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About 502 results

ALLMedicine™ Acetaminophen Toxicity Center

Research & Reviews  231 results

The developing murine lung is susceptible to acetaminophen toxicity.
https://doi.org/10.1152/ajplung.00072.2021
American Journal of Physiology. Lung Cellular and Molecul... Dobrinskikh E, Sherlock LG et. al.

Mar 24th, 2021 - Acetaminophen (N-acetyl-p-aminophenol, APAP) use in the neonatal intensive care unit is rapidly increasing. While APAP-related hepatotoxicity is rarely reported in the neonatal literature, other end-organ toxicity can occur with toxic exposures. A...

N-Acetylcysteine treatment of neonatal acetaminophen toxicity caused by transplacental ...
https://doi.org/10.1080/15563650.2021.1874405
Clinical Toxicology (Philadelphia, Pa.); McDougall G, Murphy NG et. al.

Feb 2nd, 2021 - We describe a case of maternal acetaminophen toxicity leading to Caesarean section delivery of a pre-term neonate with acetaminophen-induced hepatic injury and encephalopathy at 33 weeks gestational age. Delayed treatment with N-acetylcysteine (NA...

A Potential Role for SerpinA3N in Acetaminophen-Induced Hepatotoxicity.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7985612
Molecular Pharmacology; Tran M, Wu J et. al.

Jan 13th, 2021 - Acetaminophen (APAP) is a commonly used pain and fever reliever but is also the most frequent cause of drug-induced liver injury. The mechanism pertaining acetaminophen toxicity has been well documented, whereas mechanisms of hepatotoxicity are no...

Assessment of the biochemical pathways for acetaminophen toxicity: Implications for its...
https://doi.org/10.1016/j.yrtph.2020.104859
Regulatory Toxicology and Pharmacology : RTP; Jaeschke H, Murray FJ et. al.

Jan 3rd, 2021 - In 2019 California's Office of Environmental Health Hazard Assessment (OEHHA) initiated a review of the carcinogenic hazard potential of acetaminophen. In parallel with this review, herein we evaluated the mechanistic data related to the steps and...

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Guidelines  2 results

Acetaminophen Toxicity - StatPearls
https://www.ncbi.nlm.nih.gov/books/NBK441917/

Nov 13th, 2018 - Acetaminophen (N-acetyl-para-aminophenol, paracetamol, APAP) toxicity is common primarily because the medication is so readily available and there is a perception that it is very safe. More than 60 million Americans consume acetaminophen on a week...

FAQs on Acetaminophen Use During Pregnancy
www.teratology.org/pdf/Acetaminophen FAQ March 2014.pdf
Teratology Society

Feb 28th, 2014 - A recent article in JAMA (Journal of the American Medical Association) ? Pediatrics reported an increased risk of attention deficit hyperactive disorder (ADHD) and related behavioral problems in children whose mothers took acetaminophen during pre.

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Drugs  1 results see all →

Clinicaltrials.gov  247 results

The developing murine lung is susceptible to acetaminophen toxicity.
https://doi.org/10.1152/ajplung.00072.2021
American Journal of Physiology. Lung Cellular and Molecul... Dobrinskikh E, Sherlock LG et. al.

Mar 24th, 2021 - Acetaminophen (N-acetyl-p-aminophenol, APAP) use in the neonatal intensive care unit is rapidly increasing. While APAP-related hepatotoxicity is rarely reported in the neonatal literature, other end-organ toxicity can occur with toxic exposures. A...

N-Acetylcysteine treatment of neonatal acetaminophen toxicity caused by transplacental ...
https://doi.org/10.1080/15563650.2021.1874405
Clinical Toxicology (Philadelphia, Pa.); McDougall G, Murphy NG et. al.

Feb 2nd, 2021 - We describe a case of maternal acetaminophen toxicity leading to Caesarean section delivery of a pre-term neonate with acetaminophen-induced hepatic injury and encephalopathy at 33 weeks gestational age. Delayed treatment with N-acetylcysteine (NA...

A Potential Role for SerpinA3N in Acetaminophen-Induced Hepatotoxicity.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7985612
Molecular Pharmacology; Tran M, Wu J et. al.

Jan 13th, 2021 - Acetaminophen (APAP) is a commonly used pain and fever reliever but is also the most frequent cause of drug-induced liver injury. The mechanism pertaining acetaminophen toxicity has been well documented, whereas mechanisms of hepatotoxicity are no...

Assessment of the biochemical pathways for acetaminophen toxicity: Implications for its...
https://doi.org/10.1016/j.yrtph.2020.104859
Regulatory Toxicology and Pharmacology : RTP; Jaeschke H, Murray FJ et. al.

Jan 3rd, 2021 - In 2019 California's Office of Environmental Health Hazard Assessment (OEHHA) initiated a review of the carcinogenic hazard potential of acetaminophen. In parallel with this review, herein we evaluated the mechanistic data related to the steps and...

see more →

News  21 results

Acute Liver Failure in a 64-Year-Old Man
https://reference.medscape.com/viewarticle/911040_5

Mar 28th, 2019 - Various treatment protocols for acetaminophen toxicity are available, depending on the institution and the poison control center. For intravenous treatment (used in pregnant women, altered mental status, acetaminophen-induced liver failure, and in...

Acetaminophen Toxicity - StatPearls
https://www.ncbi.nlm.nih.gov/books/NBK441917/

Nov 13th, 2018 - Acetaminophen (N-acetyl-para-aminophenol, paracetamol, APAP) toxicity is common primarily because the medication is so readily available and there is a perception that it is very safe. More than 60 million Americans consume acetaminophen on a week...

Acute liver failure in the ED
https://www.mdedge.com/internalmedicine/article/143261/liver-disease/acute-liver-failure-ed
Jennie Smith

Jul 25th, 2017 - Acute liver failure (ALF), is a life-threatening deterioration of liver function in people without preexisting cirrhosis. It can be caused by acetaminophen toxicity, pregnancy, ischemia, hepatitis A infection, and Wilson disease, among other thing.

VIDEO: Point-of-care assay caught acetaminophen toxicity
https://www.mdedge.com/internalmedicine/article/132476/hepatology/video-point-care-assay-caught-acetaminophen-toxicity
Amy Karon

Mar 1st, 2017 - A rapid point-of-care assay for acetaminophen-related liver toxicity had a sensitivity of 100% and a specificity of 86%, compared with etiologic diagnosis, based on the results of a multicenter study published in the April issue of Clinical Gastro.

Acetaminophen Liver Failure Least Likely to Get Transplant
https://www.mdedge.com/internalmedicine/article/56694/gastroenterology/acetaminophen-liver-failure-least-likely-get
Jeff Evans

Nov 12th, 2012 - BOSTON – Acetaminophen toxicity is the most frequent cause of acute liver failure in the United States and its usually milder presentation, along with comorbid psychosocial issues, explain why fewer patients with the etiology undergo liver transpl.

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