ALLMedicine™ Hemolytic Uremic Syndrome Center

Mar 14th, 2023 - Eculizumab is a monoclonal antibody for the treatment of atypical hemolytic uremic syndrome (aHUS). Kidney damage, a common condition in patients with aHUS may result in proteinuria. As proteinuria may impact the pharmacokinetics of therapeutic pr...

Mar 8th, 2023 - This study aims to evaluate the efficacy and safety of crovalimab in pediatric participants with aHUS.

Mar 8th, 2023 - Hemolytic uremic syndrome is characterized by a triad of microangiopathic hemolytic anemia, thrombocytopenia, and acute kidney failure. Most cases are caused by Shiga-toxin-producing bacteria, especially Escherichia coli. Transmission occurs throu...

Mar 7th, 2023 - Relapse of atypical hemolytic uremic syndrome triggered by COVID-19: a lesson for the clinical nephrologist.|2023|Uwatoko R,Shindo M,Hashimoto N,Iio R,Ueda Y,|

Mar 3rd, 2023 - In Argentina, Hemolytic uremic syndrome caused by Shiga toxin-producing Escherichia coli (STEC HUS), is the main cause of acute kidney injury and the second cause of end-stage renal disease (ESRD) in children. In recent decades, strategies have be...

Jul 17th, 2016 - Atypical hemolytic uremic syndrome (aHUS) is a rare disease characterized by the triad of microangiopathic hemolytic anemia, thrombocytopenia, and acute kidney injury. In 2013, we developed diagnostic criteria to enable early diagnosis and timely ...

Apr 11th, 2015 - Atypical hemolytic uremic syndrome (aHUS) emerged during the last decade as a disease largely of complement dysregulation. This advance facilitated the development of novel, rational treatment options targeting terminal complement activation, e.g....

Aug 8th, 2014 - Guidelines for the management and investigation of hemolytic uremic syndrome.|2014|Igarashi T,Ito S,Sako M,Saitoh A,Hataya H,|standards,diagnosis,etiology,therapy,standards,

Sep 19th, 2008 - This guideline for the investigation and initial treatment of atypical hemolytic uremic syndrome (HUS) is intended to offer an approach based on opinion, as evidence is lacking. It builds on the current ability to identify the etiology of specific...

Mar 8th, 2023 - This study aims to evaluate the efficacy and safety of crovalimab in pediatric participants with aHUS.

Feb 27th, 2023 - Preeclampsia is a devastating multisystem disorder of pregnancy that manifests as hypertension with or without proteinuria and/or end organ damage caused by endothelial dysfunction and occurs in 3-5% of all pregnancies. Notably, preeclampsia accou...

Feb 24th, 2023 - This study aims to evaluate the efficacy and safety of crovalimab in adult and adolescent participants with aHUS.

Feb 14th, 2023 - Hemolytic and uremic syndrome (HUS) is a clinic-biological syndrome related to thrombotic microangiopathy affecting predominantly the kidney. Atypical HUS (aHUS) has been historically defined as HUS occurring in the absence of infectious event. Th...

Jan 27th, 2023 - Background: Hairy cell leukemia (HCL) is an indolent CD22+ B-cell leukemia comprising 2% of all leukemias, or approximately 1200 of the 62,130 new cases of leukemia/year in the US. HCL variant (HCLv), also CD22+, is 10-20% as common as HCL, but mo...

Nov 2nd, 2022 - The exploration of combination therapies with an azacitidine (Vidaza) backbone could alter the treatment landscape for patients with myelodysplastic syndromes (MDS), according Mikkael A. Sekeres, MD, MS. Data are expected soon from the phase 3...

Nov 1st, 2022 - When assessing monoclonal gammopathy it is important to rule out clinically significant associations requiring treatment. On initial patient consultation, gathering a detailed patient history and thorough physical exam can catch clinically signifi...

Mar 21st, 2022 - Reported gastrointestinal (GI) outbreaks in England were halved during the first 6 months of the COVID-19 pandemic compared with a similar period over the 5 years' prior, a retrospective ecological study found. From February to July 2020, there wa...

Dec 12th, 2021 - Minimal residual disease (MRD), assessed through next-generation sequencing (NGS) was found to inform treatment selection and duration with daratumumab (Darzalex) plus carfilzomib (Kyprolis), lenalidomide (Revlimid), and dexamethasone (Dara-KRd) f...

Sep 9th, 2021 - Introduction Epstein-Barr virus (EBV) is a herpes virus that commonly causes infectious mononucleosis (IM) and linked to different hematological conditions. Here we present a case of EBV-triggered Hemolytic Uremic Syndrome (HUS) with pulmonary inv.