About 7,123 results

ALLMedicine™ Familial Hypercholesterolemia Center

Research & Reviews  1,545 results

Updates in the management of pediatric dyslipidemia.
Current Opinion in Lipidology; Choudhari P, Patni N

Mar 22nd, 2023 - Pediatric dyslipidemias increase the risk of atherosclerosis and clinical cardiovascular disease and are the leading cause of morbidity and mortality. Lifestyle modifications and pharmacotherapies have measurably improved abnormal lipids and reduc...

Approach to the Patient with a Suboptimal Statin Response: Causes and Algorithm for Cli...
The Journal of Clinical Endocrinology and Metabolism; Sun L, Wolska A et. al.

Mar 18th, 2023 - Statins are the lipid-lowering therapy of choice for the prevention of atherosclerotic cardiovascular disease (ASCVD) but their effectiveness in lowering Low-Density Lipoprotein-Cholesterol (LDL-C) can substantially differ between individuals. In ...

Achievement Rates for Low-Density Lipoprotein Cholesterol Goals in Patients at High Ris...
Journal of Atherosclerosis and Thrombosis; Mitani H, Suzuki K et. al.

Mar 18th, 2023 - The study aimed to investigate low-density lipoprotein cholesterol (LDL-C) goal achievement rates in patients receiving LDL-C-lowering therapy using recent real-world data, following the 2017 revision of the Japan Atherosclerosis Society Guideline...

Erythrocyte-Derived microRNAs: Emerging Players in Cardiovascular and Metabolic Disease.
Arteriosclerosis, Thrombosis, and Vascular Biology; Kontidou E, Collado A et. al.

Mar 17th, 2023 - Recent studies have demonstrated a novel function of red blood cells (RBCs) beyond their classical role as gas transporters, that is, RBCs undergo functional alterations in cardiovascular and metabolic disease, and RBC dysfunction is associated wi...

Familial hypercholesterolemia: The nexus of endothelial dysfunction and lipoprotein met...
Current Opinion in Lipidology; Vuorio A, Raal F et. al.

Mar 17th, 2023 - Patients with heterozygous familial hypercholesterolemia (HeFH) are at increased risk for COVID-19 cardiovascular complications in the acute phase of the infection. Elevated levels of LDL-C and often lipoprotein(a) are present from birth and lead ...

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Guidelines  4 results

The Detection, Evaluation, and Management of Dyslipidemia in Children and Adolescents: ...
The Canadian Journal of Cardiology; Khoury M, Bigras JL et. al.

Aug 13th, 2022 - Atherosclerosis begins in youth and is directly linked with the presence and severity of cardiovascular risk factors, including dyslipidemia. Thus, the timely identification and management of dyslipidemia in childhood might slow atherosclerotic pr...

Canadian Cardiovascular Society Position Statement on Familial Hypercholesterolemia: Up...
The Canadian Journal of Cardiology; Brunham LR, Ruel I et. al.

Dec 12th, 2018 - Familial hypercholesterolemia (FH) is the most common monogenic disorder causing premature atherosclerotic cardiovascular disease. It affects 1 in 250 individuals worldwide, and of the approximately 145,000 Canadians estimated to have FH, most are...

Screening for Lipid Disorders in Children and Adolescents: US Preventive Services Task ...
JAMA , Bibbins-Domingo K et. al.

Aug 18th, 2016 - Elevations in levels of total, low-density lipoprotein, and non-high-density lipoprotein cholesterol; lower levels of high-density lipoprotein cholesterol; and, to a lesser extent, elevated triglyceride levels are associated with risk of cardiovas...

Familial hypercholesterolemia.
Journal of Atherosclerosis and Thrombosis; Teramoto T, Sasaki J et. al.

Dec 18th, 2013 - Familial hypercholesterolemia.|2013|Teramoto T,Sasaki J,Ishibashi S,Birou S,Daida H,|diagnosis,etiology,prevention & control,diagnosis,etiology,prevention & control,diagnosis,prevention & control,

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Drugs  627 results see all →

Clinicaltrials.gov  183 results

A Long-term Follow-up Study to Evaluate the Safety and Efficacy of RGX-501

Mar 9th, 2023 - Homozygous Familial Hypercholesterolemia (HoFH) is a rare genetic metabolic disorder characterized by absent or severely reduced capacity to catabolize circulating LDL particles by the hepatic LDL receptor. As a consequence, HoFH subjects present ...

Post Approval Study of Liposorber LA-15 System for the Treatment of Focal Segmental Glomerulosclerosis in Children

Mar 8th, 2023 - Liposorber® LA-15 System is a blood purification therapy that selectively removes malignant lipoproteins including low density lipoprotein from circulating blood flow and rapidly reduces the plasma cholesterol level. The system was originally deve...

Trial to Assess the Effect of Long Term Dosing of Inclisiran in Subjects With High CV Risk and Elevated LDL-C

Mar 7th, 2023 - This study will be an open label, long term extension study in subjects with atherosclerotic cardiovascular disease (ASCVD), ASCVD-risk equivalents (eg, diabetes and familial hypercholesterolemia), or heterozygous or homozygous familial hyperchole...

The Danish Familial Hypercholesterolemia Organized Coronary Screening Trial

Mar 7th, 2023 - Introduction: Familial hypercholesterolemia (FH) is the most common inherited cause of atherosclerotic cardiovascular disease (ASCVD) with a prevalence of 1/200. More than 30.000 patients in Denmark are expected to have FH, however, few of these p...

Cardiovascular Evaluation of Patients With High Cholesterol and Normal Volunteers

Mar 3rd, 2023 - Familial hypercholesterolemia is an autosomal co-dominant disorder resulting in abnormal LDL receptor function, profoundly elevated concentrations of low density lipoproteins, accelerated atherosclerosis and death by early adulthood. This disease ...

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News  477 results

Cholera Outbreak Widens; What Beethoven's DNA Revealed; Grindr's Free HIV Tests

Mar 23rd, 2023 - Note that some links may require subscriptions. Four new countries are reporting cholera outbreaks, bringing the total number of affected countries to 24, according to the World Health Organization. Come May, the White House COVID-19 task force wi...

Cardiometabolic Changes in Early Life Favor Girls

Mar 15th, 2023 - Sex differences in adult heart disease may be related to diverging trajectories in cardiometabolic disease factors beginning as early as childhood, a metabolomics study showed. With granular and high-resolution cardiovascular phenotyping, the diff...

Insomnia and MIs; LGBTQ Heart Health; Trifecta SAVR Valves Not So Durable

Feb 28th, 2023 - Meta-analysis makes the case for insomnia as a risk factor for myocardial infarction. (Clinical Cardiology) Outpatient procedures associated with postoperative heart attacks included gastrointestinal endoscopy, as well as vascular, urological/gyne...

Muscle-Related Adverse Events Associated With PCSK9 Inhibitors in a Veteran Population
Joseph Cencetti, PharmD, BCACP, CLS, Callie Abramowitz, PharmD et. al.

Feb 9th, 2023 - HMG-CoA reductase inhibitors (statins) have been shown to effectively reduce low-density lipoprotein cholesterol (LDL-C) as well as morbidity and mortality in patients who have either atherosclerotic cardiovascular disease (ASCVD) or risk factors.

SPRINT BP Control Ups cTn; FH & Eating Disorders; Cardiac Death During 'Avatar 2'

Dec 19th, 2022 - In SPRINT, intensive systolic blood pressure lowering decreased natriuretic peptide levels but increased high-sensitivity cardiac troponin T (cTn). (Circulation) The medical community braces for harmful messaging about COVID-19 vaccines after Flor...

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Patient Education  13 results see all →