About 500 results
Home use of interdental cleaning devices, in addition to toothbrushing, for preventing and controlling periodontal diseases and dental caries
Cochrane Database of Systematic Reviews; Worthington, H. et. al.

Apr 9th, 2019 - Dental caries (tooth decay) and periodontal diseases (gingivitis and periodontitis) affect the majority of people worldwide, and treatment costs place a significant burden on health services. Decay and gum disease can cause pain, eating and speaking difficulties, low self‐esteem, and even tooth loss and the need for surgery. As dental plaque is the primary cause, self‐administered daily mechani...

Oral Health Topics- Toothpastes

Aug 6th, 2018 - All toothpastes with the ADA Seal of Acceptance must contain fluoride. In addition to fluoride, toothpastes may contain active ingredients to help in ways such as lessening tooth sensitivity, whitening teeth, reducing gingivitis or tartar build-up, or preventing enamel erosion or bad breath.

Effect of deep pressure input on parasympathetic system in patients with wisdom tooth surgery

Aug 20th, 2016 - Deep pressure therapy is used to normalize physiological arousal due to stress. Wisdom tooth surgery is an invasive dental procedure with high stress levels, and an alleviation strategy is rarely applied during extraction. In this study, we investigated the effects of deep pressure input on autonomic responses to wisdom tooth extraction in healthy adults. Deep pressure therapy Methods A ran...

Diagnosis and management of xerostomia and hyposalivation

Dec 21st, 2014 - Xerostomia, the subjective complaint of dry mouth, and hyposalivation remain a significant burden for many individuals. Diagnosis of xerostomia and salivary gland hypofunction is dependent upon a careful and detailed history and thorough oral examination. There exist many options for treatment and symptom management: salivary stimulants, topical agents, saliva substitutes, and systemic sialogog...

Drug-Induced Dry Mouth

Nov 8th, 2011 - Dry mouth (xerostomia) can change speech patterns, allow dentures to rub, and contribute to dental caries. It also changes dietary preferences: who wants to eat peanut butter or saltines with a dry mouth? It may alter the sufferer’s nutritional status, causing vitamin deficiencies and caloric insufficiency—once salivary flow is reduced by half, chewing and swallowing become problematic.

Risk factors and symptoms associated with xerostomia: a cross‐sectional study
Australian Dental Journal; Villa, A. et. al.

Aug 27th, 2011 - Background: The aim of this study was to examine the symptoms and risk factors associated with self‐reported xerostomia. Methods: Data were collected from 601 self‐administered questionnaires among dental clinic attendees. Logistic regression models to estimate odds ratios and 95% confidence intervals were used to investigate the association for exposures of interest, such as socio‐demograph...

Oral lichen planus prevalence estimates go global
MDedge Dermatology; Richard Franki

Jan 10th, 2020 - The global prevalence of oral lichen planus just received its first-ever systematic review and meta-analysis, and the resulting estimates are 0. 89% for the general population and 0.

North Korea to launch medical tourism, targeting visitors from China

Dec 6th, 2019 - SEOUL (Reuters) - North Korea, one of the world’s most reclusive states, plans to branch out into medical tourism next year, offering foreign visitors, most likely from China, treatments including cataract surgery, dental implants and therapy for tumors. The ruling party’s Rodong Sinmun newspaper reported on Friday the recent launch of the “Treatment Tourism Exchange Corporation”, aimed at capi...

Roche eyes quick FDA approval in SMA race with Biogen, Novartis

Nov 25th, 2019 - FILE PHOTO: Roche tablets are seen positioned in front of a displayed Roche logo in this photo illustration January 22, 2016. REUTERS/Dado Ruvic/Illustration/File Photo ZURICH (Reuters) - Roche expects its risdiplam medicine for spinal muscular atrophy (SMA) to get U.S. approval by May, the Swiss drugmaker said on Monday, as it takes on Novartis and Biogen in the lucrative rare disease area. Th...

Fissured tongue
Satvinder Singh Bakshi, MS, DNB

Nov 1st, 2019 - A 43-year-old man presented with a 3-week history of halitosis. He was also concerned about the irregular appearance of his tongue, which he had noticed over the past 3 years.

HPV Vaccine Linked to Lower Likelihood of Oral Infection

Oct 30th, 2019 - NEW YORK (Reuters Health) - Oral human papillomavirus (HPV) infection is significantly less frequent among sexually active female adolescents who have received the quadrivalent vaccine than among their unvaccinated peers, according to new research. "This study provided real-world evidence of the potential benefits of vaccination in a population of sexually active adolescent women, which was ref...

Race, Income May Impact U.S. Oral Cancer Screening Rates

Sep 16th, 2019 - (Reuters Health) - Only about 1 in 3 U.S. adults say a dentist has ever examined them for oral cancer - and most of those who remember getting such exams are non-Hispanic whites, a new study suggests. The American Dental Association says dentists should routinely look for oral cancer. But the study, published in the American Journal of Preventive Medicine, found that screening rates were low ov...

Race, income may impact U.S. oral cancer screening rates

Sep 16th, 2019 - Only about 1 in 3 U.S. adults say a dentist has ever examined them for oral cancer - and most of those who remember getting such exams are non-Hispanic whites, a new study suggests. The American Dental Association says dentists should routinely look for oral cancer. But the study, published in the American Journal of Preventive Medicine, found that screening rates were low overall and that raci...

