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About 4,604 results

ALLMedicine™ Sickle Cell Anemia Center

Research & Reviews  2,165 results

Haptoglobin Genotypes Associated with Vaso-Occlusive Crisis in Sickle Cell Anemia Patie...
https://doi.org/10.1080/03630269.2020.1801459
Hemoglobin Meher S, Mohanty PK et. al.

Jan 4th, 2021 - Sickle cell anemia is hallmarked by hemolysis, which releases hemoglobin (Hb) into the plasma promoting vaso-occlusive crisis (VOC). Haptoglobin (Hp) clears free Hb and decreases Hb-related pathophysiology in sickle cell anemia. There are two alle...

Assessment of Ventricular Repolarization in Sickle Cell Anemia Patients: The Role of QT...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7733033
Vascular Health and Risk Management; Ajibare AO, Olabode OP et. al.

Dec 16th, 2020 - Many specific and non-specific electrocardiographic abnormalities including ventricular arrhythmias have been reported in subjects with sickle cell anemia (SCA). In SCA patients, cardiac electrical abnormalities may be the leading cause of increas...

Recommendation to reality: Closing the transcranial Doppler screening gap for children ...
https://doi.org/10.1002/pbc.28831
Pediatric Blood & Cancer REFERENCES; Singh A, Danda V et. al.

Dec 7th, 2020 - Although annual transcranial Doppler (TCD) screening is recommended for children with sickle cell anemia (SCA), compliance is low and variable. Our objective was to utilize an electronic health record (EHR)-based registry to improve TCD adherence ...

Positive effects of ultrasound-guided peripheral IV insertion on pediatric sickle cell ...
https://doi.org/10.1002/jca.21856
Journal of Clinical Apheresis REFERENCES; Mahon P, Grouchy K et. al.

Nov 28th, 2020 - Peripheral vascular access and venipuncture are major causes of distress and anxiety for children and their parents. This is especially difficult for patients with hemoglobinopathies (thalassemia major and sickle cell disease) who require chronic ...

Changes in Care Delivery for Children With Sickle Cell Anemia During the COVID-19 Pande...
https://doi.org/10.1097/MPH.0000000000002008
Journal of Pediatric Hematology/oncology; Noisette ML, Phillips S et. al.

Nov 25th, 2020 - Specialty care for children with sickle cell disease (SCD) may be disrupted during the coronavirus (COVID-19) pandemic. Our DISPLACE consortium includes 28 pediatric SCD centers. In May 2020, we surveyed the consortium on the impact of COVID-19 on...

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Guidelines  23 results

A phase 1/2 ascending dose study and open-label extension study of voxelotor in patients with sickle cell disease
http://www.bloodjournal.org/content/early/2019/01/17/blood-2018-08-868893?sso-checked=true
Howard,J,et al

Jan 16th, 2019 - New treatments directly targeting polymerization of sickle hemoglobin (HbS), the proximate event in the pathophysiology of sickle cell disease (SCD), are needed to address the severe morbidity and early mortality associated with the disease. Voxel...

Statement on Opioid Use in Patients with Hematologic Diseases and Disorders
http://www.hematology.org/Advocacy/Statements/8502.aspx
American Society of Hematology

Apr 17th, 2018 - According to the Centers for Disease Control and Prevention, overdoses from prescription opioids in the United States have contributed to the 15-year increase in opioid overdose deaths and nearly half of all opioid overdose deaths involve a prescr.

Pain Management in Vaso-occlusive Sickle Cell Crisis
https://www.emra.org/emresident/article/pain-management-in-vaso-occlusive-sickle-cell-crisis/
Amani Mahdi

Apr 10th, 2017 - To optimize patient care, considerable effort must be directed toward understanding the pathophysiology of SCD, appreciating the severity of each episode, and anticipating the likelihood of VOC recurrence. In addition, the patient's age, comorbidi.

Pediatric Pulmonary Hypertension
http://www.thoracic.org/statements/resources/pldd/pediatric-pulmonary-hypertension.pdf
Steven H. Abman

Mar 14th, 2016 - Pulmonary hypertension is associated with diverse cardiac, pulmonary, and systemic diseases in neonates, infants, and older children and contributes to significant morbidity and mortality. However, current approaches to caring for pediatric patien.

Health Maintenance and Management of Chronic Complications of Sickle Cell Disease: ASH Guide...
http://ashpocketguides.hematology.org/#/app/guides/3/pages/
American Society of Hematology

Oct 31st, 2014 - Guide for Health Maintenance and Management of Chronic Complications of Sickle Cell Disease.

