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About 213 results

ALLMedicine™ Unconjugated Hyperbilirubinemia Center

Research & Reviews  82 results

UGT1A1 mutation association with increased bilirubin levels and severity of unconjugate...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8167307
BMC Pediatrics; Yang H, Lin F et. al.

Jun 2nd, 2021 - Neonatal hyperbilirubinemia causing jaundice is common in East Asian population. Uridine diphosphate glucuronosyltransferase isoenzyme (UGT1A1) glucuronidates bilirubin and converts the toxic form of bilirubin to its nontoxic form. A retrospective...

Outcome of liver transplantation and prevalence of liver fibrosis in Crigler-Najjar syn...
https://doi.org/10.1111/ctr.14219
Clinical Transplantation; Schröder H, Junge N et. al.

Feb 5th, 2021 - Crigler-Najjar syndrome (CNS) is a rare inherited disorder that is characterized by high levels of non-hemolytic, unconjugated hyperbilirubinemia leading to brain damage and even death. Liver transplantation (LT) can correct the metabolic defect, ...

Effectiveness of FIBEROPTIC phototherapy compared to conventional phototherapy in treat...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7798326
BMC Pediatrics; Joel HN, Mchaile DN et. al.

Jan 12th, 2021 - Neonatal jaundice is one of the most common problems in neonates. Effective treatment of jaundice requires therapeutic intervention with high quality phototherapy. Over recent years, several studies reported fiberoptic phototherapy to be less effe...

Novel mutations in Uridyl-diphosphate-glucuronosyl-transferase 1A1 (UGT1A1) gene in Tun...
https://doi.org/10.1016/j.ejmg.2021.104139
European Journal of Medical Genetics; Trabelsi N, Chaouch L et. al.

Jan 9th, 2021 - Unconjugated hyperbilirubinemia (UCB) is a feature of Gilbert's syndrome (GS) and Crigler-Najjar's syndrome (CNS), which are two hereditary defects in bilirubin metabolism. Both syndromes are linked to mutations in the UGT1A1 gene, which cause eit...

The effect of ursodeoxycholic acid on indirect hyperbilirubinemia in neonates treated w...
https://doi.org/10.1080/14767058.2020.1846705
The Journal of Maternal-fetal & Neonatal Medicine : the O... Akefi R, Hashemi SM et. al.

Nov 23rd, 2020 - Indirect hyperbilirubinemia during neonatal period is a common problem, and most preterm and more than half of the term neonates find this problem. Ursodeoxycholic acid (UDCA) protects the liver against oxidative stresses and prevents cellular apo...

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Clinicaltrials.gov  2 results

The Effect of Hyperbilirubinemia on CV Disease, Neurocog Function and Renal Function
https://clinicaltrials.gov/ct2/show/NCT01475240

Apr 10th, 2014 - Use of some protease inhibitors is associated with unconjugated hyperbilirubinemia as a result of inhibition of the UGT1A1 enzyme. Elevated levels of unconjugated bilirubin are best characterized among individuals with Gilbert syndrome, which is t...

Orlistat Treatment of Crigler-Najjar Disease
https://clinicaltrials.gov/ct2/show/NCT00461799

Apr 17th, 2007 - Unconjugated hyperbilirubinemia in Crigler-Najjar (CN) disease is conventionally treated with phototherapy and/or phenobarbital. Life-long daily phototherapy has considerable disadvantages. Main problems are a decreasing efficacy with age and a pr...

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Patient Education  1 results see all →