ALLMedicine™ Botulism Center

May 6th, 2022 - Objectives: The purpose of this study is to collect serum from pediatric patients to analyze the pharmacokinetics (PK) of BAT® product to verify the currently approved pediatric dosing recommendations. Protocol Design: This is a single arm, multi-...

Apr 26th, 2022 - Botulism antitoxin heptavalent (A, B, C, D, E, F, and G - Equine; BAT) product is a sterile solution of F(ab')2 and F(ab')2 -related antibody fragments prepared from plasma obtained from horses that have been immunized with a specific serotype of ...

Apr 19th, 2022 - Botulinum neurotoxins (BoNTs) are the most toxic known proteins. Naturally occurring botulism in humans is caused by botulinum serotypes A, B, E, and F. Vaccination is an effective strategy to prevent botulism. In this study, a tetravalent botulin...

Apr 15th, 2022 - Notes from the Field: Wound Botulism Outbreak Among a Group of Persons Who Inject Drugs - Dallas, Texas, 2020.|2022|Edwards LD,Gomez I,Wada S,Swaney EM,Caruthers MB,|epidemiology,epidemiology,epidemiology,

Mar 26th, 2022 - Tetanus and botulinum neurotoxins cause the neuroparalytic syndromes of tetanus and botulism, respectively, by delivering inside different types of neurons, metalloproteases specifically cleaving the SNARE proteins that are essential for the relea...

May 6th, 2022 - Objectives: The purpose of this study is to collect serum from pediatric patients to analyze the pharmacokinetics (PK) of BAT® product to verify the currently approved pediatric dosing recommendations. Protocol Design: This is a single arm, multi-...

Dec 13th, 2021 - Hailey Hailey and Darier disease are rare genetic dermatoses. Mutations of 2 genes (ATP2C1 or ATP2A2 respectively) are responsible for the diseases. These genes have a key role in calcium pump; their defect create abnormal link between keratinocyt...

Jul 29th, 2021 - Clinical characteristics of impaired motor performance on affected upper extremity in stroke patients included muscle weakness, increased muscle tone, contracture, joint instability, or impaired motor control. Poststroke spasticity (PSS) is also a...

Aug 6th, 2020 - Over fifty percent of stroke patients experience chronic arm hand performance problems, compromising independence in daily life activities and quality of life. Traditionally, the effectiveness of rehabilitation in improving functioning for stroke ...

Mar 5th, 2020 - Clostridial toxins are amongst the most toxic substances known to science (Middlebrook, 1995). In the United States and other countries, human exposure to Clostridium botulinum toxins usually occurs through food poisoning, wound botulism and colon...

Dec 21st, 2021 - David Gerber, MD: Steve, it might be helpful at this point to go over how we diagnose and test for LEMS [Lambert-Eaton myasthenic syndrome]. Steven Vernino, MD, PhD: As neurologists, when we see conditions that make us think about paraneoplastic ...

Jun 1st, 2021 - Botulinum toxin is said to be the most lethal substance known. Inhaling just 1-3 nanograms of toxin per kilogram of body mass constitutes a lethal dose.  Now the Centers for Disease Control and Prevention (CDC) has published the first comprehensiv...

Jul 10th, 2020 - Editor's note: Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center. Infectious disease expert Anthony Fauci. Coronavirus response coordinator Deborah Birx. County health officials across the United States. The Covi...

Jul 10th, 2020 - Editor's note: Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center. Infectious disease expert Anthony Fauci. Coronavirus response coordinator Deborah Birx. County health officials across the United States. The Covi...

Feb 27th, 2020 - Eduardo Valle, MD, a second-year medical resident in Brazil, was sitting in the hospital cafeteria with his fellow residents in late December when they heard news of the emergency department's newest patient. A middle-aged man with abdominal pain,...