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ALLMedicine™ Dental Anesthesia Center - Clinicaltrials.gov

3% POLOCAINE DENTAL (Mepivacaine HCl Injection, USP)

Polocaine Dental is available in boxes of 50 cartridges of 1.7 ml with your local dealer. DENTSPLY part number for Polocaine Dental is 34416. Please refer to the full prescribing information under resources to know more about Polocaine plain DENTAL.

SEPTOCAINE® (articaine HCl and epinephrine) Injection

Features and benefits, indications, presentation of Septocaine® and epinephrine 1:100000. Online SDS - safety data sheet - package inserts, brochures and videos about Septocaine® and epinephrine 1:100000.


The state of the art digital platform for local anesthesia


For over 100 years Dentsply Sirona has been supporting dentists worldwide in their profession. Our trusted and comprehensive range of anesthetics enables dentists and hygienists to start every procedure right.

OraVerse (phentolamine mesylate) Injection

It's a whole new direction in distinguishing your practice. And doctors all over the U.S. are introducing their patients to the reality of accelerating the reversal of lingering numbness with OraVerse. OraVerse is the first and only local anesthesia reversal agent that allows you to bring patients back to normal sensation twice as ...

Statement on Sedation & Anesthesia Administration in Dental Office-Based Settings
American Society of Anesthesiologists (ASA)

Oct 24th, 2017 - To promote the optimal sedation and/or anesthesia care, ASA offers the following recommendations for sedation and anesthesia services in dental office-based settings. These recommendations are intended for use by those state and national organizations with oversight responsibilities, and state entities offering guidance to individuals providing sedation or anesthesia care in dental office-based.

Oral pre-trigeminal neuralgia pain: clinical differential diagnosis and descriptive stu...
Cranio : the Journal of Craniomandibular Practice; Wright E, Evans J

Jul 7th, 2014 - To better quantify oral pre-trigeminal neuralgia (PTN) symptoms, attempt to identify PTN symptoms that could reliably differentiate between PTN and odontogenic tooth pain, and determine whether an anesthetic test would reliably differentiate these disorders. This was accomplished through a survey of symptom recall for 49 trigeminal neuralgia patients who had PTN tooth and/or gum pain. The varia...

Anesthesia for off-floor dental and oral surgery.
Current Opinion in Anaesthesiology; Giovannitti JA

Mar 29th, 2016 - Anesthesia for dentistry is commonly performed outside the operating room. The combination of a shared airway between surgeon and anesthetist, the variety of open airway techniques, and the out-of-operating room setting often results in anxiety and avoidance of dental cases among anesthesia personnel. This review attempts to demystify dental treatment and facilitate the anesthesia provider in p...

Safety of Local Dental Anesthesia in Patients With Cardiac Channelopathies

May 2nd, 2018 - Patients of Heart Institute of the University of São Paulo with inherited cardiac channelopathies will be included, considering the criteria for inclusion and non-inclusion, after reading and signing the informed consent. They will undergo dental restorative treatment in two sessions, in the morning period, with an interval of at least seven days (wash-out) between them, and the patients will b...

Dental Anesthesia in Heart Failure Patients

Heart failure is defined as the inability of the heart to offer blood supply required to meet metabolic demand of the tissues and thus exercise adequately its role as a pump. According to data collected from the single health system (DATASUS), approximately 6.4 million Brazilians have heart failure. This large contingent of patients will require multi-professional treatment, in particular, care...

Cardiovascular effects of combined hyaluronidase and mepivacaine in dental anesthesia: ...
American Journal of Dentistry; Tornelli MJ, Prado RM et. al.

Apr 20th, 2016 - To evaluate the effects of combined administration of mepivacaine with epinephrine and the diffusion agent hyaluronidase on hemodynamic and electrocardiographic parameters in healthy individuals undergoing dental surgery. In a double-blind, split-mouth, randomized clinical trial, the cardiovascular effects induced by 2.7 mL of 2% mepivacaine with 1:100,000 epinephrine injected concomitantly wit...

Intranasal tetracaine and oxymetazoline: a newly approved drug formulation that provide...
Current Medical Research and Opinion; Hersh EV, Saraghi M et. al.

