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About 4,512 results

ALLMedicine Sickle Cell Anemia Center

Research & Reviews  2,083 results

The Impact of Sickle Cell Anemia and Mental Health on Preventive Care among Medicaid-En...
https://doi.org/10.1016/j.jpeds.2020.05.027
The Journal of Pediatrics; Gondhi JP, Dombkowski KJ et. al.

May 24th, 2020 - To examine mental health diagnoses, health care utilization, and receipt of age-appropriate preventive care, including antibiotic prophylaxis, hydroxyurea therapy, and transcranial Doppler (TCD) screenings among children with sickle cell anemia (S...

Functional polymorphisms of BCL11A and HBS1L-MYB genes affect both fetal hemoglobin lev...
https://doi.org/10.1007/s00277-020-04079-2
Annals of Hematology; Sales RR, Belisário AR et. al.

May 24th, 2020 - Fetal hemoglobin (HbF) ameliorates clinical severity of sickle cell anemia (SCA). The major loci regulating HbF levels are HBB cluster, BCL11A, and HMIP-2 (HBS1L-MYB). However, the impact of noncoding single-nucleotide polymorphisms (SNPs) in thes...

Biomarkers and genetic modulators of cerebral vasculopathy in sub-Saharan ancestry chil...
https://doi.org/10.1016/j.bcmd.2020.102436
Blood Cells, Molecules & Diseases; Silva M, Vargas S et. al.

May 20th, 2020 - We investigated biomarkers and genetic modulators of the cerebral vasculopathy (CV) subphenotype in pediatric sickle cell anemia (SCA) patients of sub-Saharan African ancestry. We found that one VCAM1 promoter haplotype (haplotype 7) and VCAM1 sin...

Biological factors associating pulp necrosis and sickle cell anemia.
https://doi.org/10.1111/odi.13415
Oral Diseases; Costa CPS, Thomaz ÉBAF et. al.

May 15th, 2020 - This study was conducted to investigate the biological factors underlying the association between pulp necrosis (PN) in subjects with permanent teeth with intact crowns and sickle cell anemia (SCA). This cohort study included 140 subjects: 125 wit...

Sickle Cell Anemia Patients Display an Intricate Cellular and Serum Biomarker Network H...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7199620
Journal of Immunology Research; Garcia NP, Júnior ALS et. al.

May 15th, 2020 - Sickle cell anemia (SCA) is associated with a chronic proinflammatory state characterized by elevated leukocyte count, mortality from severe recurrent infections, and subsequent vasoocclusive complications with leukocyte adhesion to the endotheliu...

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Guidelines  23 results

A phase 1/2 ascending dose study and open-label extension study of voxelotor in patients with sickle cell disease
http://www.bloodjournal.org/content/early/2019/01/17/blood-2018-08-868893?sso-checked=true
Howard,J,et al

Jan 16th, 2019 - New treatments directly targeting polymerization of sickle hemoglobin (HbS), the proximate event in the pathophysiology of sickle cell disease (SCD), are needed to address the severe morbidity and early mortality associated with the disease. Voxel...

Statement on Opioid Use in Patients with Hematologic Diseases and Disorders
http://www.hematology.org/Advocacy/Statements/8502.aspx
American Society of Hematology

Apr 17th, 2018 - According to the Centers for Disease Control and Prevention, overdoses from prescription opioids in the United States have contributed to the 15-year increase in opioid overdose deaths and nearly half of all opioid overdose deaths involve a prescr.

Pain Management in Vaso-occlusive Sickle Cell Crisis
https://www.emra.org/emresident/article/pain-management-in-vaso-occlusive-sickle-cell-crisis/
Amani Mahdi

Apr 10th, 2017 - To optimize patient care, considerable effort must be directed toward understanding the pathophysiology of SCD, appreciating the severity of each episode, and anticipating the likelihood of VOC recurrence. In addition, the patient's age, comorbidi.

Pediatric Pulmonary Hypertension
http://www.thoracic.org/statements/resources/pldd/pediatric-pulmonary-hypertension.pdf
Steven H. Abman

Mar 14th, 2016 - Pulmonary hypertension is associated with diverse cardiac, pulmonary, and systemic diseases in neonates, infants, and older children and contributes to significant morbidity and mortality. However, current approaches to caring for pediatric patien.

Health Maintenance and Management of Chronic Complications of Sickle Cell Disease: ASH Guide...
http://ashpocketguides.hematology.org/#/app/guides/3/pages/
American Society of Hematology

Oct 31st, 2014 - Guide for Health Maintenance and Management of Chronic Complications of Sickle Cell Disease.

