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About 860 results

ALLMedicine™ Botulism Center

Research & Reviews  289 results

Exposure-Response Modeling and Simulation to Support Human Dosing of Botulism Antitoxin...
https://doi.org/10.1002/cpt.2620
Clinical Pharmacology and Therapeutics; Beliveau M, Anderson D et. al.

Apr 26th, 2022 - Botulism Antitoxin Heptavalent (A, B, C, D, E, F, G) - (Equine) (BAT® ) product is a sterile solution of F(ab')2 and F(ab')2 -related antibody fragments prepared from plasma obtained from horses that have been immunized with a specific serotype of...

Development and evaluation of a tetravalent botulinum vaccine.
https://doi.org/10.1080/21645515.2022.2048621
Human Vaccines & Immunotherapeutics; Shi DY, Liu FJ et. al.

Apr 19th, 2022 - Botulinum neurotoxins (BoNTs) are the most toxic known proteins. Naturally occurring botulism in humans is caused by botulinum serotypes A, B, E, and F. Vaccination is an effective strategy to prevent botulism. In this study, a tetravalent botulin...

Notes from the Field: Wound Botulism Outbreak Among a Group of Persons Who Inject Drugs...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9020861
MMWR. Morbidity and Mortality Weekly Report; Edwards LD, Gomez I et. al.

Apr 15th, 2022 - Notes from the Field: Wound Botulism Outbreak Among a Group of Persons Who Inject Drugs - Dallas, Texas, 2020.|2022|Edwards LD,Gomez I,Wada S,Swaney EM,Caruthers MB,|epidemiology,epidemiology,epidemiology,

Toxicology and pharmacology of botulinum and tetanus neurotoxins: an update.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9095541
Archives of Toxicology; Pirazzini M, Montecucco C et. al.

Mar 26th, 2022 - Tetanus and botulinum neurotoxins cause the neuroparalytic syndromes of tetanus and botulism, respectively, by delivering inside different types of neurons, metalloproteases specifically cleaving the SNARE proteins that are essential for the relea...

First-in-Human Clinical Trial to Assess the Safety, Tolerability and Pharmacokinetics o...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9017376
Antimicrobial Agents and Chemotherapy; Raja SM, Guptill JT et. al.

Mar 22nd, 2022 - Botulism is a rare, life-threatening paralytic disease caused by botulinum neurotoxin (BoNT). Available treatments including an equine antitoxin and human immune globulin are given postexposure and challenging to produce and administer. NTM-1633 i...

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Drugs  4 results see all →

Clinicaltrials.gov  7 results

Functional Outcome of Hemiplegic Upper Extremity in Patients With Subacute Stroke After Kinesiotaping and Rehabilitation
https://clinicaltrials.gov/ct2/show/NCT04027985

Jul 29th, 2021 - Clinical characteristics of impaired motor performance on affected upper extremity in stroke patients included muscle weakness, increased muscle tone, contracture, joint instability, or impaired motor control. Poststroke spasticity (PSS) is also a...

Safety Study of 7 Botulinum Antitoxin Serotypes Derived From Horses
https://clinicaltrials.gov/ct2/show/NCT00360737

Mar 5th, 2020 - Clostridial toxins are amongst the most toxic substances known to science (Middlebrook, 1995). In the United States and other countries, human exposure to Clostridium botulinum toxins usually occurs through food poisoning, wound botulism and colon...

Phase 3, Randomized, Safety, Lot Consistency and Clinical Benefit Study of Recombinant Botulinum Vaccine A/B
https://clinicaltrials.gov/ct2/show/NCT01940315

Dec 4th, 2018 - Currently, there are no licensed vaccines or pre-exposure prophylactic medical countermeasures available to provide protection against botulism. The rBV A/B is under development to provide protection of adults 18 to 55 years of age from fatal botu...

Retrospective Epidemiological Study on Botulism in Intensive Care Units in France
https://clinicaltrials.gov/ct2/show/NCT03658902

Sep 6th, 2018 - Botulism poisoning is a rare but serious illness. Because of it's low incidence, it is not well known by physicians. Most studies describing botulism date back to the last century and do not take into account recent advances in intensive care. The...

Effect of Agave Syrup, Placebo, and No Treatment on Nocturnal Cough and Sleep Quality for Coughing Infants/Toddlers and Their Parents
https://clinicaltrials.gov/ct2/show/NCT01721395

Oct 23rd, 2015 - Cough is a frequent symptom in children and infants and is one of the most common reasons parents visit a healthcare provider for their child. The US Food and Drug Administration has issued a warning that over-the-counter cough and cold medicines ...

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News  39 results

Testing for LEMS
https://www.onclive.com/view/testing-for-lems

Dec 21st, 2021 - David Gerber, MD: Steve, it might be helpful at this point to go over how we diagnose and test for LEMS [Lambert-Eaton myasthenic syndrome]. Steven Vernino, MD, PhD: As neurologists, when we see conditions that make us think about paraneoplastic ...

New Botulism Guidelines Focus on Mass-Casualty Events
https://www.medscape.com/viewarticle/952251

Jun 1st, 2021 - Botulinum toxin is said to be the most lethal substance known. Inhaling just 1-3 nanograms of toxin per kilogram of body mass constitutes a lethal dose.  Now the Centers for Disease Control and Prevention (CDC) has published the first comprehensiv...

Speaking of Pandemics: The Art and Science of Risk Communication
https://www.staging.medscape.com/viewarticle/933729

Jul 10th, 2020 - Editor's note: Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center. Infectious disease expert Anthony Fauci. Coronavirus response coordinator Deborah Birx. County health officials across the United States. The Covi...

Speaking of Pandemics: The Art and Science of Risk Communication
https://www.medscape.com/viewarticle/933729

Jul 10th, 2020 - Editor's note: Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center. Infectious disease expert Anthony Fauci. Coronavirus response coordinator Deborah Birx. County health officials across the United States. The Covi...

Medical Mystery: Beer-Linked Kidney Failure and Paralysis
https://www.medscape.com/viewarticle/925834

Feb 27th, 2020 - Eduardo Valle, MD, a second-year medical resident in Brazil, was sitting in the hospital cafeteria with his fellow residents in late December when they heard news of the emergency department's newest patient. A middle-aged man with abdominal pain,...

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Patient Education  5 results see all →