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About 4,264 results

ALLMedicine™ Mastocytosis Center

Research & Reviews  1,827 results

Mast cell differentiation of leukemic blasts in diverse myeloid neoplasms: A potential ...
https://doi.org/10.1002/cyto.b.21938
Cytometry. Part B, Clinical Cytometry REFERENCES; Panda D, Chatterjee G et. al.

Jul 31st, 2020 - Myeloid neoplasm with blasts showing mast cell (MC)-differentiation and MC-component less than 10% of all nucleated cells but not fulfilling the criteria for systemic mastocytosis with associated hematological neoplasm (SM-AHN) or myelomastocytic ...

Visual Dermatology: Diffuse Cutaneous Mastocytosis With Bullous Lesions.
https://doi.org/10.1177/1203475420917380
Journal of Cutaneous Medicine and Surgery; Tan Q, Zhang J

Jul 29th, 2020 - Visual Dermatology: Diffuse Cutaneous Mastocytosis With Bullous Lesions.|2020|Tan Q,Zhang J,|

Heritable risk for severe anaphylaxis associated with increased α-tryptase-encoding ger...
https://doi.org/10.1016/j.jaci.2020.06.035
The Journal of Allergy and Clinical Immunology; Lyons JJ, Chovanec J et. al.

Jul 27th, 2020 - Elevated basal serum tryptase is associated with severe systemic anaphylaxis, most notably caused by Hymenoptera envenomation. While clonal mast cell disease is culprit in some individuals, it does not fully explain this clinical association. To d...

Pediatric mastocytosis.
https://doi.org/10.1097/MOP.0000000000000922
Current Opinion in Pediatrics; Hussain SH

Jul 21st, 2020 - The current article highlights recent developments in the field of pediatric cutaneous mastocytosis. Mastocytosis is a spectrum of conditions that range from fleetingly benign to aggressively malignant. Through recognizing the natural progression ...

The Impact of Psychological Stress on Mast Cells.
https://doi.org/10.1016/j.anai.2020.07.007
Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology; Theoharides TC

Jul 20th, 2020 - Atopic diseases worsen with psychological stress, but how stress contributes to their pathogenesis is still not clear. We review the evidence supporting the premise that stress contributes to allergic and inflammatory processes via stimulation of ...

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Guidelines  3 results

Systemic Mastocytosis, Version 2.2019, NCCN Clinical Practice Guidelines in Oncology.
https://doi.org/10.6004/jnccn.2018.0088
Journal of the National Comprehensive Cancer Network : JNCCN; Gotlib J, Gerds AT et. al.

Dec 13th, 2018 - Mastocytosis is a group of heterogeneous disorders resulting from the clonal proliferation of abnormal mast cells and their accumulation in the skin and/or in various extracutaneous organs. Systemic mastocytosis is the most common form of mastocyt...

Systemic Mastocytosis, Version 2.2019, NCCN Clinical Practice Guidelines in Oncology
http://www.jnccn.org/content/16/12/1500.full
Gotlib, J.

Nov 30th, 2018 - Mastocytosis is a group of heterogeneous disorders resulting from the clonal proliferation of abnormal mast cells and their accumulation in the skin and/or in various extracutaneous organs. Systemic mastocytosis is the most common form of mastocyt.

Proposed diagnostic algorithm for patients with suspected mastocytosis: a proposal of t...
https://doi.org/10.1111/all.12436
Allergy Valent P, Escribano L et. al.

May 19th, 2014 - Mastocytosis is an emerging differential diagnosis in patients with more or less specific mediator-related symptoms. In some of these patients, typical skin lesions are found and the diagnosis of mastocytosis can be established. In other cases, ho...

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Drugs  263 results see all →

Clinicaltrials.gov  2,119 results

Mast cell differentiation of leukemic blasts in diverse myeloid neoplasms: A potential ...
https://doi.org/10.1002/cyto.b.21938
Cytometry. Part B, Clinical Cytometry REFERENCES; Panda D, Chatterjee G et. al.

Jul 31st, 2020 - Myeloid neoplasm with blasts showing mast cell (MC)-differentiation and MC-component less than 10% of all nucleated cells but not fulfilling the criteria for systemic mastocytosis with associated hematological neoplasm (SM-AHN) or myelomastocytic ...

