About 3,848 results

ALLMedicine™ Acute Liver Failure Center

Research & Reviews  1,397 results

The application of cytokeratin-18 as a biomarker for drug-induced liver injury.
https://doi.org/10.1007/s00204-021-03121-0 10.4254/wjh.v9.i10.491 10.2353/ajpath.2009.080976 10.1155/2016/9737920 10.1016/j.therap.2018.02.004 10.1093/toxsci/kfs243 10.1093/toxsci/kfy282 10.1055/s-2003-42640 10.18632/oncotarget.12325 10.1016/j.ajpath.2018.12.006 10.1002/jps.3030470706 10.1002/(SICI)1096-9896(199807)185:3 10.1083/jcb.138.6.1379 10.1111/liv.13441 10.1002/hep.29802 10.1016/bs.apha.2019.03.001 10.1016/s0955-0674(01)00301-5 10.1124/jpet.105.088898 10.1016/j.prp.2020.152901 10.1152/ajpgi.00575.2005 10.1111/j.1600-0773.1964.tb01784.x 10.1007/s00210-019-01618-1 10.1016/S0960-9822(98)70438-5 10.5858/arpa.2014-0214-RA 10.1016/j.nmd.2013.09.004 10.1002/pds.1207 10.1111/j.1478-3231.2006.01380.x 10.1208/aapsj080106 10.1111/j.1572-0241.1999.01321.x 10.14218/jcth.2014.00014 10.1016/j.taap.2009.04.018 10.1111/j.1572-0241.2000.01707.x 10.1158/0008-5472.can-03-2455 10.1074/jbc.272.52.33197 10.1152/ajpgi.1999.277.6.G1108 10.1002/hep.20948 10.1002/(sici)1096-9896(199904)187:5 10.3181/00379727-102-25357 10.3748/wjg.v24.i37.4230 10.1177/0192623317707271 10.1533/9781908818270.1.25 10.1097/00001574-199905000-00005 10.1016/j.bbadis.2018.08.037 10.1172/JCI59755 10.1016/j.taap.2012.08.015 10.1016/0006-2952(91)90249-5 10.1080/01926230590881808 10.1016/0041-008X(88)90040-3 10.1158/1078-0432.Ccr-08-0111 10.1016/0092-8674(82)90400-7 10.1016/0140-6736(93)91818-7 10.3233/cbm-2009-0597 10.1016/j.tibs.2006.05.008 10.7326/0003-4819-137-12-200212170-00007 10.1007/s10620-015-3916-1 10.1001/archinte.1965.03860140008003 10.1245/s10434-012-2438-8 10.1053/j.gastro.2014.03.050 10.1152/ajpgi.00364.2014 10.1016/j.yexcr.2004.02.019 10.1038/209036a0 10.1016/j.bcp.2019.113664 10.1126/science.1260419 10.1016/j.cgh.2019.11.050 10.1002/hep.22633 10.1080/713611034 10.1038/clpt.2012.96 10.1016/j.taap.2015.09.022 10.1021/acs.jproteome.9b00047 10.1016/j.clinbiochem.2006.12.010 10.1186/s40779-015-0039-0 10.1111/j.1365-2036.2009.04148.x
Archives of Toxicology; Korver S, Bowen J et. al.

Jul 30th, 2021 - Drug-induced liver injury (DILI) is a frequent and dangerous adverse effect faced during preclinical and clinical drug therapy. DILI is a leading cause of candidate drug attrition, withdrawal and in clinic, is the primary cause of acute liver fail...

Distinct effects of different doses of kaempferol on D‑GalN/LPS‑induced ALF depend on t...
Molecular Medicine Reports; Tian Y, Ren F et. al.

Jul 29th, 2021 - Kaempferol, a flavonoid compound, has various biological functions, such as anti‑inflammatory and antitumor activities. Acute liver failure (ALF) is a lethal clinical syndrome that occurs due to severe damage of the liver function. In the present ...

