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About 229 results

ALLMedicine™ Opioid Toxicity Center

Research & Reviews  105 results

Countermeasures for preventing and treating opioid overdose.
https://doi.org/10.1002/cpt.2098
Clinical Pharmacology and Therapeutics; France CP, Ahern G et. al.

Oct 28th, 2020 - The only medication available currently to prevent and treat opioid overdose (naloxone) was approved by the Food and Drug Administration (FDA) nearly 50 years ago. Because of its pharmacokinetic and pharmacodynamic properties, naloxone has limited...

Management of acute opioid toxicity in the outpatient setting.
https://doi.org/10.12788/cutis.0037
Cutis Reynolds HH, Orlowski TJ et. al.

Sep 17th, 2020 - Management of acute opioid toxicity in the outpatient setting.|2020|Reynolds HH,Orlowski TJ,Huang CC,Phillips CB,|

Slow-sustained delivery of naloxone reduces typical naloxone-induced precipitated opioi...
https://doi.org/10.1002/jnr.24627
Journal of Neuroscience Research REFERENCES; Lewter LA, Johnson MC et. al.

Aug 7th, 2020 - Thousands of individuals die each year from opioid-related overdoses. While naloxone (Narcan®) is currently the most widely employed treatment to reverse opioid toxicity, high or repeated doses of this antidote often lead to precipitated opioid wi...

Comparison of rates of opioid withdrawal symptoms and reversal of opioid toxicity in pa...
https://doi.org/10.1080/15563650.2020.1758325
Clinical Toxicology (Philadelphia, Pa.); Purssell R, Godwin J et. al.

May 13th, 2020 - Introduction: When managing opioid overdose (OD) patients, the optimal naloxone regimen should rapidly reverse respiratory depression while avoiding opioid withdrawal. Published naloxone administration guidelines have not been empirically validate...

The Implausibility of Neonatal Opioid Toxicity from Breastfeeding.
https://doi.org/10.1002/cpt.1882
Clinical Pharmacology and Therapeutics; Zipursky J, Juurlink DN

May 7th, 2020 - The belief that newborns can develop opioid toxicity from breastfeeding is widely held but supported by very little data. Based largely on a single, highly publicized case report (the "Toronto case"), major health agencies worldwide now caution ag...

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Guidelines  4 results

Fentanyl and Other Synthetic Opioids Drug Overdose Deaths
https://www.drugabuse.gov/related-topics/trends-statistics/infographics/fentanyl-other-synthetic-opioids-drug-overdose-deaths

Apr 30th, 2018 - In 2016, synthetic opioids (primarily illegal fentanyl) passed prescription opioids as the most common drugs involved in overdose deaths in the United States.

ACMT and AACT position statement: preventing occupational fentanyl and fentanyl analog expos...
http://www.tandfonline.com/doi/full/10.1080/15563650.2017.1373782
Michael J. Moss

Aug 23rd, 2017 - Fentanyl and its analogs are potent opioid receptor agonists, but the risk of clinically significant exposure to emergency responders is extremely low. To date, we have not seen reports of emergency responders developing signs or symptoms consiste.

The general surgeon’s role in enhancing patient education about prescription opioids: ACS Gu...
http://bulletin.facs.org/2017/08/the-general-surgeons-role-in-enhancing-patient-education-about-prescription-opioids/#.WmZS6ainG1s
MADELINE TORRES

Aug 1st, 2017 - Understanding the patient population within the surgeon’s geographic practice area is important to determine which patients may potentially seek increased opioid prescriptions versus those who choose not to use narcotic pain management due to soci.

Use of Naloxone for the Prevention of Opioid Overdose Deaths: ASAM Guideline
https://asam.org/advocacy/find-a-policy-statement/view-policy-statement/public-policy-statements/2014/08/28/use-of-naloxone-for-the-prevention-of-drug-overdose-deaths
American Society of Addiction Medicine

Oct 7th, 2016 - Naloxone is a mu-opioid antagonist with well-established safety and efficacy that can reverse opioid overdose and prevent fatalities. Naloxone treatment of opioid overdose has been in use in hospital settings for decades.

