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About 3,774 results

ALLMedicine™ Smallpox Center

Research & Reviews  1,747 results

An overview of tecovirimat for smallpox treatment and expanded anti-orthopoxvirus appli...
https://doi.org/10.1080/14787210.2020.1819791
Expert Review of Anti-infective Therapy; Russo AT, Grosenbach DW et. al.

Sep 3rd, 2020 - Tecovirimat (TPOXX®; ST-246) was approved for the treatment of symptomatic smallpox by the USFDA in July of 2018 and has been stockpiled by the US government for use in a smallpox outbreak. While there has not been a reported case of smallpox sinc...

Zinc-finger antiviral protein (ZAP) is a restriction factor for replication of modified...
https://doi.org/10.1371/journal.ppat.1008845
PLoS Pathogens; Peng C, Wyatt LS et. al.

Aug 31st, 2020 - Modified vaccinia virus Ankara (MVA) is an approved smallpox vaccine and a promising vaccine vector for other pathogens as well as for cancer therapeutics with more than 200 current or completed clinical trials. MVA was derived by passaging the pa...

Identification of protective T-cell antigens for smallpox vaccines.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7205715
Cytotherapy Ando J, Ngo MC et. al.

Aug 4th, 2020 - E3L is an immediate-early protein of vaccinia virus (VV) that is detected within 0.5 h of infection, potentially before the many immune evasion genes of vaccinia can exert their protective effects. E3L is highly conserved among orthopoxviruses and...

Short-term and longer-term protective immune responses generated by subunit vaccination...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7456309
Vaccine Xiao Y, Zeng Y et. al.

Aug 3rd, 2020 - Smallpox, a contagious and deadly disease caused by variola virus, was eradicated by a strategy that included vaccination with vaccinia virus, a live-virus vaccine. Because the threat of bioterrorism with smallpox persists and infections with zoon...

Ectromelia-encoded virulence factor C15 specifically inhibits antigen presentation to C...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7425992
PLoS Pathogens; Forsyth KS, Roy NH et. al.

Aug 3rd, 2020 - Smallpox and monkeypox pose severe threats to human health. Other orthopoxviruses are comparably virulent in their natural hosts, including ectromelia, the cause of mousepox. Disease severity is linked to an array of immunomodulatory proteins incl...

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Guidelines  5 results

Animals in Research
http://www.aai.org/Public-Affairs/Policy-Issues/Animals-in-Research
American Association of Immunologists (AAI)

Oct 3rd, 2018 - AAI supports the humane use of animals in biomedical research. Such research has led to significant advances in both animal and human health.

Position on donors and smallpox vaccine: a committee opinion.
https://doi.org/10.1016/j.fertnstert.2012.03.043
Fertility and Sterility;

Apr 27th, 2012 - Although there is presently no definitive evidence linking vaccinia virus transmission through reproductive cells, SART/ASRM accordingly recommends that ART practitioners consider deferring donors who have recently received smallpox vaccine or con...

Guidelines for smallpox vaccination for health care workers.
https://doi.org/10.1016/j.annemergmed.2011.11.029
Annals of Emergency Medicine;

Feb 21st, 2012 - Guidelines for smallpox vaccination for health care workers.|2012| ,|standards,standards,therapeutic use,

ASBMB Is Concerned About The Decline In Support For Investigator-initiated Research: Action ...
http://www.asbmb.org/uploadedFiles/Advocacy/Positions_and_Correspondence/ASBMB%20White%20Paper%20on%20Proposals%20to%20Support%20Investigator-Initiated%20Research.pdf
Amerian Society for Biochemistry and Molecular Biology (ASBMB)

Mar 10th, 2011 - Scientific research has been a leading force in driving global prosperity over the past century, through both its economic and scientific benefits. Investment in research generates jobs and several-fold financial returns.

Society for Assisted Reproductive Technology position statement on donor suitability of...
https://doi.org/10.1016/j.fertnstert.2008.08.052
Fertility and Sterility; ,

Nov 25th, 2008 - Although there is presently no definitive evidence linking vaccinia virus transmission through reproductive cells, SART/ASRM accordingly recommends that ART practitioners consider deferring donors who have recently received smallpox vaccine or con...

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Drugs  5 results see all →

Clinicaltrials.gov  1,867 results

An overview of tecovirimat for smallpox treatment and expanded anti-orthopoxvirus appli...
https://doi.org/10.1080/14787210.2020.1819791
Expert Review of Anti-infective Therapy; Russo AT, Grosenbach DW et. al.

