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About 8,242 results

ALLMedicine™ Acute Liver Failure Center

Research & Reviews  3,985 results

Mincle signaling exacerbates acetaminophen-induced liver injury by promoting Kupffer ce...
https://doi.org/10.1124/molpharm.120.000043
Molecular Pharmacology; Zhao J, Kim JW et. al.

Dec 2nd, 2020 - Overdose of acetaminophen (APAP) has become one of the most reasons to induce acute liver failure. Macrophage-inducible C-type lectin (Mincle) acts as a key moderator in immune responses by recognizing spliceosome associated protein 130 (SAP130), ...

Role of Hepatitis E Virus Infection in North American Patients With Severe Acute Liver ...
https://doi.org/10.14309/ctg.0000000000000273
Clinical and Translational Gastroenterology; Fontana RJ, Engle RE et. al.

Dec 1st, 2020 - The aim of this study was to determine the role of hepatitis E virus (HEV) infection in a large cohort of prospectively enrolled patients with severe acute liver injury (ALI). Serum samples from 594 consecutive adults enrolled between 2008 and 201...

Betacyanins, major components in Opuntia red-purple fruits, protect against acetaminoph...
https://doi.org/10.1016/j.foodres.2020.109461
Food Research International (Ottawa, Ont.); González-Ponce HA, Martínez-Saldaña MC et. al.

Nov 25th, 2020 - Acetaminophen (APAP) misuse or overdose is the most important cause of drug-induced acute liver failure. Overdoses of acetaminophen induce oxidative stress and liver injury by the electrophilic metabolite N-acetyl-p-benzoquinone imine (NAPQI). Pla...

Differentiation of Human Parthenogenetic Embryonic Stem Cells into Functional Hepatocyt...
https://doi.org/10.1080/15476278.2020.1848237
Organogenesis Liang R, Wang Z et. al.

Nov 25th, 2020 - Stem cell and tissue engineering-based therapies for acute liver failure (ALF) have been limited by the lack of an optimal cell source. We aimed to determine the suitability of human parthenogenetic embryonic stem cells (hPESCs) for the developmen...

A Surviving Child from Acute Liver Failure after an Ingestion of Cassia occidentalis Se...
https://doi.org/10.1093/tropej/fmaa087
Journal of Tropical Pediatrics; Getsuwan S, Tanpowpong P et. al.

Nov 23rd, 2020 - Cassia occidentalis toxicity is thought to be uncommon; however, several cases have been described with acute hepatomyoencephalopathy with a high-mortality rate. We report a previously healthy, 2-year-old girl who developed acute liver failure aft...

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Guidelines  5 results

American Gastroenterological Association Institute Guidelines for the Diagnosis and Man...
https://doi.org/10.1053/j.gastro.2016.12.026
Gastroenterology Flamm SL, Yang YX et. al.

Jan 5th, 2017 - American Gastroenterological Association Institute Guidelines for the Diagnosis and Management of Acute Liver Failure.|2017|Flamm SL,Yang YX,Singh S,Falck-Ytter YT, ,|standards,standards,diagnosis,etiology,therapy,standards,

Introduction to the Revised American Association for the Study of Liver Diseases Position Pa...
https://www.aasld.org/sites/default/files/guideline_documents/AcuteLiverFailureUpdate201journalformat1.pdf
William M. Lee

Feb 29th, 2012 - Acute liver failure (ALF) is a rare condition in which rapid deterioration of liver function results in altered mentation and coagulopathy in individuals without known pre-existing liver disease. U.

Corrections to the AASLD Position Paper: The Management of Acute Liver Failure: Update 2011
https://www.aasld.org/sites/default/files/guideline_documents/ErrataAcuteLiverFailure2011.pdf
William M. Lee

Dec 1st, 2011 - In patients who do not respond to a volume challenge and norepinephrine, vasopressin and its analogues may potentiate the effects of norepinephrine and allow a decrease in its infusion rate, which in turn may avoid intense vasoconstriction in peri.

Experimental models of hepatic encephalopathy: ISHEN guidelines.
https://doi.org/10.1111/j.1478-3231.2009.02034.x
Liver International : Official Journal of the International Association for the Study of the Liver; Butterworth RF, Norenberg MD et. al.

Jul 29th, 2009 - Objectives of the International Society for Hepatic Encephalopathy and Nitrogen Metabolism Commission were to identify well-characterized animal models of hepatic encephalopathy (HE) and to highlight areas of animal modelling of the disorder that ...

ESPEN Guidelines on Parenteral Nutrition: hepatology.
https://doi.org/10.1016/j.clnu.2009.04.019
Clinical Nutrition (Edinburgh, Scotland); Plauth M, Cabré E et. al.