Exosomes derived from human umbilical cord mesenchymal stem cells alleviate acetaminoph...
Journal of Pharmacological Sciences; Wu HY, Zhang XC et. al.

Jul 24th, 2021 - This study aimed to investigate the therapeutic potential of human umbilical cord mesenchymal stem cells derived exosomes (hUCMSC-Exo) in acute liver failure (ALF) in mice as well as its underlying mechanism. We found that a single tail vein admin...

Hypophosphatemia in acute liver failure of a broad range of etiologies is associated wi...
Translational Research : the Journal of Laboratory and Cl... Zechner C, Adams-Huet B et. al.

Jul 24th, 2021 - Hypophosphatemia is a common and dangerous complication of acute liver failure (ALF) of various etiologies. While various mechanisms for ALF-associated hypophosphatemia have been proposed including high phosphate uptake into regenerating hepatocyt...

see more →

Drugs  24 results see all →

Clinicaltrials.gov  22 results

A Multi-Center Trial to Study Acute Liver Failure in Adults

Mar 9th, 2020 - Although ALF is truly an orphan disease affecting only about 2,000 persons per year, its severity, its frequency among young adults, and its high resource utilization justifies the attention paid to it. In addition, ALF has captured the interest a...

To Assess the Role of Fecal Microbiota Transplant in Acute Liver Failure

Nov 5th, 2019 - All patients of Acute liver failure not meeting the KCH (King's College Hospital) criteria/or meeting KCH criteria not having option of liver transplant will be recruited for the trial. The first group will receive Standard medical care with Fecal...

36 Weeks Short-Term Optimization Treatment of Glucocorticosteroid in the Patients With Chronic Recurrent DILI

Jan 30th, 2019 - Drug-induced liver injury (DILI) refers to liver diseases caused by drugs and toxic substances. DILI is a clinical event that can be associated with severe outcomes such as acute liver failure. Up to now, approximately 1100 drugs, herbal products,...

Hepatocyte Transplantation for Acute Decompensated Liver Failure

Jan 23rd, 2019 - Orthotopic liver transplantation has become the treatment of choice for patients with acute liver failure with poor prognostic signs. Survival following hepatic transplantation has improved in the last decade for a number of reasons. These include...

Plasma Exchange and Continuous Hemodiafiltration in Treatment of Wilson's Disease-related Liver Failure

Jul 18th, 2018 - Wilson's disease (WD) is an inherited disorder in which defective biliary excretion of copper leads to its accumulation, particularly in liver and brain. Presenting symptoms of liver disease can be highly variable, ranging from asymptomatic, with ...

see more →

News  90 results

Liver Failure Management in the ICU: Clinical Practice Guidelines (2020)

Feb 28th, 2020 - In February 2020, a panel from the Society of Critical Care Medicine published clinical practice management guidelines on adult acute and acute-on-chronic liver failure, as encountered in the intensive care unit (ICU).[1] For patients with acute l...

Inner demons

Dec 1st, 2019 - Julia Brennan sings about inner demons. They just won’t go away and they don’t play fair with angels.

Blocking TLR9 may halt brain edema in acute liver failure
Will Pass, MDedge News

Nov 6th, 2019 - A toll-like receptor 9 (TLR9) antagonist may eventually be used to combat brain edema in acute liver failure, according to investigators. This prediction is based on results of a recent study involving mouse models, which showed that ODN2088, a TL.

Infusion of Evidence: The Albumin Effect in Cirrhosis Becomes Clearer

Jul 10th, 2019 - Patients with cirrhosis have a significant reduction in cardiovascular and cardiopulmonary function. Arteriolar dilation, particularly in the splanchnic circulation, leads to a lessened arterial volume with a subsequent reduction in cardiac output...

Young, angry, and in need of a liver transplant

May 1st, 2019 - At Visit 2 in the ED, Ms. L was started on NAC because the team suspected she was experiencing drug rash with eosinophilia and systemic symptoms (DRESS) syndrome.

see more →

Patient Education  6 results see all →