ALLMedicine™ Acetaminophen Toxicity Center

Jan 18th, 2022 - BACKGROUND Chronic acetaminophen toxicity has been known to cause an anion gap metabolic acidosis (AGMA) due to accumulation of 5-oxoproline metabolites. This diagnosis requires a high index of suspicion when evaluating a patient with AGMA as occa...

Nov 14th, 2021 - Acetaminophen is a frequently used over-the-counter or prescribed medication in the United States. Exposure to acetaminophen can lead to acute liver cytolysis, acute liver failure, acute kidney injury, encephalopathy, and coagulopathy. This retros...

Oct 5th, 2021 - Medication Summary Activated charcoal (AC) and N-acetylcysteine (NAC) are used in the treatment of acetaminophen toxicity. Antiemetics are used to relieve nausea and vomiting, which can result from both acetaminophen toxicity and from AC and oral ...

Oct 5th, 2021 - Approach Considerations The serum acetaminophen (APAP) concentration is the basis for diagnosis and treatment. It is important to measure, even in the absence of clinical symptoms, because of the delay in onset of clinical toxicity. After a single...

Oct 5th, 2021 - Medication Summary Activated charcoal (AC) and N-acetylcysteine (NAC) are used in the treatment of acetaminophen toxicity. Antiemetics are used to relieve nausea and vomiting, which can result from both acetaminophen toxicity and from AC and oral ...

Aug 9th, 2021 - Introduction: Carpal tunnel syndrome (CTS) is the most prevalent and widely studied peripheral nerve entrapment syndrome, with estimates between 10-20% of the general population having clinical symptoms of CTS at least once in their lifetime. Clas...

Nov 24th, 2017 - This study is a non-intervention, multicenter study to address biomarkers of acetaminophen toxicity in children. Specifically, the study will examine acetaminophen (APAP) protein adducts and markers of liver injury in the blood samples of hospital...

Apr 12th, 2012 - It was recently reported that IL-10 is protective in Acetaminophen (APAP) toxicity and it down-regulates iNOS production. In an ongoing Pediatric Pharmacology Research Unit (PPRU) Network study, plasma IL-10 levels were higher in patients that dev...

Sep 9th, 2011 - Retrospective chart review of patients who received N-acetylcysteine for APAP toxicity to assess length of oral vs IV treatment and overall healthcare costs.

Jul 22nd, 2021 - Acetaminophen is one of the most commonly used oral analgesic and antipyretic agents, with as many as 23% of US adults using an acetaminophen-containing medicine each week. It has an excellent safety profile when administered in proper therapeutic...

Mar 29th, 2019 - Various treatment protocols for acetaminophen toxicity are available, depending on the institution and the poison control center. For intravenous treatment (used in pregnant women, altered mental status, acetaminophen-induced liver failure, and in...

May 1st, 2017 - Deterring Abuse: What Works Medscape: There have been several efforts to deter abuse. How effective have such things as prescription monitoring programs and abuse-deterrent formulations been? Dr Chou: The prescription monitoring programs have cert...

Mar 1st, 2017 - A rapid point-of-care assay for acetaminophen-related liver toxicity had a sensitivity of 100% and a specificity of 86%, compared with etiologic diagnosis, based on the results of a multicenter study published in the April issue of Clinical Gastro.

Mar 1st, 2017 - A rapid point-of-care assay for acetaminophen-related liver toxicity had a sensitivity of 100% and a specificity of 86%, compared with etiologic diagnosis, based on the results of a multicenter study published in the April issue of Clinical Gastro.