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Drugs  3 results see all →

Clinicaltrials.gov  2,273 results

Haptoglobin Genotypes Associated with Vaso-Occlusive Crisis in Sickle Cell Anemia Patie...
https://doi.org/10.1080/03630269.2020.1801459
Hemoglobin Meher S, Mohanty PK et. al.

Jan 4th, 2021 - Sickle cell anemia is hallmarked by hemolysis, which releases hemoglobin (Hb) into the plasma promoting vaso-occlusive crisis (VOC). Haptoglobin (Hp) clears free Hb and decreases Hb-related pathophysiology in sickle cell anemia. There are two alle...

Assessment of Ventricular Repolarization in Sickle Cell Anemia Patients: The Role of QT...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7733033
Vascular Health and Risk Management; Ajibare AO, Olabode OP et. al.

Dec 16th, 2020 - Many specific and non-specific electrocardiographic abnormalities including ventricular arrhythmias have been reported in subjects with sickle cell anemia (SCA). In SCA patients, cardiac electrical abnormalities may be the leading cause of increas...

Recommendation to reality: Closing the transcranial Doppler screening gap for children ...
https://doi.org/10.1002/pbc.28831
Pediatric Blood & Cancer REFERENCES; Singh A, Danda V et. al.

Dec 7th, 2020 - Although annual transcranial Doppler (TCD) screening is recommended for children with sickle cell anemia (SCA), compliance is low and variable. Our objective was to utilize an electronic health record (EHR)-based registry to improve TCD adherence ...

Positive effects of ultrasound-guided peripheral IV insertion on pediatric sickle cell ...
https://doi.org/10.1002/jca.21856
Journal of Clinical Apheresis REFERENCES; Mahon P, Grouchy K et. al.

Nov 28th, 2020 - Peripheral vascular access and venipuncture are major causes of distress and anxiety for children and their parents. This is especially difficult for patients with hemoglobinopathies (thalassemia major and sickle cell disease) who require chronic ...

Changes in Care Delivery for Children With Sickle Cell Anemia During the COVID-19 Pande...
https://doi.org/10.1097/MPH.0000000000002008
Journal of Pediatric Hematology/oncology; Noisette ML, Phillips S et. al.

Nov 25th, 2020 - Specialty care for children with sickle cell disease (SCD) may be disrupted during the coronavirus (COVID-19) pandemic. Our DISPLACE consortium includes 28 pediatric SCD centers. In May 2020, we surveyed the consortium on the impact of COVID-19 on...

see more →

News  125 results

Hydroxyurea Dose Escalation Safe, More Effective Against Childhood Sickle Cell Anemia
https://www.staging.medscape.com/viewarticle/932935

Jun 25th, 2020 - (Reuters Health) - Raising the dose of hydroxyurea by roughly 50% for children with sickle cell anemia dramatically lowers the risk of sickle-cell complications, according to a new study of 187 Ugandan children published in the New England Journal...

Hydroxyurea Dose Escalation Safe, More Effective Against Childhood Sickle Cell Anemia
https://www.medscape.com/viewarticle/932935

Jun 25th, 2020 - (Reuters Health) - Raising the dose of hydroxyurea by roughly 50% for children with sickle cell anemia dramatically lowers the risk of sickle-cell complications, according to a new study of 187 Ugandan children published in the New England Journal...

FDA approves Global Blood Therapeutics sickle cell disease drug
https://www.reuters.com/article/us-global-blood-theraprutics-fda/fda-approves-global-blood-therapeutics-sickle-cell-disease-drug-idUSKBN1XZ2E5

Nov 25th, 2019 - (Reuters) - The U.S. Food and Drug Administration said on Monday it approved a drug from Global Blood Therapeutics Inc to treat sickle cell disease in adults and children 12 years or older. The treatment will be priced at $10,417 per month, or aro...

Suicide trends among youth on Medicaid
https://www.mdedge.com/emergencymedicine/article/193150/suicide-trends-among-youth-medicaid

Jan 24th, 2019 - Younger people who are enrolled in Medicaid who commit suicide are disproportionately female, younger, and more likely to die by hanging. The risk for acute myeloid leukemia and myeloma is higher for breast cancer survivors, matched transplant imp.

Matched transplant improves stroke risk indicator in sickle cell anemia
https://www.mdedge.com/pediatrics/article/193003/anemia/matched-transplant-improves-stroke-risk-indicator-sickle-cell
Andrew D. Bowser

Jan 22nd, 2019 - In children with sickle cell anemia, matched sibling donor transplants improved an indicator of stroke risk in a multicenter French study, suggesting that this intervention may improve outcomes related to cerebral vasculopathy. Matched sibling don.

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Patient Education  15 results see all →