Jun 12th, 2009 - Parenteral nutrition (PN) offers the possibility to increase or to ensure nutrient intake in patients, in whom sufficient nutrition by oral or enteral alone is insufficient or impossible. Complementary to the ESPEN guideline on enteral nutrition o...

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Drugs  5 results see all →

Clinicaltrials.gov  4,103 results

Mincle signaling exacerbates acetaminophen-induced liver injury by promoting Kupffer ce...
https://doi.org/10.1124/molpharm.120.000043
Molecular Pharmacology; Zhao J, Kim JW et. al.

Dec 2nd, 2020 - Overdose of acetaminophen (APAP) has become one of the most reasons to induce acute liver failure. Macrophage-inducible C-type lectin (Mincle) acts as a key moderator in immune responses by recognizing spliceosome associated protein 130 (SAP130), ...

Role of Hepatitis E Virus Infection in North American Patients With Severe Acute Liver ...
https://doi.org/10.14309/ctg.0000000000000273
Clinical and Translational Gastroenterology; Fontana RJ, Engle RE et. al.

Dec 1st, 2020 - The aim of this study was to determine the role of hepatitis E virus (HEV) infection in a large cohort of prospectively enrolled patients with severe acute liver injury (ALI). Serum samples from 594 consecutive adults enrolled between 2008 and 201...

Betacyanins, major components in Opuntia red-purple fruits, protect against acetaminoph...
https://doi.org/10.1016/j.foodres.2020.109461
Food Research International (Ottawa, Ont.); González-Ponce HA, Martínez-Saldaña MC et. al.

Nov 25th, 2020 - Acetaminophen (APAP) misuse or overdose is the most important cause of drug-induced acute liver failure. Overdoses of acetaminophen induce oxidative stress and liver injury by the electrophilic metabolite N-acetyl-p-benzoquinone imine (NAPQI). Pla...

Differentiation of Human Parthenogenetic Embryonic Stem Cells into Functional Hepatocyt...
https://doi.org/10.1080/15476278.2020.1848237
Organogenesis Liang R, Wang Z et. al.

Nov 25th, 2020 - Stem cell and tissue engineering-based therapies for acute liver failure (ALF) have been limited by the lack of an optimal cell source. We aimed to determine the suitability of human parthenogenetic embryonic stem cells (hPESCs) for the developmen...

A Surviving Child from Acute Liver Failure after an Ingestion of Cassia occidentalis Se...
https://doi.org/10.1093/tropej/fmaa087
Journal of Tropical Pediatrics; Getsuwan S, Tanpowpong P et. al.

Nov 23rd, 2020 - Cassia occidentalis toxicity is thought to be uncommon; however, several cases have been described with acute hepatomyoencephalopathy with a high-mortality rate. We report a previously healthy, 2-year-old girl who developed acute liver failure aft...

see more →

News  137 results

Drug Safety Alert Issued After Fatal Cases of Liver Injury With Pirfenidone
https://www.medscape.com/viewarticle/941406

Nov 22nd, 2020 - The Medicines and Healthcare products Regulatory Agency (MHRA) has issued a drug safety alert with updated advice on liver function testing for patients receiving pirfenidone (Esbriet). The alert follows a recent European safety review that identi...

Liver Failure Management in the ICU: Clinical Practice Guidelines (2020)
https://reference.medscape.com/viewarticle/925736

Feb 27th, 2020 - In February 2020, a panel from the Society of Critical Care Medicine published clinical practice management guidelines on adult acute and acute-on-chronic liver failure, as encountered in the intensive care unit (ICU).[1] For patients with acute l...

Blocking TLR9 may halt brain edema in acute liver failure
https://www.mdedge.com/gihepnews/article/211698/liver-disease/blocking-tlr9-may-halt-brain-edema-acute-liver-failure?channel=346
Will Pass, MDedge News

Nov 6th, 2019 - A toll-like receptor 9 (TLR9) antagonist may eventually be used to combat brain edema in acute liver failure, according to investigators. This prediction is based on results of a recent study involving mouse models, which showed that ODN2088, a TL.

Young, angry, and in need of a liver transplant
https://www.mdedge.com/psychiatry/article/199883/bipolar-disorder/young-angry-and-need-liver-transplant/page/0/2?channel=41019

May 1st, 2019 - At Visit 2 in the ED, Ms. L was started on NAC because the team suspected she was experiencing drug rash with eosinophilia and systemic symptoms (DRESS) syndrome.

Acute Liver Failure in a 64-Year-Old Man
https://reference.medscape.com/viewarticle/911040_5

Mar 28th, 2019 - Various treatment protocols for acetaminophen toxicity are available, depending on the institution and the poison control center. For intravenous treatment (used in pregnant women, altered mental status, acetaminophen-induced liver failure, and in...

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Patient Education  7 results see all →