About 928 results

ALLMedicine™ Xeroderma Pigmentosum Center

Research & Reviews  356 results

Reduced levels of prostaglandin I2 synthase: a distinctive feature of the cancer-free t...
Proceedings of the National Academy of Sciences of the Un... Lombardi A, Arseni L et. al.

Jun 23rd, 2021 - The cancer-free photosensitive trichothiodystrophy (PS-TTD) and the cancer-prone xeroderma pigmentosum (XP) are rare monogenic disorders that can arise from mutations in the same genes, namely ERCC2/XPD or ERCC3/XPB Both XPD and XPB proteins belon...

Dermoscopic features of 61 skin lesions in xeroderma pigmentosum patients: A cross-sect...
Journal of the American Academy of Dermatology; Faria Licarião Rocha LK, Ferreira P et. al.

May 29th, 2021 - Dermoscopic features of 61 skin lesions in xeroderma pigmentosum patients: A cross-sectional study.|2021|Faria Licarião Rocha LK,Ferreira P,Avancini J,Castro LP,Najjar Z,|

Interaction of DNA Repair Gene XPC With Smoking and Betel Quid Chewing Behaviors of Ora...
Cancer Genomics & Proteomics; Wu CN, Chang WS et. al.

May 18th, 2021 - Xeroderma pigmentosum complementation group C (XPC) is reported to play important roles in DNA integrity and genomic instability, however, the contribution of XPC to oral carcinogenesis is largely uncertain. Therefore, we aimed at examining the co...

Xeroderma Pigmentosum group D suppresses proliferation and promotes apoptosis of HepG2 ...
International Journal of Experimental Pathology; He Y, Tao W et. al.

May 17th, 2021 - Xeroderma Pigmentosum group D (XPD) gene has been shown to suppress hepatocellular carcinoma (HCC) progression, but its mechanism remains not fully understood. ETS-related gene (ERG) is generally known as an oncogenic gene. This study aimed to exp...

Polymorphism of the DNA repair gene XDP increases the risk of systemic lupus erythemato...
Multiple Sclerosis and Related Disorders; Saravani M, Nematollahi MH et. al.

May 14th, 2021 - Xeroderma pigmentosum group D ( XPD ) is an essential component of the nucleotide excision repair (NER) pathway, which can play a major role in DNA repair processes. A deficiency in this pathway was suggested as a causative factor of autoimmune di...

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Drugs  1 results see all →

Clinicaltrials.gov  6 results

Cancer Risk in Carriers of the Gene for Xeroderma Pigmentosum

Apr 7th, 2020 - Xeroderma Pigmentosum (XP) is a rare, recessive disorder with a more than 1000-fold increase in the frequency of all major skin cancers in association with defective DNA repair. The risk of skin and other cancers among normal appearing XP heterozy...

Examination of Clinical and Laboratory Abnormalities in Patients With Defective DNA Repair: Xeroderma Pigmentosum, Cockayne Syndrome, or Trichothiodystrophy

Mar 23rd, 2020 - Four rare genetic diseases, xeroderma pigmentosum (XP), Cockayne syndrome (CS), the XP/CS complex and trichothiodystrophy (TTD) have defective DNA excision repair although only XP has increased cancer susceptibility. We plan to perform careful cli...

Gemcitabine Hydrochloride and Cisplatin or High-Dose Methotrexate, Vinblastine, Doxorubicin Hydrochloride, and Cisplatin in Treating Patients With Urothelial Cancer

Jan 29th, 2014 - PRIMARY OBJECTIVES To estimate the difference in the rate of unacceptable toxicity for dose-dense methotrexate, vinblastine, doxorubicin, and cisplatin (MVAC) and gemcitabine and cisplatin (GC) in the adjuvant treatment of urothelial cancer. SECON...

T4N5 Liposome Lotion Compared With Placebo Lotion for Preventing Actinic Keratoses in Patients With Xeroderma Pigmentosum

Nov 6th, 2013 - OBJECTIVES: I. Compare the safety and efficacy of T4N5 liposome lotion vs. a placebo lotion in reducing the incidence of actinic keratoses and protecting against other ultraviolet skin damage in patients with xeroderma pigmentosum. OUTLINE: Random...

Isotretinoin in Preventing Skin Cancer

Jun 19th, 2013 - OBJECTIVES: I. Determine the lowest effective dose of oral isotretinoin for long-term therapy that is capable of reducing the rate of formation of new skin cancers in patients with xeroderma pigmentosum or nevoid basal cell carcinoma syndrome. II....

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News  8 results

Fast Five Quiz: Malignant Melanoma

Aug 21st, 2020 - Primary risk factors and clinical warning signs for melanoma include: Changing mole (most important clinical warning sign) Presence of xeroderma pigmentosum or familial atypical mole melanoma syndrome Clinical atypical/dysplastic nevi in familial ...

NHS England Boss Knighted in New Year Honours

Dec 28th, 2019 - Simon Stevens, head of NHS England becomes a Sir, leading this year's healthcare field in the 2020 New Year Honours List. The recipients in healthcare are alongside stars of sport, entertainment, public service, politics, charity work, and "the ou...

Expert spotlights telltale clinical signs of xeroderma pigmentosum
Doug Brunk

Sep 10th, 2019 - AUSTIN, TEX. – If a child presents with acute photosensitivity at a young age, onset of freckling before the age of 2 years, and severe sun damage of the lips and eyes, think xeroderma pigmentosum (XP), a rare autosomal recessive disorder.

Small Kansas Town Turns Night Into Day for Boy With Rare Disease

Nov 1st, 2017 - A new documentary video developed by NORD shows how a small community in Kansas came together to support an 11-year-old boy who has a rare disease that makes it necessary for him to avoid sunlight. Peyton Madden has xeroderma pigmentosum (XP), a r.

Why you should use sunscreens indoors
Lily Talakoub, MD, Naissan Wesley, MD

Aug 17th, 2017 - It may be surprising that there are dermatologic risks of UV exposure from lamps and other indoor light sources that we use daily. Is long-term daily exposure to presumably low-irradiance lights of clinical significance to photodermatoses? Recent.

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