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About 4,464 results

ALLMedicine™ Sickle Cell Anemia Center

Research & Reviews  2,135 results

Using cyproterone acetate to treat recurrent ischemic priapism in a patient with sickle...
https://doi.org/10.1186/s13256-020-02527-1
Journal of Medical Case Reports; Alshahrani A

Oct 21st, 2020 - The management of recurrent ischemic priapism is unclear in contemporary practice. Yet, if left untreated, the condition may evolve into an acute ischemic priapism and in some cases result in erectile dysfunction. This report documents the results...

Randomized Control Trial of Oral Arginine Therapy for Children with Sickle Cell Anemia ...
https://doi.org/10.1002/ajh.26028
American Journal of Hematology; Onalo R, Cooper P et. al.

Oct 19th, 2020 - Low arginine bioavailability is associated with vaso-occlusive painful crisis (VOC) severity in sickle cell anemia (SCA) and predicts need for pediatric hospitalization. Intravenous arginine therapy has opioid-sparing effects and was found to sign...

TGFBR3 Polymorphisms (rs1805110 and rs7526590) Are Associated with Laboratory Biomarker...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7547350
Disease Markers; Santiago RP, Figueiredo CVB et. al.

Oct 16th, 2020 - Individuals with sickle cell anemia (SCA) present chronic anemia, hemolysis, an exacerbated inflammatory response, and heterogeneous clinical complications, which may be modulated by the transforming growth factor beta (TGF-β) pathway. Thus, we ai...

Hydroxyurea Pharmacokinetics in Pediatric Patients After Total Pancreatectomy With Isle...
https://doi.org/10.1002/jcph.1759
Journal of Clinical Pharmacology References; Boucher AA, Dong M et. al.

Oct 8th, 2020 - Total pancreatectomy with islet autotransplantation is a complex surgical approach for acute recurrent or chronic pancreatitis that frequently triggers extreme thrombocytosis (platelets ≥ 1000 × 109 /L). Thrombocytosis can be prothrombotic, so cyt...

Dynamic and reversible shape response of red blood cells in synthetic liquid crystals.
https://doi.org/10.1073/pnas.2007753117
Proceedings of the National Academy of Sciences of the United States of America; Nayani K, Evans AA et. al.

Oct 3rd, 2020 - Mammalian cells are soft, and correct functioning requires that cells undergo dynamic shape changes in vivo. Although a range of diseases are associated with stiffening of red blood cells (RBCs; e.g., sickle cell anemia or malaria), the mechanical...

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Guidelines  23 results

A phase 1/2 ascending dose study and open-label extension study of voxelotor in patients with sickle cell disease
http://www.bloodjournal.org/content/early/2019/01/17/blood-2018-08-868893?sso-checked=true
Howard,J,et al

Jan 16th, 2019 - New treatments directly targeting polymerization of sickle hemoglobin (HbS), the proximate event in the pathophysiology of sickle cell disease (SCD), are needed to address the severe morbidity and early mortality associated with the disease. Voxel...

Statement on Opioid Use in Patients with Hematologic Diseases and Disorders
http://www.hematology.org/Advocacy/Statements/8502.aspx
American Society of Hematology

Apr 17th, 2018 - According to the Centers for Disease Control and Prevention, overdoses from prescription opioids in the United States have contributed to the 15-year increase in opioid overdose deaths and nearly half of all opioid overdose deaths involve a prescr.

Pain Management in Vaso-occlusive Sickle Cell Crisis
https://www.emra.org/emresident/article/pain-management-in-vaso-occlusive-sickle-cell-crisis/
Amani Mahdi

Apr 10th, 2017 - To optimize patient care, considerable effort must be directed toward understanding the pathophysiology of SCD, appreciating the severity of each episode, and anticipating the likelihood of VOC recurrence. In addition, the patient's age, comorbidi.

Pediatric Pulmonary Hypertension
http://www.thoracic.org/statements/resources/pldd/pediatric-pulmonary-hypertension.pdf
Steven H. Abman

Mar 14th, 2016 - Pulmonary hypertension is associated with diverse cardiac, pulmonary, and systemic diseases in neonates, infants, and older children and contributes to significant morbidity and mortality. However, current approaches to caring for pediatric patien.

Health Maintenance and Management of Chronic Complications of Sickle Cell Disease: ASH Guide...
http://ashpocketguides.hematology.org/#/app/guides/3/pages/
American Society of Hematology

Oct 31st, 2014 - Guide for Health Maintenance and Management of Chronic Complications of Sickle Cell Disease.

