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About 4,684 results

ALLMedicine™ Sickle Cell Anemia Center

Research & Reviews  2,205 results

FT-4202, an oral PKR activator, has potent antisickling effects and improves RBC surviv...
https://doi.org/10.1182/bloodadvances.2020003604
Blood Advances; Shrestha A, Chi M et. al.

May 4th, 2021 - Sickle cell anemia (SCA) results from an abnormal sickle hemoglobin (HbS). HbS polymerizes upon deoxygenation, resulting in red blood cell (RBC) sickling and membrane damage that cause vaso-occlusions and hemolysis. Sickle RBCs contain less adenos...

Association of alpha-thalassemia and Glucose-6-Phosphate Dehydrogenase deficiency with ...
https://doi.org/10.1002/jcla.23802
Journal of Clinical Laboratory Analysis; Ojewunmi OO, Adeyemo TA et. al.

May 3rd, 2021 - Stroke is a devastating complication of sickle cell anemia (SCA) and can be predicted through abnormally high cerebral blood flow velocity using transcranial Doppler Ultrasonography (TCD). The evidence on the role of alpha-thalassemia and glucose-...

Evaluation of the expression of red blood cell CD36, interleukin-6 and interleukin-8 in...
https://doi.org/10.1016/j.cyto.2021.155534
Cytokine Abdul-Hussein HK, Al-Mammori HS et. al.

Apr 23rd, 2021 - Sickle cell anemia (SCA) is a complex multisystem disease characterized by acute and chronic inflammation, with alterations in inflammatory cytokines and adhesion molecules. This case-control study was carried out to assess the levels of CD36, imm...

Brain injury pathophysiology study by a multimodal approach in children with sickle cel...
https://doi.org/10.3324/haematol.2020.278226
Haematologica Brousse V, Pondarre C et. al.

Apr 22nd, 2021 - Despite its high prevalence in children with sickle cell anemia (SCA), the pathophysiology of silent cerebral infarcts (SCIs) remains elusive. The main objective of this study was to explore the respective roles of major determinants of brain perf...

Cerebral Hemodynamics and Executive Function in Sickle Cell Anemia.
https://doi.org/10.1161/STROKEAHA.120.032741
Stroke Prussien KV, Compas BE et. al.

Apr 12th, 2021 - Individuals with sickle cell anemia experience cognitive deficits, even in the absence of cerebral infarcts or strokes. This study tested the hypothesis that elevated cerebral blood flow and oxygen extraction fraction are associated with lower exe...

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Guidelines  23 results

A phase 1/2 ascending dose study and open-label extension study of voxelotor in patients with sickle cell disease
http://www.bloodjournal.org/content/early/2019/01/17/blood-2018-08-868893?sso-checked=true
Howard,J,et al

Jan 16th, 2019 - New treatments directly targeting polymerization of sickle hemoglobin (HbS), the proximate event in the pathophysiology of sickle cell disease (SCD), are needed to address the severe morbidity and early mortality associated with the disease. Voxel...

Statement on Opioid Use in Patients with Hematologic Diseases and Disorders
http://www.hematology.org/Advocacy/Statements/8502.aspx
American Society of Hematology

Apr 17th, 2018 - According to the Centers for Disease Control and Prevention, overdoses from prescription opioids in the United States have contributed to the 15-year increase in opioid overdose deaths and nearly half of all opioid overdose deaths involve a prescr.

Pain Management in Vaso-occlusive Sickle Cell Crisis
https://www.emra.org/emresident/article/pain-management-in-vaso-occlusive-sickle-cell-crisis/
Amani Mahdi

Apr 10th, 2017 - To optimize patient care, considerable effort must be directed toward understanding the pathophysiology of SCD, appreciating the severity of each episode, and anticipating the likelihood of VOC recurrence. In addition, the patient's age, comorbidi.

Pediatric Pulmonary Hypertension
http://www.thoracic.org/statements/resources/pldd/pediatric-pulmonary-hypertension.pdf
Steven H. Abman

Mar 14th, 2016 - Pulmonary hypertension is associated with diverse cardiac, pulmonary, and systemic diseases in neonates, infants, and older children and contributes to significant morbidity and mortality. However, current approaches to caring for pediatric patien.

Health Maintenance and Management of Chronic Complications of Sickle Cell Disease: ASH Guide...
http://ashpocketguides.hematology.org/#/app/guides/3/pages/
American Society of Hematology

Oct 31st, 2014 - Guide for Health Maintenance and Management of Chronic Complications of Sickle Cell Disease.

