78-b545-5e0f8ea3d698

Sep 6th, 2020 - RYANODEX® is indicated for the: Treatment of malignant hyperthermia in conjunction with appropriate supportive measures [see Dosage and Administration (2.1)] Prevention of malignant hyperthermia in patients at high risk. RYANODEX is a skeletal mus...

Malignant Hyperthermia.
https://doi.org/10.1002/aorn.13167
AORN Journal REFERENCES; Spruce L

Aug 28th, 2020 - Malignant Hyperthermia.|2020|Spruce L,|

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News  7 results

Coronavirus (COVID-19) Update: Daily Roundup June 17, 2020
http://www.fda.gov/news-events/press-announcements/coronavirus-covid-19-update-daily-roundup-june-17-2020

For Immediate Release: June 17, 2020 The U.S. Food and Drug Administration today announced the following actions taken in its ongoing response effort to the COVID-19 pandemic: On June 16, 2020, the FDA approved an abbreviated new drug application ...

Coronavirus (COVID-19) Update: Daily Roundup May 19, 2020
http://www.fda.gov/news-events/press-announcements/coronavirus-covid-19-update-daily-roundup-may-19-2020

For Immediate Release: May 19, 2020 The U.S. Food and Drug Administration today announced the following actions taken in its ongoing response effort to the COVID-19 pandemic: Today, the FDA approved succinylcholine chloride injection USP 200 mg/10...

Study explains link between malignant hyperthermia and bleeding abnormalities
https://www.mdedge.com/hematology-oncology/article/187232/thrombosis/study-explains-link-between-malignant-hyperthermia-and-bleeding
HT Staff

Jul 6th, 2016 - Lab mouse A new study helps explain why some patients with malignant hyperthermia may suffer from excessive bleeding. The findings suggest a mutation that causes malignant hyperthermia can disrupt calcium signaling in vascular smooth muscle cells,.

Surgicenters Need Plans for Malignant Hyperthermia
https://www.medpagetoday.com/surgery/anesthesiology/30430

Dec 29th, 2011 - Action Points Explain that ambulatory surgical centers need to have policies and equipment in place to handle malignant hyperthermia, a rare but potentially lethal complication of anesthesia. Point out that facilities must have the muscle relaxant...

New Mutation Linked to Malignant Hyperthermia
https://www.medpagetoday.com/surgery/anesthesiology/10635

Aug 22nd, 2008 - Action Points Explain to interested patients that malignant hyperthermia is a dangerous and often deadly reaction to some anesthetics. Note that susceptibility to the condition is currently diagnosed with an invasive test that involves removing mu...

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Patient Education  5 results see all →