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About 5,220 results

ALLMedicine™ Acute Liver Failure Center

Research & Reviews  1,807 results

Restoring cellular magnesium balance through Cyclin M4 protects against acetaminophen-i...
https://doi.org/10.1038/s41467-022-34262-0
Nature Communications; González-Recio I, Simón J et. al.

Nov 27th, 2022 - Acetaminophen overdose is one of the leading causes of acute liver failure and liver transplantation in the Western world. Magnesium is essential in several cellular processess. The Cyclin M family is involved in magnesium transport across cell me...

Absence of IκBβ/NFκB signaling does not attenuate acetaminophen-induced hepatic injury.
https://doi.org/10.1002/ar.25126
Anatomical Record (Hoboken, N.J. : 2007); Solar M, Grayck MR et. al.

Nov 26th, 2022 - Acetaminophen (N-acetyl-p-aminophenol [APAP]) toxicity is a common cause of acute liver failure. Innate immune signaling and specifically NFκB activation play a complex role in mediating the hepatic response to toxic APAP exposures. While inflamma...

Emergent TIPS as a first-line therapy in advanced cirrhotic patients with acute gastroe...
https://doi.org/10.1016/j.jvir.2022.11.015
Journal of Vascular and Interventional Radiology : JVIR; Li WC, Zhong BY et. al.

Nov 23rd, 2022 - To investigate the safety and effectiveness of emergent transjugular intrahepatic portosystemic shunt (TIPS) as a first-line therapy in advanced cirrhotic patients with acute variceal bleeding (AVB). From July 2016 to June 2019, 76 patients with a...

Intravenous acetaminophen associated with acute liver failure.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9684967
BMJ Case Reports; Lee M, McCarron J et. al.

Nov 23rd, 2022 - A woman in her mid-60s, without known liver disease, was admitted to the hospital with a partial malignant colonic obstruction. Over a 6-day course, she received a total of 13 g of intravenous acetaminophen not exceeding 4 g over a 24-hour period....

Autoimmune Hepatitis in an Immunosuppression-Free Patient Who Underwent Living Donor Li...
https://doi.org/10.1016/j.transproceed.2022.09.022
Transplantation Proceedings; Toshida K, Toshima T et. al.

Nov 18th, 2022 - Although there have been a few liver transplantations (LTs) between identical twins, to our knowledge hepatic damage after LT in an immunosuppressant-free patient has not been reported. Autoimmune liver disease recurrence after LT is also a postop...

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Guidelines  1 results

ESPEN practical guideline: Clinical nutrition in liver disease.
https://doi.org/10.1016/j.clnu.2020.09.001
Clinical Nutrition (Edinburgh, Scotland); Bischoff SC, Bernal W et. al.

Nov 21st, 2020 - The Practical guideline is based on the current scientific ESPEN guideline on Clinical Nutrition in Liver Disease. It has been shortened and transformed into flow charts for easier use in clinical practice. The guideline is dedicated to all profes...

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Drugs  42 results see all →

Clinicaltrials.gov  86 results

The Markers and Paracetamol Poisoning Study 2
https://clinicaltrials.gov/ct2/show/NCT03497104

Sep 28th, 2022 - Paracetamol overdose is one of the most common medical emergencies. Annually in the UK, 100,000 people seek medical attention and 50,000 need hospital admission. Treatment is with the antidote acetylcysteine (NAC), which is effective but takes 21 ...

Indirect Calorimeter Based Study in Patients With Liver Cirrhosis
https://clinicaltrials.gov/ct2/show/NCT03871894

Sep 6th, 2022 - Part I- Observational study In the first part , investigator would investigate and compare the energy requirements and substrate utilization in healthy subjects and in patients with liver cirrhosis of various etiologies across the disease severity...

Evaluation of the Efficacy of Fomepizole in the Treatment of Acetaminophen Overdose
https://clinicaltrials.gov/ct2/show/NCT05517668

Aug 26th, 2022 - Acetaminophen (N-acetyl-p-aminophenol, paracetamol) is a commonly used analgesic and antipyretic. The maximal recommended therapeutic dose of 4 g per day is safe and is well tolerated. Unintentional and intentional overdoses occur and can cause se...

Study of Human Umbilical Cord Mesenchymal Stem Cell in Patients With Cirrhosis Due to Hepatitis B (Compensation Stage)
https://clinicaltrials.gov/ct2/show/NCT05507762

Aug 19th, 2022 - There are about 1.7 billion people with different types of chronic liver diseases in the world, of which about 240 million are infected with chronic hepatitis B virus (HBV), and about 15%-40% of chronic hepatitis B can develop into liver cirrhosis...

TReatment for ImmUne Mediated PathopHysiology
https://clinicaltrials.gov/ct2/show/NCT04862221

Aug 8th, 2022 - Pediatric Acute Liver Failure (PALF) is a rare, devastating condition that affects an estimated 250 children per year in North America, causing death in approximately 15% and the need for liver transplantation in an additional 20-30%. In the major...

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News  137 results

Hospitalized COVID-19 Patients With GI Symptoms Have Worse Outcomes
https://www.medscape.com/viewarticle/980213

Sep 2nd, 2022 - Editor's note: Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center. Patients with COVID-19 who experience gastrointestinal symptoms have overall worse in-hospital complications but less cardiomyopathy and mortality...

Hospitalized COVID-19 patients with GI symptoms have worse outcomes
https://www.mdedge.com/internalmedicine/article/257350/gastroenterology/hospitalized-covid-19-patients-gi-symptoms-have
Carolyn Crist

Aug 26th, 2022 - Patients with COVID-19 who experience gastrointestinal symptoms have overall worse in-hospital complications but less cardiomyopathy and mortality, according to a new study. About 20% of COVID-19 patients experience gastrointestinal symptoms, such.

Novartis Reports Zolgensma Caused Two Deaths From Liver Failure
https://www.medscape.com/viewarticle/979107

Aug 12th, 2022 - (Reuters) - Novartis AG on Thursday reported two patient fatalities due to acute liver failure following treatment with Zolgensma gene therapy used to treat spinal muscular atrophy. The company has notified health authorities in markets where the ...

Two Deaths From Liver Failure Linked to Spinal Muscular Atrophy Drug
https://www.medscape.com/viewarticle/979152

Aug 12th, 2022 - Two children taking the gene therapy drug onasemnogene abeparvovec (Zolgensma, Novartis) for spinal muscular atrophy (SMA) have died from acute liver failure, according to a statement issued by the drug's manufacturer. The patients were 4 months a...

Cidofovir for Pediatric Adenovirus-Related Hepatitis Rapidly Reduces Viremia
https://www.medscape.com/viewarticle/976459

Jul 1st, 2022 - NEW YORK (Reuters Health) - Off-label use of cidofovir in children with acute liver failure and confirmed adenovirus infection cleared the virus or substantially reduced viremia in a small case series from Kings College Hospital, London. Dr. Avita...

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Patient Education  15 results see all →