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About 860 results

ALLMedicine™ Arenaviruses Center

Research & Reviews  429 results

Structural analysis of viral ExoN domains reveals polyphyletic hijacking events.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7968707
PloS One; Cruz-González A, Muñoz-Velasco I et. al.

Mar 17th, 2021 - Nidoviruses and arenaviruses are the only known RNA viruses encoding a 3'-5' exonuclease domain (ExoN). The proofreading activity of the ExoN domain has played a key role in the growth of nidoviral genomes, while in arenaviruses this domain partak...

Glycoprotein N-linked glycans play a critical role in arenavirus pathogenicity.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7951981
PLoS Pathogens; Koma T, Huang C et. al.

Mar 1st, 2021 - Several arenaviruses cause hemorrhagic fevers in humans with high case fatality rates. A vaccine named Candid#1 is available only against Junin virus (JUNV) in Argentina. Specific N-linked glycans on the arenavirus surface glycoprotein (GP) mask i...

Identification of Coronaviruses, Paramyxoviruses, Reoviruses, and Rotaviruses among Bat...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7941819
The American Journal of Tropical Medicine and Hygiene; Kia GSN, Tao Y et. al.

Feb 3rd, 2021 - Bats are often consumed by some ethnic groups in Nigeria despite association of bats with many important emerging viruses. More than 300 bats representing eight species were captured during 2010-2011 in eight locations of northern Nigeria. Availab...

Inhibition of Arenaviruses by Combinations of Orally Available Approved Drugs.
https://doi.org/10.1128/AAC.01146-20 10.3389/fimmu.2019.00372 10.3389/fmicb.2018.01751 10.1056/NEJMoa073785 10.1086/514211 10.1016/j.ijid.2019.07.015 10.1128/JVI.01744-18 10.1128/JVI.01140-08 10.1016/j.antiviral.2011.02.012 10.1128/JVI.01587-15 10.1038/nri3158 10.1016/j.antiviral.2015.05.003 10.3390/v12080857 10.1016/j.antiviral.2019.03.014 10.1128/JVI.02275-13 10.1016/j.antiviral.2018.07.009 10.1002/jmv.25024 10.1038/nature17180 10.3201/eid2409.180233 10.1016/j.antiviral.2019.104558 10.1128/JVI.00954-18 10.1126/scitranslmed.3006827 10.1126/scitranslmed.aaa5597 10.1016/j.tim.2018.04.004 10.1038/nbt.1549 10.1093/infdis/jiy304 10.1016/j.antiviral.2016.11.017 10.1128/JVI.02185-18 10.1128/JVI.01902-16 10.1111/tra.12389 10.1073/pnas.1617020114 10.1128/JVI.02077-15 10.1016/j.antiviral.2013.08.008 10.1016/j.antiviral.2014.04.006 10.1186/1743-422X-3-56 10.1038/s41598-018-27224-4 10.1021/bi700181j 10.1038/s41421-020-0169-8 10.3390/v12060642 10.1016/j.antiviral.2018.10.025 10.1021/acs.jmedchem.7b01249 10.1128/AAC.00819-20 10.1038/s41598-019-45095-1 10.1371/journal.ppat.1002976 10.1371/journal.pntd.0006715 10.1128/JVI.01154-16 10.1128/JVI.02705-15 10.1093/jac/11.5.427 10.3791/57713 10.1093/nar/gkaa216 10.1093/bioinformatics/btx162 10.1038/s41591-018-0233-1 10.1016/j.ccell.2018.01.004 10.1093/nar/gkz1007 10.1126/scitranslmed.3005471 10.1038/nature18615 10.3390/v11020176 10.1021/acsinfecdis.0c00486 10.1016/j.jinf.2020.03.002 10.5582/bst.2020.01030 10.5414/CP201843 10.1128/AAC.02282-12 10.1016/j.clinthera.2009.04.016 10.1177/0091270003261901 10.1080/15622970701361255 10.1097/YIC.0000000000000023 10.2165/00003088-200241150-00002 10.1056/NEJMoa1208809 10.1016/j.coviro.2016.03.004 10.1016/j.tmaid.2020.101589 10.1073/pnas.0601266103 10.1128/AAC.03036-14 10.1128/JVI.01218-20 10.1038/s41586-020-2577-1 10.1016/j.antiviral.2020.104854 10.1053/j.gastro.2007.02.038 10.1111/j.1744-7348.1939.tb06990.x
Antimicrobial Agents and Chemotherapy; Herring S, Oda JM et. al.

Jan 20th, 2021 - Neglected diseases caused by arenaviruses such as Lassa virus (LASV) and filoviruses like Ebola virus (EBOV) primarily afflict resource-limited countries, where antiviral drug development is often minimal. Previous studies have shown that many app...

High-Throughput Screening of an FDA-Approved Drug Library Identifies Inhibitors against...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7671101
ACS Infectious Diseases; Wan W, Zhu S et. al.

