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About 655 results

ALLMedicine™ Nerve Agents Center

Research & Reviews  243 results

A Hidden Gem: Highlighting the Indispensable Capabilities and History of the DoD Cholin...
https://doi.org/10.1093/milmed/usad079
Military Medicine; Ke P, Stidham RA et. al.

Mar 18th, 2023 - The DoD Cholinesterase Monitoring Program and Cholinesterase Reference Laboratory have safeguarded U.S. government employees in chemical defense for over five decades. Considering Russia's potential deployment of chemical warfare nerve agents in U...

Contaminated disposable rubber gloves as evidence samples after a chemical attack with ...
https://doi.org/10.1002/dta.3468
Drug Testing and Analysis; Rozsypal T

Mar 14th, 2023 - Nerve agents have been used recently in the Syrian civil war. Collecting relevant samples for retrospective identification of an attack is often problematic. The article deals with the possibility of using contaminated gloves as an analytical samp...

Phosphonylated tyrosine and lysine residues as biomarkers of local exposure of human ha...
https://doi.org/10.1002/dta.3459
Drug Testing and Analysis; John H, Lindl T et. al.

Feb 15th, 2023 - We herein present for the first time a micro liquid chromatography-electrospray ionization high-resolution tandem-mass spectrometry (μLC-ESI MS/HR MS) procedure to detect phosphonylated tyrosine (Tyr) and lysine (Lys) residues obtained from human ...

Human butyrylcholinesterase in Cohn fraction IV-4 purified in a single chromatography s...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9838835
PloS One; M Schopfer L, David E et. al.

Jan 14th, 2023 - Protection from the toxicity of nerve agents is achieved by pretreatment with human butyrylcholinesterase (BChE). Current methods for purifying large quantities of BChE from frozen Cohn fraction IV-4 produce 99% pure enzyme, but the yield is low (...

Pretreatment of rhesus monkeys with transdermal patches containing physostigmine and pr...
https://doi.org/10.1007/s00204-022-03438-4
Archives of Toxicology; Nam JH, Kim MS et. al.

Jan 13th, 2023 - Physostigmine (Phs) is a reversible inhibitor of acetylcholinesterase (AChE) that penetrates the blood-brain barrier (BBB) and could be used to protect the central nervous system (CNS) against the effects of nerve agents. For prophylactic effectiv...

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Guidelines  1 results

Responding to nerve agent poisoning: a guide for emergency nurses. Part 2.
https://doi.org/10.7748/en.2019.e1925
Emergency Nurse : the Journal of the RCN Accident and Eme... McGhee S, Finnegan A et. al.

Aug 31st, 2019 - The release of chemical agents can cause loss of life and result in major incidents. Chemical agent-related major incidents require a modified response by emergency services due to the chemicals' transmissibility, lethality, latency and persistenc...

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Drugs  7 results see all →

Clinicaltrials.gov  3 results

A Study of Plasma-Derived Human Butyrylcholinesterase Administered Intramuscularly
https://clinicaltrials.gov/ct2/show/NCT00333528

May 5th, 2021 - The purpose of this placebo-controlled study is to evaluate the safety, tolerability and pharmacokinetics of a single dosage of human butyrylcholinesterase (HuBChE) in healthy adults. HuBChE, which occurs naturally in human plasma, is being evalua...

Pharmacokinetic (PK) and Safety Study of Plasma-derived Human Butyrylcholinesterase Administered Intravenously
https://clinicaltrials.gov/ct2/show/NCT00333515

May 5th, 2021 - The purpose of this placebo-controlled study is to evaluate the safety, tolerability and pharmacokinetics of a single dose regimen of human butyrylcholinesterase (HuBChE) in healthy adults at 3 ascending dosage levels administered IV. HuBChE, whic...

Scalp Application of LED Therapy to Improve Thinking and Memory in Veterans With Gulf War Illness
https://clinicaltrials.gov/ct2/show/NCT01782378

Jan 22nd, 2020 - Rationale: Impaired cognition is one of the 3 major symptom areas of GWVI. Mitochondrial dysfunction is reported in Gulf War Illness (GWI) veterans, associated with neurotoxicant exposures during deployment - e.g., organophosphate pesticides (OP);...

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News  7 results

As Virus Explodes, World Races to Mask Up
https://www.staging.medscape.com/viewarticle/927513

Mar 26th, 2020 - ZURICH (Reuters) - Spiez Lab, a government-run institute in the Swiss mountains, was set up to protect the nation from nuclear, biological and chemical threats. "For a world without weapons of mass destruction," runs its slogan. It is now fighting...

Chemical-Biological Terrorism Response Plans Should Include Children
https://www.medscape.com/viewarticle/924339

Jan 29th, 2020 - NEW YORK (Reuters Health) - Children are disproportionately affected by chemical and biological events, so they must be included in the planning and response when terrorism strikes, according to a policy statement from the American Academy of Pedi...

Emergency Use Authorization
http://www.fda.gov/emergency-preparedness-and-response/mcm-legal-regulatory-and-policy-framework/emergency-use-authorization

Image On this page: About Emergency Use Authorizations (EUAs) EUA Guidance  COVID-19 EUAs In Vitro Diagnostic Products High Complexity Molecular-Based Laboratory Developed Tests SARS-CoV-2 Antibody Tests Personal Protective Equipment and Related M...

Use of Expired Auto-Injectors OK'd by FDA
https://www.medpagetoday.com/emergencymedicine/emergencymedicine/43149

Nov 29th, 2013 - WASHINGTON -- The FDA cautioned emergency medical staff to retain nearly and recently expired auto-injectors by Meridian Medical Technologies and to use them in emergencies if no other product is available. The action arises because of a supply ch...

Gulf War illness linked to chemical exposure
https://www.reuters.com/article/us-gulfwar-chemicals/gulf-war-illness-linked-to-chemical-exposure-idUSN1059348220080310

Mar 10th, 2008 - CHICAGO (Reuters) - Exposure to pesticides, nerve agents and other chemicals may explain the chronic, multi-symptom health problems experienced by up to one-third of Gulf War veterans, U.S. researchers said on Monday. They said an analysis of a ho...

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Patient Education  1 results see all →