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About 6,693 results

ALLMedicine™ Familial Hypercholesterolemia Center

Research & Reviews  1,492 results

Impact of High-Density Lipoprotein Function, Rather Than High-Density Lipoprotein Chole...
https://doi.org/10.1253/circj.CJ-22-0560
Circulation Journal : Official Journal of the Japanese Ci... Tada H, Okada H et. al.

Nov 28th, 2022 - Recently, the function of high-density lipoprotein (HDL), rather than the HDL cholesterol (HDL-C) level, has been attracting more attention in risk prediction for coronary artery disease (CAD).Methods and Results: Patients with clinically diagnose...

Persistence with long-term PCSK9 inhibitors treatment and its effectiveness in Familial...
https://doi.org/10.1093/eurjpc/zwac277
European Journal of Preventive Cardiology; Alonso R, Arroyo-Olivares R et. al.

Nov 24th, 2022 - Most heterozygous familial hypercholesterolemia (FH) patients require intensive lipid-lowering therapy (LLT) including PCSK9 inhibitors (PCSK9i) to reach current LDL-C goals. Persistence with chronic treatment is important to reduce the burden of ...

Equivalent Impact of Elevated Lipoprotein(a) and Familial Hypercholesterolemia in Patie...
https://doi.org/10.1016/j.jacc.2022.09.021
Journal of the American College of Cardiology; Hedegaard BS, Bork CS et. al.

Nov 18th, 2022 - Genetically elevated plasma lipoprotein(a) and familial hypercholesterolemia each result in premature atherosclerotic cardiovascular disease (ASCVD); however, a direct comparison in the same population is needed of these 2 genetic traits on the ri...

ANGPTL3 as a Drug Target in Hyperlipidemia and Atherosclerosis.
https://doi.org/10.1007/s11883-022-01071-1
Current Atherosclerosis Reports; Mohamed F, Mansfield BS et. al.

Nov 12th, 2022 - Elevated low-density lipoprotein cholesterol (LDL-C) and triglyceride-rich lipoproteins (TRLs) or remnants are important risk factors for the development of atherosclerotic cardiovascular disease (ASCVD). The ongoing challenge of not being able to...

Assessing the genetic burden of familial hypercholesterolemia in a large middle eastern...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9635206
Journal of Translational Medicine; Gandhi GD, Aamer W et. al.

Nov 5th, 2022 - The genetic architecture underlying Familial Hypercholesterolemia (FH) in Middle Eastern Arabs is yet to be fully described, and approaches to assess this from population-wide biobanks are important for public health planning and personalized medi...

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Guidelines  4 results

The Detection, Evaluation, and Management of Dyslipidemia in Children and Adolescents: ...
https://doi.org/10.1016/j.cjca.2022.05.002
The Canadian Journal of Cardiology; Khoury M, Bigras JL et. al.

Aug 13th, 2022 - Atherosclerosis begins in youth and is directly linked with the presence and severity of cardiovascular risk factors, including dyslipidemia. Thus, the timely identification and management of dyslipidemia in childhood might slow atherosclerotic pr...

Canadian Cardiovascular Society Position Statement on Familial Hypercholesterolemia: Up...
https://doi.org/10.1016/j.cjca.2018.09.005
The Canadian Journal of Cardiology; Brunham LR, Ruel I et. al.

Dec 12th, 2018 - Familial hypercholesterolemia (FH) is the most common monogenic disorder causing premature atherosclerotic cardiovascular disease. It affects 1 in 250 individuals worldwide, and of the approximately 145,000 Canadians estimated to have FH, most are...

Screening for Lipid Disorders in Children and Adolescents: US Preventive Services Task ...
https://doi.org/10.1001/jama.2016.9852
JAMA , Bibbins-Domingo K et. al.

Aug 18th, 2016 - Elevations in levels of total, low-density lipoprotein, and non-high-density lipoprotein cholesterol; lower levels of high-density lipoprotein cholesterol; and, to a lesser extent, elevated triglyceride levels are associated with risk of cardiovas...

Familial hypercholesterolemia.
https://www.ncbi.nlm.nih.gov/pubmed/24335046
Journal of Atherosclerosis and Thrombosis; Teramoto T, Sasaki J et. al.

