About 2,413 results

ALLMedicine™ Sickle Cell Anemia Center

Research & Reviews  796 results

Effects of hydroxyurea on brain function in children with sickle cell anemia.
Pediatric Blood & Cancer; Wang WC, Zou P et. al.

Aug 1st, 2021 - Sickle cell anemia (SCA) results in numerous adverse effects on the brain, including neurocognitive dysfunction. Hydroxyurea has been utilized extensively for management of SCA, but its effects on brain function have not been established. We exami...

Implications of gender-based variabilities in bone mineral density and hemoglobin levels.
BMC Musculoskeletal Disorders; Zhou Y, Liu S et. al.

Aug 1st, 2021 - Studies reported that there is a relationship between volumetric bone mineral density (vBMD) and hemoglobin (HGB) in sickle cell anemia, chronic obstructive pulmonary disease, inflammatory bowel disease, and chronic kidney disease, it is not clear...

Novel kidney injury biomarkers in a large cohort of children with sickle cell anemia.
Biomarkers in Medicine; Belisário AR, S Filha RD et. al.

Jul 23rd, 2021 - Aim: The aim of this study was to compare novel kidney injury biomarkers in sickle cell anemia (SCA) children with and without albuminuria or glomerular hyperfiltration. Materials & methods: A total of 358 Brazilian children with SCA were studied....

Characterizing Intracranial Hemodynamics in Sickle Cell Anemia: Impact of Patient-Speci...
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Cardiovascular Engineering and Technology; Keller SB, Bumpus JM et. al.

Jul 22nd, 2021 - Pediatric and adult patients with sickle cell anemia (SCA) are at increased risk of stroke and cerebrovascular accident. In the general adult population, there is a relationship between arterial hemodynamics and pathology; however, this relationsh...

Acute soft head syndrome in a sickle cell disease patient.
Journal of Radiology Case Reports; Zadeh C, Rameh V et. al.

Jul 20th, 2021 - Acute soft head syndrome is an extremely rare complication in children with sickle cell anemia. We present a 16-year old male patient known to have sickle cell anemia who presented to our emergency department with low grade fever, headache, skull ...

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Drugs  4 results see all →

Clinicaltrials.gov  73 results

Establishment of Functional MRI Imaging Parameters for Use in the Evaluation of Sickle Cell Disease

May 5th, 2020 - Patients with sickle cell anemia (SCA) are at increased risk for episodes of stroke, both overt clinically evident and subclinical lesions only seen on imaging, which have associated morbidity and mortality. In addition, SCA patients demonstrate r...

Secondary Pulmonary Hypertension in Adults With Sickle Cell Anemia

May 5th, 2020 - Sickle cell anemia is an autosomal recessive disorder and the most common genetic disease affecting African-Americans. Approximately 0.15% of African-Americans are homozygous for sickle cell disease, and 8% have sickle cell trait. Acute pain crisi...

Primary Prevention of Stroke in Children With SCD in Sub-Saharan Africa II

May 1st, 2020 - Strokes in sickle cell anemia (SCA), particularly in children living in Africa, are associated with significant morbidity and an increased risk of premature death. In the US, primary stroke prevention in children with SCA involves screening for el...

Sickle Cell Anemia WE CARE

Apr 3rd, 2020 - Social determinants of health (SDoH)-the conditions in which people are born, grow, work, live, and age-are key drivers of health and health disparities. Children with medical complexity are particularly at-risk given their high healthcare need an...

Kidney Function in Sickle Cell Anemia

Mar 24th, 2020 - Sickle cell disease is a severe monogenic disorder which affects approximately 80,000 patients in the US. It is characterized by a vasculopathy with involvement of multiple organs and resulting in complications such as ischemic stroke, pulmonary h...

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News  84 results

Fast Five Quiz: Are You Prepared to Confront Sickle Cell Disease?

Nov 2nd, 2020 - Urgent replacement of blood is often required for symptomatic anemia due to parvovirus B19 infection or acute splenic sequestration. Transfusions are not needed for asymptomatic chronic anemia or worsening anemia occurring during episodes of pain ...

Hydroxyurea Dose Escalation Safe, More Effective Against Childhood Sickle Cell Anemia

Jun 26th, 2020 - (Reuters Health) - Raising the dose of hydroxyurea by roughly 50% for children with sickle cell anemia dramatically lowers the risk of sickle-cell complications, according to a new study of 187 Ugandan children published in the New England Journal...

Hydroxyurea Dose Escalation Safe, More Effective Against Childhood Sickle Cell Anemia

Jun 26th, 2020 - (Reuters Health) - Raising the dose of hydroxyurea by roughly 50% for children with sickle cell anemia dramatically lowers the risk of sickle-cell complications, according to a new study of 187 Ugandan children published in the New England Journal...

Fast Five Quiz: Fingernail and Toenail Conditions

Feb 7th, 2020 - Concerns about fingernail and toenail conditions affect individuals of all ages. Although many are benign, some require medical intervention. Fungal nail infections (onychomycosis) are common, with a reported prevalence as high as 14% in North Ame...

FDA approves Global Blood Therapeutics sickle cell disease drug

Nov 26th, 2019 - (Reuters) - The U.S. Food and Drug Administration said on Monday it approved a drug from Global Blood Therapeutics Inc to treat sickle cell disease in adults and children 12 years or older. The treatment will be priced at $10,417 per month, or aro...

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Patient Education  8 results see all →