ALLMedicine™ Crohn Disease Center

Sep 23rd, 2021 - Fistulizing perianal disease is a frequent, chronic, and often debilitating manifestation of Crohn disease (CD) in adults and children, which in the past was relatively refractory to treatment. The advent of biologic agents such as anti-tumor necr...

Sep 8th, 2021 - Children with perianal fistulizing Crohn disease require intensive medical management but also have a higher risk for subsequent surgical interventions. We performed a retrospective study to identify patient factors and perianal anatomical feature...

Aug 28th, 2021 - An important goal of clinical genomics is to be able to estimate the risk of adverse disease outcomes. Between 5% and 10% of individuals with ulcerative colitis (UC) require colectomy within 5 years of diagnosis, but polygenic risk scores (PRSs) u...

Aug 4th, 2021 - Background Dual-energy CT enterography (DECTE) has been shown to be useful in characterizing Crohn disease activity compared with clinical markers of inflammation but, to the knowledge of the authors, comparison has not been made with histopatholo...

Jul 28th, 2021 - CD38 is a cell surface receptor capable of generating calcium-mobilizing second messengers. It has been implicated in host defense and cancer biology, but signaling mechanisms downstream of CD38 remain unclear. Mutations in LRRK2 (leucine-rich rep...

May 7th, 2020 - Three common clinical scenarios involving use of imaging in Crohn disease are covered. These include the initial evaluation of Crohn disease when the diagnosis has not been previously established, the evaluation for anticipated exacerbation of kno...

Mar 28th, 2019 - Very early onset inflammatory bowel disease (VEO-IBD) is defined as disease presenting before the age of 6. These children require a tailored imaging approach because conventional imaging studies can be difficult to perform at such a young age. Un...

Mar 8th, 2017 - The incidence of Crohn disease (CD) has been increasing and surgery needs to be contemplated in a substantial number of cases. The relevant advent of biological treatment has changed but not eliminated the need for surgery in many patients. Despit...

Jun 3rd, 2021 - Clinical practice guidelines on the management of emergent inflammatory bowel disease by the World Society of Emergency Surgery and the American Association for the Surgery of Trauma were published in May 2021 in the World Journal of Emergency Sur...

Jun 3rd, 2021 - Clinical practice guidelines on the management of emergent inflammatory bowel disease by the World Society of Emergency Surgery and the American Association for the Surgery of Trauma were published in May 2021 in the World Journal of Emergency Sur...

Jan 5th, 2021 - A diagnosis of atopic dermatitis in individuals ages 15 years or older, compared with controls without atopic dermatitis, was nearly twice as likely to be associated with autoimmune disease, in a case control study derived from Swedish national he...

Jul 28th, 2020 - In July 2020, the American Society of Colon and Rectal Surgeons published clinical practice guidelines on the surgical management of Crohn disease.[1] Medically refractory disease Surgery should be considered for patients in whom the response to m...

Apr 17th, 2020 - The patient's signs and symptoms should raise suspicion for inflammatory bowel disease, due to its chronic and relapsing character. Physical examination shows extraintestinal manifestations of Crohn disease. Fistulization between abdominal structu...