Red patches on the tongue with white borders • history of geographic tongue • incompletely treated celiac disease • Dx?
MDedge Family Medicine;

Sep 6th, 2019 - Other oral and dental manifestations of celiac disease include enamel defects, delayed tooth eruption, recurrent aphthous ulcers, cheilosis, oral lichen planus, and atrophic glossitis. 10 Our patient also reported anxiety, “foggy mind,” diffuse arthralgia, and abdominal pain, which are symptoms of uncontrolled celiac disease.

Gum bacteria and Alzheimer’s: A hypothesis inches forward
Jennie Smith

Jul 18th, 2019 - LOS ANGELES – Scientists testing an unusual hypothesis about the pathogenesis of Alzheimer’s disease say that use of an experimental antimicrobial drug to target a common oral infection was associated with biomarker improvements in people with the disease. At the Alzheimer’s Association International Conference, Michael Detke, MD, PhD, of Cortexyme in South San Francisco, Calif.

Antimalarial may be effective, safe for erosive oral lichen planus
Andrew D. Bowser

Jun 21st, 2019 - MILAN – Hydroxychloroquine sulfate may be an effective and relatively safe treatment option for moderate to severe oral lichen planus, an investigator reported at the World Congress of Dermatology. Andrew Bowser/MDedge News Dr.

Good Nutrition Essential for Healthy Aging

May 7th, 2019 - "Healthy eating is one key determinant of health, and as geriatricians, we can provide patients with the tools they need to maintain their health," said Marissa Black, MD, at the American Geriatrics Society 2019 Annual Scientific Meeting in Portland, Oregon. For seniors, eating well can be a challenge. They might live in a neighborhood with plenty of fast-food chains but no grocery store, they ...

ASCO: Deintensified treatment in p16+ oropharyngeal cancer needs evaluation
Caleb Rans

May 2nd, 2019 - Treatment deintensification for patients with p16+ oropharyngeal cancer (OPC) should occur only in the context of a clinical trial, according to a provisional clinical opinion released by the American Society of Clinical Oncology (ASCO). “The hypothesis that deescalation of treatment intensity for patients with p16+ OPC can reduce long-term toxicity without compromising survival is compelling a.

'Whitish Patch': Increase in Oral Dysplasia in Young Adults

May 1st, 2019 - Most 8-year-olds with a wiggly tooth expect the Tooth Fairy to tuck some money under their pillow. In the case of one little Canadian boy, his wiggly tooth got him an incisional biopsy, a diagnosis of oral squamous cell carcinoma (OSCC), a partial maxillectomy, and a defect that was closed with local advancement flaps. "This was the most unusual case we've seen," said Marco A. Magalhaes, DDS, P...

Poor Oral Hygiene, Infections in Kids May Promote Atherosclerosis in Adulthood

Apr 30th, 2019 - Children with evidence of oral infections, including cavities and bleeding gums, were significantly likely to be in the top tier for carotid intima-media thickness (IMT) measured more than 25 years later in an analysis based on the prospective Cardiovascular Risk in Young Finns Study cohort. Signs of oral infection in kids were also significantly associated with conventional cardiovascular (CV)...

Oral Health in Childhood Matters in Subsequent Adult CVD Risk

Apr 26th, 2019 - Subclinical atherosclerosis in adults can be traced to suboptimal oral health in childhood in some cases, according to a Finnish cohort study. Kids who'd had periodontal disease or cavities were more likely to exhibit intima-media thickening in the carotid artery as adults in their 30s, per multiple linear regression analyses by a group of researchers led by Pirkko Pussinen, PhD, of the Univers...

Valproate, topiramate prescribed in young women despite known teratogenicity risks
Alicia Gallegos

Apr 3rd, 2019 - Despite their known teratogenic risks, both valproate and topiramate are being prescribed relatively often in women of childbearing age, results of a retrospective analysis suggest. Antonio_Diaz/Thinkstock Topiramate, linked to increased risk of cleft palate and smaller-than-gestational-age newborns, was among the top three antiepileptic drugs (AEDs) prescribed to women 15-44 years of age in th.

Morning Break: Saudi Doctor Torture; Purdue Bankruptcy? J&J Ordered to Pay

Mar 14th, 2019 - Note that some links may require subscriptions. Saudi Arabia tortured a doctor with American citizenship arrested as part of the country's corruption crackdown in 2017, his family charged. (New York Times) An outbreak of viral parotitis aboard the USS Fort McHenry has kept the vessel and its 703 crew members at sea more than two months -- and Navy regulations on shipboard diseases may keep it o...

FDA advisory panel split over Sanofi-Lexicon diabetes drug

Jan 17th, 2019 - (Reuters) - An advisory panel to the U.S. Food and Drug Administration was divided over whether to recommend approval of a treatment for type 1 diabetes developed by Lexicon Pharmaceuticals Inc and France’s Sanofi SA. The panel on Thursday voted 8-8 when asked to assess the once-daily oral medicine, sotagliflozin, an add-on to insulin therapy. Insulin has been used to treat diabetes for decades...

