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About 2,312 results

ALLMedicine Cocaine Center

Research & Reviews  1,151 results

Cocaine reward and memory after chemogenetic inhibition of distinct serotonin neuron su...
https://doi.org/10.1007/s00213-020-05560-6
Psychopharmacology Baskin BM, Mai JJ et. al.

Jun 2nd, 2020 - We probed serotonin neurons, those denoted by their developmental gene expression as r2Hoxa2-Pet1 (experiment 1) and Drd1a-Pet1 (experiment 2), for differential modulation of cocaine reward and memory as revealed by the expression and development ...

Pharmacokinetic and pharmacodynamic analyses of cocaine and its metabolites in behavior...
https://doi.org/10.1111/gbb.12666
Genes, Brain, and Behavior REFERENCES; Zhu J, Beechinor RJ et. al.

May 9th, 2020 - Cocaine (COC) is a psychostimulant with a high potential for abuse and addiction. Risk for COC use disorder is driven, in part, by genetic factors. Animal models of addiction-relevant behaviors have proven useful for studying both genetic and nong...

Investigation of topical intranasal cocaine for sinonasal procedures: a randomized, pha...
https://doi.org/10.1002/alr.22561
International Forum of Allergy & Rhinology References; McGrath J, McGrath A et. al.

May 7th, 2020 - The objective of this trial was to demonstrate the clinical efficacy and safety of topical cocaine as part of the effort to gain regulatory approval from the United States Food and Drug Administration. This phase III, randomized, prospective, doub...

Effects of acute and repeated treatment with methocinnamox, a mu opioid receptor antago...
https://doi.org/10.1038/s41386-020-0698-8
Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology; Maguire DR, Gerak LR et. al.

May 6th, 2020 - Methocinnamox (MCAM), a mu opioid receptor antagonist with a long duration of action, attenuates heroin self-administration in rhesus monkeys, suggesting it could be an effective treatment for opioid use disorder (OUD). This study examined effects...

Cocaine-induced changes in behaviour and DNA methylation in rats are influenced by inte...
https://doi.org/10.1177/0269881120916137
Journal of Psychopharmacology (Oxford, England); Vaher K, Anier K et. al.

Apr 27th, 2020 - Individual differences in behavioural traits influence susceptibility to addictive disorders. Drug addiction involves changes in gene expression, proposed to occur via DNA methylation (DNAm). To investigate DNAm changes in reward-related brain str...

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Clinicaltrials.gov  1,157 results

Cocaine reward and memory after chemogenetic inhibition of distinct serotonin neuron su...
https://doi.org/10.1007/s00213-020-05560-6
Psychopharmacology Baskin BM, Mai JJ et. al.

Jun 2nd, 2020 - We probed serotonin neurons, those denoted by their developmental gene expression as r2Hoxa2-Pet1 (experiment 1) and Drd1a-Pet1 (experiment 2), for differential modulation of cocaine reward and memory as revealed by the expression and development ...

Pharmacokinetic and pharmacodynamic analyses of cocaine and its metabolites in behavior...
https://doi.org/10.1111/gbb.12666
Genes, Brain, and Behavior REFERENCES; Zhu J, Beechinor RJ et. al.

May 9th, 2020 - Cocaine (COC) is a psychostimulant with a high potential for abuse and addiction. Risk for COC use disorder is driven, in part, by genetic factors. Animal models of addiction-relevant behaviors have proven useful for studying both genetic and nong...

Investigation of topical intranasal cocaine for sinonasal procedures: a randomized, pha...
https://doi.org/10.1002/alr.22561
International Forum of Allergy & Rhinology References; McGrath J, McGrath A et. al.

May 7th, 2020 - The objective of this trial was to demonstrate the clinical efficacy and safety of topical cocaine as part of the effort to gain regulatory approval from the United States Food and Drug Administration. This phase III, randomized, prospective, doub...

Effects of acute and repeated treatment with methocinnamox, a mu opioid receptor antago...
https://doi.org/10.1038/s41386-020-0698-8
Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology; Maguire DR, Gerak LR et. al.

May 6th, 2020 - Methocinnamox (MCAM), a mu opioid receptor antagonist with a long duration of action, attenuates heroin self-administration in rhesus monkeys, suggesting it could be an effective treatment for opioid use disorder (OUD). This study examined effects...

Cocaine-induced changes in behaviour and DNA methylation in rats are influenced by inte...
https://doi.org/10.1177/0269881120916137
Journal of Psychopharmacology (Oxford, England); Vaher K, Anier K et. al.

Apr 27th, 2020 - Individual differences in behavioural traits influence susceptibility to addictive disorders. Drug addiction involves changes in gene expression, proposed to occur via DNA methylation (DNAm). To investigate DNAm changes in reward-related brain str...

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News  4 results

Substance Abuse: Good News, Not So Good News
https://www.mdedge.com/fedprac/article/106251/addiction-medicine/substance-abuse-good-news-not-so-good-news
Jan Dyer

Jan 21st, 2016 - Admissions to publicly funded substance abuse treatment have declined slightly for alcohol abuse and markedly for cocaine use, according to a new report from the Substance Abuse and Mental Health Services Administration (SAMHSA). Related The Stati.

Heroin Use Rising in the US
https://www.medscape.com/viewarticle/843761

Apr 26th, 2015 - Heroin use in the United States, though still uncommon relative to the use of other illicit substances, has risen significantly since 2002, a new report indicates. Rachel Lipari, PhD, and Arthur Hughes, from the Substance Abuse and Mental Health S...

Drug Abuse Among Doctors: Easy, Tempting, and Not Uncommon
https://www.medscape.com/viewarticle/819223

Jan 28th, 2014 - Tomorrow -- Tomorrow, I Will Stop That's what Marc Myer, a family practice physician in Minnesota, told himself each day as he stole prescription opiates from his patients to feed his addiction. But for Dr. Myer and many physicians like him, "tomo...

Cocaine-related Sudden Death: A Prospective Investigation in South-west Spain
https://www.medscape.com/viewarticle/719346

Abstract and Introduction Abstract Aims With an estimated 12 million consumers in Europe, cocaine (COC) is the illicit drug leading to the most emergency department visits. The aim of this study was to examine a consecutive series of sudden deaths...

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