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About 4,672 results

ALLMedicine Hemolytic Uremic Syndrome Center

Research & Reviews  2,195 results

Is ravulizumab the new treatment of choice for atypical hemolytic uremic syndrome (aHUS)?
https://doi.org/10.1016/j.kint.2020.03.011
Kidney International; Menne J

May 23rd, 2020 - Ravulizumab, a new long-acting C5 inhibitor, recently received FDA approval for the treatment of aHUS. Rates of complete thrombotic microangiopathy response were similar to those observed in major eculizumab trials; however, fewer patients in the ...

Ten-year outcome of Eculizumab in kidney transplant recipients with atypical hemolytic ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238522
BMC Nephrology; Kant S, Bhalla A et. al.

May 21st, 2020 - Atypical hemolytic uremic syndrome (aHUS) can result in severe kidney dysfunction, secondary to thrombotic microangiopathy. Eculizumab has been used to treat this disorder, and has resulted in favourable outcomes in both, native and transplanted k...

Renal Biopsy Prognostic Findings in Children With Atypical Hemolytic Uremic Syndrome.
https://doi.org/10.1177/1093526620925947
Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society; Yüksel S, Işık Gönül İ et. al.

May 13th, 2020 - The aim of this study was to investigate the histopathological findings in kidney biopsies in children with atypical hemolytic uremic syndrome (aHUS) and to determine whether specific pathological findings in aHUS have a prognostic value. Renal bi...

Long-term outcomes and response to treatment in diacylglycerol kinase epsilon nephropathy.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7242908
Kidney International; Brocklebank V, Kumar G et. al.

May 10th, 2020 - Recessive mutations in diacylglycerol kinase epsilon (DGKE) display genetic pleiotropy, with pathological features reported as either thrombotic microangiopathy or membranoproliferative glomerulonephritis (MPGN), and clinical features of atypical ...

Atypical Hemolytic Uremic Syndrome (p.Gly1110Ala) with Autoimmune Disease.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7214013
The American Journal of Case Reports; Park S, Lee YJ et. al.

May 3rd, 2020 - BACKGROUND Hemolytic uremic syndrome (HUS) can be categorized as primary (typical or atypical) or secondary (with a coexisting diseases). Typical HUS usually means shiga-toxin-medicated and thrombotic thrombocytopenic purpura. Secondary HUS is oft...

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Guidelines  9 results

Outbreak of E. coli Infections
https://www.cdc.gov/ecoli/2019/o103-04-19/index.html

Apr 4th, 2019 - As of April 4, 2019, 72 people infected with the outbreak strain of E. coli O103 have been reported from five states. Eight people have been hospitalized. No cases of hemolytic uremic syndrome (HUS) or deaths have been reported.

Clinical guides for atypical hemolytic uremic syndrome in Japan.
https://doi.org/10.1007/s10157-016-1276-6
Clinical and Experimental Nephrology; Kato H, Nangaku M et. al.

Jul 16th, 2016 - Atypical hemolytic uremic syndrome (aHUS) is a rare disease characterized by the triad of microangiopathic hemolytic anemia, thrombocytopenia, and acute kidney injury. In 2013, we developed diagnostic criteria to enable early diagnosis and timely ...

An international consensus approach to the management of atypical hemolytic uremic synd...
https://doi.org/10.1007/s00467-015-3076-8
Pediatric Nephrology (Berlin, Germany); Loirat C, Fakhouri F et. al.

Apr 10th, 2015 - Atypical hemolytic uremic syndrome (aHUS) emerged during the last decade as a disease largely of complement dysregulation. This advance facilitated the development of novel, rational treatment options targeting terminal complement activation, e.g....

Guidelines for the management and investigation of hemolytic uremic syndrome.
https://doi.org/10.1007/s10157-014-0995-9
Clinical and Experimental Nephrology; Igarashi T, Ito S et. al.

Aug 7th, 2014 - Guidelines for the management and investigation of hemolytic uremic syndrome.|2014|Igarashi T,Ito S,Sako M,Saitoh A,Hataya H,|standards,diagnosis,etiology,therapy,standards,

Diagnostic criteria for atypical hemolytic uremic syndrome proposed by the Joint Commit...
https://doi.org/10.1007/s10157-013-0911-8
Clinical and Experimental Nephrology; Sawai T, Nangaku M et. al.

Dec 17th, 2013 - Atypical hemolytic uremic syndrome (aHUS) is rare and comprises the triad of microangiopathic hemolytic anemia, thrombocytopenia, and acute kidney injury. Recently, abnormalities in the mechanisms underlying complement regulation have been focused...

