About 3,855 results

ALLMedicine™ Smallpox Center

Research & Reviews  1,005 results

Anticipating the transmissibility of the 2022 mpox outbreak.
Journal of Medical Virology; Liu T, Yang S et. al.

Mar 18th, 2023 - An ongoing outbreak of monkeypox virus (MPXV) was first reported in the United Kingdom (UK) on 6 May 2022. As of 17 November, there had been a total of 80,221 confirmed MPXV cases in over 110 countries. Based on data reported between 6 May and 30 ...

Effectiveness of one dose of MVA-BN smallpox vaccine against mpox in England using the ...
The Lancet. Infectious Diseases; Bertran M, Andrews N et. al.

Mar 17th, 2023 - The UK experienced a national outbreak of mpox (formerly known as monkeypox) disease that started in May, 2022, as did many other countries worldwide, with case numbers rising rapidly, mainly among gay, bisexual, and other men who have sex with me...

Smallpox vaccine acceptability among French men having sex with men living with HIV in ...
AIDS (London, England); Von Tokarski F, Fourn E et. al.

Mar 16th, 2023 - Smallpox vaccine acceptability among French men having sex with men living with HIV in settings of monkeypox outbreak.|2023|Von Tokarski F,Fourn E,Faucheron A,Chan Hew Wai A,Farfour E,|epidemiology,prevention & control,epidemiology,prevention & co...

Therapeutics for treating mpox in humans.
The Cochrane Database of Systematic Reviews; Fox T, Gould S et. al.

Mar 15th, 2023 - Mpox was declared a Public Health Emergency of International Concern (PHEIC) by the World Health Organization (WHO) on 23 July 2022, following the identification of thousands of cases in several non-endemic countries in previous months. There are ...

Poxes Great and Small: The Stories Behind Their Names.
Clinics in Dermatology; Czinn AB, Hoenig LJ

Mar 12th, 2023 - The word "pox" indicated, during the late 15th Century, a disease characterized by eruptive sores. When an outbreak of syphilis began in Europe during that time, it was called by many names including the French term "La Grosse Verole" ("the great ...

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Guidelines  9 results

Monkeypox: Fractional vaccine doses will be piloted as new treatment trial launches
BMJ Mahase E.

Aug 23rd, 2022 - Smaller doses of the smallpox vaccine, used to provide protection against monkeypox, will be piloted at NHS sites in London and Manchester to maximise supply, the UK Health Security Agency (UKHSA) has announced. In the pilot scheme—which will t...

How effective is the monkeypox vaccine? Scientists scramble for clues as trials ramp up
Science Kupferschmidt K.

Aug 10th, 2022 - When monkeypox suddenly started spreading globally in May, the world was fortunate in one respect: a vaccine was available. MVA, originally developed by Bavarian Nordic as a smallpox vaccine, was already licensed for monkeypox in Canada and the Un...

Breakthrough infections after post-exposure vaccination against Monkeypox
Medrxiv Thy M, .

Aug 4th, 2022 - A third-generation smallpox vaccine was recommended in France for individuals who had a high-risk contact with a PCR-confirmed Monkeypox patient. We aimed to describe the outcomes of high-risk contacts receiving third-generation smallpox vaccine...

Monkeypox - Factsheet
World Health Organization (WHO)

May 19th, 2022 - Monkeypox is a viral zoonosis (a virus transmitted to humans from animals) with symptoms similar to those seen in the past in smallpox patients, although it is clinically less severe. With the eradication of smallpox in 1980 and subsequent cessati...

As monkeypox threat grows, scientists debate best vaccine strategy
Science Kupferschmidt K.

May 7th, 2022 - In 1959, German microbiologist Anton Mayr took a strain of vaccinia, a poxvirus used to inoculate against smallpox, and started to grow it in cells taken from chicken embryos. After several years of transferring the strain to fresh cells every few...

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Drugs  19 results see all →

Clinicaltrials.gov  104 results

Safety and Tolerability Study of the VAC∆6 Vaccine in Volunteers Aged 18-40 Years

Mar 9th, 2023 - This study is an open-label, controlled, parallel-group clinical trial. The study included 60 healthy volunteers of both sexes aged 18-40 years who had not been vaccinated against smallpox, had no vaccine marks and anti-smallpox virus neutralizing...

VA-005 Clinical Outcomes of VIGIV Treatment of Smallpox Vaccination Complications or Vaccinia Infection

Mar 9th, 2023 - This is an open-label Phase 4 study designed to collect additional data to assess the safety and efficacy of VIGIV [CNJ-016, Vaccinia Immune Globulin Intravenous (Human), sterile solution] in the first 100 consented patients treated with VIGIV.

Smallpox Vaccine for Mpox Post-Exposure Prophylaxis: A Cluster RCT

Feb 27th, 2023 - An important unanswered question is the efficacy of post-exposure prophylaxis with a smallpox vaccine in reducing the risk of mpox. There are no randomized trials to date that have answered this question, which is why it is important to do a study...

Follow-up of People at Risk of Monkeypox Infection: a Prospective Cohort Study

Feb 13th, 2023 - Indication for Post-Exposure vaccination (PEP) : PEP has demonstrated its interest in different situations, in particular rabies, tetanus or hepatitis B, as recalled in the report "Guide for post-exposure immunization: vaccination and immunoglobul...

A Trial to Evaluate the Safety, Reactogenicity, and Immunogenicity of MVA-BN Yellow Fever Vaccine With and Without Montanide ISA-720 Adjuvant in 18-45 Year Old Healthy Volunteers

Dec 5th, 2022 - This study is a multi-center, double-blind, placebo-controlled, Phase I study to evaluate the safety, reactogenicity, tolerability, and immunogenicity of Modified Vaccinia Ankara-Bavarian Nordic-Yellow Fever (MVA-BN-YF) in Flavivirus-naive healthy...

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News  383 results

CDC Offers Tentative Guidance for Severe Mpox Treatment

Mar 2nd, 2023 - With no clinical trial data yet available for treating severe mpox, the CDC has published an interim report with guidance. There are many FDA-regulated drugs and biologics stockpiled for smallpox preparedness that can be used to treat severe mpox;...

Cardiac Adverse Events Following COVID-19 Vaccination in Patients With Prior Vaccine-Associated Myocarditis
Jay R. Montgomery, MD, Donna L. Hoffman, MSN et. al.

Jan 17th, 2023 - Vaccinations have substantially reduced morbidity and mortality from many infectious diseases. Despite the clear value of vaccinations in public health, efforts to better understand adverse events (AEs) following immunization are important to sust.

Early retirement and the terrible, horrible, no good, very bad cognitive decline
Lucas Franki, Richard Franki et. al.

Jan 12th, 2023 - The ‘scheme’ in the name should have been a clue Retirement. The shiny reward to a lifetime’s worth of working and saving.


Monkeypox (mpox) is a rare disease caused by a virus from the same family as the virus that causes smallpox.

Collect More Data or Begin Widespread Distribution? An Historical Perspective on the Vaccine Test Dilemma

Dec 8th, 2022 - Poliomyelitis is on the radar screen once again, but it's not only because of the recent case of paralytic polio striking in Rockland County, New York, and the related findings of vaccine-derived poliovirus type 2 in city sewage systems. It also d...

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Patient Education  22 results see all →