The New England Journal of Medicine; Cardemil CV, Dahl RM et. al.
Sep 6th, 2017 - The effect of a third dose of the measles-mumps-rubella (MMR) vaccine in stemming a mumps outbreak is unknown. During an outbreak among vaccinated students at the University of Iowa, health officials implemented a widespread MMR vaccine campaign. We evaluated the effectiveness of a third dose for outbreak control and assessed for waning immunity. Of 20,496 university students who were enrolled ...
Advances in Dermatology and Venereology; Dand N, et al
Jan 29th, 2020 - Psoriasis is a common inflammatory skin disease caused by the interplay between multiple genetic and environmental risk factors. This review summarises recent progress in elucidating the genetic basis of psoriasis, particularly through large genome-wide association studies. We illustrate the power of genetic analyses for disease stratification. Psoriasis can be stratified by phenotype (common p...
Nov 30th, 2019 - A rare form of skin cancer may sometimes start with cancer-causing mutations in hair follicle stem cells. A better understanding of how melanoma arises may lead to ways to detect and treat the disease earlier.
J National Cancer Institute; Deshmukh AA, et al
Nov 18th, 2019 - Squamous cell carcinoma of the anus (SCCA) incidence is rising in the United States (US). Study of incidence trends by stage at diagnosis, age-specific and birth cohort patterns, and trends in mortality could provide evidence for a true increase and etiological clues for this rise.
Oct 28th, 2019 - Biologic drugs are complex medications produced from living organisms or their parts. They include vaccines and drugs to treat conditions like rheumatoid arthritis, psoriasis, and cancer. Some biologic drugs, like insulin, can only be delivered by injection. If taken by mouth, stomach acid would destroy the drug before it could take effect.
Oct 28th, 2019 - Shingles (also known as herpes zoster) results from infection by the varicella zoster virus. This common virus causes chickenpox (also known as varicella), which is characterized by itchy spots on the skin that cover the whole body and usually occurs in childhood or adolescence. After the body fights the initial infection, the varicella zoster virus remains in nerve cells for the rest of a per...
Oct 17th, 2019 - Foamix Pharmaceuticals Ltd. (Nasdaq: FOMX) (“Foamix” or the “Company”), a specialty pharmaceutical company, today announced that the U.S. Food and Drug Administration (FDA) has approved its novel AMZEEQTM (minocycline) topical foam, 4%. AMZEEQ, formerly known as FMX101, is indicated for the treatment of inflammatory lesions of non-nodular moderate to severe acne vulgaris in adults and pediatric...
American Family Physician;
Oct 14th, 2019 - A seven-year-old boy presented with abnormal growth of his fingernails that began two weeks prior. He had no other symptoms, including pain or pruritus on his hands or around his nails. He did not have fevers, chills, nausea, vomiting, or change in activity. He had hand-foot-and-mouth disease two months earlier that was diagnosed based on vesicular lesions in his mouth and on his hands and feet...
American Family Physician;
Oct 14th, 2019 - Acne vulgaris is the most prevalent chronic skin disease in the United States, affecting nearly 50 million people per year, mostly adolescents and young adults. Potential sequelae of acne, such as scarring, dyspigmentation, and low self-esteem, may result in significant morbidity. Typical acne lesions involve the pilosebaceous follicles and the interrelated processes of sebum production, Cutiba...
Oct 10th, 2019 - Two histologic types account for the majority of malignant esophageal neoplasms: adenocarcinoma and squamous cell carcinoma. Adenocarcinomas typically start in the lower esophagus and squamous cell carcinoma can develop throughout the esophagus. The epidemiology of these types varies markedly.
Morbidity and Mortality Weekly Report; Patel, M. et. al.
Oct 3rd, 2019 - What is already known about this topic? Measles was eliminated in the United States in 2000. High national coverage with measles, mumps, and rubella vaccine and rapid implementation of measles control measures prevent widespread measles transmission. What is added by this report? During January–September 2019, 1,249 U.S. measles cases were reported, the highest annual number since 1992...
Oct 3rd, 2019 - The FDA recently approved Galderma’s topical retinoid cream, known as Aklief, for the treatment of acne vulgaris. Additionally, the company reported positive safety profiles for Aklief in two phase 3 clinical trials on acne of both the face and trunk in patients aged 9 years and older, according to a news release issued by the company.
American Family Physician; Saguil, A. et. al.