Updates in Sjögren Syndrome

Nov 5th, 2018 - A Multidisciplinary, Multiagency Meeting The 14th International Sjögren's Symposium was held April 18-21, 2018, in Washington, DC. Experts in ophthalmology, oral medicine, rheumatology, internal medicine, neurology, radiology, pathology, and basic research gathered at this interdisciplinary meeting to discuss diagnostic and clinical advances from the past 3 years. In addition, speakers from the...

HPV16 Vaccine Yields Added Benefit in Recurrent Throat Cancer

Oct 3rd, 2018 - NEW YORK CITY -- Adding a tumor-specific vaccine to PD-1 checkpoint inhibition was safe and effective in HPV16-positive patients with recurrent or metastatic oropharyngeal cancer, a small phase II trial found. Among 24 patients treated with nivolumab (Opdivo) and the ISA101 long peptide vaccine, 22 of whom had oropharyngeal cancer, 33% responded and median overall survival was 17.5 months, Corn...

HPV Oral Infection Rates 'Lower Than Previously Thought'

Aug 20th, 2018 - The prevalence of oral infection with high-risk human papillomavirus (HR-HPV) was lower than expected in a sample of adults in Sheffield, a study found. The research, led by the University of Sheffield, found strong evidence that smoking, having more sexual partners, and oral sex were risk factors for oral HPV infection, which can lead to oropharyngeal (throat) cancer. Increasing Rates of Throa...

FDA Approves First Oral Drug for Fabry Disease

Aug 12th, 2018 - The US Food and Drug Administration (FDA) has approved migalastat (Galafold, Amicus Therapeutics) for adults with Fabry disease and a genetic mutation determined to be amenable to treatment with the drug on the basis of in vitro assay data. Migalastat is the first oral medicine for Fabry disease and the first new therapy approved to treat this rare disease in the United States in more than 15 y...

Tofacitinib (Xeljanz) Gets FDA Nod for Ulcerative Colitis

May 29th, 2018 - The US Food and Drug Administration (FDA) has expanded the indication for tofacitinib (Xeljanz, Pfizer) to include adults with moderate to severe active ulcerative colitis. More than 900,000 adults in the United States have ulcerative colitis, or a chronic inflammation affecting the colon. Tofacitinib becomes the first oral medicine approved for long-term use in ulcerative colitis. Other FDA-ap...

Fast Five Quiz: Test Your Knowledge on Key Aspects of Human Bite Wounds

Apr 1st, 2018 - Approximately 10%-15% of human bite wounds become infected owing to multiple factors. The bacterial inoculum of human bite wounds contains as many as 100 million organisms per mL and is made up of as many as 190 different species. Many of these are anaerobes that flourish in the low redox environment of tartar that lies between human teeth or in areas of gingivitis. Most injuries due to human b...

Management Strategies for Oral Potentially Malignant Disorders

Mar 15th, 2018 - Oral Potentially Malignant Disorders Oral potentially malignant disorders (OPMDs) include oral leukoplakia (OL), oral erythroplakia, oral submucous fibrosis, oral lichen planus, proliferative verrucous leukoplakia, and actinic keratosis. Once an OPMD has been clinically diagnosed, execution of management strategy is critical. When formulating the strategy, healthcare providers should consider h...

Treatment of Melasma Using Tranexamic Acid: What’s Known and What’s Next
Sarah L. Sheu, MD

Feb 22nd, 2018 - Tranexamic acid is a synthetic lysine derivative that inhibits plasminogen activation by blocking lysine-binding sites on the plasminogen molecule. Although the US Food and Drug Administration–approved indications for tranexamic acid include treatment of patients with menorrhagia and reduction or prevention of hemorrhage in patients with hemophilia undergoing tooth extraction, the potential eff.

Risk of Oral Clefts with Topiramate May Be Dose-Dependent

Dec 30th, 2017 - Action Points The risk of oral clefts (cleft lip or palate) at birth was almost threefold higher among infants born to women exposed to topiramate compared with an unexposed group, with greater risk among women taking higher higher doses of the drug, in a study of women enrolled in Medicaid. Note that unplanned pregnancies are common, occurring at a rate of about 50%, and topiramate is not reco...

Dentures and Tooth Loss Linked to Malnutrition

Dec 11th, 2017 - Losing teeth and wearing dentures can increase your risk of malnutrition, according to a study. A reduced ability to chew properly can lead to people over the age of 50 avoiding some healthier foods, say researchers at King's College London. Muscle and Bone Frailty The main problems they identified were frailty in joints and muscles and subsequent vulnerability to falls. The study, published in...

Gum infections tied to increased risk of stomach cancer precursor

Dec 7th, 2017 - (Reuters Health) - Gum infections may increase people’s risk for sores in the digestive tract that can lead to stomach cancer, a small study suggests. Researchers focused on what’s known as periodontal disease, serious infections in the mouth caused by bacteria in dental plaque. Daily brushing and flossing can prevent gingivitis, the milder form of periodontal disease, but untreated cases can l...

Text-message ‘blast’ can expand access to surgical services

Nov 30th, 2017 - (Reuters Health) - Dozens of patients in Zimbabwe undergoing cleft lip and palate surgery had first learned about the opportunity from an SMS text to their phones, a small study found. So-called mobile health, including text-message “blasts” to a wide swath of mobile phone users, could be the key to communicating with hard-to-reach patients in sub-Saharan Africa and other remote parts of the wo...