Visual Dermatology: Diffuse Cutaneous Mastocytosis With Bullous Lesions.
https://doi.org/10.1177/1203475420917380
Journal of Cutaneous Medicine and Surgery; Tan Q, Zhang J

Jul 29th, 2020 - Visual Dermatology: Diffuse Cutaneous Mastocytosis With Bullous Lesions.|2020|Tan Q,Zhang J,|

Heritable risk for severe anaphylaxis associated with increased α-tryptase-encoding ger...
https://doi.org/10.1016/j.jaci.2020.06.035
The Journal of Allergy and Clinical Immunology; Lyons JJ, Chovanec J et. al.

Jul 27th, 2020 - Elevated basal serum tryptase is associated with severe systemic anaphylaxis, most notably caused by Hymenoptera envenomation. While clonal mast cell disease is culprit in some individuals, it does not fully explain this clinical association. To d...

Pediatric mastocytosis.
https://doi.org/10.1097/MOP.0000000000000922
Current Opinion in Pediatrics; Hussain SH

Jul 21st, 2020 - The current article highlights recent developments in the field of pediatric cutaneous mastocytosis. Mastocytosis is a spectrum of conditions that range from fleetingly benign to aggressively malignant. Through recognizing the natural progression ...

The Impact of Psychological Stress on Mast Cells.
https://doi.org/10.1016/j.anai.2020.07.007
Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology; Theoharides TC

Jul 20th, 2020 - Atopic diseases worsen with psychological stress, but how stress contributes to their pathogenesis is still not clear. We review the evidence supporting the premise that stress contributes to allergic and inflammatory processes via stimulation of ...

see more →

News  47 results

Gene-targeting therapy shown to reduce mastocytosis symptoms
https://www.mdedge.com/familymedicine/article/219888/asthma/gene-targeting-therapy-shown-reduce-mastocytosis-symptoms?channel=39313
CHEST Physician; Richard Mark Kirkner

Mar 31st, 2020 - A small-molecule kinase inhibitor that targets a gene mutation complicit in systemic mastocytosis has been found to reduce symptoms by about 30%, according to early results of a clinical trial scheduled to be presented at the American Academy of A.

Update on Rosacea Classification and Its Controversies
https://www.mdedge.com/dermatology/article/204310/rosacea/update-rosacea-classification-and-its-controversies/page/0/1?channel=291

Jul 9th, 2019 - However, the Expert Committee still did not define either the length of time of flushing or nontransient erythema. It also did not specify convex surfaces of the face with periocular sparing as the characteristic pattern or provide additional info.

Inhibitor can improve symptoms of systemic mastocytosis
https://www.mdedge.com/hematology-oncology/article/190755/cythemias/inhibitor-can-improve-symptoms-systemic-mastocytosis?channel=50517
Jen Smith

Dec 8th, 2018 - Photo by Jen Smith Jason R. Gotlib, MD SAN DIEGO—The KIT D816V inhibitor avapritinib can improve symptoms of systemic mastocytosis (SM), according to researchers.

A Case of Systemic Mastocytosis With Associated Clonal Hematological Non-Mast Cell Lineage Disease at VA Pittsburgh Healthcare System
https://www.mdedge.com/fedprac/avaho/article/174895/lymphoma-plasma-cell-disorders/case-systemic-mastocytosis-associated
Liman AD, Gandhi A et. al.

Sep 14th, 2018 - Introduction: Systemic mastocytosis (SM) is a rare myeloid neoplasm that is caused by accumulation of abnormal mast cells in the bone marrow, liver, spleen, and skin. The KIT D816V mutation encodes a constitutively activated receptor tyrosine kina.

Avapritinib produces durable responses in SM
https://www.mdedge.com/hematology-oncology/article/184888/leukemia-myelodysplasia-transplantation/avapritinib-produces-durable
HT Staff

Jun 25th, 2018 - Photo from EHA Poster session at the 23rd Congress of the European Hematology Association (EHA) STOCKHOLM—The KIT/PDGFRA inhibitor avapritinib has produced durable responses in patients with systemic mastocytosis (SM). In the phase 1 EXPLORER tria.

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Patient Education  5 results see all →