About 16,885 results

ALLMedicine™ Herpes Simplex Center

Research & Reviews  5,644 results

Associations between severe and notifiable respiratory infections during the first trim...
BMC Pregnancy and Childbirth; Chughtai AA, He WQ et. al.

Mar 26th, 2023 - Evidence regarding the association between acute respiratory infections during pregnancy and congenital anomalies in babies, is limited and conflicting. The aim of this study was to examine the association between acute respiratory infections duri...

Practice trends in pediatric sudden sensorineural hearing loss management: An unresolve...
American Journal of Otolaryngology; Luu K, Shaffer AD et. al.

Mar 25th, 2023 - Assess practice patterns amongst pediatric otolaryngologist for the management of children with SSNHL. A cross-sectional online survey of members of the American Society of Pediatric Otolaryngology (ASPO) was performed; 135 responded. Patterns in ...

Memory T cells possess an innate-like function in local protection from mucosal infection.
The Journal of Clinical Investigation; Arkatkar T, Davé VA et. al.

Mar 24th, 2023 - Mucosal infections pose a significant global health burden. Antigen-specific tissue resident T cells are critical to maintaining barrier immunity. Previous studies in the context of systemic infection suggest that memory CD8 T cells may also provi...

Adaptation of transgene mRNA translation boosts the anticancer efficacy of oncolytic HSV1.
Journal for Immunotherapy of Cancer; Hoang HD, Said A et. al.

Mar 24th, 2023 - Transgenes deliver therapeutic payloads to improve oncolytic virus immunotherapy. Transgenes encoded within oncolytic viruses are designed to be highly transcribed, but protein synthesis is often negatively affected by viral infection, compromisin...

Commentary: Herpes simplex virus and SLE: though uncommon yet with significant implicat...
Journal of Medical Virology; Mahroum N, Elsalti A et. al.

Mar 23rd, 2023 - The relation between infectious agents, particularly viruses, with autoimmunity and autoimmune diseases, has been extensively studied during the last decades. Recently, the association was shown to be even stronger during the pandemic of COVID-19,...

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Guidelines  12 results

Serologic Screening for Genital Herpes Infection: US Preventive Services Task Force Rea...
JAMA , Mangione CM et. al.

Feb 15th, 2023 - Genital herpes is a common sexually transmitted infection caused by 2 related viruses, herpes simplex type 1 (HSV-1) and herpes simplex type 2 (HSV-2). Infection is lifelong; currently, there is no cure for HSV infection. Antiviral medications may...

Management of herpesvirus reactivations in patients with solid tumours and hematologic ...
Annals of Hematology; Henze L, Buhl C et. al.

Jan 8th, 2022 - Clinical reactivations of herpes simplex virus or varicella zoster virus occur frequently among patients with malignancies and manifest particularly as herpes simplex stomatitis in patients with acute leukaemia treated with intensive chemotherapy ...

Sexually Transmitted Infections Treatment Guidelines, 2021.
MMWR. Recommendations and Reports : Morbidity and Mortali... Workowski KA, Bachmann LH et. al.

Jul 23rd, 2021 - These guidelines for the treatment of persons who have or are at risk for sexually transmitted infections (STIs) were updated by CDC after consultation with professionals knowledgeable in the field of STIs who met in Atlanta, Georgia, June 11-14, ...

Management of Genital Herpes in Pregnancy: ACOG Practice Bulletinacog Practice Bulletin...
Obstetrics and Gynecology;

Apr 26th, 2020 - Genital herpes simplex virus (HSV) infection during pregnancy poses a risk to the developing fetus and newborn. Genital herpes is common in the United States. Among 14- to 49-year-old females, the prevalence of HSV-2 infection is 15.9%. However, t...

Management of Genital Herpes in Pregnancy: ACOG Practice Bulletin Summary, Number 220.
Obstetrics and Gynecology Reference;

Apr 26th, 2020 - Genital herpes simplex virus (HSV) infection during pregnancy poses a risk to the developing fetus and newborn. Genital herpes is common in the United States. Among 14- to 49-year-old females, the prevalence of HSV-2 infection is 15.9%. However, t...

