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ALLMedicine™ Liposarcoma Center

Research & Reviews  796 results

Dedifferentiated Liposarcoma: A Comprehensive Historical Review With Proposed Evidence-...
Advances in Anatomic Pathology; Kilpatrick SE

Jul 31st, 2021 - Among all sarcoma types, liposarcoma is the most common sarcoma that develops "dedifferentiation." Since its initial description by Dr Harry Evans, the spectrum of what is now acceptably included under the rubric of "dedifferentiated liposarcoma" ...

The utility of fluorescence in situ hybridization (FISH) in determining DNA damage-indu...
Pathology, Research and Practice; Kuczkiewicz-Siemion O, Wiśniewski P et. al.

Jul 30th, 2021 - Dedifferentiated liposarcoma (DDLPS) is characterized by non-lipogenic sarcoma fields coexisting with adipocyte-rich well-differentiated areas. Amplification of the 12q13-15 region includes the MDM2 and DDIT3 genes. MDM2 amplification is considere...

Abdominal actinomycosis after reparative surgery for cholecystogastric fistula in an im...
BMJ Case Reports; Fra MC, Brenna M et. al.

Jul 25th, 2021 - A male patient, aged over 75 years, was referred to the emergency room for pain in his right hypochondrium. This pain, which persisted for approximately 3 days, radiated to his right flank and right iliac quadrant and worsened after meals. The pat...

Myositis and myasteniform syndrome related to pembrolizumab.
BMJ Case Reports; Sanchez-Sancho P, Selva-O'Callaghan A et. al.

Jul 23rd, 2021 - This case report concerns a 63-year-old man affected by metastatic undifferentiated liposarcoma. After receiving pembrolizumab as a second-line treatment in a clinical trial, the patient experienced an immune-mediated myocarditis, myositis and mya...

Pleomorphic liposarcoma of the male breast: lessons from a rare malignancy during COVID...
BMJ Case Reports; Singh BK, Pol MM et. al.

Jul 22nd, 2021 - A 52-year-old man presented with a recurrent right side breast lump. He had undergone excision of a lump on the right breast followed by adjuvant chemoradiotherapy 1 year ago for a diagnosis of pleomorphic liposarcoma. Imaging revealed a 47×36 mm ...

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Drugs  9 results see all →

Clinicaltrials.gov  25 results

Nivolumab With and Without Ipilimumab and Radiation Therapy in Treating Patients With Recurrent or Resectable Undifferentiated Pleomorphic Sarcoma or Dedifferentiated Liposarcoma Before Surgery

Mar 4th, 2020 - PRIMARY OBJECTIVES: I. To assess the pathologic response of nivolumab monotherapy and nivolumab and ipilimumab combination therapy administered in the neoadjuvant setting with and without radiation in patients with treatment-naive primary or local...

Eribulin and Radiation in Treating Patients With Retroperitoneal Liposarcoma That Can Be Removed by Surgery

Feb 19th, 2020 - PRIMARY OBJECTIVE: I. To determine the recommended phase 2 dose (RP2D) of radiation and eribulin mesylate (eribulin) when used in combination for the preoperative treatment of retroperitoneal liposarcoma. SECONDARY OBJECTIVES: I. To assess the fea...

The FGF/FGFR Signalling Pathway:

Nov 21st, 2018 - Liposarcomas are the most common type of soft tissue sarcomas (STS). Among liposarcomas, well-differentiated liposarcoma (WDLPS)/dedifferentiated liposarcoma (DDLPS) are the most frequent types. WDLPS are composed mostly of mature fat whereas DDLP...

Selinexor in Advanced Liposarcoma

Nov 1st, 2018 - In the Phase 2 portion of the study, 57 patients were randomized to selinexor (60 mg) or placebo at a 1:1 allocation ratio. In the Phase 3 portion of the study, approximately 222 patients will be randomized to selinexor (60 mg) or placebo with a 2...

MAGE-A4ᶜ¹º³²T for Multi-Tumor

Oct 19th, 2018 - This study will investigate the safety and tolerability of MAGE-A4ᶜ¹º³²T cell therapy in subjects who have the appropriate HLA-A2 tissue marker and whose urinary bladder, melanoma, head and neck, ovarian, non-small cell lung, esophageal, gastric, ...

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News  41 results

De-intensification of Radiotherapy Possible in Rare Liposarcoma

Nov 17th, 2020 - De-intensification of preoperative radiation therapy is both effective and oncologically safe in patients with myxoid liposarcoma, an extremely rare type of soft tissue sarcoma (STS). The lower doses of radiotherapy were also associated with far l...

Clinical trials in sarcoma bring hope and promise
William D. Tap, MD

Sep 17th, 2019 - In this issue of The Sarcoma Journal , we highlight research and developments presented at the 2019 ASCO annual meeting. Despite the rarity of sarcoma, it was not lost among the thousands of abstracts, posters, and talks presented during the four-.

Primary Site and Other Prognostic Factors Affecting Myxoid Liposarcoma Survivorship
Dickan A, Gootee J et. al.

Sep 9th, 2019 - Background: Myxoid liposarcomas (MLS) are intermediate to high grade liposarcomas, which are the most common type of soft tissue sarcoma. Although MLS most frequently develops in the legs, it can arise in any of the body’s soft tissue adipose.

Primary Anatomical Site as a Prognostic Factor for Pleomorphic Liposarcoma
Lee HG, Aurit S et. al.

Sep 9th, 2019 - Background: Pleomorphic liposarcomas is an aggressive, high grade subtype of soft tissue sarcoma representing < 15% of liposarcomas. It most commonly arises in the retroperitoneum and proximal upper extremities.

Surgical Margins and Other Important Prognostic Factors in Dedifferentiated Liposarcoma Survival
Nguyen K, Gootee J et. al.

Sep 5th, 2019 - Background: Liposarcoma is the most common malignant soft tissue sarcoma (STS). Surgical resection is the most utilized therapeutic option.

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Patient Education  13 results see all →