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About 615 results

ALLMedicine™ Nerve Agents Center

Research & Reviews  228 results

Are the current commercially available oximes capable of reactivating acetylcholinester...
https://doi.org/10.1007/s00204-022-03316-z 10.1016/j.softx.2015.06.001 10.1073/pnas.1523362113 10.1016/S0065-2423(04)38006-6 10.2174/138955707780619581 10.1107/S0907444902003451 10.1021/acs.chemrestox.8b00294 10.1007/s00204-022-03273-7 10.1126/science.1853201 10.1063/1.2408420 10.1016/j.cbi.2019.05.048 10.1080/14756366.2019.1609953 10.1186/1756-0500-5-1 10.21577/0100-4042.20170278 10.2174/1385272823666190806114017 10.3390/ijms20051222 10.1590/s0103-50532006000500022 10.1590/s0103-50532010000100025 10.1007/s00204-016-1827-3 10.1021/ct500161f 10.1002/minf.201100135 10.1002/rcm.7757 10.1016/0263-7855(96)00018-5 10.1039/D0RA05086E 10.1098/rsos.190414 10.1021/acscatal.8b01612 10.1021/ja9621760 10.1080/14756366.2021.1916009 10.1016/j.chemosphere.2019.01.054 10.1021/jm0302997 10.1110/ps.03318603 10.1007/s00204-018-2377-7 10.1021/ci500020m 10.1080/03071847.2018.1529889 10.1038/356083a0 10.3390/molecules23092291 10.1093/toxsci/kfs013 10.1016/j.fct.2018.09.015 10.1007/s00204-018-2290-0 10.1016/j.bmcl.2006.06.063 10.1063/1.328693 10.1016/S0022-2836(63)80023-6 10.1590/S0103-50532008000700031 10.1002/jcc.20425 10.1016/j.fct.2022.113084 10.1016/S0140-6736(20)32644-1 10.1111/j.1476-5381.1993.tb13498.x 10.1021/jm051197e 10.1002/jcc.20857
Archives of Toxicology; Santos MC, Botelho FD et. al.

Jun 7th, 2022 - The misuse of novichok agents in assassination attempts has been reported in the international media since 2018. These relatively new class of neurotoxic agents is claimed to be more toxic than the agents of the G and V series and so far, there is...

Countermeasures in organophosphorus intoxication: pitfalls and prospects.
https://doi.org/10.1016/j.tips.2022.04.008
Trends in Pharmacological Sciences; Gorecki L, Soukup O et. al.

Jun 2nd, 2022 - High lethality, fast action, and simple synthesis make nerve agents (NAs) the most dreaded chemical weapons (CWs) of mass destruction in the world. Disturbances of the autonomic nervous system and neuromuscular junction (NMJ) by NAs and organophos...

Diisopropylfluorophosphate (DFP) volatizes and cross-contaminates wells in a common 96-...
https://doi.org/10.1016/j.vascn.2022.107173
Journal of Pharmacological and Toxicological Methods; Mundy PC, Mendieta R et. al.

May 12th, 2022 - Diisopropylfluorophosphate (DFP) is an organophosphate (OP) that is commonly used as a surrogate of OP nerve agents to study the neurotoxic effects of acute OP intoxication. In preliminary studies, we discovered abnormally high incidence of deaths...

Imidazole-Functionalized Y-Shaped Push-Pull Dye for Nerve Agent Sensing as well as a Ca...
https://doi.org/10.1021/acs.joc.1c01488
The Journal of Organic Chemistry; Dey N, Kulhánek J et. al.

Oct 15th, 2021 - A Y-shaped push-pull dye (1) with N,N-dimethylanilino donors and a benzonitrile acceptor connected via an imidazole-based π-conjugated spacer was designed. It showed a dark yellow color in solution due to facile intramolecular charge-transfer inte...

CBRNE - Nerve Agents, G-series - Tabun, Sarin, Soman
https://emedicine.medscape.com/article/831648-overview

Oct 2nd, 2021 - Practice Essentials The organophosphate nerve agents tabun (GA), sarin (GB), soman (GD), and cyclosarin (GF) are among the most toxic chemical warfare agents known. [1, 2] Together they comprise the G-series nerve agents, thus named because German...

