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About 1,093 results

ALLMedicine™ Nerve Agents Center

Research & Reviews  529 results

Profiling the Tox21 Chemical Collection for Acetylcholinesterase Inhibition.
https://doi.org/10.1289/EHP6993
Environmental Health Perspectives; Li S, Zhao J et. al.

Apr 12th, 2021 - Inhibition of acetylcholinesterase (AChE), a biomarker of organophosphorous and carbamate exposure in environmental and occupational human health, has been commonly used to identify potential safety liabilities. So far, many environmental chemical...

Intramuscularly administered A1 adenosine receptor agonists as delayed treatment for or...
https://doi.org/10.1016/j.taap.2021.115515
Toxicology and Applied Pharmacology; Loughery TN, Whitten KA et. al.

Apr 2nd, 2021 - Exposure to organophosphorus nerve agents (NAs) like sarin (GB) and soman (GD) can lead to sustained seizure activity, or status epilepticus (SE). Previous research has shown that activation of A1 adenosine receptors (A1ARs) can inhibit neuronal e...

Efficacy of atropine and scopolamine on airway contractions following exposure to the n...
https://doi.org/10.1016/j.taap.2021.115512
Toxicology and Applied Pharmacology; Wigenstam E, Forsberg E et. al.

Mar 31st, 2021 - Nerve agents are highly toxic organophosphorus compounds that inhibit acetylcholinesterase resulting in rapid accumulation of the neurotransmitter acetylcholine (ACh) causing a cholinergic syndrome including respiratory failure. In the present stu...

Forensic analysis of soman exposure using characteristic fragment ions from protein add...
https://doi.org/10.1177/09603271211001111
Human & Experimental Toxicology; Fu F, Guo Y et. al.

Mar 17th, 2021 - The verification of exposure to nerve agents is a serious challenge, especially in cases of soman (GD) poisoning. Protein adducts are reliable biomarkers, that provide forensic information and evidence during incidents of terrorism or sporadic poi...

Reactivation of organophosphate-inhibited serum butyrylcholinesterase by novel substitu...
https://doi.org/10.1016/j.tox.2021.152719
Toxicology Nichols RH, Chambers JE

Feb 16th, 2021 - Organophosphorus compounds (OPs) include nerve agents and insecticides that potently inhibit acetylcholinesterase (AChE), an essential enzyme found throughout the nervous system. High exposure levels to OPs lead to seizures, cardiac arrest, and de...

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Guidelines  1 results

Responding to nerve agent poisoning: a guide for emergency nurses. Part 2.
https://doi.org/10.7748/en.2019.e1925
Emergency Nurse : the Journal of the RCN Accident and Eme... McGhee S, Finnegan A et. al.

Aug 30th, 2019 - The release of chemical agents can cause loss of life and result in major incidents. Chemical agent-related major incidents require a modified response by emergency services due to the chemicals' transmissibility, lethality, latency and persistenc...

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Drugs  9 results see all →

Clinicaltrials.gov  549 results

Profiling the Tox21 Chemical Collection for Acetylcholinesterase Inhibition.
https://doi.org/10.1289/EHP6993
Environmental Health Perspectives; Li S, Zhao J et. al.

Apr 12th, 2021 - Inhibition of acetylcholinesterase (AChE), a biomarker of organophosphorous and carbamate exposure in environmental and occupational human health, has been commonly used to identify potential safety liabilities. So far, many environmental chemical...

Intramuscularly administered A1 adenosine receptor agonists as delayed treatment for or...
https://doi.org/10.1016/j.taap.2021.115515
Toxicology and Applied Pharmacology; Loughery TN, Whitten KA et. al.

Apr 2nd, 2021 - Exposure to organophosphorus nerve agents (NAs) like sarin (GB) and soman (GD) can lead to sustained seizure activity, or status epilepticus (SE). Previous research has shown that activation of A1 adenosine receptors (A1ARs) can inhibit neuronal e...

Efficacy of atropine and scopolamine on airway contractions following exposure to the n...
https://doi.org/10.1016/j.taap.2021.115512
Toxicology and Applied Pharmacology; Wigenstam E, Forsberg E et. al.

Mar 31st, 2021 - Nerve agents are highly toxic organophosphorus compounds that inhibit acetylcholinesterase resulting in rapid accumulation of the neurotransmitter acetylcholine (ACh) causing a cholinergic syndrome including respiratory failure. In the present stu...

Forensic analysis of soman exposure using characteristic fragment ions from protein add...
https://doi.org/10.1177/09603271211001111
Human & Experimental Toxicology; Fu F, Guo Y et. al.

Mar 17th, 2021 - The verification of exposure to nerve agents is a serious challenge, especially in cases of soman (GD) poisoning. Protein adducts are reliable biomarkers, that provide forensic information and evidence during incidents of terrorism or sporadic poi...

Reactivation of organophosphate-inhibited serum butyrylcholinesterase by novel substitu...
https://doi.org/10.1016/j.tox.2021.152719
Toxicology Nichols RH, Chambers JE

Feb 16th, 2021 - Organophosphorus compounds (OPs) include nerve agents and insecticides that potently inhibit acetylcholinesterase (AChE), an essential enzyme found throughout the nervous system. High exposure levels to OPs lead to seizures, cardiac arrest, and de...

see more →

News  4 results

Gulf War illness linked to chemical exposure
https://www.reuters.com/article/us-gulfwar-chemicals/gulf-war-illness-linked-to-chemical-exposure-idUSN1059348220080310

Mar 10th, 2008 - CHICAGO (Reuters) - Exposure to pesticides, nerve agents and other chemicals may explain the chronic, multi-symptom health problems experienced by up to one-third of Gulf War veterans, U.S. researchers said on Monday. They said an analysis of a ho...

Pediatric Approval of Chemical and Pesticide Poison Antidote
https://www.mdedge.com/content/pediatric-approval-chemical-and-pesticide-poison-antidote
Elizabeth Mechcatie

A drug that has been used to treat nerve gas and other types of pesticide and chemical poisoning in children off-label for years is now approved for pediatric use, the Food and Drug Administration announced on Sept. 9.

FDA Approves Chemical-Poisoning Antidote for Kids
https://www.mdedge.com/familymedicine/article/31793/pediatrics/fda-approves-chemical-poisoning-antidote-kids
Family Practice News; Elizabeth Mechcatie

A drug that has been used to treat nerve gas and other types of pesticide and chemical poisoning in children off label for years is now approved for pediatric use, the Food and Drug Administration announced. The drug, pralidoxime chloride, availab.

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Patient Education  1 results see all →