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About 331 results

ALLMedicine™ Iron Toxicity Center

Research & Reviews  163 results

Novel mutations in ATP13A2 associated with mixed neurological presentations and iron to...
https://doi.org/10.1016/j.brainres.2020.147167
Brain Research; Kırımtay K, Temizci B et. al.

Oct 22nd, 2020 - Kufor-Rakeb Syndrome (KRS) is an autosomal recessive disease characterized by Parkinsonism, pyramidal signs, dementia, and supranuclear gaze palsy. KRS is caused by mutations in ATP13A2producing a transmembrane protein responsible for the regulati...

Potential amelioration of waterborne iron toxicity in channel catfish (Ictalurus puncta...
https://doi.org/10.1016/j.ecoenv.2020.111337
Ecotoxicology and Environmental Safety; Yadav AK, Sinha AK et. al.

Sep 26th, 2020 - Iron overload in water is a problem in many areas of the world, which could exert toxic effects on fish. To achieve maximum growth and overall fitness, iron induced toxicity must be alleviated. Therefore, this research was undertaken to investigat...

Iron Induces Cell Death and Strengthens the Efficacy of Antiandrogen Therapy in Prostat...
https://doi.org/10.1158/1078-0432.CCR-20-3182
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research; Bordini J, Morisi F et. al.

Sep 15th, 2020 - In search of novel strategies to improve the outcome of advanced prostate cancer, we considered that prostate cancer cells rearrange iron homeostasis, favoring iron uptake and proliferation. We exploited this adaptation by exposing prostate cancer...

Neutrophils from hereditary hemochromatosis patients are protected from iron excess and...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7448602
Blood Advances; Renassia C, Louis S et. al.

Aug 18th, 2020 - Iron is required for the oxidative response of neutrophils to allow the production of reactive oxygen species (ROS). However, neutrophil function may be severely altered in conditions of iron overload, as observed in chronically transfused patient...

Differential effects of Fe2+ and Fe3+ on osteoblasts and the effects of 1,25(OH)2D3, de...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7259719
PloS One; Lertsuwan K, Nammultriputtar K et. al.

May 29th, 2020 - One of the potential contributing factors for iron overload-induced osteoporosis is the iron toxicity on bone forming cells, osteoblasts. In this study, the comparative effects of Fe3+ and Fe2+ on osteoblast differentiation and mineralization were...

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Clinicaltrials.gov  165 results

Novel mutations in ATP13A2 associated with mixed neurological presentations and iron to...
https://doi.org/10.1016/j.brainres.2020.147167
Brain Research; Kırımtay K, Temizci B et. al.

Oct 22nd, 2020 - Kufor-Rakeb Syndrome (KRS) is an autosomal recessive disease characterized by Parkinsonism, pyramidal signs, dementia, and supranuclear gaze palsy. KRS is caused by mutations in ATP13A2producing a transmembrane protein responsible for the regulati...

Potential amelioration of waterborne iron toxicity in channel catfish (Ictalurus puncta...
https://doi.org/10.1016/j.ecoenv.2020.111337
Ecotoxicology and Environmental Safety; Yadav AK, Sinha AK et. al.

Sep 26th, 2020 - Iron overload in water is a problem in many areas of the world, which could exert toxic effects on fish. To achieve maximum growth and overall fitness, iron induced toxicity must be alleviated. Therefore, this research was undertaken to investigat...

Iron Induces Cell Death and Strengthens the Efficacy of Antiandrogen Therapy in Prostat...
https://doi.org/10.1158/1078-0432.CCR-20-3182
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research; Bordini J, Morisi F et. al.

Sep 15th, 2020 - In search of novel strategies to improve the outcome of advanced prostate cancer, we considered that prostate cancer cells rearrange iron homeostasis, favoring iron uptake and proliferation. We exploited this adaptation by exposing prostate cancer...

Neutrophils from hereditary hemochromatosis patients are protected from iron excess and...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7448602
Blood Advances; Renassia C, Louis S et. al.

Aug 18th, 2020 - Iron is required for the oxidative response of neutrophils to allow the production of reactive oxygen species (ROS). However, neutrophil function may be severely altered in conditions of iron overload, as observed in chronically transfused patient...

Differential effects of Fe2+ and Fe3+ on osteoblasts and the effects of 1,25(OH)2D3, de...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7259719
PloS One; Lertsuwan K, Nammultriputtar K et. al.

May 29th, 2020 - One of the potential contributing factors for iron overload-induced osteoporosis is the iron toxicity on bone forming cells, osteoblasts. In this study, the comparative effects of Fe3+ and Fe2+ on osteoblast differentiation and mineralization were...

see more →

News  3 results

Will We Make Artificial Blood Soon? (STAT)
https://www.medpagetoday.com/criticalcare/intensivists/63444

Feb 27th, 2017 - Researchers have sought a blood substitute for over 150 years, and they've all failed. Now, one candidate has demonstrated promising early results, while another nears clinical trials again, reported STAT. ErythroMer encloses hemoglobin in a synth...

Study challenges previous notions about RBC disposal
https://www.mdedge.com/hematology-oncology/article/187203/anemia/study-challenges-previous-notions-about-rbc-disposal
HT Staff

Jul 19th, 2016 - Red blood cells A new study contradicts previous beliefs about how the body disposes of red blood cells (RBCs) and recycles their iron. The work suggests the accumulation and removal of aged or damaged RBCs largely takes place in the liver rather.

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