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Drugs  219 results see all →

Clinicaltrials.gov  252 results

The Natural History of Severe Viral Infections and Characterization of Immune Defects in Patients Without Known Immunocompromise

Mar 17th, 2023 - Viral infections in the normal host are usually self-limited as the innate and acquired immune systems mount successful antiviral responses. However, in some instances, apparently immunocompetent persons manifest infections with viruses that would...

A Clinical Trial in Healthy Volunteers to Study the Safety, Tolerability, and Immune Responses After Vaccination With an Investigational Vaccine Designed to Prevent Genital Herpes Lesions

Mar 16th, 2023 - This exploratory trial will have two parts. While Part A will focus on the safety evaluations, vaccine-induced immune responses (specifically neutralizing antibodies) will also be analyzed to assess if there is a dose-response. Part B of the trial...

A Study on the Reactogenicity, Safety, Immune Response, and Efficacy of a Vaccine Against HSV-2 in Healthy Participants Aged 18-40 Years or in Participants Aged 18-60 Years With Recurrent HSV-2 Gen...

Mar 16th, 2023 - The purpose of this first-time-in-human (FTiH) study is to evaluate the reactogenicity, safety, immune response, and efficacy of an investigational herpes simplex virus (HSV) vaccine. The study will be conducted in 2 parts: Part I assessing differ...

Treating Genital Herpes Infection to Reduce Racial Disparities in the Risk of Severe Maternal Morbidity

Mar 15th, 2023 - Severe Maternal Morbidity (SMM), as defined by the CDC, has been repeatedly associated with maternal mortality, fetal risk, and long-term maternal risk. SMM is one of PCORI's research priorities (Special Areas of Emphasis, SAE). Racial disparities...

Neonatal Phase 1 Valacyclovir Study

Mar 10th, 2023 - A Phase 1, open label multicenter trial to assess the safety and pharmacokinetics (PKs) of oral valacyclovir in neonates who are at risk of acquiring neonatal herpes simplex virus disease. This study will determine the valacyclovir dose that resul...

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News  584 results

Widespread Erosions in Intertriginous Areas
Alejandra Méndez, MPH, Jonathan Webster, MD et. al.

Mar 15th, 2023 - The Diagnosis: Darier Disease A clinical diagnosis of Darier disease was made from the skin findings of pruritic, malodorous, keratotic papules in a seborrheic distribution and pathognomonic nail dystrophy, along with a family history that demonst.

Kaposi Varicelliform Eruption of Mpox in a Peeling Sunburn
Jennifer L. Adams, MD, Elizabeth R. Schnaubelt, MD et. al.

Mar 14th, 2023 - To the Editor: The recent global mpox (monkeypox) outbreak that started in May 2022 has distinctive risk factors, clinical features, and patient attributes that can portend dissemination of infection. We report a case of Kaposi varicelliform erupt.

Skin reactions from melanoma targeted and immune therapies range from pruritus to SJS
Doug Brunk

Mar 3rd, 2023 - SAN DIEGO – A downside of the revolutionary advances in targeted and immune therapies used to treat melanoma are their potential to trigger a wide range of skin reactions, from acneiform eruptions to Stevens-Johnson Syndrome (SJS). “These skin rea.

CDC Offers Tentative Guidance for Severe Mpox Treatment

Mar 2nd, 2023 - With no clinical trial data yet available for treating severe mpox, the CDC has published an interim report with guidance. There are many FDA-regulated drugs and biologics stockpiled for smallpox preparedness that can be used to treat severe mpox;...

USPSTF recommends against routine herpes screening for asymptomatic teens and adults
Heidi Splete

Feb 14th, 2023 - Asymptomatic adults, teens, and pregnant women with no known history or symptoms of herpes infection need not undergo routine screening, according to the latest recommendation from the U. S.

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Patient Education  43 results see all →