Sep 3rd, 2020 - Tecovirimat (TPOXX®; ST-246) was approved for the treatment of symptomatic smallpox by the USFDA in July of 2018 and has been stockpiled by the US government for use in a smallpox outbreak. While there has not been a reported case of smallpox sinc...

Zinc-finger antiviral protein (ZAP) is a restriction factor for replication of modified...
https://doi.org/10.1371/journal.ppat.1008845
PLoS Pathogens; Peng C, Wyatt LS et. al.

Aug 31st, 2020 - Modified vaccinia virus Ankara (MVA) is an approved smallpox vaccine and a promising vaccine vector for other pathogens as well as for cancer therapeutics with more than 200 current or completed clinical trials. MVA was derived by passaging the pa...

Identification of protective T-cell antigens for smallpox vaccines.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7205715
Cytotherapy Ando J, Ngo MC et. al.

Aug 4th, 2020 - E3L is an immediate-early protein of vaccinia virus (VV) that is detected within 0.5 h of infection, potentially before the many immune evasion genes of vaccinia can exert their protective effects. E3L is highly conserved among orthopoxviruses and...

Short-term and longer-term protective immune responses generated by subunit vaccination...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7456309
Vaccine Xiao Y, Zeng Y et. al.

Aug 3rd, 2020 - Smallpox, a contagious and deadly disease caused by variola virus, was eradicated by a strategy that included vaccination with vaccinia virus, a live-virus vaccine. Because the threat of bioterrorism with smallpox persists and infections with zoon...

Ectromelia-encoded virulence factor C15 specifically inhibits antigen presentation to C...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7425992
PLoS Pathogens; Forsyth KS, Roy NH et. al.

Aug 3rd, 2020 - Smallpox and monkeypox pose severe threats to human health. Other orthopoxviruses are comparably virulent in their natural hosts, including ectromelia, the cause of mousepox. Disease severity is linked to an array of immunomodulatory proteins incl...

see more →

News  137 results

Coronavirus lockdown is nothing new for some Moscow residents
https://www.reuters.com/article/us-health-coronavirus-moscow-smallpox/coronavirus-lockdown-is-nothing-new-for-some-moscow-residents-idUSKBN21P1N3

Apr 7th, 2020 - MOSCOW (Reuters) - For some elderly Moscow residents, the coronavirus lockdown has a familiar feel - they lived through something like it during a dramatic Soviet-era smallpox outbreak six decades ago. Soviet artist Alexei Kokorekin, two-time winn...

Disease fighters to mark partial victory in polio eradication battle
https://www.reuters.com/article/us-health-polio/disease-fighters-to-mark-partial-victory-in-polio-eradication-battle-idUSKBN1X210S

Oct 23rd, 2019 - LONDON (Reuters) - Global health officials will on Thursday announce a partial victory in the decades-long fight to end polio, with a second of three strains of the crippling virus certified as eradicated worldwide. The ending of wild polio virus ...

FDA approves first live vaccine for smallpox, monkeypox prevention
https://www.mdedge.com/jcomjournal/article/208800/vaccines/fda-approves-first-live-vaccine-smallpox-monkeypox-prevention?channel=234
Lucas Franki

Sep 25th, 2019 - The Food and Drug Administration has approved Jynneos, a live, nonreplicating vaccine based on the vaccinia virus, for smallpox and monkeypox, becoming the first FDA-approved vaccine for the prevention of monkeypox disease. FDA approval for Jynneo.

Morning Break: 9th Vaping Death; CBD Guidelines for Arthritis; Big Wasabi Mistake
https://www.medpagetoday.com/primarycare/smoking/82367

Sep 25th, 2019 - Note that some links may require subscriptions. Another person has died from "vaping illness," Kansas Gov. Laura Kelly announced -- bringing the national total to nine. In Massachusetts, Gov. Charlie Baker imposed a 4-month ban on sales of all vap...

Morning Break: Trebek Needs More Chemo; Smallpox Lab Explosion; 'Poop Shame'
https://www.medpagetoday.com/gastroenterology/pancreaticdiseases/82225

Sep 18th, 2019 - Note that some links may require subscriptions. "Jeopardy!" host Alex Trebek told "Good Morning America" that he's had a setback in his fight against pancreatic cancer. Biogen's promising drug for idiopathic pulmonary fibrosis, BG00011, proved in ...

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Patient Education  13 results see all →