Text-message ‘Blast’ Can Expand Access to Surgical Services

Nov 27th, 2017 - (Reuters Health) - Dozens of patients in Zimbabwe undergoing cleft lip and palate surgery had first learned about the opportunity from an SMS text to their phones, a small study found. So-called mobile health, including text-message “blasts” to a wide swath of mobile phone users, could be the key to communicating with hard-to-reach patients in sub-Saharan Africa and other remote parts of the wo...

VIDEO: A challenging case of lichen planus
Heidi Splete

Nov 3rd, 2017 - LAS VEGAS – For challenging cases of oral or cutaneous lichen planus, bullous pemphigoid, or lupus, Miriam S. Bettencourt, MD, recommends thinking outside the box and considering off-label treatments.

Risk for HPV-Related Throat Cancer Is 'Reassuringly' Low

Oct 26th, 2017 - The risk of developing oropharyngeal cancer (OPC) related to oral human papillomavirus (HPV) infection is very low in the general population and even in people with specific behavioral risk factors, a new study suggests. "Oropharyngeal cancer has been in the news lately. The incidence of oropharyngeal cancer has doubled over the past several decades, but this research is very reassuring in show...

Oral Sex, Smoking Increase Men's HPV Risk

Oct 23rd, 2017 - Action Points Men who smoked and had five or more lifetime oral sex partners had the highest prevalence of oral oncogenic human papilloma virus (HPV) infection (14.9%). The study suggests that even though the prevalence of infection is higher in men, large numbers would need to be screened, and their lifetime risk of developing oropharyngeal cancer (OPC) is still low. Men who smoked and had fiv...

Anxiety, depression greatest in younger kids with facial birth defects

Oct 6th, 2017 - (Reuters Health) - Elementary school children with cleft lip, cleft palate and other facial anomalies may struggle more than older kids with anger, anxiety, depression and stress, according to a recent study. Compared to older kids and teens, those between ages 8 and 10 have the highest risk for psychosocial dysfunction, the study team reports in Plastic and Reconstructive Surgery. “The ultimat...

Novel Approach Reduces Treatment Toxicities in Patients With HPV-Related Oropharyngeal Cancer

Oct 4th, 2017 - Paul Dent, PhD   Surgeon Chief of Head and Neck Service Andrew S. Poklepovic, MD   Radiation Oncologist Vice Chair, Department of Radiation Oncology, Experimental Therapeutics The incidence of mouth and throat cancer is on the rise due to transmission of the human papilloma virus (HPV), but physicians at Memorial Sloan Kettering (MSK) Cancer Center have managed to significantly reduce the inten...

Oral Cues to Disease

Sep 18th, 2017 - 1. A 21-year-old man complains of prolonged diarrhea with steady abdominal pain and recent weight loss.

What a Child's Mouth Can Reveal About Abuse or Neglect

Sep 17th, 2017 - The Mouth—A Focus of Abuse and Neglect The physical or sexual abuse of a child frequently involves the mouth; more than 50% of abused children suffer injuries to the head or neck. In addition to oral trauma, maltreated children are more likely to show evidence of dental neglect, including gingivitis, caries, and other oral health problems. Examination findings that should raise suspicion of abu...

Oral Cancer Screening: New Analytic Technique for Autofluorescence Interpretation

Sep 11th, 2017 - Oral Cancer Screening Techniques Oral cancer screening techniques have expanded beyond the conventional physical examination over the last several decades. The conventional oral cancer screening, with head and neck examination, encompasses multiple checkpoints extra- and intraorally[1] and is the first step in physically screening patients for oral pathology, including oral cancer. Scalpel biop...

Gum infections linked to several cancers in women

Aug 1st, 2017 - Reuters Health - Older women with gum infections are more likely to get many common cancers than their peers who have perfect oral health, a recent study suggests. Researchers focused on what’s known as periodontal disease, serious infections in the mouth that are caused by bacteria in dental plaque. Daily brushing and flossing can prevent gingivitis, the milder form of periodontal disease, but...

FDA approves generic tranexamic acid
HT Staff

Jul 21st, 2017 - Photo by Bill Branson Vials of drug Zydus Cadila has received approval from the US Food and Drug Administration (FDA) to market a tranexamic acid product for use in patients with hemophilia. The company’s product—Tranexamic Acid Injection, 1000 mg/10 mL (100 mg/mL) Single Dose Vial—can be used to prevent or reduce bleeding in hemophilia patients undergoing tooth extraction.

Dental Implants Safe for Most Patients With Kidney Disease

Jul 5th, 2017 - Clinicians should take special precautions when placing dental implants in patients with chronic kidney disease, according to proposed guidelines. "Most people don't want to treat these patients because of the risk," Yuan Quan, DDS, PhD, from Sichuan University in Chengdu, China, told Medscape Medical News. "So in this paper we wanted to show practitioners which procedure they should follow." D...

Black hairy tongue cured concurrently with respiratory infection
Fátima Tous-Romero, MD, Sara Burillo-Martínez, MD et. al.

Jun 1st, 2017 - A 54-year-old female smoker was admitted to the hospital for fever and respiratory infection. On the day of admission, she reported lesions of the oral mucosa for the past several months.