Sep 20th, 2016 - An intranasal formulation of 3% tetracaine and 0.05% oxymetazoline (Kovanaze) received FDA approval on 29 June 2016. This formulation appears to provide sufficient local anesthesia to perform routine dental restorative (filling) procedures in maxillary teeth from second premolar forward. The aim of this paper is to provide an overview of the efficacy, pharmacokinetics and tolerability of 3% tet...

Needle fracture as a complication of dental local anesthesia: recommendations for preve...
Clinical Oral Investigations; Acham S, Truschnegg A et. al.

Jun 30th, 2018 - The aim of this publication is to provide a concept for prevention and a standardized step-by-step clinical approach to this rare but serious and potentially preventable complication of dental local anesthesia. We collected data with a PUBMED search using the key words "local anesthesia," "dental anesthesia/anesthesia" OR "mandibular block anesthesia," "complication," "hypodermic needle," "need...

Ethics Rounds: Death After Pediatric Dental Anesthesia: An Avoidable Tragedy?
Pediatrics Lee H, Milgrom P et. al.

Nov 8th, 2017 - Early childhood caries (ECC) is the single most common chronic childhood disease. In the treatment of ECC, children are often given moderate sedation or general anesthesia. An estimated 100 000 to 250 000 pediatric dental sedations are performed annually in the United States. The most common medications are benzodiazepines, opioids, local anesthetics, and nitrous oxide. All are associated with ...

Second-Degree Atrioventricular Block Occurring After Tooth Extraction.
Anesthesia Progress; Kamatani T, Akizuki A et. al.

Sep 1st, 2016 - Although cardiac arrhythmias are occasionally associated with dental extractions and dental anesthesia, atrioventricular block is rarely seen during dental procedures. We report a rare case of type I second-degree atrioventricular block (Wenckebach phenomenon) occurring after bilateral extraction of impacted mandibular third molars under general anesthesia in a 16-year-old Japanese girl. Under ...

Peroxynitrite affects lidocaine by acting on membrane-constituting lipids.
Journal of Anesthesia; Ueno T, Mizogami M et. al.

Nov 17th, 2008 - Inflammation frequently decreases local anesthetic effects, especially in dental anesthesia in patients with pulpitis and periodontitis. The pharmacokinetics and the mode of action of local anesthetics are closely associated with the hydrophobic interactions between these drugs and lipid bilayers that change the membrane physicochemical property, fluidity. A lipid oxidant, peroxynitrite, is pro...

Severe methemoglobinemia after dental anesthesia: a warning about propitocaine-induced ...
Journal of Anesthesia; Doko Y, Iranami H et. al.

Aug 13th, 2010 - Methemoglobinemia is a fatal complication of local anesthesia. We describe a case report of female neonate who developed severe methemoglobinemia after extraction of neonatal teeth conducted with general anesthesia plus local injection of Citanest-Octapressin(®) (propitocaine of approximately 10 mg/kg). Central cyanosis appeared within an hour after surgery. The percentage of methemoglobin reac...

Hypnosis and dental anesthesia in children: a prospective controlled study.
The International Journal of Clinical and Experimental Hy... Huet A, Lucas-Polomeni MM et. al.

Aug 26th, 2011 - The authors of this prospective study initially hypothesized that hypnosis would lower the anxiety and pain associated with dental anesthesia. Thirty children aged 5 to 12 were randomly assigned to 2 groups receiving hypnosis (H) or not (NH) at the time of anesthesia. Anxiety was assessed at inclusion in the study, initial consultation, installation in the dentist's chair, and at the time of an...

Advanced techniques and armamentarium for dental local anesthesia.
Dental Clinics of North America; Clark TM, Yagiela JA

Sep 13th, 2010 - Computer-controlled local anesthetic delivery (C-CLAD) devices and systems for intraosseous (IO) injection are important additions to the dental anesthesia armamentarium. C-CLAD using slow infusion rates can significantly reduce the discomfort of local anesthetic infusion, especially in palatal tissues, and facilitate palatal approaches to pulpal nerve block that find special use in cosmetic de...

Adverse events during pediatric dental anesthesia and sedation: a review of closed malp...
Pediatric Dentistry; Chicka MC, Dembo JB et. al.

Jul 16th, 2012 - The purpose of this study of closed malpractice insurance claims was to provide descriptive data of adverse events related to child sedation and anesthesia in the dental office. The malpractice claims databases of two professional liability carriers were searched using pre-determined keywords for all closed claims involving anesthesia in pediatric dental patients from 1993-2007. The database se...