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Drugs  3 results see all →

Clinicaltrials.gov  2,313 results

FT-4202, an oral PKR activator, has potent antisickling effects and improves RBC surviv...
https://doi.org/10.1182/bloodadvances.2020003604
Blood Advances; Shrestha A, Chi M et. al.

May 4th, 2021 - Sickle cell anemia (SCA) results from an abnormal sickle hemoglobin (HbS). HbS polymerizes upon deoxygenation, resulting in red blood cell (RBC) sickling and membrane damage that cause vaso-occlusions and hemolysis. Sickle RBCs contain less adenos...

Association of alpha-thalassemia and Glucose-6-Phosphate Dehydrogenase deficiency with ...
https://doi.org/10.1002/jcla.23802
Journal of Clinical Laboratory Analysis; Ojewunmi OO, Adeyemo TA et. al.

May 3rd, 2021 - Stroke is a devastating complication of sickle cell anemia (SCA) and can be predicted through abnormally high cerebral blood flow velocity using transcranial Doppler Ultrasonography (TCD). The evidence on the role of alpha-thalassemia and glucose-...

Evaluation of the expression of red blood cell CD36, interleukin-6 and interleukin-8 in...
https://doi.org/10.1016/j.cyto.2021.155534
Cytokine Abdul-Hussein HK, Al-Mammori HS et. al.

Apr 23rd, 2021 - Sickle cell anemia (SCA) is a complex multisystem disease characterized by acute and chronic inflammation, with alterations in inflammatory cytokines and adhesion molecules. This case-control study was carried out to assess the levels of CD36, imm...

Brain injury pathophysiology study by a multimodal approach in children with sickle cel...
https://doi.org/10.3324/haematol.2020.278226
Haematologica Brousse V, Pondarre C et. al.

Apr 22nd, 2021 - Despite its high prevalence in children with sickle cell anemia (SCA), the pathophysiology of silent cerebral infarcts (SCIs) remains elusive. The main objective of this study was to explore the respective roles of major determinants of brain perf...

Cerebral Hemodynamics and Executive Function in Sickle Cell Anemia.
https://doi.org/10.1161/STROKEAHA.120.032741
Stroke Prussien KV, Compas BE et. al.

Apr 12th, 2021 - Individuals with sickle cell anemia experience cognitive deficits, even in the absence of cerebral infarcts or strokes. This study tested the hypothesis that elevated cerebral blood flow and oxygen extraction fraction are associated with lower exe...

see more →

News  125 results

Hydroxyurea Dose Escalation Safe, More Effective Against Childhood Sickle Cell Anemia
https://www.staging.medscape.com/viewarticle/932935

Jun 25th, 2020 - (Reuters Health) - Raising the dose of hydroxyurea by roughly 50% for children with sickle cell anemia dramatically lowers the risk of sickle-cell complications, according to a new study of 187 Ugandan children published in the New England Journal...

Hydroxyurea Dose Escalation Safe, More Effective Against Childhood Sickle Cell Anemia
https://www.medscape.com/viewarticle/932935

Jun 25th, 2020 - (Reuters Health) - Raising the dose of hydroxyurea by roughly 50% for children with sickle cell anemia dramatically lowers the risk of sickle-cell complications, according to a new study of 187 Ugandan children published in the New England Journal...

FDA approves Global Blood Therapeutics sickle cell disease drug
https://www.reuters.com/article/us-global-blood-theraprutics-fda/fda-approves-global-blood-therapeutics-sickle-cell-disease-drug-idUSKBN1XZ2E5

Nov 25th, 2019 - (Reuters) - The U.S. Food and Drug Administration said on Monday it approved a drug from Global Blood Therapeutics Inc to treat sickle cell disease in adults and children 12 years or older. The treatment will be priced at $10,417 per month, or aro...

Suicide trends among youth on Medicaid
https://www.mdedge.com/emergencymedicine/article/193150/suicide-trends-among-youth-medicaid

Jan 24th, 2019 - Younger people who are enrolled in Medicaid who commit suicide are disproportionately female, younger, and more likely to die by hanging. The risk for acute myeloid leukemia and myeloma is higher for breast cancer survivors, matched transplant imp.

Matched transplant improves stroke risk indicator in sickle cell anemia
https://www.mdedge.com/pediatrics/article/193003/anemia/matched-transplant-improves-stroke-risk-indicator-sickle-cell
Andrew D. Bowser

Jan 22nd, 2019 - In children with sickle cell anemia, matched sibling donor transplants improved an indicator of stroke risk in a multicenter French study, suggesting that this intervention may improve outcomes related to cerebral vasculopathy. Matched sibling don.

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Patient Education  15 results see all →