Malignant Potential of Oral Lichen Planus/Lichenoid Lesions

May 30th, 2017 - Oral Lichen Planus and Oral Lichenoid Lesions Oral lichen planus (OLP) affects 0.22%-5% of the population worldwide and is considered to be a relatively common, chronic, oral mucocutaneous inflammatory disease that is poorly understood.[1,2,3] T lymphocytes are thought to mediate a reaction to an exogenous antigen or an autoantigen expressed by epithelial cells.[4] The various clinical forms of...

Oral HPV infections sharply lower for vaccinated youth
Oncology Practice; Susan London

May 23rd, 2017 - Vaccination against human papillomavirus (HPV) appears to be highly effective at preventing oral infection with oncogenic types of the virus, based on the results of a cohort study of a nationally representative sample of more than 2,600 U. S.

A burning sensation in the mouth
Satvinder Singh Bakshi, MS, DNB

May 1st, 2017 - A 38-year-old man presented with a burning sensation in the mouth for the previous 2 months. He was currently a smoker.

The American Cleft Palate- Craniofacial Association

Apr 16th, 2017 - The American Cleft Palate-Craniofacial Association (ACPA) is a non-profit (501(c)(3)) association of interested individuals and health care professionals who treat and/or perform research on oral cleft and craniofacial conditions. ACPA is unique ? it is a multidisciplinary organization of over 2,500 members who represent more than 30 disciplines in 60 countries and support patients and families...

Acute Submandibular Sialadenitis
Alan Lucerna, DO, James Espinosa, MD

Mar 7th, 2017 - Case A 21-year-old woman presented to the ED with pain and swelling on the right side of her neck. She stated the pain started earlier that morning and worsened when she ate or swallowed.

Healing Arts: The Synergy of Medicine and the Humanities

Mar 5th, 2017 - I witness many goodbyes. My job as an anesthesiologist is to care for people at their most vulnerable in the journey from goodbye to hello. Working at the Veterans Affairs Palo Alto Health Care System, I meet my patient and his family shortly before the time of surgery. We are all strangers. My patient, in a lavender, disposable gown, lies on a wheeled gurney, tucked under a hospital-issue blan...

Mumps on a New Hampshire University Campus

Oct 24th, 2016 - Key Points and Recommendations: Healthcare providers should be aware that in the last couple of months there have been three, apparently unlinked, cases of mumps on the University of New Hampshire Durham campus. Mumps is an acute viral infection typically characterized by swelling and tenderness of one or more salivary glands, typically the parotid gland (parotitis). Patients can also develop n...

PodMed: A Medical News Roundup From Johns Hopkins

Oct 1st, 2016 - PodMed is a weekly podcast from Johns Hopkins Medicine. In it, Elizabeth Tracey, director of electronic media for Johns Hopkins Medicine, and Rick Lange, MD, president of the Texas Tech University Health Sciences Center in El Paso, look at the top medical stories of the week. This week's topics include roller coasters and kidney stones, colonoscopy in those older than 70, benefits of exercise i...

Long-term Effect of Oral Cleft Depends on Type

Sep 27th, 2016 - The prognosis for infants born with oral clefts in the absence of any other congenital anomalies largely depends on the type of cleft, according to a population-based cohort study conducted among nearly 1.5 million individuals in Norway. At approximately 30 years of age, individuals born with a cleft lip, with or without cleft palate, did not have an elevated risk for death and had fairly small...

Geographic tongue
Ceena Neena Jacob, MD, Teny Mathew John, MD, DNB et. al.

Aug 1st, 2016 - A previously healthy 35-year-old woman presented with reddish discoloration of her tongue for the past 7 days, accompanied by mild soreness over the area when eating spicy foods. The lesion had also changed shape repeatedly.

A 52-Year-Old Man With a Large Jaw Opening

Jul 12th, 2016 - Editor's Note: The Case Challenge series includes difficult-to-diagnose conditions, some of which are not frequently encountered by most clinicians but are nonetheless important to accurately recognize. Test your diagnostic and treatment skills using the following patient scenario and corresponding questions. If you have a case you would like to suggest for a future Case Challenge, please conta...

Nail Biting: A Habit or a Disease?

May 18th, 2016 - An Oral Parafunctional Habit Nail biting (onychophagia) is an oral parafunctional habit—the use of the mouth for a purpose other than speaking, eating, or drinking, a category that includes bruxism (grinding teeth), digit sucking, pencil chewing, and mouth breathing. Nail biting begins during childhood, increases substantially during adolescence, and declines with age, although the habit may co...

No Excess Risk for Orofacial Cleft in Lamotrigine-Exposed Babies

Apr 6th, 2016 - Despite a previous signal of increased risk, a new study has confirmed that babies born to mothers who took the antiepileptic drug (AED) lamotrigine during pregnancy don't appear to have an excess risk for orofacial cleft (OC). Earlier research published by Holmes et al in 2008 uncovered a six-fold risk for OCs, specifically of cleft palate, in babies exposed to lamotrigine during pregnancy. Bu...

Cleft Surgery Boosts Economy, Gives Developing Nations Reason to Smile - Charity

Mar 24th, 2016 - DAKAR (Thomson Reuters Foundation) - Born in Ghana with a cleft lip and palate, baby Kodjo was on the brink of being drowned in a river by his family in a religious sacrifice until a passing villager intervened. The baby, who had been unable to feed properly due to the birth defect and was considered cursed because of it, was sent to local cleft surgeon Solomon Obiri-Yeboah, who repaired the sp...

