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About 405 results

ALLMedicine™ Arenaviruses Center

Research & Reviews  162 results

Lassa fever amidst the COVID-19 Pandemic in Africa: A rising concern, Efforts, Challeng...
https://doi.org/10.1002/jmv.27219
Journal of Medical Virology; Uwishema O, Alshareif BAA et. al.

Jul 21st, 2021 - Lassa fever, caused by the Lassa virus of the Arenaviruses family, is a re-emerging public health concern that has led to 300,000 infections and 5,000 deaths annually in Africa. Highly prevalent in Sierra Leone, Liberia, Guinea, Nigeria, Côte d'lv...

Potent inhibition of arenavirus infection by a novel fusion inhibitor.
https://doi.org/10.1016/j.antiviral.2021.105125
Antiviral Research; Gowen BB, Naik S et. al.

Jul 1st, 2021 - Several arenaviruses, including Lassa and Lujo viruses in Africa and five New World arenavirus (NWA) species in the Americas, cause life-threatening viral hemorrhagic fevers. In the absence of licensed antiviral therapies, these viruses pose a sig...

Cryo-EM structures of Lassa and Machupo virus polymerases complexed with cognate regula...
https://doi.org/10.1038/s41564-021-00916-w
Nature Microbiology; Xu X, Peng R et. al.

Jun 15th, 2021 - Zoonotic arenaviruses can lead to life-threating diseases in humans. These viruses encode a large (L) polymerase that transcribes and replicates the viral genome. At the late stage of replication, the multifunctional Z protein interacts with the L...

Signal-regulatory protein alpha is an anti-viral entry factor targeting viruses using e...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8211255
PLoS Pathogens; Sarute N, Cheng H et. al.

Jun 7th, 2021 - Signal-regulatory protein alpha (SIRPA) is a well-known inhibitor of phagocytosis when it complexes with CD47 expressed on target cells. Here we show that SIRPA decreased in vitro infection by a number of pathogenic viruses, including New World an...

Structural analysis of viral ExoN domains reveals polyphyletic hijacking events.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7968707
PloS One; Cruz-González A, Muñoz-Velasco I et. al.

Mar 17th, 2021 - Nidoviruses and arenaviruses are the only known RNA viruses encoding a 3'-5' exonuclease domain (ExoN). The proofreading activity of the ExoN domain has played a key role in the growth of nidoviral genomes, while in arenaviruses this domain partak...

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