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About 2,043 results

ALLMedicine™ Smallpox Center

Research & Reviews  621 results

Monkeypox
https://www.cdc.gov/poxvirus/monkeypox/index.html
Centers for Disease Control and Prevention (CDC)

Monkeypox was first discovered in 1958 when two outbreaks of a pox-like disease occurred in colonies of monkeys kept for research, hence the name ‘monkeypox.’ The first human case of monkeypox was recorded in 1970 in the Democratic Republic of Con...

The contributions of William Money MRCS to smallpox vaccination and control - A little-...
https://doi.org/10.1016/j.vaccine.2021.06.082
Vaccine O'Dell FJ, Williams AN et. al.

Jul 18th, 2021 - This history of vaccinology article outlines the work of William Money (1790-1843), who conducted a study related to smallpox disease, immunity, and vaccination. His hitherto unpublished study demonstrated that smallpox could be contracted more th...

Thrombosis with Thrombocytopenia Syndrome (TTS) following AstraZeneca ChAdOx1 nCoV-19 (...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8270740
Vaccine MacIntyre CR, Veness B et. al.

Jul 18th, 2021 - The AstraZeneca ChAdOx1 nCoV-19 (AZD1222) vaccine is associated with Thrombosis with Thrombocytopenia Syndrome (TTS) in 3/100,000 vaccinations with high fatality rates reported in many countries. We conducted a risk-benefit analysis for Australian...

Spontaneous and targeted mutations in the decapping enzyme enhance replication of modif...
https://doi.org/10.1128/JVI.01104-21
Journal of Virology; Erez N, Wyatt LS et. al.

Jul 8th, 2021 - Modified vaccinia virus Ankara (MVA) was derived by repeated passaging in chick fibroblasts, during which deletions and mutations rendered the virus unable to replicate in most mammalian cells. Marker rescue experiments demonstrated that the host ...

Facial Masking and SAMPPs: Potential "Variolation" in COVID-19.
https://www.ncbi.nlm.nih.gov/pubmed/34210915
The Journal of Contemporary Dental Practice; Sharma NK, Sarode SC et. al.

Jul 3rd, 2021 - Variolation is an important phenomenon in the field of immunology and has a rich historical background that has changed the perception of immunity reinforcement in human beings.1 This methodology was first used to immunize humans against smallpox ...

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Guidelines  1 results

Monkeypox
https://www.cdc.gov/poxvirus/monkeypox/index.html
Centers for Disease Control and Prevention (CDC)

Monkeypox was first discovered in 1958 when two outbreaks of a pox-like disease occurred in colonies of monkeys kept for research, hence the name ‘monkeypox.’ The first human case of monkeypox was recorded in 1970 in the Democratic Republic of Con...

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Drugs  7 results see all →

Clinicaltrials.gov  51 results

Monkeypox
https://www.cdc.gov/poxvirus/monkeypox/index.html
Centers for Disease Control and Prevention (CDC)

Monkeypox was first discovered in 1958 when two outbreaks of a pox-like disease occurred in colonies of monkeys kept for research, hence the name ‘monkeypox.’ The first human case of monkeypox was recorded in 1970 in the Democratic Republic of Con...

VA-005 Clinical Outcomes of VIGIV Treatment of Smallpox Vaccination Complications or Vaccinia Infection
https://clinicaltrials.gov/ct2/show/NCT01374984

Mar 18th, 2020 - This is an open-label Phase 4 study designed to collect additional data to assess the safety and efficacy of VIGIV [CNJ-016, Vaccinia Immune Globulin Intravenous (Human), sterile solution] in the first 100 consented patients treated with VIGIV.

VA-008 ACAM2000® Vaccination of Plasma Donors for the Production of VIGIV
https://clinicaltrials.gov/ct2/show/NCT02443623

Mar 18th, 2020 - This protocol is being conducted to vaccinate plasma donors with the ACAM2000 smallpox vaccine thereby inducing an immune response resulting in high anti-vaccinia antibody titers. The collection of donor plasma will be used in the manufacturing of...

Freeze-Dried MVA-BN® Lot Consistency Smallpox Trial
https://clinicaltrials.gov/ct2/show/NCT03699124

Jan 22nd, 2020 - This is a Phase 3 multicenter trial to evaluate safety and immune response of three consecutive production lots of freeze-dried (FD) MVA-BN smallpox vaccine. The vaccine will be given to healthy subjects who do not have a smallpox scar. Approximat...

A Safety and Immunology Study of a Modified Vaccinia Vaccine for HER-2(+) Metastatic Breast Cancer
https://clinicaltrials.gov/ct2/show/NCT00485277

Mar 14th, 2019 - MVA-BN®-HER2 is a candidate breast cancer immunotherapy product comprised of a highly attenuated non-replicating vaccinia virus, MVA-BN®, engineered to encode a modified form of the Her-2 protein. MVA-BN® is a well-characterized, clonal strain of ...

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News  132 results

Monkeypox
https://www.cdc.gov/poxvirus/monkeypox/index.html
Centers for Disease Control and Prevention (CDC)

Monkeypox was first discovered in 1958 when two outbreaks of a pox-like disease occurred in colonies of monkeys kept for research, hence the name ‘monkeypox.’ The first human case of monkeypox was recorded in 1970 in the Democratic Republic of Con...

Tracking Down the Last Person to Get Naturally Infected With Smallpox and Why We Need a Cure for a Disease That Doesn't Exist
https://www.medscape.com/viewarticle/952835

Jun 10th, 2021 - Why would you approve a drug for a disease that no longer exists? The simple answer is that the virus that causes the disease still exists, and if it got loose, it would be a weapon of unimaginable catastrophe. That is the rationale for the US Foo...

FDA Approves Brincidofovir to Treat Smallpox
https://www.medscape.com/viewarticle/952788

Jun 9th, 2021 - The US Food and Drug Administration (FDA) has approved Chimerix's brincidofovir (BCV, Tembexa) to treat smallpox. Fearful of a possible bioweapon attack, the United States has been steadily preparing a defense through BARDA, the Biomedical Advance...

Risk Expert Heidi J. Larson on Vaccine Hesitancy
https://www.medscape.com/viewarticle/951642

May 21st, 2021 - Editor's note: Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center. Experts have long pointed to mass vaccination as the key to bringing the Covid-19 pandemic under control. And while the percentage of Americans wh...

Old Records Shed New Light on Smallpox Outbreaks in 1700s
https://www.medscape.com/viewarticle/951653

May 21st, 2021 - A prayer Rev. Ebenezer Storer, a pastor in Cambridge, Massachusetts, wrote in which he gives thanks for the recovery of family members from the disease. In the prayer, he praises the discovery of means used in the late 18th century to treat the di...

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Patient Education  5 results see all →