Pfizer's Xeljanz meets goals in ulcerative colitis trials

Mar 18th, 2016 - (Reuters) - Pfizer Inc said on Friday its Xeljanz rheumatoid arthritis drug succeeded in meeting primary and secondary goals of a pair of late stage clinical trials in ulcerative colitis, results that could help pave the way for an additional approval for the oral medicine. A company logo is seen at a Pfizer office in Dublin, Ireland November 24, 2015. REUTERS/Cathal McNaughton/Files The larges...

Melkersson-Rosenthal Syndrome Successfully Treated With Adalimumab

Mar 11th, 2016 - Melkersson-Rosenthal syndrome (MRS) is a rare condition comprised of unilateral peripheral facial nerve palsy, episodic or progressive facial edema, and lingua plicata (also known as fissured tongue). Melkersson-Rosenthal syndrome is a subtype of orofacial granulomatosis and often is mistaken for angioedema or pseudoangioedema due to the swelling of the lips and eyelids.

Mumps Outbreak on New Hampshire College Campus: Health Alert for New Hampshire Providers

Feb 28th, 2016 - Key Points and Recommendations: Healthcare providers should be aware of a mumps outbreak identified on a New Hampshire college campus. Students are preparing to go on spring break next week and possibly travel to other areas of the state or country. Mumps is an acute viral infection typically characterized by swelling and tenderness of one or more salivary glands, typically the parotid gland (p...

Oral Leukoedema with Mucosal Desquamation Caused by Toothpaste Containing Sodium Lauryl Sulfate
James B. MacDonald, MD, Courtney A. Tobin, MD et. al.

Jan 15th, 2016 - To the Editor: A 34-year-old woman presented for evaluation of dry mouth and painless peeling of the oral mucosa of 2 months’ duration. She denied any other skin eruptions, dry eyes, vulvar or vaginal pain, or recent hair loss.

Certain birth defects linked to abuse of infants and toddlers

Nov 30th, 2015 - (Reuters Health) - Babies with certain birth defects are much more likely to be abused as infants and toddlers than other young children, a U.S. study suggests. Babies with malformations of the mouth and jaw known as cleft lip and palate were 40 percent more likely to be abused by their second birthday than those born without birth defects, the analysis of about 3 million children in Texas foun...

Oral Lichen Planus With Malignant Transformation to Invasive Squamous Cell Carcinoma
Kristopher Adam Braun, MD, Laurie Massa, MD

Sep 1st, 2015 - To the Editor: A 62-year-old woman with an extensive history of cutaneous and oral lichen planus (OLP) presented with gradual worsening of oral pain refractory to previously successful treatment regimens. The pains were described as sharp sensations originating in the right superior oral cavity, occurring almost constantly over the course of 2 months.

Three-Dimensional Printer Technology Approved for Dentures

Aug 17th, 2015 - The first-ever three-dimensional (3D) printer system to manufacture denture bases has been cleared for marketing by the US Food and Drug Administration. Although currently designed for use in laboratories, the Dentca Denture Base may soon allow dentists to make dentures in their offices, said Dentca Chief Executive Officer Sun Kwon in a news release. "This clearance completely revolutionizes th...

HPV Persistence Predicts Poor Prognosis in Head/Neck Cancer

Jul 29th, 2015 - Among patients with human papillomavirus–positive oropharyngeal cancer (HPV-OPC), persistence of HPV following treatment is associated with a poorer prognosis. Results of a new study show that the persistence of HPV16 DNA, detected in oral rinses after treatment has ended, may be predictive of disease recurrence. In a cohort of 124 patients with HPV-OPC, HPV16 DNA was detected in oral rinses fr...

Patients can spot trouble with new dental implants

Jul 9th, 2015 - (Reuters Health) - Patients with new dental implants may be able to detect signs of trouble early enough to help prevent complications that can damage gums and bone, a British study suggests. When researchers asked 75 people who received dental implants in the past year if they had complications such as bleeding, pus or loose replacement-tooth “roots,” they expected clinicians to routinely catc...

WCD: Red gums raise red flag in oral lichen planus
Family Practice News; M. Alexander Otto

Jun 22nd, 2015 - VANCOUVER – Gum involvement in oral lichen planus raises the risk of multisite or systemic disease, according to Dr. Roy Rogers, professor of dermatology at the Mayo Clinic in Rochester, Minn.

Dental Implants to Charge Mobile Devices? That's Improbable!

Jun 13th, 2015 - Charge your phone by chewing gum with this newly patented, tooth-implantable power generator. Interacting with women can impair men's cognitive performance. (But women function just fine around men.) Sticky, stretchy, and slimy little men succumb to gravity. Scientists study disorganizational behavior and entropy to understand the origin of messes. Read about the physics of the Theremin touchle...

Oral Medicine in the 21st Century

Jun 10th, 2015 - The Practice of Oral Medicine in the United States in the Twenty-First Century: An Update Pinto A, Khalaf M, Miller CS Oral Surg Oral Med Oral Pathol Oral Radiol. 2015;119:408-415 Study Summary The discipline of oral medicine is critical to dental education and the clinical practice of dentistry.[1,2] A cornerstone of modern healthcare is the connection between oral and systemic health, which i...