Dec 18th, 2013 - Familial hypercholesterolemia.|2013|Teramoto T,Sasaki J,Ishibashi S,Birou S,Daida H,|diagnosis,etiology,prevention & control,diagnosis,etiology,prevention & control,diagnosis,prevention & control,

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Drugs  523 results see all →

Clinicaltrials.gov  176 results

Effect of Breastfeeding on Lipid Profile and Cardiovascular Risk Markers in Women With Familial Hypercholesterolemia
https://clinicaltrials.gov/ct2/show/NCT05367310

Oct 13th, 2022 - Patients with familial hypercholesterolemia (FH) have elevated plasma levels of LDL-cholesterol from first years of life. Cholesterol burden through life defines risk of cardiovascular disease. In women with FH, cholesterol levels increase during ...

A Study of VERVE-101 in Patients With Familial Hypercholesterolemia and Cardiovascular Disease
https://clinicaltrials.gov/ct2/show/NCT05398029

Oct 10th, 2022 - VT-1001 is an open-label, phase 1b, single-ascending dose study that will evaluate the safety of VERVE-101 administered to patients with heterozygous familial hypercholesterolemia (HeFH), atherosclerotic cardiovascular disease (ASCVD), and uncontr...

In Vivo Metabolism of apoB-containing Lipoproteins in ANGPTL3 Deficient Subjects
https://clinicaltrials.gov/ct2/show/NCT05569928

Oct 10th, 2022 - Working hypothesis The overall working hypothesis is that the normal physiological action of ANGPTL3 is to slow lipolysis and inhibit remnant clearance by the liver. In this way, the protein causes an increase in the flux of apoB particles transit...

Study to Evaluate Efficacy and Safety of Inclisiran in Adolescents With Heterozygous Familial Hypercholesterolemia
https://clinicaltrials.gov/ct2/show/NCT04652726

Oct 6th, 2022 - This is a two-part (1 year double-blind inclisiran versus placebo / 1 year open-label inclisiran) multicenter study designed to evaluate safety, tolerability, and efficacy of inclisiran in adolescents with heterozygous familial hypercholesterolemi...

HoFH, the International Clinical Collaborators Registry
https://clinicaltrials.gov/ct2/show/NCT04815005

Sep 29th, 2022 - The HICC registry is an observational, multicenter, international registry collecting de-identified clinical and genetic information from patients with homozygous Familial Hypercholesterolemia (HoFH) worldwide. Patients are eligible to be enrolled...

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News  469 results

Elevated Lp(a) Tied to More Early CV Events Than FH
https://www.medscape.com/viewarticle/984693

Nov 28th, 2022 - Many more people are at risk for early cardiovascular events because of raised Lp(a) levels than from having familial hypercholesterolemia (FH), a new study suggests. The Danish study set out to try and establish a level of Lp(a) that would be ass...

New Heart Pump Approved; Scams After a Stroke; Cardiac Rehab Falls Further
https://www.medpagetoday.com/cardiology/prevention/101525

Nov 1st, 2022 - Abiomed announces FDA approval of the Impella RP Flex with SmartAssist with the indication for temporary right ventricular support in people with acute right heart failure. The American College of Cardiology provides a framework for treating patie...

Screening Gaps Miss Childhood Heart Problems
https://www.medscape.com/viewarticle/982430

Oct 13th, 2022 - People with a rare genetic condition that causes extremely elevated levels of low-density lipoprotein cholesterol (LDL-C) may miss out on decades of treatment because of a lack of lipid screening in childhood, researchers reported at the 2022 annu...

Monkeypox Myocarditis; Early DOACs After Stroke; Saturated Fats Absolved?
https://www.medpagetoday.com/cardiology/prevention/100551

Sep 6th, 2022 - The American College of Cardiology said clinicians should be on the lookout for heart problems in patients with monkeypox after a 31-year-old man developed acute myocarditis. Lingering cardiac symptoms in people who initially had only mild COVID-1...

USPSTF Keeps Status Quo for Primary Prevention Statins
https://www.medpagetoday.com/cardiology/prevention/100350

Aug 23rd, 2022 - For higher-risk adults without prior cardiovascular disease (CVD) events, the U.S. Preventive Services Task Force (USPSTF) continues to broadly recommend statins for primary prevention while differing from other American guidelines in certain key ...

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Patient Education  13 results see all →