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Drugs  3 results see all →

Clinicaltrials.gov  2,203 results

Using cyproterone acetate to treat recurrent ischemic priapism in a patient with sickle...
https://doi.org/10.1186/s13256-020-02527-1
Journal of Medical Case Reports; Alshahrani A

Oct 21st, 2020 - The management of recurrent ischemic priapism is unclear in contemporary practice. Yet, if left untreated, the condition may evolve into an acute ischemic priapism and in some cases result in erectile dysfunction. This report documents the results...

Randomized Control Trial of Oral Arginine Therapy for Children with Sickle Cell Anemia ...
https://doi.org/10.1002/ajh.26028
American Journal of Hematology; Onalo R, Cooper P et. al.

Oct 19th, 2020 - Low arginine bioavailability is associated with vaso-occlusive painful crisis (VOC) severity in sickle cell anemia (SCA) and predicts need for pediatric hospitalization. Intravenous arginine therapy has opioid-sparing effects and was found to sign...

TGFBR3 Polymorphisms (rs1805110 and rs7526590) Are Associated with Laboratory Biomarker...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7547350
Disease Markers; Santiago RP, Figueiredo CVB et. al.

Oct 16th, 2020 - Individuals with sickle cell anemia (SCA) present chronic anemia, hemolysis, an exacerbated inflammatory response, and heterogeneous clinical complications, which may be modulated by the transforming growth factor beta (TGF-β) pathway. Thus, we ai...

Hydroxyurea Pharmacokinetics in Pediatric Patients After Total Pancreatectomy With Isle...
https://doi.org/10.1002/jcph.1759
Journal of Clinical Pharmacology References; Boucher AA, Dong M et. al.

Oct 8th, 2020 - Total pancreatectomy with islet autotransplantation is a complex surgical approach for acute recurrent or chronic pancreatitis that frequently triggers extreme thrombocytosis (platelets ≥ 1000 × 109 /L). Thrombocytosis can be prothrombotic, so cyt...

Siklos - hydroxyurea tablet, film coated-Medunik
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=76957c0d-0f98-4376-bb06-eee651adc09d

Oct 8th, 2020 - SIKLOS® is indicated to reduce the frequency of painful crises and to reduce the need for blood transfusions in pediatric patients, 2 years of age and older, with sickle cell anemia with recurrent moderate to severe painful crises. SIKLOS is an an...

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News  85 results

FDA approves Global Blood Therapeutics sickle cell disease drug
https://www.reuters.com/article/us-global-blood-theraprutics-fda/fda-approves-global-blood-therapeutics-sickle-cell-disease-drug-idUSKBN1XZ2E5

Nov 25th, 2019 - (Reuters) - The U.S. Food and Drug Administration said on Monday it approved a drug from Global Blood Therapeutics Inc to treat sickle cell disease in adults and children 12 years or older. The treatment will be priced at $10,417 per month, or aro...

Suicide trends among youth on Medicaid
https://www.mdedge.com/emergencymedicine/article/193150/suicide-trends-among-youth-medicaid

Jan 24th, 2019 - Younger people who are enrolled in Medicaid who commit suicide are disproportionately female, younger, and more likely to die by hanging. The risk for acute myeloid leukemia and myeloma is higher for breast cancer survivors, matched transplant imp.

Matched transplant improves stroke risk indicator in sickle cell anemia
https://www.mdedge.com/pediatrics/article/193003/anemia/matched-transplant-improves-stroke-risk-indicator-sickle-cell
Andrew D. Bowser

Jan 22nd, 2019 - In children with sickle cell anemia, matched sibling donor transplants improved an indicator of stroke risk in a multicenter French study, suggesting that this intervention may improve outcomes related to cerebral vasculopathy. Matched sibling don.

A phase 1/2 ascending dose study and open-label extension study of voxelotor in patients with sickle cell disease
http://www.bloodjournal.org/content/early/2019/01/17/blood-2018-08-868893?sso-checked=true
Howard,J,et al

Jan 16th, 2019 - New treatments directly targeting polymerization of sickle hemoglobin (HbS), the proximate event in the pathophysiology of sickle cell disease (SCD), are needed to address the severe morbidity and early mortality associated with the disease. Voxel...

Despite risks, exercise is important for patients with sickle cell
https://www.mdedge.com/familymedicine/article/190912/anemia/despite-risks-exercise-important-patients-sickle-cell?channel=39313
Hematology News; Randy Dotinga

Dec 11th, 2018 - SAN DIEGO – Don’t let all your patients with sickle cell anemia (SCA) and sickle cell trait (SCT) off the hook when it comes to exercise. That was the advice from Robert I.

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Patient Education  15 results see all →