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Drugs  3 results see all →

Clinicaltrials.gov  2,227 results

The Impact of Sickle Cell Anemia and Mental Health on Preventive Care among Medicaid-En...
https://doi.org/10.1016/j.jpeds.2020.05.027
The Journal of Pediatrics; Gondhi JP, Dombkowski KJ et. al.

May 24th, 2020 - To examine mental health diagnoses, health care utilization, and receipt of age-appropriate preventive care, including antibiotic prophylaxis, hydroxyurea therapy, and transcranial Doppler (TCD) screenings among children with sickle cell anemia (S...

Functional polymorphisms of BCL11A and HBS1L-MYB genes affect both fetal hemoglobin lev...
https://doi.org/10.1007/s00277-020-04079-2
Annals of Hematology; Sales RR, Belisário AR et. al.

May 24th, 2020 - Fetal hemoglobin (HbF) ameliorates clinical severity of sickle cell anemia (SCA). The major loci regulating HbF levels are HBB cluster, BCL11A, and HMIP-2 (HBS1L-MYB). However, the impact of noncoding single-nucleotide polymorphisms (SNPs) in thes...

Biomarkers and genetic modulators of cerebral vasculopathy in sub-Saharan ancestry chil...
https://doi.org/10.1016/j.bcmd.2020.102436
Blood Cells, Molecules & Diseases; Silva M, Vargas S et. al.

May 20th, 2020 - We investigated biomarkers and genetic modulators of the cerebral vasculopathy (CV) subphenotype in pediatric sickle cell anemia (SCA) patients of sub-Saharan African ancestry. We found that one VCAM1 promoter haplotype (haplotype 7) and VCAM1 sin...

Biological factors associating pulp necrosis and sickle cell anemia.
https://doi.org/10.1111/odi.13415
Oral Diseases; Costa CPS, Thomaz ÉBAF et. al.

May 15th, 2020 - This study was conducted to investigate the biological factors underlying the association between pulp necrosis (PN) in subjects with permanent teeth with intact crowns and sickle cell anemia (SCA). This cohort study included 140 subjects: 125 wit...

Sickle Cell Anemia Patients Display an Intricate Cellular and Serum Biomarker Network H...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7199620
Journal of Immunology Research; Garcia NP, Júnior ALS et. al.

May 15th, 2020 - Sickle cell anemia (SCA) is associated with a chronic proinflammatory state characterized by elevated leukocyte count, mortality from severe recurrent infections, and subsequent vasoocclusive complications with leukocyte adhesion to the endotheliu...

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News  161 results

FDA approves Global Blood Therapeutics sickle cell disease drug
https://www.reuters.com/article/us-global-blood-theraprutics-fda/fda-approves-global-blood-therapeutics-sickle-cell-disease-drug-idUSKBN1XZ2E5

Nov 25th, 2019 - (Reuters) - The U.S. Food and Drug Administration said on Monday it approved a drug from Global Blood Therapeutics Inc to treat sickle cell disease in adults and children 12 years or older. The treatment will be priced at $10,417 per month, or aro...

Hydroxyurea Remains Underused in Children With Sickle Cell Disease
https://www.medscape.com/viewarticle/914774

Jun 23rd, 2019 - NEW YORK (Reuters Health) - Despite recent increases in use of hydroxyurea for sickle cell disease (SCD), only about one in four children with SCD received hydroxyurea in 2015, according to an analysis of Medicaid data. Recent studies have clearly...

Suicide trends among youth on Medicaid
https://www.mdedge.com/emergencymedicine/article/193150/suicide-trends-among-youth-medicaid

Jan 24th, 2019 - Younger people who are enrolled in Medicaid who commit suicide are disproportionately female, younger, and more likely to die by hanging. The risk for acute myeloid leukemia and myeloma is higher for breast cancer survivors, matched transplant imp.

Stem Cell Transplant a Promising Option in Sickle Cell Anemia
https://www.medscape.com/viewarticle/908093

Jan 22nd, 2019 - NEW YORK (Reuters Health) - Matched sibling donor hematopoietic stem cell transplantation (MSD-HSCT) is a promising option for children with sickle cell anemia (SCA) requiring chronic transfusion due to elevated transcranial Doppler velocity (TCD)...

Matched transplant improves stroke risk indicator in sickle cell anemia
https://www.mdedge.com/pediatrics/article/193003/anemia/matched-transplant-improves-stroke-risk-indicator-sickle-cell
Andrew D. Bowser

Jan 22nd, 2019 - In children with sickle cell anemia, matched sibling donor transplants improved an indicator of stroke risk in a multicenter French study, suggesting that this intervention may improve outcomes related to cerebral vasculopathy. Matched sibling don.

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Patient Education  15 results see all →