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About 875 results

ALLMedicine™ Botulism Center

Research & Reviews  290 results

BT-011 Pharmacokinetics of Botulism Antitoxin Heptavalent in Pediatric Patients
https://clinicaltrials.gov/ct2/show/NCT02051062

May 6th, 2022 - Objectives: The purpose of this study is to collect serum from pediatric patients to analyze the pharmacokinetics (PK) of BAT® product to verify the currently approved pediatric dosing recommendations. Protocol Design: This is a single arm, multi-...

Exposure-Response Modeling and Simulation to Support Human Dosing of Botulism Antitoxin...
https://doi.org/10.1002/cpt.2620
Clinical Pharmacology and Therapeutics; Beliveau M, Anderson D et. al.

Apr 26th, 2022 - Botulism antitoxin heptavalent (A, B, C, D, E, F, and G - Equine; BAT) product is a sterile solution of F(ab')2 and F(ab')2 -related antibody fragments prepared from plasma obtained from horses that have been immunized with a specific serotype of ...

Development and evaluation of a tetravalent botulinum vaccine.
https://doi.org/10.1080/21645515.2022.2048621
Human Vaccines & Immunotherapeutics; Shi DY, Liu FJ et. al.

Apr 19th, 2022 - Botulinum neurotoxins (BoNTs) are the most toxic known proteins. Naturally occurring botulism in humans is caused by botulinum serotypes A, B, E, and F. Vaccination is an effective strategy to prevent botulism. In this study, a tetravalent botulin...

Notes from the Field: Wound Botulism Outbreak Among a Group of Persons Who Inject Drugs...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9020861
MMWR. Morbidity and Mortality Weekly Report; Edwards LD, Gomez I et. al.

Apr 15th, 2022 - Notes from the Field: Wound Botulism Outbreak Among a Group of Persons Who Inject Drugs - Dallas, Texas, 2020.|2022|Edwards LD,Gomez I,Wada S,Swaney EM,Caruthers MB,|epidemiology,epidemiology,epidemiology,

Toxicology and pharmacology of botulinum and tetanus neurotoxins: an update.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9095541
Archives of Toxicology; Pirazzini M, Montecucco C et. al.

Mar 26th, 2022 - Tetanus and botulinum neurotoxins cause the neuroparalytic syndromes of tetanus and botulism, respectively, by delivering inside different types of neurons, metalloproteases specifically cleaving the SNARE proteins that are essential for the relea...

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Drugs  4 results see all →

Clinicaltrials.gov  10 results

BT-011 Pharmacokinetics of Botulism Antitoxin Heptavalent in Pediatric Patients
https://clinicaltrials.gov/ct2/show/NCT02051062

May 6th, 2022 - Objectives: The purpose of this study is to collect serum from pediatric patients to analyze the pharmacokinetics (PK) of BAT® product to verify the currently approved pediatric dosing recommendations. Protocol Design: This is a single arm, multi-...

Evaluation of the Improvement of Quality of Life of Patients Suffering From Hailey Hailey or Darier Disease After Injections of Botulism Toxin Into Large Folds.
https://clinicaltrials.gov/ct2/show/NCT02782702

Dec 13th, 2021 - Hailey Hailey and Darier disease are rare genetic dermatoses. Mutations of 2 genes (ATP2C1 or ATP2A2 respectively) are responsible for the diseases. These genes have a key role in calcium pump; their defect create abnormal link between keratinocyt...

Functional Outcome of Hemiplegic Upper Extremity in Patients With Subacute Stroke After Kinesiotaping and Rehabilitation
https://clinicaltrials.gov/ct2/show/NCT04027985

Jul 29th, 2021 - Clinical characteristics of impaired motor performance on affected upper extremity in stroke patients included muscle weakness, increased muscle tone, contracture, joint instability, or impaired motor control. Poststroke spasticity (PSS) is also a...

Effects of EMG-driven Robot-assisted Therapy for the Distal Upper Limb Motor Function in the Chronic Stroke Patients With Botox Injections
https://clinicaltrials.gov/ct2/show/NCT04502264

Aug 6th, 2020 - Over fifty percent of stroke patients experience chronic arm hand performance problems, compromising independence in daily life activities and quality of life. Traditionally, the effectiveness of rehabilitation in improving functioning for stroke ...

Safety Study of 7 Botulinum Antitoxin Serotypes Derived From Horses
https://clinicaltrials.gov/ct2/show/NCT00360737

Mar 5th, 2020 - Clostridial toxins are amongst the most toxic substances known to science (Middlebrook, 1995). In the United States and other countries, human exposure to Clostridium botulinum toxins usually occurs through food poisoning, wound botulism and colon...

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News  41 results

Testing for LEMS
https://www.onclive.com/view/testing-for-lems

Dec 21st, 2021 - David Gerber, MD: Steve, it might be helpful at this point to go over how we diagnose and test for LEMS [Lambert-Eaton myasthenic syndrome]. Steven Vernino, MD, PhD: As neurologists, when we see conditions that make us think about paraneoplastic ...

New Botulism Guidelines Focus on Mass-Casualty Events
https://www.medscape.com/viewarticle/952251

Jun 1st, 2021 - Botulinum toxin is said to be the most lethal substance known. Inhaling just 1-3 nanograms of toxin per kilogram of body mass constitutes a lethal dose.  Now the Centers for Disease Control and Prevention (CDC) has published the first comprehensiv...

Speaking of Pandemics: The Art and Science of Risk Communication
https://www.staging.medscape.com/viewarticle/933729

Jul 10th, 2020 - Editor's note: Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center. Infectious disease expert Anthony Fauci. Coronavirus response coordinator Deborah Birx. County health officials across the United States. The Covi...

Speaking of Pandemics: The Art and Science of Risk Communication
https://www.medscape.com/viewarticle/933729

Jul 10th, 2020 - Editor's note: Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center. Infectious disease expert Anthony Fauci. Coronavirus response coordinator Deborah Birx. County health officials across the United States. The Covi...

Medical Mystery: Beer-Linked Kidney Failure and Paralysis
https://www.medscape.com/viewarticle/925834

Feb 27th, 2020 - Eduardo Valle, MD, a second-year medical resident in Brazil, was sitting in the hospital cafeteria with his fellow residents in late December when they heard news of the emergency department's newest patient. A middle-aged man with abdominal pain,...

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Patient Education  5 results see all →