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About 3,343 results

ALLMedicine™ Sickle Cell Anemia Center

Research & Reviews  1,035 results

Risk Clinical Stratification of Sickle Cell Disease in Nigeria, Assessment of Efficacy/Safety of Hydroxyurea Treatment
https://clinicaltrials.gov/ct2/show/NCT02149537

Aug 11th, 2022 - The vast majority of births with sickle cell disease (SCD) occur in Africa and 90% are thought to die before the age of five. Hydroxyurea (HU) is the only drug approved by the FDA for the treatment of sickle cell anemia. Although HU is used to tre...

Structural connectivity mediates the relationship between blood oxygenation and cogniti...
https://doi.org/10.1182/bloodadvances.2021006751
Blood Advances; Clayden JD, Stotesbury H et. al.

Aug 11th, 2022 - In sickle cell disease (SCD), the relative importance of reduced hemoglobin and peripheral oxygen saturation (SpO2) on brain structure remains uncertain. We applied graph-theoretical analysis to diffusion MRI data to investigate the effect of stru...

Secondary Pulmonary Hypertension in Adults With Sickle Cell Anemia
https://clinicaltrials.gov/ct2/show/NCT00011648

Aug 8th, 2022 - Sickle cell anemia is an autosomal recessive disorder and the most common genetic disease affecting African-Americans. Approximately 0.15% of African-Americans are homozygous for sickle cell disease, and 8% have sickle cell trait. Acute pain crisi...

Modulation of blood pressure regulatory genes in the Agtrap-Plod1 locus associated with...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9353118
Physiological Reports; Klemens CA, Dissanayake LV et. al.

Aug 6th, 2022 - The AGTRAP-PLOD1 locus is a conserved gene cluster containing several blood pressure regulatory genes, including CLCN6, MTHFR, NPPA, and NPPB. Previous work revealed that knockout of Clcn6 on the Dahl Salt-Sensitive (SS) rat background (SS-Clcn6) ...

Meteorological parameters and hospitalizations of patients with sickle cell anemia: a 2...
https://doi.org/10.1080/09603123.2022.2098258
International Journal of Environmental Health Research; Alagbe AE, Corozolla W et. al.

Aug 3rd, 2022 - To investigate the influence of climate on hospitalizations of sickle cell anemia (SCA) adults and children, we analyzed the health and meteorological parameters from a metropolis (1999-2018). 1462 hospitalizations were coded for SCA patients in c...

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Guidelines  1 results

Cardiovascular function and treatment in β-thalassemia major: a consensus statement fro...
https://doi.org/10.1161/CIR.0b013e31829b2be6
Circulation Pennell DJ, Udelson JE et. al.

Jun 19th, 2013 - This aim of this statement is to report an expert consensus on the diagnosis and treatment of cardiac dysfunction in β-thalassemia major (TM). This consensus statement does not cover other hemoglobinopathies, including thalassemia intermedia and s...

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Drugs  3 results see all →

Clinicaltrials.gov  162 results

Risk Clinical Stratification of Sickle Cell Disease in Nigeria, Assessment of Efficacy/Safety of Hydroxyurea Treatment
https://clinicaltrials.gov/ct2/show/NCT02149537

Aug 11th, 2022 - The vast majority of births with sickle cell disease (SCD) occur in Africa and 90% are thought to die before the age of five. Hydroxyurea (HU) is the only drug approved by the FDA for the treatment of sickle cell anemia. Although HU is used to tre...

Secondary Pulmonary Hypertension in Adults With Sickle Cell Anemia
https://clinicaltrials.gov/ct2/show/NCT00011648

Aug 8th, 2022 - Sickle cell anemia is an autosomal recessive disorder and the most common genetic disease affecting African-Americans. Approximately 0.15% of African-Americans are homozygous for sickle cell disease, and 8% have sickle cell trait. Acute pain crisi...

Imatinib for Pain in Sickle Cell Anemia
https://clinicaltrials.gov/ct2/show/NCT03997903

Jul 29th, 2022 - In this protocol, the investigators propose to evaluate the biochemical effects of imatinib on sickle red blood cells (RBCs). Patients will be administered imatinib mesylate orally following the guidelines previously established for use of imatini...

Crizanlizumab Improves Tissue Oxygen Supply Demand Matching in Patients With Sickle Cell Anemia
https://clinicaltrials.gov/ct2/show/NCT05469828

Jul 22nd, 2022 - Objectives Primary Objectives 1. The investigators will test whether SEG101 improves Supply-Demand Matching in patients with sickle cell anemia measured by the change in tissue oxygenation by NIRS. a) This is measured as a percent oxyhemoglobin sa...

Omega-3, Nigella Sativa, Indian Costus, Quinine, Anise Seed, Deglycyrrhizinated Licorice, Artemisinin, Febrifugine on Immunity of Patients With (COVID-19)
https://clinicaltrials.gov/ct2/show/NCT04553705

Jul 19th, 2022 - Natural supplementations have many reported effects on the human health ranged from immunity boosting to effective antiviral effect. Omeg-3 as an example affect the human health by many mechanisms e.g. Anti-oxidant, immunity boosting agent. Moreov...

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News  127 results

Essential strategies and tactics for managing sickle cell disease
https://www.mdedge.com/familymedicine/article/256319/hematology/essential-strategies-and-tactics-managing-sickle-cell
MDedge Family Medicine; Robert Allen Perkins, MD, MPH, Ann Payne- Johnson, MD et. al.

Jul 18th, 2022 - The group of disorders known as sickle cell disease (SCD) is one of the more common genetic hemoglobinopathies. Homozygous production of the S variant of hemoglobin (Hb) in red blood cells (RBCs) results in profound sickling under conditions of ph.

Are We Any Closer to Intestinal Gene Therapy in Crohn's Disease?
https://www.medscape.com/viewarticle/967621

May 24th, 2022 - This transcript has been edited for clarity. Peter Higgins, MD, PhD: Hello. I'm Dr Peter Higgins, and welcome to Medscape's InDiscussion series on Crohn's disease. Today we'll be discussing gene therapy trials. Given the recent successes with sick...

Longer Hydroxyurea Tied to Improved Sickle-Cell Heart Issues
https://www.medpagetoday.com/hematologyoncology/hematology/94540

Sep 16th, 2021 - Prolonged treatment with hydroxyurea may improve -- and possibly even reverse -- cardiac complications in pediatric patients with sickle cell anemia, a retrospective study found. Those on hydroxyurea for less than 1 year had a significantly greate...

Sickle Cell Disease Tied to COVID-19 Mortality, Hospitalizations
https://www.medpagetoday.com/hematologyoncology/hematology/93683

Jul 21st, 2021 - Sickle cell disease (SCD) was associated with a significantly increased risk of COVID-19-related hospitalization and death in adults, U.K. researchers found. Their cohort study showed that having SCD quadrupled a person's risk for COVID-19-related...

Transfusion Dependence in Adult Sickle Cell Anemia
https://www.onclive.com/view/transfusion-dependence-in-adult-sickle-cell-anemia

Apr 2nd, 2021 - Transfusion is 1 of 2 disease-modifying therapies for adults with sickle cell anemia, the other being hydroxyurea, explains Morey Blinder, MD. There are several indications for transfusion in patients with sickle cell disease, with the best studie...

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Patient Education  9 results see all →