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Guidelines  1 results

Responding to nerve agent poisoning: a guide for emergency nurses. Part 2.
https://doi.org/10.7748/en.2019.e1925
Emergency Nurse : the Journal of the RCN Accident and Eme... McGhee S, Finnegan A et. al.

Aug 31st, 2019 - The release of chemical agents can cause loss of life and result in major incidents. Chemical agent-related major incidents require a modified response by emergency services due to the chemicals' transmissibility, lethality, latency and persistenc...

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Drugs  7 results see all →

Clinicaltrials.gov  3 results

A Study of Plasma-Derived Human Butyrylcholinesterase Administered Intramuscularly
https://clinicaltrials.gov/ct2/show/NCT00333528

May 5th, 2021 - The purpose of this placebo-controlled study is to evaluate the safety, tolerability and pharmacokinetics of a single dosage of human butyrylcholinesterase (HuBChE) in healthy adults. HuBChE, which occurs naturally in human plasma, is being evalua...

Pharmacokinetic (PK) and Safety Study of Plasma-derived Human Butyrylcholinesterase Administered Intravenously
https://clinicaltrials.gov/ct2/show/NCT00333515

May 5th, 2021 - The purpose of this placebo-controlled study is to evaluate the safety, tolerability and pharmacokinetics of a single dose regimen of human butyrylcholinesterase (HuBChE) in healthy adults at 3 ascending dosage levels administered IV. HuBChE, whic...

Scalp Application of LED Therapy to Improve Thinking and Memory in Veterans With Gulf War Illness
https://clinicaltrials.gov/ct2/show/NCT01782378

Jan 22nd, 2020 - Rationale: Impaired cognition is one of the 3 major symptom areas of GWVI. Mitochondrial dysfunction is reported in Gulf War Illness (GWI) veterans, associated with neurotoxicant exposures during deployment - e.g., organophosphate pesticides (OP);...

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News  7 results

As Virus Explodes, World Races to Mask Up
https://www.staging.medscape.com/viewarticle/927513

Mar 26th, 2020 - ZURICH (Reuters) - Spiez Lab, a government-run institute in the Swiss mountains, was set up to protect the nation from nuclear, biological and chemical threats. "For a world without weapons of mass destruction," runs its slogan. It is now fighting...

Chemical-Biological Terrorism Response Plans Should Include Children
https://www.medscape.com/viewarticle/924339

Jan 29th, 2020 - NEW YORK (Reuters Health) - Children are disproportionately affected by chemical and biological events, so they must be included in the planning and response when terrorism strikes, according to a policy statement from the American Academy of Pedi...

Emergency Use Authorization
http://www.fda.gov/emergency-preparedness-and-response/mcm-legal-regulatory-and-policy-framework/emergency-use-authorization

Image On this page: About Emergency Use Authorizations (EUAs) EUA Guidance  COVID-19 EUAs In Vitro Diagnostic Products High Complexity Molecular-Based Laboratory Developed Tests SARS-CoV-2 Antibody Tests Personal Protective Equipment and Related M...

Use of Expired Auto-Injectors OK'd by FDA
https://www.medpagetoday.com/emergencymedicine/emergencymedicine/43149

Nov 29th, 2013 - WASHINGTON -- The FDA cautioned emergency medical staff to retain nearly and recently expired auto-injectors by Meridian Medical Technologies and to use them in emergencies if no other product is available. The action arises because of a supply ch...

Gulf War illness linked to chemical exposure
https://www.reuters.com/article/us-gulfwar-chemicals/gulf-war-illness-linked-to-chemical-exposure-idUSN1059348220080310

Mar 10th, 2008 - CHICAGO (Reuters) - Exposure to pesticides, nerve agents and other chemicals may explain the chronic, multi-symptom health problems experienced by up to one-third of Gulf War veterans, U.S. researchers said on Monday. They said an analysis of a ho...

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