Sep 30th, 2019 - Hand-foot-and-mouth disease is caused by human enteroviruses and coxsackieviruses. Outbreaks can occur in the spring to fall and are common in North America, and most cases occur in patients younger than 10 years. Hand-foot-and-mouth disease is transmitted by fecal-oral, oral-oral, and respiratory droplet contact. Patients present with a low-grade fever, a maculopapular or papulovesicular rash ...
Sep 23rd, 2019 - Although androgen excess can manifest in many ways, the most common and recognizable symptoms are hirsutism and acne. Reports of hirsutism and acne should be taken seriously because of their possible association with medical disorders, their substantial effect on self-esteem and quality of life, and the potential for psychosocial morbidity. In patients with symptoms of androgen excess, the diff...
Sep 19th, 2019 - Psoriatic arthritis (PsA) is chronic inflammatory arthritis associated with psoriasis (PsO) and found in about 20 to 30% of such patients. It shares many clinical features with other spondyloarthropathies and also rheumatoid arthritis (RA). It is usually seronegative, but a small percentage of patients may be positive for rheumatoid factor (RF) and anti-cyclic citrullinated peptide antibodi...
The Lancet Infectious Diseases;
Sep 9th, 2019 - Historically, the human pathogen Streptococcus pyogenes (group A streptococcus) was a major cause of death as a result of sepsis and fatal epidemics of scarlet fever.1 Despite a decline in the incidence and severity of these toxin-mediated diseases over the past century in high-income countries, group A streptococcus is still among the top ten infectious causes of human mortality, with more tha...
Sep 9th, 2019 - Since 2014, England has seen increased scarlet fever activity unprecedented in modern times. In 2016, England's scarlet fever seasonal rise coincided with an unexpected elevation in invasive Streptococcus pyogenes infections. We describe the molecular epidemiological investigation of these events.
Aug 25th, 2019 - 2018 - 2019 Measles Outbreak in Rockland County: As of August 26, 2019, there are 312* confirmed reported cases of measles in Rockland County. *On Monday, August 26, 2019, 16 historical cases of measles were added to the current total. These cases occurred between early February 2019 and mid-May 2019.
Aug 15th, 2019 - Treatment for children with laryngeal tumors depends upon the type; most are rhabdomyosarcoma and treated with chemotherapy and radiation therapy. Squamous cell carcinoma is managed with surgery and radiation therapy. Get detailed treatment information in this summary for clinicians.
Aug 11th, 2019 - There are >12 million patients with peripheral artery disease in the United States. The most severe form of peripheral artery disease is critical limb ischemia (CLI). The diagnosis and management of CLI is often challenging. Ethnic differences in comorbidities and presentation of CLI exist. Compared with white patients, black and Hispanic patients have higher prevalence rates of diabetes m...
Jul 31st, 2019 - Cutaneous squamous cell carcinoma (CSCC) is the second most common cancer in the U.S. and more common than breast, lung, and prostate cancers combined.1,2 As a skin cancer, it often takes a backseat to melanoma, even though it is roughly five times more common.3,4 While CSCC has a good prognosis when treated early, approximately 40,000 of the 1 million cases diagnosed annually (roughly 4 pe...
JAMA Dermatology; Kim, J. et. al.
Jul 30th, 2019 - Question Is vitamin A intake associated with reduced cutaneous squamous cell carcinoma risk? Findings In this cohort study of 48 400 US men and 75 170 US women, during a follow-up period of more than 26 years, higher total vitamin A intake was associated with a reduction in cutaneous squamous cell carcinoma risk. Meaning This study found an inverse association between intake of vitamin...
Jul 30th, 2019 - On July 30, 2019, the Food and Drug Administration approved pembrolizumab (KEYTRUDA, Merck) for patients with recurrent, locally advanced or metastatic, squamous cell carcinoma of the esophagus (ESCC) whose tumors express PD-L1 (Combined Positive Score [CPS] ≥10), as determined by an FDA-approved test, with disease progression after one or more prior lines of systemic therapy.
Jul 30th, 2019 - Merck (NYSE: MRK), known as MSD outside the United States and Canada, today announced that the U.S. Food and Drug Administration (FDA) has approved KEYTRUDA, Merck’s anti-PD-1 therapy, as monotherapy for the treatment of patients with recurrent locally advanced or metastatic squamous cell carcinoma of the esophagus whose tumors express PD-L1 (Combined Positive Score [CPS] ≥10) as determined by ...
