ALLMedicine™ Metabolic Acidosis Center

Oct 1st, 2022 - To understand the risk factors associated with adverse events during exchange transfusion (ET) in severe neonatal hyperbilirubinemia. We conducted a retrospective study of infants with hyperbilirubinemia who underwent ET within 30 days of birth fr...

Sep 30th, 2022 - Metabolic Acidosis-Is It the Elephant in the Room?|2022|Narayanan M,Wesson D,|

Sep 30th, 2022 - The various mechanisms responsible for the development of metabolic acidosis are briefly reviewed, and the metabolic acidoses are categorized both by mechanism and by the presence or absence of an increased anion gap. When a diagnosis of metabolic...

Sep 30th, 2022 - Acid accumulation sufficient to reduce plasma bicarbonate concentration, thereby recognized as chronic metabolic acidosis, harms bones and muscles and appears to enhance progression of CKD. Evolving evidence supports that progressive acid accumula...

Sep 30th, 2022 - Eating a net acid-producing diet can produce an "acid stress" of severity proportional to the diet net acid load, as indexed by the steady-state renal net acid excretion rate. Depending on how much acid or base is ingested or produced from endogen...

Dec 27th, 2012 - Small-bowel obstruction (SBO) represents as many as 16% of surgical admissions and more than 300,000 operations annually in the United States. The optimal strategies for the diagnosis and management of SBO continue to evolve secondary to advances ...

Sep 28th, 2022 - Background: A prospective cohort of Inherited Bone Marrow Failure Syndrome (IBMFS) will provide new information regarding cancer rates and types in these disorders. Pathogenic variant(s) in IBMFS genes are relevant to carcinogenesis in sporadic ca...

Sep 23rd, 2022 - This is a randomized, double-blind, placebo-controlled trial. Eligible subjects will be randomized in a 1:1 ratio to TRC101 or placebo. The primary endpoint of the study will be progression of renal disease, defined by time to first occurrence of ...

Sep 16th, 2022 - Acute kidney injury (AKI) is characterized by a rapid decrease in renal function. It is frequent in hospitalized patients and its incidence is higher in critically ill patients. It is associated with high rates of morbidity and mortality. AKI affe...

Sep 15th, 2022 - Some robotic endoscopic surgeries require a steep Trendelenburg position and a carbon dioxide pneumoperitoneum. This minimally invasive approach has the advantages of less postoperative pain, shorter hospital stay and faster recovery. After prolon...

Sep 13th, 2022 - Acute respiratory distress syndrome (ARDS) is an inflammatory condition that results in severe respiratory failure and the need for mechanical ventilation. It is a syndrome with significant global burden and accounts for approximately 24% of mecha...

Apr 13th, 2022 - Evidence summary Bicarbonate therapy demonstrates benefit in 2 meta-analyses Two recent meta-analyses evaluated studies of bicarbonate therapy in patients with CKD, and both found benefit. 1,2 A 2020 meta-analysis included 15 RCTs (N = 2445) of adu.

Jan 19th, 2022 - On the basis of the patient's history and clinical presentation, the likely diagnosis is ketosis-prone diabetes (KPD) type 2. KPD is widely thought of as an atypical diabetes syndrome, though some groups consider it to be a common clinical present.

Oct 8th, 2021 - Vancomycin is a widely used IV antibiotic due to its broad-spectrum of activity, bactericidal nature, and low rates of resistance; however, adverse effects (AEs), including nephrotoxicity, are commonly associated with its use. 1 The vancomycin ther.

May 12th, 2021 - An 88-year-old male veteran with a medical history of chronic obstructive pulmonary disease (COPD) on home oxygen, chronic alcohol use, squamous cell carcinoma of the lung status after left upper lobectomy, and a 5. 7 cm thoracic aortic aneurysm wa.

Apr 30th, 2021 - FDA expanded the indication for dapagliflozin (Farxiga) into chronic kidney disease (CKD). The drug, which first entered the market for type 2 diabetes in 2014, was approved to reduce the risk of kidney function decline, kidney failure, cardiovasc...