×
About 303 results

ALLMedicine™ Opioid Toxicity Center

Research & Reviews  88 results

Opioid toxicity: histamine, hypersensitivity, and MRGPRX2.
https://doi.org/10.1007/s00204-022-03402-2
Archives of Toxicology; Baldo BA, Pham NH

Nov 8th, 2022 - Insights into the pathophysiology of many non-immune-mediated drug reactions referred to as toxicities, sensitivities, intolerances, or pseudoallergies have resulted from research identifying the mastocyte-related G-protein-coupled receptor (GPCR)...

The onset and severity of acute opioid toxicity in heroin overdose cases: a retrospecti...
https://doi.org/10.1080/15563650.2022.2126371
Clinical Toxicology (Philadelphia, Pa.); Stam NC, Cogger S et. al.

Oct 7th, 2022 - To differentiate the severity of acute opioid toxicity and describe both the clinical and physiological features associated with heroin overdose in a cohort of witnessed overdose cases. Witnessed heroin overdose cases over a 12-month period (30 Ju...

Naloxone Auto-injector as a Universal Precaution for Patients With Opioid Substance Use Disorder
https://clinicaltrials.gov/ct2/show/NCT02669901

Sep 10th, 2022 - The purpose of this pilot-study is to to distribute naloxone auto-injector in a "Universal Precaution" manner to patients with opioid substance use disorder. The objectives are to decrease the number of fatal and nonfatal overdose deaths, to exami...

Precision Medicine in Anesthesia
https://clinicaltrials.gov/ct2/show/NCT04495452

Sep 10th, 2022 - Opioids are key analgesic drugs. Unfortunately, they have a high potential for abuse with potentially lethal consequences, more specifically death due to respiratory suppression. In both Canada and the US, the number of deaths from opioid overdose...

National patterns of cessation of prescription opioids among Medicare beneficiaries, 20...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9410627
Medicine Westra J, Raji M et. al.

Sep 1st, 2022 - To understand the changes in opioid cessation surrounding the release of CDC guidelines and changes in state Medicaid coverage at the individual patient level. This study used a 20% national sample of Medicare beneficiaries between 2013 and 2018 w...

see more →

Drugs  9 results see all →

Clinicaltrials.gov  8 results

Precision Medicine in Anesthesia
https://clinicaltrials.gov/ct2/show/NCT04495452

Sep 10th, 2022 - Opioids are key analgesic drugs. Unfortunately, they have a high potential for abuse with potentially lethal consequences, more specifically death due to respiratory suppression. In both Canada and the US, the number of deaths from opioid overdose...

Naloxone Auto-injector as a Universal Precaution for Patients With Opioid Substance Use Disorder
https://clinicaltrials.gov/ct2/show/NCT02669901

Sep 10th, 2022 - The purpose of this pilot-study is to to distribute naloxone auto-injector in a "Universal Precaution" manner to patients with opioid substance use disorder. The objectives are to decrease the number of fatal and nonfatal overdose deaths, to exami...

Comparing Opioid Prescription Patterns in Total Joint Arthroplasty Patients
https://clinicaltrials.gov/ct2/show/NCT03236155

Aug 17th, 2021 - A recent paper by Kim et al prospectively investigated opioid utilization after upper extremity surgery. This study (n=1,416) showed an opioid utilization rate of just 34%, taking an average 8.1 pills out of 24 prescribed. Patients age 30-39, thos...

Safety, Tolerability and Pharmacokinetics of Single Ascending Doses of REL-1017 (d-Methadone)
https://clinicaltrials.gov/ct2/show/NCT03637361

Aug 1st, 2019 - This was a phase 1, single-center study carried out in healthy male and female subjects to investigate the safety, tolerability, and PK of d-methadone. This was a double-blind, randomized, placebo-controlled study in 6 sequential cohorts of health...

Safety, Tolerability, and Pharmacokinetics of Multiple Ascending Doses of REL-1017 (d-Methadone)
https://clinicaltrials.gov/ct2/show/NCT03638869

Aug 20th, 2018 - This was a phase 1, single-center study carried out in healthy male and female subjects to investigate the safety, tolerability, and PK of multiple doses (25mg, 50mg, and 75mg once daily) of d-methadone for 10 days. It was a double-blind, randomiz...

see more →

News  16 results

Homelessness Overrepresented in Canadian Overdose Deaths
https://www.medscape.com/viewarticle/976712

Jul 7th, 2022 - People experiencing homelessness were overrepresented among those who died of substance-related acute toxicity in Canada in 2016 and 2017, according to a new report. Among those who were homeless at the time of their death, at least 1 in 10 were r...

Opioid-Related Deaths Reach Record High in Canada
https://www.medscape.com/viewarticle/976491

Jul 1st, 2022 - Canada's opioid and stimulant-related death rate has reached an all-time high, according to a statement from the Public Health Agency of Canada (PHAC). The number of apparent opioid toxicity deaths increased by 96% in the first year of the pandemi...

Characterizing Opioid Response in Older Veterans in the Post-Acute Setting
https://www.mdedge.com/fedprac/article/252840/pain/characterizing-opioid-response-older-veterans-post-acute-setting
Victoria D. Powell, MD, Christine T. Cigolle, MD et. al.

Mar 17th, 2022 - Older adults admitted to post-acute settings frequently have complex rehabilitation needs and multimorbidity, which predisposes them to pain management challenges. 1,2 The prevalence of pain in post-acute and long-term care is as high as 65%, and o.

How to identify, evaluate, and treat patients with ‘Percocet use disorder’
https://www.mdedge.com/psychiatry/article/233007/addiction-medicine/how-identify-evaluate-and-treat-patients-percocet-use
Faisal A. Islam, MD, MBA, BCMAS, Zia Choudhry, MD, PhD, MBA

Dec 7th, 2020 - In recent years, Percocet (oxycodone/paracetamol) has experienced a meteoric rise to prominence because of the presence of conspicuous references in pop culture and the ever-evolving hip-hop scene,1 so much so that even propafenone is being mislab.

Management of Acute Opioid Toxicity in the Outpatient Setting
https://www.mdedge.com/dermatology/article/226936/mixed-topics/management-acute-opioid-toxicity-outpatient-setting
H. Harris Reynolds, MD, Timothy J. Orlowski, MD et. al.

Aug 13th, 2020 - Dermatologists’ offices are not immune from potentially fatal medical events. As a result, it is imperative that dermatologists are well versed in how to manage emergency situations in an outpatient setting.

see more →