×
About 5,570 results

ALLMedicine™ Hypokalemia Center

Research & Reviews  1,357 results

Phase I Trial of a Novel Anti-HER2 Antibody-Drug Conjugate, ARX788, for the Treatment o...
https://doi.org/10.1158/1078-0432.CCR-22-0456
Clinical Cancer Research : an Official Journal of the Ame... Zhang J, Ji D et. al.

Jun 30th, 2022 - ARX788 is a novel antibody-drug conjugate (ADC) comprised of an anti-HER2 mAb and a potent tubulin inhibitor payload AS269 that is site-specifically conjugated to the antibody via a nonnatural amino acid incorporated into the antibody. Herein, we ...

Ambulatory fludrocortisone suppression test in the diagnosis of primary aldosteronism: ...
https://doi.org/10.1111/cen.14793
Clinical Endocrinology; Carasel A, Calissendorff J et. al.

Jun 29th, 2022 - The aims of this study were to explore if the ambulatory FST was safe, accurate, and cost-effective. The diagnosis of primary aldosteronism (PA) remains time-consuming and complex. The fludrocortisone suppression test (FST) is used to confirm PA, ...

Exposure-safety relationship for acyclovir in the treatment of neonatal herpes simplex ...
https://doi.org/10.1016/j.earlhumdev.2022.105616
Early Human Development; Ericson JE, Benjamin DK et. al.

Jun 29th, 2022 - Neonatal herpes simplex virus (HSV) disease has been treated with high-dose (20 mg/kg/dose) acyclovir since 1991. Determine the safety of acyclovir in infants with neonatal HSV treated with high-dose acyclovir; examine the association between acyc...

Osmotic demyelination syndrome: novel risk factors and proposed pathophysiology.
https://doi.org/10.1111/imj.15855
Internal Medicine Journal; Ambati R, Kho LK et. al.

Jun 20th, 2022 - Osmotic demyelination syndrome (ODS) is non inflammatory demyelination in response to an osmotic challenge. It can be pontine or extrapontine in presentation AIM: Retrospective review of cases involving ODS and define the spectrum of causes, risk ...

see more →

Guidelines  1 results

Case detection, diagnosis, and treatment of patients with primary aldosteronism: an end...
https://doi.org/10.1210/jc.2008-0104
The Journal of Clinical Endocrinology and Metabolism; Funder JW, Carey RM et. al.

Jun 17th, 2008 - Our objective was to develop clinical practice guidelines for the diagnosis and treatment of patients with primary aldosteronism. The Task Force comprised a chair, selected by the Clinical Guidelines Subcommittee (CGS) of The Endocrine Society, si...

see more →

Drugs  538 results see all →

Clinicaltrials.gov  79 results

A Multicenter, Prospective, Non-interventional Cohort Study to Evaluate the Safety and Treatment Pattern of Sodium Zirconium Cyclosilicate for Hyperkalaemia Management in Real World Practice in China
https://clinicaltrials.gov/ct2/show/NCT05271266

Jun 15th, 2022 - Background/Rationale: Hyperkalaemia (HK) is a common electrolyte disturbance in clinical practice, defined as serum potassium (sK) beyond the normal range. The cut-off value for HK diagnosis is 5.0 mmol/L in most international guidelines[1, 2]. HK...

Mineralocorticoid Receptor Antagonism Clinical Evaluation in Atherosclerosis Add-On
https://clinicaltrials.gov/ct2/show/NCT03597035

May 16th, 2022 - There is substantial interest in preventing cardiovascular (CV) and renal disease progression in the Type 2 diabetic. Activation of the renin angiotensin aldosterone axis (RAS) and the mineralocorticoid receptor (MR) results in pro-inflammatory ef...

Effect of Genetic Polymorphisms of UGT on the PKs of Indapamide in Egyptians
https://clinicaltrials.gov/ct2/show/NCT05294484

Mar 24th, 2022 - Indapamide is a thiazide-type diuretic commonly prescribed to treat mild to moderate hypertension. As it has fewer side effects in inducing metabolic derangements than other thiazide diuretics, indapamide is well accepted to be used as initial the...

Preventing Metabolic Side Effects of Thiazide Diuretics With KMgCitrate
https://clinicaltrials.gov/ct2/show/NCT02665117

Feb 11th, 2022 - CTD- induced metabolic side effects were though to be dependent on hypokalemia, but subsequent studies suggested that CTD - induced side effects were independent from hypokalemia. On the other hand, magnesium depletion has been linked to increased...

Establishment of Aldosterone and Renin Reference Range
https://clinicaltrials.gov/ct2/show/NCT05232162

Feb 9th, 2022 - Despite old beliefs that Primary Aldosteronism (PA) is uncommon and warrants screening only when patients present with hypertension and hypokalemia, it is now believed that PA is in fact the most common cause of secondary hypertension, accounting ...

see more →

News  253 results

Potassium Abnormalities Boost Hospital Visits for Kidney Disease
https://www.medscape.com/viewarticle/972652

Apr 25th, 2022 - Patients with advanced chronic kidney disease (CKD) are at higher risk of hospitalization or requiring an emergency room (ER) visit in the short-term if they have abnormal potassium levels, a nationally representative cohort of US veterans with ad...

Pegcetacoplan Improves Efficacy in Complement Inhibitor–Naïve Paroxysmal Nocturnal Hemoglobinuria
https://www.onclive.com/view/pegcetacoplan-improves-efficacy-in-complement-inhibitor-na-ve-paroxysmal-nocturnal-hemoglobinuria

Apr 9th, 2022 - Pegcetacoplan (Empaveli) treatment was associated with hemoglobin stabilization and normalization, as well as a superior change from baseline in hemoglobin levels, which showed a meaningful correction of anemia, in patients with complement inhibit...

Avapritinib Approved in Europe for Advanced Systemic Mastocytosis
https://www.onclive.com/view/avapritinib-approved-in-europe-for-advanced-systemic-mastocytosis

Mar 25th, 2022 - The European Commission has expanded the current indication for avapritinib (Ayvakyt) to include use as a single agent in adult patients with aggressive systemic mastocytosis, systemic mastocytosis with an associated hematologic neoplasm, or mast ...

Pembrolizumab Plus Gemcitabine/Hypofractionated Radiotherapy Demonstrates Promising Efficacy in Muscle-Invasive Bladder Cancer
https://www.onclive.com/view/pembrolizumab-plus-gemcitabine-hypofractionated-radiotherapy-demonstrates-promising-efficacy-in-muscle-invasive-bladder-cancer

Mar 1st, 2022 - Pembrolizumab (Keytruda) in combination with gemcitabine and concurrent hypofractionated radiotherapy (RT) appears to be a promising and efficacious, bladder-sparing regimen for patients with muscle-invasive bladder cancer (MIBC), according to fin...

Bowel prep: Electrolyte disturbances remain rare but serious
https://www.mdedge.com/internalmedicine/article/251532/gastroenterology/bowel-prep-electrolyte-disturbances-remain-rare
Heidi Splete

Feb 7th, 2022 - Patients undergoing bowel prep for colonoscopy had significantly greater decreases in potassium after prep with sodium phosphate, compared with those whose prep involved polyethylene glycol, based on data from a meta-analysis of more than 2,000 pa.

see more →