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About 414 results

ALLMedicine™ Cold Agglutinin Disease Center

Research & Reviews  201 results

Sutimlimab in Cold Agglutinin Disease.
https://doi.org/10.1056/NEJMoa2027760
The New England Journal of Medicine; Röth A, Barcellini W et. al.

Apr 7th, 2021 - Cold agglutinin disease is a rare autoimmune hemolytic anemia characterized by hemolysis that is caused by activation of the classic complement pathway. Sutimlimab, a humanized monoclonal antibody, selectively targets the C1s protein, a C1 complex...

Multifocal thrombosis with peripheral gangrene in a young boy: Mycoplasma infection tri...
https://doi.org/10.1016/j.imbio.2021.152075
Immunobiology Sudhakar M, Mohandoss V et. al.

Mar 12th, 2021 - Cold agglutinin disease (CAD) is extremely rare in children. We report an 8-year-old boy who presented with gangrene of right foot with hypertension and absent lower limb pulses. Blood peripheral smear evidence of autoagglutination and falsely ele...

How I treat cold agglutinin disease.
https://doi.org/10.1182/blood.2019003809
Blood Berentsen S

Jan 29th, 2021 - The last decades have seen great progress in the treatment of cold agglutinin disease (CAD). Comparative trials are lacking, and recommendations must be based mainly on nonrandomized trials and will be influenced by personal experience. Herein, cu...

In from the cold: M-protein light chain glycosylation is positively associated with col...
https://doi.org/10.1111/trf.16279
Transfusion Juskewitch JE, Murray JD et. al.

Jan 27th, 2021 - Primary cold agglutinin disease (CAD) is a monoclonal antibody (M-protein) and complement-mediated chronic hemolytic disease process. Antibody glycosylation can play a role in both antibody half-life and complement fixation. Recently, M-protein li...

Pembrolizumab-Induced Cold Agglutinin Disease.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7491957
The American Journal of Case Reports; Atiq O, Atiq SO et. al.

Sep 5th, 2020 - BACKGROUND The introduction of immunotherapy in the management of metastatic lung cancer appears to be changing their natural history. Most patients tolerate immunotherapy without any significant adverse events. Nevertheless, a significant number ...

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Guidelines  1 results

FDA grants orphan drug designation to APL-2 for autoimmune hemolytic anemia
https://www.healio.com/hematology-oncology/hematology/news/online/%7B2785cd04-4008-4105-91cc-e82f5573ee6f%7D/fda-grants-orphan-drug-designation-to-apl-2-for-autoimmune-hemolytic-anemia

Feb 4th, 2019 - The FDA granted orphan drug designation to the C3 complement inhibitor APL-2 for the treatment of autoimmune hemolytic anemia. Autoimmune hemolytic anemia refers to both cold agglutinin disease and warm autoimmune hemolytic anemia, which affect a ...

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Clinicaltrials.gov  205 results

Sutimlimab in Cold Agglutinin Disease.
https://doi.org/10.1056/NEJMoa2027760
The New England Journal of Medicine; Röth A, Barcellini W et. al.

Apr 7th, 2021 - Cold agglutinin disease is a rare autoimmune hemolytic anemia characterized by hemolysis that is caused by activation of the classic complement pathway. Sutimlimab, a humanized monoclonal antibody, selectively targets the C1s protein, a C1 complex...

Multifocal thrombosis with peripheral gangrene in a young boy: Mycoplasma infection tri...
https://doi.org/10.1016/j.imbio.2021.152075
Immunobiology Sudhakar M, Mohandoss V et. al.

Mar 12th, 2021 - Cold agglutinin disease (CAD) is extremely rare in children. We report an 8-year-old boy who presented with gangrene of right foot with hypertension and absent lower limb pulses. Blood peripheral smear evidence of autoagglutination and falsely ele...

How I treat cold agglutinin disease.
https://doi.org/10.1182/blood.2019003809
Blood Berentsen S

Jan 29th, 2021 - The last decades have seen great progress in the treatment of cold agglutinin disease (CAD). Comparative trials are lacking, and recommendations must be based mainly on nonrandomized trials and will be influenced by personal experience. Herein, cu...

In from the cold: M-protein light chain glycosylation is positively associated with col...
https://doi.org/10.1111/trf.16279
Transfusion Juskewitch JE, Murray JD et. al.

Jan 27th, 2021 - Primary cold agglutinin disease (CAD) is a monoclonal antibody (M-protein) and complement-mediated chronic hemolytic disease process. Antibody glycosylation can play a role in both antibody half-life and complement fixation. Recently, M-protein li...

Pembrolizumab-Induced Cold Agglutinin Disease.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7491957
The American Journal of Case Reports; Atiq O, Atiq SO et. al.

Sep 5th, 2020 - BACKGROUND The introduction of immunotherapy in the management of metastatic lung cancer appears to be changing their natural history. Most patients tolerate immunotherapy without any significant adverse events. Nevertheless, a significant number ...

see more →

News  7 results

Sanofi gets priority U.S. FDA review for sutimlimab product
https://www.reuters.com/article/us-sanofi-products/sanofi-gets-priority-u-s-fda-review-for-sutimlimab-product-idUSKBN22Q0JI

May 14th, 2020 - FILE PHOTO: The logo of Sanofi is seen at the company's headquarters in Paris, France, April 24, 2020. REUTERS/Charles Platiau PARIS (Reuters) - French healthcare company Sanofi said on Thursday that the U.S. Food & Drug Administration (FDA) regul...

Sutimlimab boosts hemoglobin, quality of life in cold agglutinin disease
https://www.mdedge.com/hematology-oncology/article/214191/anemia/sutimlimab-boosts-hemoglobin-quality-life-cold-agglutinin?channel=39313
Neil Osterweil

Dec 12th, 2019 - ORLANDO – An investigational selective inhibitor of the complement pathway, sutimlimab, induced rapid and sustained benefits in patients with cold agglutinin disease, a rare autoimmune hemolytic anemia with no currently approved effective therapie.

FDA grants orphan drug designation to APL-2 for autoimmune hemolytic anemia
https://www.healio.com/hematology-oncology/hematology/news/online/%7B2785cd04-4008-4105-91cc-e82f5573ee6f%7D/fda-grants-orphan-drug-designation-to-apl-2-for-autoimmune-hemolytic-anemia

Feb 4th, 2019 - The FDA granted orphan drug designation to the C3 complement inhibitor APL-2 for the treatment of autoimmune hemolytic anemia. Autoimmune hemolytic anemia refers to both cold agglutinin disease and warm autoimmune hemolytic anemia, which affect a ...

Potential treatment on the horizon for cold agglutinin disease
https://www.mdedge.com/hematology-oncology/article/192203/anemia/potential-treatment-horizon-cold-agglutinin-disease
HT Staff

Jan 2nd, 2019 - Red blood cells In a first-in-human trial, sutimlimab rapidly halted hemolysis, corrected anemia, precluded the need for transfusion, and caused no serious adverse effects in patients with cold agglutinin disease. Sutimlimab also “induced clinical.

Drug granted orphan designation for hemolytic anemia
https://www.mdedge.com/hematology-oncology/article/188833/anemia/drug-granted-orphan-designation-hemolytic-anemia
HT Staff

Mar 1st, 2016 - Red blood cells The European Commission (EC) has granted orphan drug designation for TNT009 to treat autoimmune hemolytic anemia, including cold agglutinin disease. TNT009 is a monoclonal antibody that selectively inhibits the classical complement.

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