ALLMedicine™ Iron Toxicity Center

Sep 29th, 2022 - This study aims to determine whether high resolution MRI at 7T and Quantitative Susceptibility Mapping (QSM) can demonstrate a specific pattern of iron overload in strategically important areas of brain as a sensitive marker of pathological Alzhei...

Sep 22nd, 2022 - The Food and Drug Administration approved drug Monoferric has a unique structure that allows for a slow, sustained release and bioavailability without free iron toxicity. Efficacy studies demonstrated a faster change in hemoglobin concentration fr...

Aug 26th, 2022 - Hemopexin, a heme scavenging protein, accumulates in the kidneys during acute kidney injury (AKI). However, the function of this accumulated hemopexin in the kidney is unclear. In both the cisplatin-induced and the unilateral kidney ischemia-reper...

Aug 5th, 2022 - Objectives: To determine the most effective oral iron supplementation regimen for repletion of iron deficiency in patients who have had gastric bypass or sleeve gastrectomy. In iron deficient patients, two supplement regimens will be compared: Fer...

Jul 6th, 2022 - We analysed iron biomarkers and their relationships in 30 subjects with HFE mutations and moderate hyperferritinaemia undergoing iron removal at our blood donation centre. Body mass index (BMI) and liver enzymes were assessed. Serum iron (SI), fer...

Sep 29th, 2022 - This study aims to determine whether high resolution MRI at 7T and Quantitative Susceptibility Mapping (QSM) can demonstrate a specific pattern of iron overload in strategically important areas of brain as a sensitive marker of pathological Alzhei...

Sep 22nd, 2022 - The Food and Drug Administration approved drug Monoferric has a unique structure that allows for a slow, sustained release and bioavailability without free iron toxicity. Efficacy studies demonstrated a faster change in hemoglobin concentration fr...

Aug 5th, 2022 - Objectives: To determine the most effective oral iron supplementation regimen for repletion of iron deficiency in patients who have had gastric bypass or sleeve gastrectomy. In iron deficient patients, two supplement regimens will be compared: Fer...

Apr 5th, 2022 - A serum ferritin level can reflect the total body iron content, thus a very low serum ferritin is commonly used as an indicator of iron deficiency and a very high serum ferritin is commonly used as a marker of iron overload. Ferritin is a shell of...

Mar 21st, 2022 - Sickle cell disease (SCD) and thalassemia are genetic disorders inducing anemia of differing pathophysiology. A primary therapy for preventing certain SCD complications (e.g., stroke) and for thalassemia major is regular red blood cell (RBC) trans...

Feb 27th, 2017 - Researchers have sought a blood substitute for over 150 years, and they've all failed. Now, one candidate has demonstrated promising early results, while another nears clinical trials again, reported STAT. ErythroMer encloses hemoglobin in a synth...

Jul 19th, 2016 - Red blood cells A new study contradicts previous beliefs about how the body disposes of red blood cells (RBCs) and recycles their iron. The work suggests the accumulation and removal of aged or damaged RBCs largely takes place in the liver rather.

Aug 21st, 2013 - Action Points Patients with hemochromatosis were taller on average than those in a reference population. The deviation in height did not correlate with the type of HFE mutation, serum ferritin level, liver enzyme elevation, liver fibrosis, or clin...