ALLMedicine™ Antidepressant Toxicity Center

Jan 31st, 2023 - Practice Essentials Cyclic antidepressants (CAs) have been used in the treatment of major depression since the late 1950s. Originally termed tricyclic antidepressants (TCAs), they are more accurately called cyclic antidepressants because some newe...

Jan 31st, 2023 - Approach Considerations As with any overdose, good supportive care is the mainstay of treatment and the first priority is to assess and treat any abnormalities in airway, breathing, and circulation (the ABCs). The rapid onset of toxicity from cycl...

Jan 31st, 2023 - Medication Summary Pharmacologic therapy in patients with cyclic antidepressant (CA) toxicity is directed toward cardiac and central nervous system (CNS) effects of these drugs. Cardiotoxicity Sodium bicarbonate therapy is the cornerstone of treat...

Jan 31st, 2023 - Laboratory Studies As in all patients with potential overdose, the following should be routinely monitored in cases of cyclic antidepressant (CA) poisoning: Complete blood cell count (CBC) Serum acetaminophen level Electrolyte levels (with determi...

Jan 31st, 2023 - Practice Essentials Cyclic antidepressants (CAs) have been used in the treatment of major depression since the late 1950s. Originally termed tricyclic antidepressants (TCAs), they are more accurately called cyclic antidepressants because some newe...

Jul 21st, 2016 - Boxed Warning Section Antidepressants increased the risk compared to placebo of suicidal thinking and behavior (suicidality) in children, adolescents, and young adults in short-term studies of major depressive disorder (MDD) and other psychiatric ...