About 115 results

ALLMedicine™ Toxicology Center

Research & Reviews  43 results

Systems Modeling to Quantify Safety Risks in Early Drug Development: Using Bifurcation ...
https://doi.org/10.1208/s12248-021-00580-2 10.1002/cpt.7 10.1007/s11095-011-0467-9 10.1111/cts.12629 10.1093/bib/bbx160 10.1021/acs.chemrestox.9b00499 10.1098/rsfs.2012.0087 10.1039/C9LC01168D 10.1039/C9LC01107B 10.1039/C9LC00962K 10.1039/C9LC00857H 10.1039/C9LC00768G 10.1177/1535370214542068 10.1177/0192623318809065 10.1146/annurev-pharmtox-010617-052722 10.1063/1.5097675 10.2165/00002018-200326100-00003 10.1038/nature25022 10.1007/s12185-016-1984-4 10.1056/NEJMra052706 10.1002/cpt.1080 10.1051/mmnp/201611106 10.1200/JCO.2002.02.140 10.1007/s10637-010-9603-3 10.1007/s11538-016-0179-8 10.1007/s10637-005-6730-3 10.1007/s10637-014-0118-1 10.1124/jpet.115.223776 10.1002/psp4.12194 10.1002/psp4.12459 10.1371/journal.pcbi.1007620 10.3934/mbe.2011.8.643 10.1007/s10928-017-9560-y 10.1371/journal.pcbi.1006775 10.1371/journal.pone.0065630 10.3389/fphar.2016.00414 10.1038/nature06196 10.1073/pnas.92.24.11130 10.1016/j.jtbi.2006.08.022 10.1073/pnas.0611179104 10.1096/fj.201601002 10.1038/s41419-018-1275-5 10.1186/s12976-017-0071-8 10.1371/journal.pcbi.1005688 10.1046/j.0960-7722.2001.00216.x 10.1371/journal.pcbi.1001045 10.1016/j.cpc.2009.07.019 10.1371/journal.pone.0037115 10.1002/psp4.12255 10.1186/1742-4682-10-66 10.1016/j.ydbio.2017.10.013 10.1073/pnas.1921205117 10.1136/gut.48.6.803 10.1016/j.devcel.2020.07.009 10.1152/ajpgi.00535.2011 10.1016/S0378-4274(98)00273-2 10.1098/rstb.1998.0246 10.1124/jpet.119.262287 10.1038/s41577-020-0306-5 10.1016/j.eng.2018.11.010 10.1038/mt.2011.272 10.4155/fmc.14.66 10.1002/psp4.12313 10.1002/psp4.12376 10.1016/j.tips.2014.07.001 10.1016/j.tips.2017.12.005 10.3389/fonc.2018.00649 10.1152/ajprenal.00202.2018
The AAPS Journal; Pin C, Collins T et. al.

May 21st, 2021 - Quantitative Systems Toxicology (QST) models, recapitulating pharmacokinetics and mechanism of action together with the organic response at multiple levels of biological organization, can provide predictions on the magnitude of injury and recovery...

Improved Inhibitory and Absorption, Distribution, Metabolism, Excretion, and Toxicology...
The Journal of Pharmacology and Experimental Therapeutics; Gyimesi M, Rauscher AÁ et. al.

Jan 20th, 2021 - Blebbistatin, para-nitroblebbistatin (NBleb), and para-aminoblebbistatin (AmBleb) are highly useful tool compounds as they selectively inhibit the ATPase activity of myosin-2 family proteins. Despite the medical importance of the myosin-2 family a...

The Toxicology Investigators Consortium Case Registry-the 2019 Annual Report.
Journal of Medical Toxicology : Official Journal of the A... Spyres MB, Farrugia LA et. al.

Oct 2nd, 2020 - The Toxicology Investigators Consortium (ToxIC) Registry was established by the American College of Medical Toxicology (ACMT) in 2010. The Registry collects data from participating sites with the agreement that all bedside medical toxicology consu...

Transitioning to Virtual: ACMT's 2020 Annual Scientific Meeting.
Journal of Medical Toxicology : Official Journal of the A... Kopec KT, Stolbach A

Aug 25th, 2020 - The American College of Medical Toxicology (ACMT) 2020 Annual Scientific Meeting (ASM) was scheduled to be held in New York City, March 12-15, 2020, and had the largest conference registration in the history of ACMT's ASM. In the week prior to the...

Quantitative Systems Toxicology Modeling Predicts that Reduced Biliary Efflux Contribut...
Clinical Pharmacology and Therapeutics; Beaudoin JJ, Brock WJ et. al.

Aug 4th, 2020 - Patients with autosomal dominant polycystic kidney disease (ADPKD) exhibit enhanced susceptibility to tolvaptan hepatotoxicity relative to other patient populations. In a rodent model of ADPKD, the expression and function of the biliary efflux tra...

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Guidelines  1 results

ACMT Position Statement: Hospital Privileges for Physicians Practicing Medical Toxicology.
Journal of Medical Toxicology : Official Journal of the A... American College Of Medical Toxicology

Aug 16th, 2016 - ACMT Position Statement: Hospital Privileges for Physicians Practicing Medical Toxicology.|2016|American College Of Medical Toxicology ,|standards,standards,standards,standards,standards,

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Drugs  1 results see all →

Clinicaltrials.gov  1 results

Dichloroacetate Kinetics, Metabolism and Toxicology

Sep 3rd, 2006 - Dichloroacetate (DCA) is a product of water chlorination and a metabolite of certain industrial solvents, thus making it a chemical of environmental concern. However, DCA is also used as an investigational drug for treating various diseases of adu...

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