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About 2,343 results

ALLMedicine™ Cocaine Center

Research & Reviews  1,171 results

Risperidone and 5-HT2A receptor antagonists attenuate and reverse cocaine-induced hyper...
https://doi.org/10.1093/ijnp/pyaa065
The International Journal of Neuropsychopharmacology; Okada T, Shioda K et. al.

Aug 20th, 2020 - Cocaine (benzoylmethylecgonine) is one of the most widely used illegal psychostimulant drugs used worldwide, and mortality from acute intoxication is increasing. Suppressing hyperthermia is effective in reducing cocaine-related mortality, but a de...

Preclinical support for the therapeutic potential of zolmitriptan as a treatment for co...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7398918
Translational Psychiatry; Garcia R, Le T et. al.

Aug 4th, 2020 - Serotonin 1B receptor (5-HT1BR) agonists enhance cocaine intake in rats during daily self-administration but attenuate cocaine intake after prolonged abstinence. Here we investigated whether the less selective but clinically available 5-HT1D/1BR a...

Single Cocaine Exposure Inhibits GABA Uptake via Dopamine D1-Like Receptors in Adolesce...
https://doi.org/10.1007/s12640-020-00259-0
Neurotoxicity Research; Kubrusly RCC, Martins RS et. al.

Jul 22nd, 2020 - Cocaine (COC) is a psychostimulant that acts by increasing catecholaminergic neurotransmission mainly due to its effects on the dopamine transporter (DAT). However, other neurotransmitter systems may also be regulated by COC, including the GABAerg...

Taking Rapid and Intermittent Cocaine Infusions Enhances Both Incentive Motivation for ...
https://doi.org/10.1016/j.neuroscience.2020.05.058
Neuroscience Minogianis EA, Samaha AN

Jul 19th, 2020 - A goal in addiction research is to distinguish forms of neuroplasticity that are involved in the transition to addiction from those involved in mere drug taking. Animal models of drug self-administration are essential in this context. Here, we com...

Effects of the Alpha-2 Adrenergic Receptor Agonist Lofexidine on Food-Cocaine Choice in...
https://doi.org/10.1124/jpet.120.266007
The Journal of Pharmacology and Experimental Therapeutics; Czoty PW, Nader MA

Jul 6th, 2020 - Although norepinephrine (NE) does not appear to play prominent a role in mediating the abuse-related effects of cocaine, studies have indicated that NE alpha-2 receptor agonists can attenuate reinstatement of extinguished cocaine self-administrati...

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Clinicaltrials.gov  1,171 results

Risperidone and 5-HT2A receptor antagonists attenuate and reverse cocaine-induced hyper...
https://doi.org/10.1093/ijnp/pyaa065
The International Journal of Neuropsychopharmacology; Okada T, Shioda K et. al.

Aug 20th, 2020 - Cocaine (benzoylmethylecgonine) is one of the most widely used illegal psychostimulant drugs used worldwide, and mortality from acute intoxication is increasing. Suppressing hyperthermia is effective in reducing cocaine-related mortality, but a de...

Preclinical support for the therapeutic potential of zolmitriptan as a treatment for co...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7398918
Translational Psychiatry; Garcia R, Le T et. al.

Aug 4th, 2020 - Serotonin 1B receptor (5-HT1BR) agonists enhance cocaine intake in rats during daily self-administration but attenuate cocaine intake after prolonged abstinence. Here we investigated whether the less selective but clinically available 5-HT1D/1BR a...

Single Cocaine Exposure Inhibits GABA Uptake via Dopamine D1-Like Receptors in Adolesce...
https://doi.org/10.1007/s12640-020-00259-0
Neurotoxicity Research; Kubrusly RCC, Martins RS et. al.

Jul 22nd, 2020 - Cocaine (COC) is a psychostimulant that acts by increasing catecholaminergic neurotransmission mainly due to its effects on the dopamine transporter (DAT). However, other neurotransmitter systems may also be regulated by COC, including the GABAerg...

Taking Rapid and Intermittent Cocaine Infusions Enhances Both Incentive Motivation for ...
https://doi.org/10.1016/j.neuroscience.2020.05.058
Neuroscience Minogianis EA, Samaha AN

Jul 19th, 2020 - A goal in addiction research is to distinguish forms of neuroplasticity that are involved in the transition to addiction from those involved in mere drug taking. Animal models of drug self-administration are essential in this context. Here, we com...

Effects of the Alpha-2 Adrenergic Receptor Agonist Lofexidine on Food-Cocaine Choice in...
https://doi.org/10.1124/jpet.120.266007
The Journal of Pharmacology and Experimental Therapeutics; Czoty PW, Nader MA

Jul 6th, 2020 - Although norepinephrine (NE) does not appear to play prominent a role in mediating the abuse-related effects of cocaine, studies have indicated that NE alpha-2 receptor agonists can attenuate reinstatement of extinguished cocaine self-administrati...

see more →

News  1 results

Substance Abuse: Good News, Not So Good News
https://www.mdedge.com/fedprac/article/106251/addiction-medicine/substance-abuse-good-news-not-so-good-news
Jan Dyer

Jan 21st, 2016 - Admissions to publicly funded substance abuse treatment have declined slightly for alcohol abuse and markedly for cocaine use, according to a new report from the Substance Abuse and Mental Health Services Administration (SAMHSA). Related The Stati.

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