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About 311 results

ALLMedicine Essential Thrombocytosis Center

Research & Reviews  151 results

Thrombopoietin is required for full phenotype expression in a JAK2V617F transgenic mous...
https://doi.org/10.1371/journal.pone.0232801
PloS One; Spivak JL, Merchant A et. al.

Jun 1st, 2020 - The myeloproliferative neoplasms, polycythemia vera, essential thrombocytosis and primary myelofibrosis are hematopoietic stem cell disorders and share driver mutations that either directly activate the thrombopoietin receptor, MPL, or activate it...

Atypical myeloproliferative neoplasm with concurrent BCR-ABL1 fusion and CALR mutation:...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7004640
Medicine Liu C, Hu R et. al.

Jan 31st, 2020 - Concurrent calreticulin (CALR) mutation and BCR-ABL1 fusion are extremely rare in chronic myelogenous leukemia; to date, only 12 cases have been reported. A 57-year-old male who had an 11-year history of essential thrombocytosis presented to our h...

Quantification of IGF-1 receptor is useful in the differential diagnosis of essential t...
https://doi.org/10.1111/ejh.13323
European Journal of Haematology REFERENCES; Wang JC, Shi G et. al.

Sep 3rd, 2019 - To make a definite diagnosis of essential thrombocytosis (ET) from reactive thrombocytosis (RT), the most reliable criteria are the presence of driver mutations, namely JAK2, CALR, or MPL gene mutations. In the absence of these driver mutations, s...

Primary Myelofibrosis
https://emedicine.medscape.com/article/197954-overview

Aug 21st, 2019 - Practice Essentials Primary myelofibrosis is a clonal disorder arising from the neoplastic transformation of early hematopoietic stem cells. [1, 2, 3, 4] Older terms for this disorder include agnogenic myeloid metaplasia with myelofibrosis and chr...

Essential Thrombocytosis
https://emedicine.medscape.com/article/206697-overview

Aug 21st, 2019 - Practice Essentials Essential thrombocytosis (primary thrombocythemia) is a nonreactive, chronic myeloproliferative disorder in which sustained megakaryocyte proliferation leads to an increase in the number of circulating platelets  [1] (see the i...

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Clinicaltrials.gov  155 results

Thrombopoietin is required for full phenotype expression in a JAK2V617F transgenic mous...
https://doi.org/10.1371/journal.pone.0232801
PloS One; Spivak JL, Merchant A et. al.

Jun 1st, 2020 - The myeloproliferative neoplasms, polycythemia vera, essential thrombocytosis and primary myelofibrosis are hematopoietic stem cell disorders and share driver mutations that either directly activate the thrombopoietin receptor, MPL, or activate it...

Atypical myeloproliferative neoplasm with concurrent BCR-ABL1 fusion and CALR mutation:...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7004640
Medicine Liu C, Hu R et. al.

Jan 31st, 2020 - Concurrent calreticulin (CALR) mutation and BCR-ABL1 fusion are extremely rare in chronic myelogenous leukemia; to date, only 12 cases have been reported. A 57-year-old male who had an 11-year history of essential thrombocytosis presented to our h...

Quantification of IGF-1 receptor is useful in the differential diagnosis of essential t...
https://doi.org/10.1111/ejh.13323
European Journal of Haematology REFERENCES; Wang JC, Shi G et. al.

Sep 3rd, 2019 - To make a definite diagnosis of essential thrombocytosis (ET) from reactive thrombocytosis (RT), the most reliable criteria are the presence of driver mutations, namely JAK2, CALR, or MPL gene mutations. In the absence of these driver mutations, s...

Primary Myelofibrosis
https://emedicine.medscape.com/article/197954-overview

Aug 21st, 2019 - Practice Essentials Primary myelofibrosis is a clonal disorder arising from the neoplastic transformation of early hematopoietic stem cells. [1, 2, 3, 4] Older terms for this disorder include agnogenic myeloid metaplasia with myelofibrosis and chr...

Essential Thrombocytosis
https://emedicine.medscape.com/article/206697-overview

Aug 21st, 2019 - Practice Essentials Essential thrombocytosis (primary thrombocythemia) is a nonreactive, chronic myeloproliferative disorder in which sustained megakaryocyte proliferation leads to an increase in the number of circulating platelets  [1] (see the i...

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News  5 results

Leukemia Cutis Presenting as Scrotal Ulcerations in a Patient With Acute Myelogenous Leukemia
https://www.mdedge.com/dermatology/article/100170/leukemia-cutis-presenting-scrotal-ulcerations-patient-acute-myelogenous/page/0/1

Jun 3rd, 2015 - The differential diagnosis of painful cutaneous ulcers in the setting of hematologic malignancy includes a variety of infectious and inflammatory etiologies such as ulcerative HSV, cytomegalovirus, Epstein-Barr virus, amoebic skin ulcerations, opp.

JAK2 Mutations and JAK Inhibitors in the Management of Myeloproliferative Neoplasms
https://www.onclive.com/publications/contemporary-oncology/2015/february-2015/jak2-mutations-and-jak-inhibitors-in-the-management-of-myeloproliferative-neoplasms

Jan 30th, 2015 - The Philadelphia chromosome–negative myeloproliferative neoplasms (MPNs) are clonal disorders characterized by common mutations, but with distinct clinical features, treatment considerations, and prognostic outlooks.1 Identification of the JAK2 (J...

Case Report: Headache in a Postpartum Patient With Essential Thrombocytosis
https://www.mdedge.com/emergencymedicine/article/82551/hematology/case-report-headache-postpartum-patient-essential/page/0/1

May 1st, 2014 - Conclusion This case describes a patient with two risk factors for CVT, a life-threatening condition. It should be considered in patients with ET and/or pregnant and postpartum patients presenting with headache or other neurological symptoms.

C. albicans appendicitis in a neutropenic patient after induction chemotherapy
https://www.mdedge.com/hematology-oncology/article/77462/leukemia-myelodysplasia-transplantation/c-albicans-appendicitis
Rohtesh S. Mehta, MD, MPH, MS, David Cohen, MD

Sep 4th, 2013 - A 62-year-old white man with a past medical history of hypertension and essential thrombocytosis diagnosed 17 years ago presented at our institution. He was being treated with hydroxyurea, with which he required occasional blood transfusions and p.

Comparison of the Mutational Profiles of Primary Myelofibrosis, Polycythemia Vera, and Essential Thrombocytosis
https://www.medscape.com/viewarticle/884417

Abstract and Introduction Abstract Objectives: To compare the mutational profiles of patients with primary myelofibrosis (PMF), polycythemia vera (PV), and essential thrombocytosis (ET). Methods: Next-generation sequencing results of 75 cases of P...

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