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Drugs  1 results see all →

Clinicaltrials.gov  115 results

Countermeasures for preventing and treating opioid overdose.
https://doi.org/10.1002/cpt.2098
Clinical Pharmacology and Therapeutics; France CP, Ahern G et. al.

Oct 28th, 2020 - The only medication available currently to prevent and treat opioid overdose (naloxone) was approved by the Food and Drug Administration (FDA) nearly 50 years ago. Because of its pharmacokinetic and pharmacodynamic properties, naloxone has limited...

Management of acute opioid toxicity in the outpatient setting.
https://doi.org/10.12788/cutis.0037
Cutis Reynolds HH, Orlowski TJ et. al.

Sep 17th, 2020 - Management of acute opioid toxicity in the outpatient setting.|2020|Reynolds HH,Orlowski TJ,Huang CC,Phillips CB,|

Slow-sustained delivery of naloxone reduces typical naloxone-induced precipitated opioi...
https://doi.org/10.1002/jnr.24627
Journal of Neuroscience Research REFERENCES; Lewter LA, Johnson MC et. al.

Aug 7th, 2020 - Thousands of individuals die each year from opioid-related overdoses. While naloxone (Narcan®) is currently the most widely employed treatment to reverse opioid toxicity, high or repeated doses of this antidote often lead to precipitated opioid wi...

Comparison of rates of opioid withdrawal symptoms and reversal of opioid toxicity in pa...
https://doi.org/10.1080/15563650.2020.1758325
Clinical Toxicology (Philadelphia, Pa.); Purssell R, Godwin J et. al.

May 13th, 2020 - Introduction: When managing opioid overdose (OD) patients, the optimal naloxone regimen should rapidly reverse respiratory depression while avoiding opioid withdrawal. Published naloxone administration guidelines have not been empirically validate...

The Implausibility of Neonatal Opioid Toxicity from Breastfeeding.
https://doi.org/10.1002/cpt.1882
Clinical Pharmacology and Therapeutics; Zipursky J, Juurlink DN

May 7th, 2020 - The belief that newborns can develop opioid toxicity from breastfeeding is widely held but supported by very little data. Based largely on a single, highly publicized case report (the "Toronto case"), major health agencies worldwide now caution ag...

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News  4 results

Assessing adverse events tied to outpatient opioid use in children
https://www.mdedge.com/neurology/article/170349/pain/assessing-adverse-events-tied-outpatient-opioid-use-children
Heidi Splete

Jul 16th, 2018 - Nearly three-quarters of opioid-related adverse events seen in children were related to therapeutic opioid use, based on data from more than a million prescriptions. BackyardProduction/Thinkstock Prescription of opioids to children for outpatient.

Fentanyl and Other Synthetic Opioids Drug Overdose Deaths
https://www.drugabuse.gov/related-topics/trends-statistics/infographics/fentanyl-other-synthetic-opioids-drug-overdose-deaths

Apr 30th, 2018 - In 2016, synthetic opioids (primarily illegal fentanyl) passed prescription opioids as the most common drugs involved in overdose deaths in the United States.

Reports of Incidental Fentanyl Exposure Exaggerate Danger (STAT)
https://www.medpagetoday.com/emergencymedicine/emergencymedicine/67203

Aug 10th, 2017 - Media reports linking brief, incidental fentanyl exposure to opioid toxicity may exaggerate the dangers to first responders and others, according to STAT News. Although the synthetic opioid is 50 to 100 times more potent than morphine, experts tol...

Case Studies in Toxicology: Double Take—Is Re-exposure Necessary to Explain Delayed Recurrent Opioid Toxicity?
https://www.mdedge.com/emergencymedicine/article/98183/toxicology/case-studies-toxicology-double-take-re-exposure-necessary/page/0/1

Mar 1st, 2015 - Patients presenting with heroin overdose should be monitored for at least 2 hours after naloxone administration (some suggest 3 hours) to determine whether or not additional dosing will be necessary. After oral opioid exposures, particularly with.

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