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Drugs  5 results see all →

Clinicaltrials.gov  2,311 results

Is ravulizumab the new treatment of choice for atypical hemolytic uremic syndrome (aHUS)?
https://doi.org/10.1016/j.kint.2020.03.011
Kidney International; Menne J

May 23rd, 2020 - Ravulizumab, a new long-acting C5 inhibitor, recently received FDA approval for the treatment of aHUS. Rates of complete thrombotic microangiopathy response were similar to those observed in major eculizumab trials; however, fewer patients in the ...

Ten-year outcome of Eculizumab in kidney transplant recipients with atypical hemolytic ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238522
BMC Nephrology; Kant S, Bhalla A et. al.

May 21st, 2020 - Atypical hemolytic uremic syndrome (aHUS) can result in severe kidney dysfunction, secondary to thrombotic microangiopathy. Eculizumab has been used to treat this disorder, and has resulted in favourable outcomes in both, native and transplanted k...

Renal Biopsy Prognostic Findings in Children With Atypical Hemolytic Uremic Syndrome.
https://doi.org/10.1177/1093526620925947
Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society; Yüksel S, Işık Gönül İ et. al.

May 13th, 2020 - The aim of this study was to investigate the histopathological findings in kidney biopsies in children with atypical hemolytic uremic syndrome (aHUS) and to determine whether specific pathological findings in aHUS have a prognostic value. Renal bi...

Long-term outcomes and response to treatment in diacylglycerol kinase epsilon nephropathy.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7242908
Kidney International; Brocklebank V, Kumar G et. al.

May 10th, 2020 - Recessive mutations in diacylglycerol kinase epsilon (DGKE) display genetic pleiotropy, with pathological features reported as either thrombotic microangiopathy or membranoproliferative glomerulonephritis (MPGN), and clinical features of atypical ...

Atypical Hemolytic Uremic Syndrome (p.Gly1110Ala) with Autoimmune Disease.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7214013
The American Journal of Case Reports; Park S, Lee YJ et. al.

May 3rd, 2020 - BACKGROUND Hemolytic uremic syndrome (HUS) can be categorized as primary (typical or atypical) or secondary (with a coexisting diseases). Typical HUS usually means shiga-toxin-medicated and thrombotic thrombocytopenic purpura. Secondary HUS is oft...

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News  147 results

FDA Clears Ravulizumab for Atypical Hemolytic Uremic Syndrome
https://www.medscape.com/viewarticle/920120

Oct 20th, 2019 - The US Food and Drug Administration (FDA) has approved ravulizumab (Ultomiris, Alexion Pharmaceuticals) to inhibit complement-mediated thrombotic microangiopathy (TMA) in adults and children age 1 month or older with atypical hemolytic uremic synd...

FDA approves Alexion's Ultomiris for another rare blood disease
https://www.reuters.com/article/us-alexion-pharms-fda/fda-approves-alexions-ultomiris-for-another-rare-blood-disease-idUSKBN1WY00B

Oct 18th, 2019 - (Reuters) - The U.S. Food and Drug Administration on Friday approved Alexion Pharmaceuticals Inc’s treatment for a second rare blood disorder, the company said. The treatment, Ultomiris, has already been approved in the United States, Japan and th...

Eculizumab Changed the Course of Atypical Hemolytic Uremic Syndrome
https://www.medscape.com/viewarticle/914157

Jun 11th, 2019 - NEW YORK (Reuters Health) - The approval of the monoclonal antibody eculizumab for treatment of atypical hemolytic uremic syndrome led to significant improvements in outcomes, according to a study of French patients presented June 3 at American Tr...

Hemolytic Uremic Syndrome With Severe Neurologic Complications in an Adult
https://www.mdedge.com/fedprac/article/202331/neurology/hemolytic-uremic-syndrome-severe-neurologic-complications-adult?channel=258
Ayan Nasir*, Nimai Patel* et. al.

Jun 5th, 2019 - Hemolytic uremic syndrome (HUS) is a rare illness that can be acquired through the consumption of food products contaminated with strains of Shiga toxin-producing Escherichia coli (E coli ; STEC). 1 Between 6% and 15% of individuals infected with.

June 2019 Management of Neurologic Disorders in Federal Health Care
https://www.mdedge.com/fedprac/article/203582/june-2019-management-neurologic-disorders-federal-health-care?channel=27011

Jun 1st, 2019 - Click here to access June 2019 Management of Neurologic Disorders in Federal Health Care Table of Contents Early and Accurate Identification of Parkinson Disease Among US Veterans Proton Pump Inhibitor Use and Risk of Dementia in the Veteran Popul.

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Patient Education  5 results see all →