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ALLMedicine™ Bacterial Sepsis Center - Clinicaltrials.gov

Does Early Goal-Directed Therapy Decrease Mortality Compared with Standard Care in Patients ...
http://www.aaem.org/UserFiles/DoesEarlyGoal-DirectedTherapyDecreaseMortalityComparedwithStandardCareinPatientswithSepticShock_.pdf
Robert Sherwin, Michael Winters

Feb 16th, 2016 - Improvements in usual care can largely be attributed to the emphasis that the EGDT study placed on caring for patients with sepsis. Patients in the usual care arms of the ProCESS, ARISE, and ProMISE trials received aggressive intravenous fluids and early antibiotic medications.

Beating the Clock to Reduce Sepsis Mortality
https://news.aamc.org/patient-care/article/beating-clock-reduce-sepsis-mortality/
Robin Warshaw

Dec 11th, 2017 - Often overlooked and more difficult to identify than many other life-threatening conditions, sepsis causes one-third to one-half of all deaths in U. S.

Management of Neonates Born at ?34 6/7 Weeks’ Gestation With Suspected or Proven Early-Onset...
http://pediatrics.aappublications.org/content/142/6/e20182896
Puopolo, Karen M.

Nov 30th, 2018 - Early-onset sepsis (EOS) remains a serious and often fatal illness among infants born preterm, particularly among newborn infants of the lowest gestational age. Currently, most preterm infants with very low birth weight are treated empirically with antibiotics for risk of EOS, often for prolonged periods, in the absence of a culture-confirmed infection.

Plasma presepsin level is an early diagnostic marker of severe febrile neutropenia in h...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5217328
BMC Infectious Diseases; Koizumi Y, Shimizu K et. al.

Jan 6th, 2017 - Febrile neutropenia (FN) is a common infectious complication in chemotherapy. The mortality of FN is higher in hematologic malignancy patients, and early diagnostic marker is needed. Presepsin is a prompt and specific marker for bacterial sepsis, but its efficacy in severe febrile neutropenia (FN) is not well confirmed. We tried to clarify whether it is a useful maker for early diagnosis of FN ...

Transfusion-transmitted Yersinia enterocolitica sepsis.
https://doi.org/10.1093/cid/cir452
Clinical Infectious Diseases : an Official Publication Of... Guinet F, Carniel E et. al.

Aug 25th, 2011 - Bacterial sepsis has become the most frequent infectious complication of transfusion. Although Yersinia enterocolitica is a common enteropathogen usually causing relatively mild disease, it is nevertheless a prominent cause of life-threatening post-transfusion infection. To gain a better understanding of the clinical presentation and prognosis of this rare occurrence, we performed a systematic ...

Safety and efficacy of high-dose daptomycin as salvage therapy for severe gram-positive...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3571896
BMC Infectious Diseases; Lai CC, Sheng WH et. al.

Feb 5th, 2013 - Increasing the dosage of daptomycin may be advantageous in severe infection by enhancing bactericidal activity and pharmacodynamics. However, clinical data on using daptomycin at doses above 6 mg/kg in Asian population are limited. A retrospective observational cohort study of all hospitalized adult patients treated with daptomycin (> 6 mg/kg) for at least 72 hours was performed in Taiwan. A to...

Toxin Mediates Sepsis Caused by Methicillin-Resistant Staphylococcus epidermidis.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5289634
PLoS Pathogens; Qin L, Da F et. al.

Feb 5th, 2017 - Bacterial sepsis is a major killer in hospitalized patients. Coagulase-negative staphylococci (CNS) with the leading species Staphylococcus epidermidis are the most frequent causes of nosocomial sepsis, with most infectious isolates being methicillin-resistant. However, which bacterial factors underlie the pathogenesis of CNS sepsis is unknown. While it has been commonly believed that invariant...

Management of neonates with suspected or proven early-onset bacterial sepsis.
https://doi.org/10.1542/peds.2012-0541
Pediatrics Polin RA,

May 1st, 2012 - With improved obstetrical management and evidence-based use of intrapartum antimicrobial therapy, early-onset neonatal sepsis is becoming less frequent. However, early-onset sepsis remains one of the most common causes of neonatal morbidity and mortality in the preterm population. The identification of neonates at risk for early-onset sepsis is frequently based on a constellation of perinatal r...

Detection of respiratory viral infections in neonates treated for suspicion of nosocomi...
https://doi.org/10.1097/INF.0000000000000008
The Pediatric Infectious Disease Journal; Kidszun A, Hansmann A et. al.

Sep 25th, 2013 - There is a lack of knowledge concerning the frequency and significance of respiratory viral infections that occur in the neonatal intensive care unit. In the present study, all neonates with suspected nosocomial bacterial sepsis were screened for a panel of respiratory viruses. Respiratory viral infections were detected in 10% of these cases. This was comparable with the frequency of a blood-cu...

Fatal Sepsis Associated with Bacterial Contamination of Platelets - Utah and California...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6023189
MMWR. Morbidity and Mortality Weekly Report; Horth RZ, Jones JM et. al.

Jun 28th, 2018 - During August 2017, two separate clusters of platelet transfusion-associated bacterial sepsis were reported in Utah and California. In Utah, two patients died after platelet transfusions from the same donation. Clostridium perfringens isolates from one patient's blood, the other patient's platelet bag, and donor skin swabs were highly related by whole genome sequencing (WGS). In California, one...

