About 6,975 results

ALLMedicine™ Cutaneous Melanoma Center

Research & Reviews  2,336 results

Gain of CCND1 May Occur Too Infrequently in Cutaneous Melanoma, and Too Late in Melanom...
The American Journal of Dermatopathology; McFadden JR, Chaudhari AS et. al.

Mar 21st, 2023 - Genomic analysis is an important tool in the diagnosis of histologically ambiguous melanocytic neoplasms. Melanomas, in contrast to nevi, are characterized by the presence of multiple copy number alterations. One such alteration is gain of the pro...

The Association of Guideline-Concordant Sentinel Lymph Node Biopsy for Melanoma at Mino...
Annals of Surgical Oncology; Greene AC, Wong WG et. al.

Mar 21st, 2023 - Minority-serving hospitals (MSHs) have been associated with lower guideline adherence and worse outcomes for various cancers. However, the relationship among MSH status, concordance with sentinel lymph node biopsy (SLNB) guidelines, and overall su...

Does Stage Migration Occur as a Consequence of Omitting Completion Lymph Node Dissectio...
Annals of Surgical Oncology; Senders ZJ, Bartlett EK et. al.

Mar 20th, 2023 - Completion lymph node dissection (CLND) is no longer recommended routinely in the treatment of melanoma. CLND omission may understage patients for whom the distinction between stage IIIA and IIIB-C could alter adjuvant therapy recommendations. The...

Racial and Ethnic Health Disparities in Dermatology.
Dermatologic Clinics; Brown SG, Cobb CBC et. al.

Mar 19th, 2023 - Health disparities are differences in health or disease incidence, prevalence, severity, or disease burden that are experienced by disadvantaged populations. Their root causes are attributed in large part to socially determined factors, including ...

SMG7-AS1 AS a prognostic biomarker and predictor of immunotherapy responses for skin cu...
Genomics Xu X, Ju Y et. al.

Mar 18th, 2023 - Skin cutaneous melanoma (SKCM) is the most life-threatening skin cancer and lacks early detection and effective treatment strategies. Many long noncoding RNAs are associated with the development of tumors and may serve as potential immunotherapeut...

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Guidelines  9 results

European consensus-based interdisciplinary guideline for melanoma. Part 2: Treatment - ...
European Journal of Cancer (Oxford, England : 1990); Garbe C, Amaral T et. al.

May 28th, 2022 - A unique collaboration of multidisciplinary experts from the European Dermatology Forum (EDF), the European Association of Dermato-Oncology (EADO), and the European Organization of Research and Treatment of Cancer (EORTC) was formed to make recomm...

SEOM clinical guideline for the management of cutaneous melanoma (2020).
Clinical & Translational Oncology : Official Publication ... Majem M, Manzano JL et. al.

Mar 3rd, 2021 - Melanoma affects about 6000 patients a year in Spain. A group of medical oncologists from Spanish Society of Medical Oncology (SEOM) and Spanish Multidisciplinary Melanoma Group (GEM) has designed these guidelines to homogenize the management of t...

Systemic Therapy for Melanoma: ASCO Guideline.
Journal of Clinical Oncology : Official Journal of the Am... Seth R, Messersmith H et. al.

Apr 2nd, 2020 - To provide guidance to clinicians regarding the use of systemic therapy for melanoma. ASCO convened an Expert Panel and conducted a systematic review of the literature. A systematic review, one meta-analysis, and 34 additional randomized trials we...

Guidelines of care for the management of primary cutaneous melanoma.
Journal of the American Academy of Dermatology; Swetter SM, Tsao H et. al.

Nov 6th, 2018 - The incidence of primary cutaneous melanoma continues to increase each year. Melanoma accounts for the majority of skin cancer-related deaths, but treatment is usually curative following early detection of disease. In this American Academy of Derm...

An update on the Society for Immunotherapy of Cancer consensus statement on tumor immun...
Journal for Immunotherapy of Cancer; Sullivan RJ, Atkins MB et. al.

Jun 1st, 2018 - Cancer immunotherapy has been firmly established as a standard of care for patients with advanced and metastatic melanoma. Therapeutic outcomes in clinical trials have resulted in the approval of 11 new drugs and/or combination regimens for patien...

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Drugs  1 results see all →

Clinicaltrials.gov  138 results

Study of TBio-6517 Given Alone or in Combination With Pembrolizumab in Solid Tumors

Mar 10th, 2023 - This is a Phase 1/2a dose escalation study with TBio-6517 administered by direct injection into tumor(s) or by intravenous infusion. The Phase 1 portion has 4 arms; the first arm (Arm A) will determine the RP2D of TBio-6517 alone when directly inj...

A Study of TAK-981 Given With Pembrolizumab in Participants With Select Advanced or Metastatic Solid Tumors

Mar 8th, 2023 - The drug being tested in this study is called TAK-981. TAK-981 is being tested to treat people who have select advanced or metastatic solid tumors. The study will include a dose escalation phase and a dose expansion phase. The study will enroll ap...

Melanoma Margins Trial-II: 1cm v 2cm Wide Surgical Excision Margins for AJCC Stage II Primary Cutaneous Melanoma

Mar 7th, 2023 - This study will determine whether there is a difference in disease-free survival rates for patients with primary cutaneous melanoma with Breslow thickness > 2mm or 1-2mm with ulceration (pT2b-pT4b, AJCC 8th edition), treated with either a 1cm exci...

Phase 1b/2 Study of the Combination of IMCgp100 With Durvalumab and/or Tremelimumab in Advanced Cutaneous Melanoma

Mar 7th, 2023 - This study is a Phase Ib/II, multi-center, open-label study of tebentafusp (IMCgp100) as a single agent and in combination with durvalumab (MEDI4736) and/or tremelimumab in metastatic cutaneous melanoma. The purpose of this study is to characteriz...

Adjuvant Encorafenib and Binimetinib in High-risk Stage II Melanoma With a BRAF Mutation.

Mar 6th, 2023 - This is a randomized triple-blind placebo-controlled international multicenter phase III superiority clinical trial. Participants with completely resected cutaneous melanoma and documented BRAF V600E/K status by central assay will be randomized 1 ...

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News  306 results

More than 97K new cutaneous melanoma diagnoses expected in 2023
Doug Brunk

Feb 14th, 2023 - SAN DIEGO – According to the latest American Cancer Society (ACS) data, cutaneous melanoma was the 5th most common cancer in 2022, with an estimated 99,780 new cases and 7,650 deaths, following cancer of the colorectal area, lung and bronchus, pro.

Dermoscopy, other modalities for improving melanoma diagnoses reviewed
Doug Brunk

Feb 7th, 2023 - San Diego – Despite advances in dermoscopy and other techniques for diagnosing cutaneous melanoma, histology remains the gold standard. “I don’t think that’s going to change in the short term,” Travis W.

The Role of Dietary Antioxidants in Melanoma and Nonmelanoma Skin Cancer
Kimberly A. Sable, MD, Bridget E. Shields, MD

Dec 30th, 2022 - Nonmelanoma skin cancer (NMSC) is the most common cancer in the United States, and cutaneous melanoma is projected to be the fifth most common form of cancer in 2022, with increasing incidence and high potential for mortality. 1-3 Estimates indicat.

Melanoma Mortality Rates Fell in 2010s as New Therapies Took Hold

Dec 13th, 2022 - A new generation of treatments appears to have caused U.S. melanoma mortality rates to plunge between 2013 and 2017 for the first time in 4 decades, a new study finds, although the dip appeared to stabilize over the next 2 years. Dr Navkirat Kahlo...

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