ALLMedicine™ Antidepressant Toxicity Center

Oct 11th, 2021 - Prehospital Care Endotracheal intubation is necessary in a patient who is obtunded and unable to protect the airway. Intravenous access should be established as soon as possible. Administer intravenous fluid if the patient is hypotensive. Prompt t...

Oct 11th, 2021 - Practice Essentials Tricyclic antidepressants (TCAs) are so called because the original agents in this class contain a 3-ring molecular structure. However, some newer agents have a four-ring structure, so the term cyclic antidepressants (CAs) is m...

Mar 18th, 2020 - Practice Essentials Cyclic antidepressants (CAs) have been used in the treatment of major depression since the late 1950s. Originally termed tricyclic antidepressants (TCAs), they are more accurately called cyclic antidepressants because some newe...

Nov 8th, 2014 - Tricyclic antidepressants (TCAs) are highly lipophilic medications used to treat posttraumatic stress disorder and chronic pain. Intravenous lipid emulsion (ILE) is a recent antidote for lipophilic drug overdose with unclear effectiveness. ILE has...