Viral illness often precedes genital aphthous ulcers in adolescents
MDedge ObGyn; Sharon Worcester

May 5th, 2015 - ORLANDO – Infectious processes, such as those associated with vulvar abscesses and aphthous ulcers, are among the more common culprits in young patients who present to the emergency department with pelvic pain, according to Dr. Heather Appelbaum.

Surgery Oral Board Review Courses still available in 2015

Mar 16th, 2015 - Two Clinical Performance and Oral Examinations in Surgery courses will take place on the East Coast in 2015, including Amelia Island, FL, May 7–12; and Stowe, VT, September 16–21. Register online now for 2015 courses at http://www.

Influenza Season Update #2: Alert for New Hampshire Clinicians

Feb 4th, 2015 - The Centers for Disease Control and Prevention (CDC) is investigating numerous cases of influenza-associated parotitis. The clinical significance of these findings is not clear, and the CDC is continuing to investigate the clinical syndrome in order to inform prevention and control measures. Key Points and Recommendations: The CDC nationally is investigating cases of influenza-associated paroti...

Dental Implants Safe in Patients With Uncontrolled Diabetes

Dec 9th, 2014 - Dentists can safely place dental implants in patients with uncontrolled diabetes, a new study shows. The finding contradicts common recommendations. "We failed to identify any association between elevated blood sugar and implant failure or implant complications," first author Thomas W. Oates Jr, DMD, PhD, told Medscape Medical News. Along with his colleagues, Dr Oates, a professor in the Depart...

Dental Trauma May Play a Role in Oral Cancers

Nov 6th, 2014 - Chronic dental irritation might play a role in the development of oral cancers, especially in nonsmokers, according to a study published online November 6 in JAMA Otolaryngology–Head & Neck Surgery. The authors note that oral cavity cancers occur predominantly at sites of potential dental and denture trauma; this is particularly true for nonsmokers who lack other established risk factors. But m...

A Natural Remedy for Canker Sores?

Oct 15th, 2014 - Efficacy of Honey in Comparison to Topical Corticosteroid for Treatment of Recurrent Minor Aphthous Ulceration: A Randomized, Blind, Controlled, Parallel, Double-Center Clinical Trial El-Haddad SA, Asiri FY, Al-Qahtani HH, Al-Ghmlas AS Quintessence Int. 2014;45:691-701 Study Summary Aphthous ulcers (canker sores) are among the most common oral soft tissue diseases encountered in clinical dental...

GSK melanoma pill backed by UK cost watchdog with price cut

Sep 17th, 2014 - The logo of GlaxoSmithKline (GSK) is seen on its office building in Shanghai July 12, 2013. REUTERS/Aly Song LONDON (Reuters) - Britain’s healthcare cost agency NICE has recommended a third new drug for melanoma, this time from GlaxoSmithKline, after the drugmaker offered to supply it at a discount to the state-run National Health Service. GSK currently markets Tafinlar but the product will soo...

U.S. FDA approves expanded use of Medivation prostate cancer drug

Sep 10th, 2014 - (Reuters) - U.S. health regulators approved the use of Medivation Inc’s and Astellas Pharma Inc’s advanced prostate cancer drug Xtandi in men who have not yet received chemotherapy, the companies said on Wednesday, significantly expanding the potential patient population for the oral medicine. The expanded Food and Drug Administration approval will also enable the drug to better compete with Jo...

Powered toothbrushes really are better than manual ones at plaque control
Cardiology News; Jon O. Ebbert, MD

Jul 29th, 2014 - Maintaining close collaborative relationships with my dental colleagues is one of the many benefits of my primary care practice. I never cease to be amazed by how much my dental colleagues know about medicine and how little I know about dentistry.

Study Finds Mouth Rinse Alleviates Oral Mucositis Symptoms in Head and Neck Cancers

Jul 27th, 2014 - Stephen T. Sonis, DMD, DMSc Professor of Oral Medicine Harvard School of Dental Medicine Chief, Divisions of Oral Medicine Dana-Farber Cancer Institute and Brigham and Women’s Hospital Boston, MA A growing understanding of the biological pathways at work in the development of oral mucositis in patients treated with cytotoxic cancer therapies has helped spur interest in steering symptom manageme...

TNF Inhibitor Therapy Effective for Behcet's Disease Uveitis

Jul 20th, 2014 - NEW YORK (Reuters Health) - When uveitis due to Behcet's disease fails to respond to conventional therapy, anti-TNF-alpha therapy may help, according to a Spanish study. Anti-TNF-alpha therapy was "effective and relatively safe" in patients with Bechet's disease uveitis refractory to conventional treatment, including high-dose corticosteroids and at least one immunosuppressant, the researchers ...

UK body blocks earlier use of J&J prostate cancer drug

May 13th, 2014 - LONDON (Reuters) - Britain’s healthcare cost-effectiveness agency NICE said on Wednesday that a Johnson & Johnson prostate cancer drug, originally invented in Britain, was not worth giving to patients who have yet to receive chemotherapy. Although Zytiga, or abiraterone, is already cleared for use in some men after chemotherapy, a green light for its earlier use would allow many more patients t...