American Family Physician;
Jul 28th, 2019 - Measles is one of the most highly transmissible diseases, with 90% of unvaccinated persons infected after contact.1 In 2000, the Centers for Disease Control and Prevention (CDC) declared that measles was eliminated in the United States, but that elimination status may be revoked if the current chain of measles transmission and outbreaks continues for one year, through the fall of 2019. As ...
Jul 23rd, 2019 - Samsung Bioepis Co., Ltd. today announced that the US Food and Drug Administration (FDA) has approved HADLIMA™ (adalimumab-bwwd), a biosimilar referencing HUMIRA® i (adalimumab), for the treatment of rheumatoid arthritis, juvenile idiopathic arthritis, psoriatic arthritis, ankylosing spondylitis, adult Crohn’s disease, ulcerative colitis and plaque psoriasis. Please see below the full indicatio...
The Lancet Oncology;
Jul 21st, 2019 - Pembrolizumab improved progression-free survival and overall survival versus ipilimumab in patients with advanced melanoma and is now a standard of care in the first-line setting. However, the optimal duration of anti-PD-1 administration is unknown. We present results from 5 years of follow-up of patients in KEYNOTE-006
Jul 17th, 2019 - Measles is one of the most easily transmitted viruses known to man. It spreads via the respiratory system – much like influenza and TB. An infected person coughs the virus and others inhale it. The measles virus remains infectious in the air up to two hours after the infectious individual has left the area.
Jul 15th, 2019 - Squamous cell carcinoma is a cancer that arises from particular cells called squamous cells. Squamous cells are found in the outer layer of skin and in the mucous membranes, which are the moist tissues that line body cavities such as the airways and intestines. Head and neck squamous cell carcinoma (HNSCC) develops in the mucous membranes of the mouth, nose, and throat.
Jul 8th, 2019 - Psoriatic arthritis is a condition involving joint inflammation (arthritis) that usually occurs in combination with a skin disorder called psoriasis. Psoriasis is a chronic inflammatory condition characterized by patches of red, irritated skin that are often covered by flaky white scales. People with psoriasis may also have changes in their fingernails and toenails, such as nails that become pi...
Jul 1st, 2019 - Shingles resources and references include Shingrix and Zostavax vaccination recommendations, as well as disease- and vaccine-related resources and articles.
Jun 30th, 2019 - “It’s important to have treatment targets because, while we all think we’re doing the best job we possibly can for our patients, having goals that we can objectively measure ourselves against keeps us from growing complacent,” says Abby Van Voorhees, M.D., chair of dermatology at Eastern Virginia Medical School and chair of NPF's medical board.
Jun 30th, 2019 - Learn more about shingles surveillance, including shingles hospitalizations, trends, and vaccination rates
Jun 30th, 2019 - Learn about varicella zoster virus (VZV) laboratory testing and about the CDC National VDZ Laboratory.
Jun 30th, 2019 - Doxycycline is an antibiotic used to treat bacterial infections like urinary tract infections, acne and chlamydia. Includes side effects, interactions and indications.
Jun 24th, 2019 - Atopic dermatitis is a chronic, itchy skin condition that is very common in children but may occur at any age. It is also known as eczema and atopic eczema and was formerly known as Besnier prurigo. It is the most common form of dermatitis. Atopic dermatitis usually occurs in people who have an 'atopic tendency'. This means they may develop any or all of three closely linked conditions; atop...
Jun 9th, 2019 - On June 10, 2019, the Food and Drug Administration approved pembrolizumab (KEYTRUDA, Merck) for the first-line treatment of patients with metastatic or unresectable recurrent head and neck squamous cell carcinoma (HNSCC). Pembrolizumab was approved for use in combination with platinum and fluorouracil (FU) for all patients and as a single agent for patients whose tumors express PD‑L1 (Combin...
Nemeth, V. et. al.
Jun 3rd, 2019 - Eczema, also known as atopic dermatitis, is the most common form of dermatitis. Genetic as well as environmental factors are thought to play a part in the pathogenesis. Eczema is most commonly seen in children but can be seen in adults. People with the disease tend to have dry, itchy skin that is prone to infection. Eczema is commonly known as the "itch that rashes" due to dry skin that lea...
May 29th, 2019 - Today, CDC is reporting 971 cases of measles in the United States thus far in 2019. This is the greatest number of cases reported in the U.S. since 1994, when 963 cases were reported for the entire year. CDC continues to work with affected state and local health departments to get ongoing outbreaks under control.
