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ALLMedicine™ Ebola Virus Center

Research & Reviews  272 results

Recent developments and strategies of Ebola virus vaccines.
https://doi.org/10.1016/j.coph.2021.06.008
Current Opinion in Pharmacology; Sharma AR, Lee YH et. al.

Jul 31st, 2021 - The Filovirus family member, Ebola virus (EBOV), is a highly infectious pathogen responsible for viral hemorrhagic fever. EBOV has a fatality rate in the range 50%-90% in primates. The lethal viral hemorrhagic attack in 2014 by EBOV has forced the...

Ebola virus requires phosphatidylserine scrambling activity for efficient budding and o...
https://doi.org/10.1128/JVI.01165-21
Journal of Virology; Acciani MD, Lay Mendoza MF et. al.

Jul 29th, 2021 - Ebola virus (EBOV) attaches to target cells using two categories of cell surface receptors, C-type lectins and phosphatidylserine (PS) receptors. PS receptors typically bind to apoptotic cell membrane PS and orchestrate the uptake and clearance of...

Construction and evaluation of DNA vaccine encoding Ebola virus glycoprotein fused with...
https://doi.org/10.1016/j.antiviral.2021.105141
Antiviral Research; Liu Y, Sun B et. al.

Jul 19th, 2021 - Ebola virus (EBOV) of the genus Ebolavirus belongs to the family Filoviridae, which cause disease in both humans and non-human primates. Zaire Ebola virus accounts for the highest fatality rate, reaching 90%. Considering that EBOV has a high infec...

A naturally occurring polymorphism in the base of Sudan virus glycoprotein decreases gl...
https://doi.org/10.1128/JVI.01073-21
Journal of Virology; Lennemann NJ, Dillard J et. al.

Jul 8th, 2021 - Sudan virus (SUDV) is one of five filoviruses that compose the genus Ebolavirus that has been responsible for episodic outbreaks in Central Africa. While the SUDV glycoprotein (GP) structure has been solved, GP residues that affect SUDV entry have...

Natural history of disease in cynomolgus monkeys exposed to Ebola virus Kikwit strain d...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8253449
PloS One; Niemuth NA, Fallacara D et. al.

Jul 3rd, 2021 - Filoviruses (Family Filoviridae genera Ebolavirus and Marburgvirus) are negative-stranded RNA viruses that cause severe health effects in humans and non-human primates, including death. Except in outbreak settings, vaccines and other medical count...

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Clinicaltrials.gov  1 results

Safety Study of Single Administration Post-Exposure Prophylaxis Treatment for Ebola Virus
https://clinicaltrials.gov/ct2/show/NCT01353027

Mar 28th, 2012 - Ebola hemorrhagic fever (EHF) is a rare human disease caused by Ebola Virus (EBOV), a filamentous single-stranded, negative-sense RNA virus. Since 1976 several Ebolavirus outbreaks have occurred with fatality rates ranging from 57% to 90%, with mo...

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News  15 results

CDC Panel Recommends Ebola Vaccine for Adults With Exposure Risk
https://www.medscape.com/viewarticle/925810

Feb 27th, 2020 - The Centers for Disease Control and Prevention's (CDC's) Advisory Committee on Immunization Practices (ACIP) unanimously recommended preexposure vaccination with the first-ever US Food and Drug Administration (FDA)–approved vaccine against Ebola v...

FDA OKs First Vaccine Against Deadly Ebola Virus
https://www.medscape.com/viewarticle/922973

Dec 20th, 2019 - The US Food and Drug Administration (FDA) has approved the first vaccine for the prevention of Ebola caused by the deadly Zaire strain of the virus, which killed more than 11,000 people during the 2014 West Africa outbreak and is behind more than ...

FDA OKs First Vaccine Against Deadly Ebola Virus
https://www.staging.medscape.com/viewarticle/922973

Dec 20th, 2019 - The US Food and Drug Administration (FDA) has approved the first vaccine for the prevention of Ebola caused by the deadly Zaire strain of the virus, which killed more than 11,000 people during the 2014 West Africa outbreak and is behind more than ...

'Trojan Horse' Might Take Ebola by Surprise
https://www.medpagetoday.com/infectiousdisease/ebola/60105

Sep 8th, 2016 - A new approach to antibody-based therapies might one day allow clinicians to target all strains of Ebola with a broad-spectrum drug. In early research, the "Trojan horse" antibodies were effective in preventing all five varieties of Ebola from inf...

Ebola Sexual Transmission 6 Months After Illness Confirmed
https://www.medscape.com/viewarticle/852693

Oct 14th, 2015 - Two Ebola virus (EBOV) studies published online today in the New England Journal of Medicine translate to one piece of advice: Men who have survived Ebola virus disease (EVD) should use condoms and treat semen as a potential source of infection, a...

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