About 288 results

ALLMedicine™ Opioid Toxicity Center

Research & Reviews  84 results

A Chronic Condition Disguised as an Acute Event: the Case for Re-thinking Stimulant Ove...
Journal of General Internal Medicine; Riley ED, Hsue PY et. al.

Jun 18th, 2022 - Recent reports indicate that stimulant-related deaths are increasing dramatically. People who die from acute stimulant toxicity have high rates of pre-existing cardiovascular disease (CVD), much of which is undiagnosed. Moreover, people who use st...

Identification of a novel opioid, N-piperidinyl etonitazene (etonitazepipne), in patien...
Clinical Toxicology (Philadelphia, Pa.); Calello DP, Aldy K et. al.

Jun 17th, 2022 - Novel opioids in the illicit drug supply, such as the "nitazene" group of synthetic opioids, present an ongoing public health problem due to high potency and respiratory depressant effects. We describe three patients in whom N-piperidinyl etonitaz...

Acute Opioid Withdrawal Following Intramuscular Administration of Naloxone 1.6 mg: A Pr...
Annals of Emergency Medicine; Isoardi KZ, Parker L et. al.

May 2nd, 2022 - Large doses of intramuscular (IM) naloxone are commonly used in out-of-hospital settings to reverse opioid toxicity; however, they are used less commonly in hospitals because of concerns about opioid withdrawal, particularly agitation. We aimed to...

Loperamide Cardiac Toxicity: Pathophysiology, Presentation, and Management.
The Canadian Journal of Cardiology; Wu PE, Juurlink DN

Apr 18th, 2022 - Loperamide is a nonprescription medication commonly used to treat diarrhea. Although it is an opioid, it is very poorly absorbed and well tolerated, with no systemic toxicity at standard doses. In recent years, however, loperamide has been ingeste...

Predictors of severe outcome following opioid intoxication in children.
Clinical Toxicology (Philadelphia, Pa.); Cohen N, Mathew M et. al.

Mar 26th, 2022 - While the opioid crisis has claimed the lives of nearly 500,000 in the U.S. over the past two decades, and pediatric cases of opioid intoxications are increasing, only sparse data exist regarding risk factors for severe outcome in children followi...

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Drugs  8 results see all →

Clinicaltrials.gov  8 results

Precision Medicine in Anesthesia

Oct 12th, 2021 - Opioids are key analgesic drugs. Unfortunately, they have a high potential for abuse with potentially lethal consequences, more specifically death due to respiratory suppression. In both Canada and the US, the number of deaths from opioid overdose...

Comparing Opioid Prescription Patterns in Total Joint Arthroplasty Patients

Aug 17th, 2021 - A recent paper by Kim et al prospectively investigated opioid utilization after upper extremity surgery. This study (n=1,416) showed an opioid utilization rate of just 34%, taking an average 8.1 pills out of 24 prescribed. Patients age 30-39, thos...

Safety, Tolerability and Pharmacokinetics of Single Ascending Doses of REL-1017 (d-Methadone)

Aug 1st, 2019 - This was a phase 1, single-center study carried out in healthy male and female subjects to investigate the safety, tolerability, and PK of d-methadone. This was a double-blind, randomized, placebo-controlled study in 6 sequential cohorts of health...

Safety, Tolerability, and Pharmacokinetics of Multiple Ascending Doses of REL-1017 (d-Methadone)

Aug 20th, 2018 - This was a phase 1, single-center study carried out in healthy male and female subjects to investigate the safety, tolerability, and PK of multiple doses (25mg, 50mg, and 75mg once daily) of d-methadone for 10 days. It was a double-blind, randomiz...

Addressing the Risks of Long-Term Opioid Therapy in Chronic Noncancer Pain

Jun 28th, 2018 - Chronic pain is a devastating disease often treated inadequately. More than 30 percent of the world population suffers from chronic pain. Among a plethora of treatment options, opioid agonists is one of treatment options for moderate to severe chr...

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News  15 results

Homelessness Overrepresented in Canadian Overdose Deaths

Jul 7th, 2022 - People experiencing homelessness were overrepresented among those who died of substance-related acute toxicity in Canada in 2016 and 2017, according to a new report. Among those who were homeless at the time of their death, at least 1 in 10 were r...

Opioid-Related Deaths Reach Record High in Canada

Jul 1st, 2022 - Canada's opioid and stimulant-related death rate has reached an all-time high, according to a statement from the Public Health Agency of Canada (PHAC). The number of apparent opioid toxicity deaths increased by 96% in the first year of the pandemi...

Characterizing Opioid Response in Older Veterans in the Post-Acute Setting
Victoria D. Powell, MD, Christine T. Cigolle, MD et. al.

Mar 17th, 2022 - Older adults admitted to post-acute settings frequently have complex rehabilitation needs and multimorbidity, which predisposes them to pain management challenges. 1,2 The prevalence of pain in post-acute and long-term care is as high as 65%, and o.

How to identify, evaluate, and treat patients with ‘Percocet use disorder’
Faisal A. Islam, MD, MBA, BCMAS, Zia Choudhry, MD, PhD, MBA

Dec 7th, 2020 - In recent years, Percocet (oxycodone/paracetamol) has experienced a meteoric rise to prominence because of the presence of conspicuous references in pop culture and the ever-evolving hip-hop scene,1 so much so that even propafenone is being mislab.

Management of Acute Opioid Toxicity in the Outpatient Setting
H. Harris Reynolds, MD, Timothy J. Orlowski, MD et. al.

Aug 13th, 2020 - Dermatologists’ offices are not immune from potentially fatal medical events. As a result, it is imperative that dermatologists are well versed in how to manage emergency situations in an outpatient setting.

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