Nov 13th, 2020 - Arenaviruses are a large family of enveloped negative-strand RNA viruses that include several causative agents of severe hemorrhagic fevers. Currently, there are no FDA-licensed drugs to treat arenavirus infection except for the off-labeled use of...

see more →

Clinicaltrials.gov  431 results

Structural analysis of viral ExoN domains reveals polyphyletic hijacking events.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7968707
PloS One; Cruz-González A, Muñoz-Velasco I et. al.

Mar 17th, 2021 - Nidoviruses and arenaviruses are the only known RNA viruses encoding a 3'-5' exonuclease domain (ExoN). The proofreading activity of the ExoN domain has played a key role in the growth of nidoviral genomes, while in arenaviruses this domain partak...

Glycoprotein N-linked glycans play a critical role in arenavirus pathogenicity.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7951981
PLoS Pathogens; Koma T, Huang C et. al.

Mar 1st, 2021 - Several arenaviruses cause hemorrhagic fevers in humans with high case fatality rates. A vaccine named Candid#1 is available only against Junin virus (JUNV) in Argentina. Specific N-linked glycans on the arenavirus surface glycoprotein (GP) mask i...

Identification of Coronaviruses, Paramyxoviruses, Reoviruses, and Rotaviruses among Bat...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7941819
The American Journal of Tropical Medicine and Hygiene; Kia GSN, Tao Y et. al.

Feb 3rd, 2021 - Bats are often consumed by some ethnic groups in Nigeria despite association of bats with many important emerging viruses. More than 300 bats representing eight species were captured during 2010-2011 in eight locations of northern Nigeria. Availab...

Inhibition of Arenaviruses by Combinations of Orally Available Approved Drugs.
https://doi.org/10.1128/AAC.01146-20 10.3389/fimmu.2019.00372 10.3389/fmicb.2018.01751 10.1056/NEJMoa073785 10.1086/514211 10.1016/j.ijid.2019.07.015 10.1128/JVI.01744-18 10.1128/JVI.01140-08 10.1016/j.antiviral.2011.02.012 10.1128/JVI.01587-15 10.1038/nri3158 10.1016/j.antiviral.2015.05.003 10.3390/v12080857 10.1016/j.antiviral.2019.03.014 10.1128/JVI.02275-13 10.1016/j.antiviral.2018.07.009 10.1002/jmv.25024 10.1038/nature17180 10.3201/eid2409.180233 10.1016/j.antiviral.2019.104558 10.1128/JVI.00954-18 10.1126/scitranslmed.3006827 10.1126/scitranslmed.aaa5597 10.1016/j.tim.2018.04.004 10.1038/nbt.1549 10.1093/infdis/jiy304 10.1016/j.antiviral.2016.11.017 10.1128/JVI.02185-18 10.1128/JVI.01902-16 10.1111/tra.12389 10.1073/pnas.1617020114 10.1128/JVI.02077-15 10.1016/j.antiviral.2013.08.008 10.1016/j.antiviral.2014.04.006 10.1186/1743-422X-3-56 10.1038/s41598-018-27224-4 10.1021/bi700181j 10.1038/s41421-020-0169-8 10.3390/v12060642 10.1016/j.antiviral.2018.10.025 10.1021/acs.jmedchem.7b01249 10.1128/AAC.00819-20 10.1038/s41598-019-45095-1 10.1371/journal.ppat.1002976 10.1371/journal.pntd.0006715 10.1128/JVI.01154-16 10.1128/JVI.02705-15 10.1093/jac/11.5.427 10.3791/57713 10.1093/nar/gkaa216 10.1093/bioinformatics/btx162 10.1038/s41591-018-0233-1 10.1016/j.ccell.2018.01.004 10.1093/nar/gkz1007 10.1126/scitranslmed.3005471 10.1038/nature18615 10.3390/v11020176 10.1021/acsinfecdis.0c00486 10.1016/j.jinf.2020.03.002 10.5582/bst.2020.01030 10.5414/CP201843 10.1128/AAC.02282-12 10.1016/j.clinthera.2009.04.016 10.1177/0091270003261901 10.1080/15622970701361255 10.1097/YIC.0000000000000023 10.2165/00003088-200241150-00002 10.1056/NEJMoa1208809 10.1016/j.coviro.2016.03.004 10.1016/j.tmaid.2020.101589 10.1073/pnas.0601266103 10.1128/AAC.03036-14 10.1128/JVI.01218-20 10.1038/s41586-020-2577-1 10.1016/j.antiviral.2020.104854 10.1053/j.gastro.2007.02.038 10.1111/j.1744-7348.1939.tb06990.x
Antimicrobial Agents and Chemotherapy; Herring S, Oda JM et. al.

Jan 20th, 2021 - Neglected diseases caused by arenaviruses such as Lassa virus (LASV) and filoviruses like Ebola virus (EBOV) primarily afflict resource-limited countries, where antiviral drug development is often minimal. Previous studies have shown that many app...

High-Throughput Screening of an FDA-Approved Drug Library Identifies Inhibitors against...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7671101
ACS Infectious Diseases; Wan W, Zhu S et. al.

Nov 13th, 2020 - Arenaviruses are a large family of enveloped negative-strand RNA viruses that include several causative agents of severe hemorrhagic fevers. Currently, there are no FDA-licensed drugs to treat arenavirus infection except for the off-labeled use of...

see more →