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About 233 results

ALLMedicine™ Iron Toxicity Center

Research & Reviews  87 results

Reduction of iron toxicity in the heart of iron-overloaded mice with natural compounds.
https://doi.org/10.1016/j.ejphar.2022.174981
European Journal of Pharmacology; Alikhani M, Aalikhani M et. al.

Apr 30th, 2022 - Iron-overload is one of the risk factors in susceptible individuals. Iron-overload causes complications such as diastolic dysfunction, arrhythmias, ventricular dilation, and systolic dysfunction in the heart. Therefore, particular care is needed f...

Porphyromonas gingivalis outer membrane vesicles as the major drivers of and source for...
https://doi.org/10.1002/alz.056458
Alzheimer's & Dementia : the Journal of the Alzheimer's A... Nara PL

Feb 4th, 2022 - Alzheimer's disease (AD) is a progressive neuroinflammatory and neurodegenerative disease of the brain, defined by the accumulation and deposition of beta-amyloid, which has recently been identified as an antimicrobial peptide suggesting an infect...

Suppressed farnesoid X receptor by iron overload in mice and humans potentiates iron-in...
https://doi.org/10.1002/hep.32270
Hepatology (Baltimore, Md.); Xiong H, Zhang C et. al.

Dec 7th, 2021 - Iron overload (IO) is a frequent finding in the general population. As the major iron storage site, the liver is subject to iron toxicity. Farnesoid X receptor (FXR) regulates bile acid metabolism and is implicated in various liver diseases. We ai...

Iron toxicity in intracerebral hemorrhage: Physiopathological and therapeutic implicati...
https://doi.org/10.1016/j.brainresbull.2021.11.014
Brain Research Bulletin; Wei Y, Song X et. al.

Nov 29th, 2021 - Intracerebral hemorrhage (ICH)-induced brain injury is a continuous pathological process that involves the deterioration of neurological functions, such as sensory, cognitive or motor functions. Cytotoxic byproducts of red blood cell lysis, especi...

Iron toxicity-induced regulation of key secondary metabolic processes associated with t...
https://doi.org/10.1016/j.ecoenv.2021.112648
Ecotoxicology and Environmental Safety; Wang Q, Jin Q et. al.

Aug 28th, 2021 - Panax ginseng and Panax quinquefolius can survive for long periods of time in iron toxicity-stressed environments, which cause rusty roots and reduced productivity. To reveal the proteomic changes in these two Panax species in response to iron tox...

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Clinicaltrials.gov  4 results

Iron Status in BTM With Blood Transfusion
https://clinicaltrials.gov/ct2/show/NCT04947540

Jul 19th, 2021 - Thalassemia is derived from the Greek words, thals, which means sea, and emia, which means blood, signifying that it is more common in the Mediterranean region . Globally, among humans, thalassemia is the commonest single-gene disorder. It is defi...

Denosumab Versus Zoledronic Acid in Thalassemia-Induced Osteoporosis
https://clinicaltrials.gov/ct2/show/NCT03040765

Dec 12th, 2019 - Despite the significant improvements in the therapeutic management of beta thalassemia major (BTM) over the past few decades, osteoporosis is still a common finding, even in optimally treated patients. The relationships between bone mineral densit...

Observational Study of Deferiprone (Ferriprox®) in the Treatment of Superficial Siderosis
https://clinicaltrials.gov/ct2/show/NCT01284127

Sep 23rd, 2019 - First described over 100 years ago, superficial siderosis is a rare neurodegenerative disease caused by iron toxicity in the CNS due to chronic subarachnoid bleeding. Iron from red blood cells in the subarachnoid space is preferentially taken up b...

Changes in Pituitary Iron and Volume With Deferasirox
https://clinicaltrials.gov/ct2/show/NCT01376622

Jun 20th, 2011 - Despite continuing advances in iron chelation therapy, iron toxicity of endocrine glands, particularly the pituitary gland, remains common in patients with transfusion dependent anemias. We would like to establish accurate population norms of pitu...

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News  2 results

Will We Make Artificial Blood Soon? (STAT)
https://www.medpagetoday.com/criticalcare/intensivists/63444

Feb 27th, 2017 - Researchers have sought a blood substitute for over 150 years, and they've all failed. Now, one candidate has demonstrated promising early results, while another nears clinical trials again, reported STAT. ErythroMer encloses hemoglobin in a synth...

Excess Iron May Boost Adult Height
https://www.medpagetoday.com/hematologyoncology/hematology/41120

Aug 21st, 2013 - Action Points Patients with hemochromatosis were taller on average than those in a reference population. The deviation in height did not correlate with the type of HFE mutation, serum ferritin level, liver enzyme elevation, liver fibrosis, or clin...

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