Diagnostic accuracy of procalcitonin in critically ill immunocompromised patients.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3170614
BMC Infectious Diseases; Bele N, Darmon M et. al.

Aug 25th, 2011 - Recognizing infection is crucial in immunocompromised patients with organ dysfunction. Our objective was to assess the diagnostic accuracy of procalcitonin (PCT) in critically ill immunocompromised patients. This prospective, observational study included patients with suspected sepsis. Patients were classified into one of three diagnostic groups: no infection, bacterial sepsis, and nonbacterial...

The role of procalcitonin in the identification of invasive fungal infection-a systemic...
https://doi.org/10.1016/j.diagmicrobio.2013.04.023
Diagnostic Microbiology and Infectious Disease; Dou YH, Du JK et. al.

May 28th, 2013 - We aimed to summarize evidence on the accuracy of procalcitonin (PCT) test in differentiating fungal infection from other causes of infection. We searched electronic database for original researches that reported diagnostic performance of PCT alone or compare with other biomarkers to diagnose invasive fungal infection (IFI). We included 8 qualifying studies studying 474 episodes of suspected fu...

Bacteraemia in Kenyan children with sickle-cell anaemia: a retrospective cohort and cas...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2768782
Lancet (London, England); Williams TN, Uyoga S et. al.

Sep 14th, 2009 - In sub-Saharan Africa, more than 90% of children with sickle-cell anaemia die before the diagnosis can be made. The causes of death are poorly documented, but bacterial sepsis is probably important. We examined the risk of invasive bacterial diseases in children with sickle-cell anaemia. This study was undertaken in a rural area on the coast of Kenya, with a case-control approach. We undertook ...

B-1a Cells Protect Mice from Sepsis: Critical Role of CREB.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5531203
Journal of Immunology (Baltimore, Md. : 1950); Aziz M, Holodick NE et. al.

Jun 20th, 2017 - Bacterial sepsis is a serious life-threatening condition caused by an excessive immune response to infection. B-1 cells differ from conventional B-2 cells by their distinct phenotype and function. A subset of B-1 cells expressing CD5, known as B-1a cells, exhibits innate immune activity. Here we report that B-1a cells play a beneficial role in sepsis by mitigating exaggerated inflammation throu...

Oral azithromycin given during labour decreases bacterial carriage in the mothers and t...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4936760
Clinical Microbiology and Infection : the Official Public... Roca A, Oluwalana C et. al.

Mar 30th, 2016 - Bacterial sepsis remains a leading cause of death among neonates with Staphylococcus aureus, group B streptococcus (GBS) and Streptococcus pneumoniae identified as the most common causative pathogens in Africa. Asymptomatic bacterial colonization is an intermediate step towards sepsis. We conducted a phase III, double-blind, placebo-controlled randomized trial to determine the impact of giving ...

Follistatin-like protein 1 enhances NLRP3 inflammasome-mediated IL-1β secretion from mo...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4004659
European Journal of Immunology; Chaly Y, Fu Y et. al.

Jan 28th, 2014 - Follistatin-like protein 1 (FSTL-1) is overexpressed in a number of inflammatory conditions characterized by elevated IL-1β. Here, we found that FSTL-1 serum concentration was increased threefold in patients with bacterial sepsis and fourfold following administration of LPS to mice. To test the contribution of FSTL-1 to IL-1β secretion, WT and FSTL-1-deficient mice were injected with LPS. While...

Malaria and bacterial sepsis: similar mechanisms of endothelial apoptosis and its preve...
https://doi.org/10.1097/CCM.0b013e31818441ee
Critical Care Medicine; Hemmer CJ, Vogt A et. al.

Aug 5th, 2008 - Apoptotic endothelial damage contributes to multiorgan failure in Plasmodium falciparum malaria and in sepsis. In malaria, endothelial apoptosis is amplified by neutrophils and their secretory products, and reduced by inhibitors of neutrophil-derived substances in vitro. We compared the mechanisms of endothelial apoptosis in malaria and in sepsis, using the human umbilical vein endothelial cell...

Prevention of bacterial infections in the newborn by pre-delivery administration of azi...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4653934
BMC Pregnancy and Childbirth; Roca A, Oluwalana C et. al.

Nov 20th, 2015 - Neonatal deaths, estimated at approximately 4 million annually, now account for almost 40% of global mortality in children aged under-five. Bacterial sepsis is a leading cause of neonatal mortality. Assuming the mother is the main source for bacterial transmission to newborns, the primary objective of the trial is to determine the impact of one oral dose of azithromycin, given to women in labou...

ZnuD, a potential candidate for a simple and universal Neisseria meningitidis vaccine.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3676005
Infection and Immunity; Hubert K, Devos N et. al.

Mar 19th, 2013 - Neisseria meningitidis serogroup B (MenB) is a major cause of bacterial sepsis and meningitis, with the highest disease burden in young children. Available vaccines are based on outer membrane vesicles (OMVs) obtained from wild-type strains. However, particularly in toddlers and infants, they confer protection mostly against strains expressing the homologous protein PorA, a major and variable o...