ALLMedicine™ Antidepressant Toxicity Center

Apr 12th, 2022 - Diagnostic Considerations Serotonin syndrome produces a clinical picture that is very similar to neuroleptic malignant syndrome (NMS). Both syndromes are associated with autonomic dysfunction, alteration of mental status, rigidity, and hyperthermi...

Oct 11th, 2021 - Practice Essentials Tricyclic antidepressants (TCAs) are so called because the original agents in this class contain a 3-ring molecular structure. However, some newer agents have a four-ring structure, so the term cyclic antidepressants (CAs) is m...

Oct 11th, 2021 - Practice Essentials Tricyclic antidepressants (TCAs) are so called because the original agents in this class contain a 3-ring molecular structure. However, some newer agents have a four-ring structure, so the term cyclic antidepressants (CAs) is m...

Oct 11th, 2021 - Laboratory Studies Studies have shown that serum cyclic antidepressant (CA) level does not correlate well with severity of CA toxicity and is a poor predictor of clinical outcome. However, because multisubstance ingestion is common, routine screen...

Oct 11th, 2021 - Medication Summary Treatment of cyclic antidepressant (CA) toxicity focuses on airway management, dysrhythmias, seizures, and hypotension. Sodium bicarbonate, benzodiazepines, and norepinephrine are the drugs of choice for these complications. Nex...

Jul 21st, 2016 - Boxed Warning Section Antidepressants increased the risk compared to placebo of suicidal thinking and behavior (suicidality) in children, adolescents, and young adults in short-term studies of major depressive disorder (MDD) and other psychiatric ...