May 12th, 2019 - Psoriasis is a chronic, inflammatory disease that affects over 8 million Americans. Psoriasis can profoundly decrease quality of life without appropriate treatment. Additionally, psoriasis is associated with comorbidities including cardiovascular disease, inflammatory arthritis, depression and others. Primary care providers play an important role in both managing overall health and screening...
Apr 28th, 2019 - Samsung Bioepis Co., Ltd. today announced that the US Food and Drug Administration (FDA) has approved ETICOVO™ (etanercept-ykro), a biosimilar referencing ENBREL® (etanercept), across all eligible indications for the treatment of rheumatoid arthritis, ankylosing spondylitis, plaque psoriasis, psoriatic arthritis and polyarticular juvenile idiopathic arthritis. ETICOVO™ is Samsung Bioepis’ secon...
Apr 25th, 2019 - The United States is currently experiencing the greatest number of reported cases of measles, also known as rubeola, since the disease was eliminated in 20001. Outbreaks have been confirmed in 22 states and the number of cases and their distribution is increasing rapidly. These measles outbreaks have been linked to travelers bringing back cases of measles from other countries. This situation co...
Apr 24th, 2019 - Bausch Health Companies Inc. (NYSE/TSX: BHC) and its dermatology business, Ortho Dermatologics, one of the largest prescription dermatology health care businesses, announced today that the U.S. Food and Drug Administration (FDA) has approved the New Drug Application for DUOBRII™ (halobetasol propionate and tazarotene) Lotion, 0.01%/0.045%, indicated for the topical treatment of plaque psoriasis...
Apr 22nd, 2019 - AbbVie (NYSE: ABBV), a research-based global biopharmaceutical company, today announced that the U.S. Food and Drug Administration (FDA) approved SKYRIZI™ (risankizumab-rzaa), an interleukin-23 (IL-23) inhibitor, for the treatment of moderate to severe plaque psoriasis in adults who are candidates for systemic therapy or phototherapy.3 In clinical trials, SKYRIZI produced high rates of durable ...
Apr 14th, 2019 - Measles, Also Known As Rubeola, Is A Highly Contagious Airborne Viral Illness That Infects Approximately Nine Out Of Ten Exposed Susceptible Individuals. Measles Infection Was Common Until The Measles, Mumps, And Rubella (MMR) Vaccine Was Licensed In 1963 And Became Part Of The Routine Immunization Schedule. By 2000, Measles Was Essentially Eliminated From The United States. In The Last Decade,...
Apr 3rd, 2019 - This is the fifth edition of The Psoriasis and Psoriatic Arthritis Pocket Guide: Treatment Algorithms and Management Options. Since the publication of the fourth edition, several new psoriatic disease treatments have become available, and the medical community has more experience with biological treatments in the management of psoriatic disease. The National Psoriasis Foundation has revis...
Mar 31st, 2019 - Measles Cases in 2019 From January 1 to February 21, 2019, 159** individual cases of measles have been confirmed in 10 states. In a given year, more measles cases can occur for any of the following reasons: an increase in the number of travelers who get measles abroad and bring it into the U.S., and/or further spread of measles in U.S. communities with pockets of unvaccinated people.
Mar 31st, 2019 - For adjuvant treatment of melanoma in patients rendered free of disease by surgery, traditional systemic therapy approaches have proven to be ineffective. Adjuvant interferon alfa (IFN alfa), particularly high-dose IFN alfa, has been widely used in patients with melanoma for many years. A large body of clinical evidence has amassed from prospective randomized trials comparing adjuvant IFN alfa ...
Mar 31st, 2019 - Images of Varicosities Varicose veins (varicosities) are twisted, enlarged veins at the skin surface. The word comes from the Latin word varix, which means "twisted." Varicose veins occur due to poor functioning (malfunction) of valves in the deeper leg veins (venous insufficiency), making blood back up (pool) in the legs, with the resulting pressure causing surface veins to enlarge.
Mar 17th, 2019 - This clinical report updates and replaces a 2008 clinical report from the American Academy of Pediatrics, which addressed the roles of maternal and early infant diet on the prevention of atopic disease, including atopic dermatitis, asthma, and food allergy. As with the previous report, the available data still limit the ability to draw firm conclusions about various aspects of atopy prevention ...