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About 6,028 results

ALLMedicine™ Hypertriglyceridemia Center

Research & Reviews  1,618 results

Endogenous Leptin Concentrations Poorly Predict Metreleptin Response in Patients with P...
https://doi.org/10.1210/clinem/dgab760
The Journal of Clinical Endocrinology and Metabolism; Meral R, Malandrino N et. al.

Oct 23rd, 2021 - Leptin replacement with metreleptin improves glycemia and hypertriglyceridemia in severely hypoleptinemic patients with Generalized Lipodystrophy (GLD), but its effects are variable in partially leptin-deficient patients with Partial Lipodystrophy...

A Study to Examine the Effects of the Leptin Receptor (LEPR) Agonist Antibody REGN4461 in Adult Patients With Familial Partial Lipodystrophy (FPLD)
https://clinicaltrials.gov/ct2/show/NCT05088460

Oct 22nd, 2021 - Two cohorts are being studied based on leptin levels. Cohort A is composed of patients with baseline leptin <8.0 ng/mL and Cohort B is composed of patients with baseline leptin 8.0 to ≤20.0 ng/mL The primary objectives will be evaluated for patien...

Effects of Lovaza on Lipoprotein Composition and Function in Mild Hypertriglyceridemia
https://clinicaltrials.gov/ct2/show/NCT00959842

Oct 20th, 2021 - This study will build upon a previous finding that showed a triglyceride lowering effect of prescription omega-3 in combined therapy with statins. The proposed study will use a simple change from baseline design on 15 subjects who are hypertriglyc...

Transcriptomic therapy for dyslipidemias utilizing nucleic acids targeted at ANGPTL3.
https://doi.org/10.2217/fca-2021-0096
Future Cardiology; Watts GF, Raal FJ et. al.

Oct 16th, 2021 - Angiopoietin-like protein 3 (ANGPTL3) is a key physiological regulator of plasma lipid and lipoprotein metabolism that involves the control of enzymes, lipoprotein and endothelial lipases. Inhibition of ANGPTL3 offers a new approach for correcting...

The association of metabolic syndrome and COVID-19 deterioration.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8386103
Nutrition, Metabolism, and Cardiovascular Diseases : NMCD; Ouedraogo E, Allard L et. al.

Oct 12th, 2021 - To evaluate the prevalence and prognostic value of metabolic syndrome (MetS) in patients admitted for coronavirus disease 2019 (COVID-19). In this monocentric cohort retrospective study, we consecutively included all adult patients admitted to COV...

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Guidelines  1 results

2021 ACC Expert Consensus Decision Pathway on the Management of ASCVD Risk Reduction in...
https://doi.org/10.1016/j.jacc.2021.06.011
Journal of the American College of Cardiology; Virani SS, Morris PB et. al.

Aug 2nd, 2021 - 2021 ACC Expert Consensus Decision Pathway on the Management of ASCVD Risk Reduction in Patients With Persistent Hypertriglyceridemia: A Report of the American College of Cardiology Solution Set Oversight Committee.|2021|Virani SS,Morris PB,Agarwa...

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Drugs  599 results see all →

Clinicaltrials.gov  49 results

A Study to Examine the Effects of the Leptin Receptor (LEPR) Agonist Antibody REGN4461 in Adult Patients With Familial Partial Lipodystrophy (FPLD)
https://clinicaltrials.gov/ct2/show/NCT05088460

Oct 22nd, 2021 - Two cohorts are being studied based on leptin levels. Cohort A is composed of patients with baseline leptin <8.0 ng/mL and Cohort B is composed of patients with baseline leptin 8.0 to ≤20.0 ng/mL The primary objectives will be evaluated for patien...

Effects of Lovaza on Lipoprotein Composition and Function in Mild Hypertriglyceridemia
https://clinicaltrials.gov/ct2/show/NCT00959842

Oct 20th, 2021 - This study will build upon a previous finding that showed a triglyceride lowering effect of prescription omega-3 in combined therapy with statins. The proposed study will use a simple change from baseline design on 15 subjects who are hypertriglyc...

Postprandial VLDL-triglyceride Metabolism in Type 2 Diabetes Patients With and Without NAFLD
https://clinicaltrials.gov/ct2/show/NCT05044130

Sep 24th, 2021 - Non-alcoholic fatty liver disease (NAFLD) covers a spectrum from simple reversible hepatic steatosis to inflammation and fibrosis termed steatohepatitis (NASH). The mechanisms behind why some subjects progress from NAFLD to NASH are not clear and ...

Omega-3 Fatty Acid Dietary Intervention (O3DI)
https://clinicaltrials.gov/ct2/show/NCT05025943

Aug 30th, 2021 - Elevated cholesterol, including triglyceride levels, can lead to the development of cardiovascular disease in adulthood. A diet that is rich in omega-3 fatty acids (O3FA) can improve triglyceride levels in a way that is safe and does not require m...

Phase 2 Study of Orlistat and SLx-4090 for the Treatment of Type 1 Hyperlipoproteinemia
https://clinicaltrials.gov/ct2/show/NCT01675154

Aug 19th, 2021 - Type I hyperlipoproteinemia is a rare, autosomal recessive metabolic disorder characterized by extreme hypertriglyceridemia due to a deficiency in lipoprotein lipase or related proteins. Treatment of these patients is challenging as triglyceride-l...

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News  144 results

ACC Issues Decision Pathway for Hypertriglyceridemia Management
https://www.medscape.com/viewarticle/955658

Jul 29th, 2021 - A new decision pathway for the management of hypertriglyceridemia, prompted by a large and growing body of evidence that elevated triglycerides to a targetable risk factor for atherosclerotic cardiovascular disease (ASCVD), has been issued by the ...

Adverse Effects of Hormone Therapy in Prostate Cancer
https://www.onclive.com/view/adverse-effects-of-hormone-therapy-in-prostate-cancer

Apr 2nd, 2021 - Transcript: Susan F. Slovin, MD, PhD: Going into a chemical-induced menopause is not great for a lot of men. It’s interesting when we discuss adverse effects to really keep in mind that while there is a huge number of adverse effects that occu...

Painful hand and foot plaques
https://www.mdedge.com/familymedicine/article/235724/dermatology/painful-hand-and-foot-plaques
MDedge Family Medicine;

Feb 25th, 2021 - This patient had hand and foot psoriasis with the classic thick scale and erythema on his palms and soles. Additionally, in the area of the sole toward the heel, he had hyperpigmented macules called mahogany spots that are another hallmark of psor.

Anakinra for Gout Flares: Is There a Role?
https://www.medpagetoday.com/rheumatology/generalrheumatology/91319

Feb 23rd, 2021 - The interleukin (IL)-1 receptor antagonist anakinra (Kineret) was not superior to triamcinolone for relieving gout flares, but had similar effects for pain reduction as the glucocorticoid, a randomized phase II study found. The mean change from ba...

Rolling Submission for Surufatinib Started for Advanced Neuroendocrine Tumors
https://www.onclive.com/view/rolling-submission-for-surufatinib-started-for-advanced-neuroendocrine-tumors

Dec 29th, 2020 - The filing of a new drug application (NDA) has been initiated with the FDA for surufatinib for the treatment of patients with pancreatic and non-pancreatic neuroendocrine tumors.1 Hutchison China MediTech Limited (Chi-Med), the developer of suruf...

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