American Association for Dental Research (AADR) 2014 Focuses on Oral Medicine and Biology

Apr 6th, 2014 - Cognitive Function and Oral Perception The 43rd Annual Meeting and Exhibition of the American Association for Dental Research (AADR) and Canadian Association for Dental Research (CADR) was held March 20-22, 2014, in Charlotte, North Carolina. More than 1600 original peer-reviewed oral and poster presentations reported on original research -- basic, clinical, epidemiologic, and behavioral -- foc...

Palmoplantar Keratoderma With Progressive Gingivitis and Recurrent Pyodermas
Tyler A. Moss, DO, Anne P. Spillane, MD et. al.

Apr 4th, 2014 - Papillon-Lefèvre syndrome (PLS) is a rare inherited palmoplantar keratoderma (PPK) that is associated with progressive gingivitis and recurrent pyodermas. We present a case exhibiting classic features of this autosomal-recessive condition and review the current understanding of its pathophysiology, diagnosis, and treatment.

FDA approves Paladin drug to treat tropical disease

Mar 19th, 2014 - (Reuters) - U.S. regulators on Wednesday approved a drug, Impavido, to treat the tropical disease leishmaniasis, which is caused by a parasite transmitted to humans through fly bites. The drug, also known as miltefosine, is already approved for sale in Europe, the Indian subcontinent and Central and South America. Leishmaniasis occurs primarily in people who live in the tropics and subtropics. ...

J&J, Pharmacyclics drug wins U.S. approval for leukemia

Feb 12th, 2014 - (Reuters) - U.S. health regulators on Wednesday approved the Johnson & Johnson and Pharmacyclics Inc cancer drug Imbruvica to treat chronic lymphocytic leukemia, a slowly progressing form of blood cancer. The Food and Drug Administration decision marks the second approval recently for the oral medicine, known chemically as ibrutinib. In November, the drug won U.S. approval to treat a rare and a...

Pediatric News; Suzanne C. Boulter, MD, Melinda Clark, MD

Feb 6th, 2014 - A new clinical report published in Pediatrics entitled "Management of Dental Trauma in a Primary Care Setting" expands the knowledge base for pediatricians who care for children in the primary care setting (2014;133:e466-e476). Recommendations for pediatricians go beyond caries preventive messages (brush, floss, limit juice consumption, no bottles in bed, first dental visit at 1 year of age) to.

Parents, docs can help save kids' broken teeth: report

Jan 28th, 2014 - NEW YORK (Reuters Health) - Kids with serious tooth injuries are often taken to emergency rooms or primary care doctors first, so physicians and parents need to know how to treat broken teeth until a dentist can step in, according to a new report. The new American Academy of Pediatrics guidelines on managing dental trauma are intended for doctors who need to be prepared when kids show up with s...

Dental Trauma: Guidelines for Pediatricians Updated

Jan 26th, 2014 - Nondentists can play a key role in preventing and treating dental trauma, according to a new report by the American Academy of Pediatrics. In guidelines published online January 27 in Pediatrics, the academy lays out the basics of prevention, diagnosis, and treatment for injured teeth. In children 6 years of age and younger, oral injuries are the second most common injury, accounting for almost...

Straumann to cut prices of some dental implants

Dec 29th, 2013 - ZURICH (Reuters) - The world’s largest dental implant maker, Straumann, will cut the price of its standard titanium implants by around 15 percent next year in Germany, Austria and Switzerland, the firm’s chief executive told a Swiss newspaper on Sunday. The Swiss company said its price gap with rivals must be reduced, and that it may adjust prices in other parts of Europe at a later date. Premi...

Surgery Costs More Than Scaling for Advanced Periodontitis

Dec 22nd, 2013 - Immediate surgery for severe chronic periodontitis costs more than scaling and root planing but reduces antibiotic usage, a new study shows. Surgery costs €700 ($957) more per patient than scaling and root planing, researchers from Belgium and Sweden report in an article published online November 21 in the Journal of Clinical Periodontology. "Altogether, surgery did not turn out to be as cost-e...

Periodontal Therapy Doesn't Improve Diabetes Control

Dec 19th, 2013 - Periodontal treatment doesn't improve glycemic control among patients with type 2 diabetes who have advanced chronic periodontitis, a new randomized clinical trial has found. The results were published December 18 inthe Journal of the American Medical Association (JAMA)by Steven P. Engebretson, DMD, from the department of periodontology and implant dentistry of New York University, New York, an...

Impact of Dental Plaque on Gingival Oral Lichen Planus

Dec 16th, 2013 - Plaque Control Improves the Painful Symptoms of Oral Lichen Planus Gingival Lesions. A Short-term Study Salgado DS, Jeremias F, Capela MV, Onofre MA, Massucato EM, Orrico SR J Oral Pathol Med. 2013 May 31. [Epub ahead of print] Oral Lichen Planus Lichen planus is a common mucocutaneous disorder that affects up to 2% of the global population.[1] This immune-mediated condition stimulates developm...

USPSTF: Little Evidence for Oral Cancer Screening

Nov 26th, 2013 - Action Points Insufficient evidence exists to recommend for or against screening for oral cancer by primary care physicians, the USPSTF concluded. Note that the panel recommended continued research is needed to determine the accuracy of primary care providers, dental hygienists, dentists, or other trained persons screening U.S. patients who are at increased risk. Insufficient evidence exists to...