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About 398 results

ALLMedicine™ Arenaviruses Center

Research & Reviews  159 results

Isolation of reconstructed functional ribonucleoprotein complexes of Machupo virus.
https://doi.org/10.1128/JVI.01054-21
Journal of Virology; Pyle JD, Whelan SPJ

Aug 26th, 2021 - Arenaviruses initiate infection by delivering a transcriptionally-competent ribonucleoprotein (RNP) complex into the cytosol of host cells. The arenavirus RNP consists of the large (L) RNA-dependent RNA polymerase (RdRP) bound to a nucleoprotein (...

Lassa fever amidst the COVID-19 pandemic in Africa: A rising concern, efforts, challeng...
https://doi.org/10.1002/jmv.27219
Journal of Medical Virology; Uwishema O, Alshareif BAA et. al.

Jul 22nd, 2021 - Lassa fever, caused by the Lassa virus of the Arenaviruses family, is a re-emerging public health concern that has led to 300,000 infections and 5000 deaths annually in Africa. Highly prevalent in Sierra Leone, Liberia, Guinea, Nigeria, Côte d'lvo...

Potent inhibition of arenavirus infection by a novel fusion inhibitor.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8378549
Antiviral Research; Gowen BB, Naik S et. al.

Jul 2nd, 2021 - Several arenaviruses, including Lassa and Lujo viruses in Africa and five New World arenavirus (NWA) species in the Americas, cause life-threatening viral hemorrhagic fevers. In the absence of licensed antiviral therapies, these viruses pose a sig...

Cryo-EM structures of Lassa and Machupo virus polymerases complexed with cognate regula...
https://doi.org/10.1038/s41564-021-00916-w
Nature Microbiology; Xu X, Peng R et. al.

Jun 16th, 2021 - Zoonotic arenaviruses can lead to life-threating diseases in humans. These viruses encode a large (L) polymerase that transcribes and replicates the viral genome. At the late stage of replication, the multifunctional Z protein interacts with the L...

Signal-regulatory protein alpha is an anti-viral entry factor targeting viruses using e...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8211255
PLoS Pathogens; Sarute N, Cheng H et. al.

Jun 8th, 2021 - Signal-regulatory protein alpha (SIRPA) is a well-known inhibitor of phagocytosis when it complexes with CD47 expressed on target cells. Here we show that SIRPA decreased in vitro infection by a number of pathogenic viruses, including New World an...

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