ALLMedicine™ Organ Transplantation Center

Dec 2nd, 2022 - Combined heart and liver transplantation (CHLT) is an uncommon but increasingly performed procedure with rising need as the population who has undergone Fontan palliation for single ventricle physiology grows. This article reviews the current lite...

Dec 2nd, 2022 - Burkitt lymphoma arising in paediatric post-solid-organ transplantation-Burkitt lymphoma (PSOT-BL) is a clinically aggressive malignancy and a rare form of post-transplant lymphoproliferative disorder (PTLD). We evaluated 35 patients diagnosed wit...

Dec 1st, 2022 - This study aims to translate the Pediatric Transplant Rating Instrument (P-TRI) to conduct a validity and reliability study on Turkish children and define a cutoff value of this scale. A total of 151 pediatric kidney transplant patients were inclu...

Dec 1st, 2022 - To explore the acceptances and associated influences of organ donation in mainland China. The shortage of organ donors has limited the development of organ transplantation in China. It is important to recognise the target population who has high i...

Nov 30th, 2022 - Tacrolimus (Tac) is a common immunosuppressant that used in organ transplantation. However, its therapeutic index is narrow, and it is prone to adverse side effects, along with an increased risk of toxicity, namely, cardio-, nephro-, hepato-, and ...

Apr 5th, 2022 - Controlled organ donation after circulatory determination of death is increasingly being used for the donation of organs also in thoracic transplantation. This document outlines the position of the International Society for Heart and Lung Transpla...

Mar 31st, 2021 - Cancer immunotherapy based on the use of antibodies targeting the so-called checkpoint inhibitors, such as programmed cell death-1 receptor, its ligand, or CTLA-4, has shown durable clinical benefit and survival improvement in melanoma and other t...

Jul 2nd, 2020 - Chronic metabolic alterations such as post-transplant diabetes mellitus (PTDM), dyslipidaemias and overweight/obesity significantly impact on kidney transplant (KT) outcomes. This joint position statement is based on the evidence on the management...

Jun 7th, 2020 - Intraoperative transesophageal echocardiography is a standard diagnostic and monitoring tool employed in the management of patients undergoing an entire spectrum of cardiac surgical procedures, ranging from "routine" surgical coronary revasculariz...

Mar 9th, 2020 - Significant practice-changing developments have occurred in the care of heart transplantation candidates and recipients over the past decade. This Canadian Cardiovascular Society/Canadian Cardiac Transplant Network Position Statement provides evid...

Oct 14th, 2022 - As defined by the European Hernia Society, eventration or incisional hernia is any defect in the abdominal wall with or without an associated bulge in the area of a surgical scar that is noticeable or palpable by physical examination or imaging te...

Oct 14th, 2022 - The hypothesis is that Sirolimus, (Rapamycin (R)) which is currently used in organ transplantation and works by blocking the activity of T effector cells but preserving T regulatory cells, as well as by inducing autophagy (protein degradation), wi...

Oct 14th, 2022 - Human leukocyte antigen (HLA) alloimmunization is common in patients undergoing frequent platelet transfusion, and is the most important cause of immune platelet refractoriness. Management strategies in HLA alloimmune platelet-refractory patients ...

Oct 12th, 2022 - Acute rejection (AR) occurs within the first 6 months after transplantation in 20 percent of heart transplant patients and in 50 percent of lung-transplant patients. Given the often silent clinical presentation of AR, these patients require monito...

Sep 21st, 2022 - Methylmalonic acidemia (MMA), one of the most common inborn errors of organic acid metabolism, is heterogeneous in etiology and clinical manifestations. Affected patients with cblA, cblB and mut classes of MMA are medically fragile and can suffer ...

Nov 21st, 2022 - CTX130, an investigational allogeneic, CRISP/Cas9 gene-edited, anti-CD70 CAR T-cell therapy, was found to be safe with early signs of clinical activity in patients with advanced clear cell renal cell carcinoma (RCC), according to findings from the...

Nov 17th, 2022 - Onatasertib (ATG-008) plus toripalimab elicited an objective response rate (ORR) of 52.4% in patients with relapsed or metastatic cervical cancer, irrespective of PD-L1 expression, according to preliminary data from the phase 2 TORCH trial (NCT035...

Nov 15th, 2022 - The mTOR inhibitor nab-sirolimus (ABI-009) may emerge as an effective and tolerable treatment in patients with gynecologic cancers with TSC1 and TSC2 mutations, according to Kathleen N. Moore, MD, MS. The phase 2 PRECISION 1 trial (NCT05103358) i...

Oct 11th, 2022 - In 2016, the Organ Procurement and Transplantation Network (OPTN), which is administered by the United Network for Organ Sharing (UNOS), approved a new heart allocation policy that went into effect October 18, 2018. The revised policy reflected th...

Sep 14th, 2022 -   1 Million Transplants, but Problems Remain It's a milestone: The United States has seen 1 million organ transplants since the first one was performed here in 1954. The record was reported by the United Network for Organ Sharing, the private nonp...