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About 183 results

ALLMedicine™ Norwalk Virus Center

Research & Reviews  60 results

Norovirus Challenge Study
https://clinicaltrials.gov/ct2/show/NCT05212168

Apr 28th, 2022 - Study Population Healthy male and female adult volunteers age 18 to 49 years inclusive with blood type O or A and who are confirmed H type-1 antigen secretory positive Investigational Product Active Vaccine: Norovirus GI.1 Norwalk VP1 Vaccine (VXA...

Retraction notice to "Immunogenicity of newcastle disease virus vectors expressing norw...
https://doi.org/10.1016/j.virol.2021.03.001
Virology Kim SH, Chen S et. al.

Mar 15th, 2021 - Retraction notice to "Immunogenicity of newcastle disease virus vectors expressing norwalk virus capsid protein in the presence or absence of VP2 protein" Virology (484) (October 2015) 163-169.|2021|Kim SH,Chen S,Jiang X,Green KY,Samal SK,|

Less severe clinical symptoms of Norwalk virus 8fIIb inoculum compared to its precursor...
https://doi.org/10.1002/jmv.26578
Journal of Medical Virology; Liu P, Rahman M et. al.

Oct 6th, 2020 - Noroviruses (NoV) are a leading cause of epidemic gastroenteritis. Human challenge studies have been used to examine the infectivity, pathogenicity, and host immune response to NoV as well as vaccine efficacy. The goal of this study was to conduct...

Production and Clinical Evaluation of Norwalk GI.1 Virus Lot 001-09NV in Norovirus Vacc...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7050988
The Journal of Infectious Diseases; Mateo R, Lindesmith LC et. al.

Oct 20th, 2019 - Human noroviruses (HuNoV) are the leading cause of gastroenteritis. No vaccine is currently available to prevent norovirus illness or infection. Safe, infectious challenge strains are needed to assess vaccine efficacy in the controlled human infec...

Bile Salts Alter the Mouse Norovirus Capsid Conformation: Possible Implications for Cel...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6744230
Journal of Virology; Sherman MB, Williams AN et. al.

Jul 26th, 2019 - Caliciviruses are single-stranded RNA viruses with 180 copies of capsid protein comprising the T=3 icosahedral capsids. The main capsid feature is a pronounced protruding (P) domain dimer formed by adjacent subunits on the icosahedral surface whil...

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Drugs  1 results see all →

Clinicaltrials.gov  7 results

Norovirus Challenge Study
https://clinicaltrials.gov/ct2/show/NCT05212168

Apr 28th, 2022 - Study Population Healthy male and female adult volunteers age 18 to 49 years inclusive with blood type O or A and who are confirmed H type-1 antigen secretory positive Investigational Product Active Vaccine: Norovirus GI.1 Norwalk VP1 Vaccine (VXA...

Norwalk Vaccine Study
https://clinicaltrials.gov/ct2/show/NCT00973284

Aug 8th, 2017 - The drug being tested in this study is called intranasal Norwalk virus-like particle (VLP) vaccine. Norwalk VLP vaccine is being tested to prevent viral acute gastroenteritis (AGE). This study will look at the illness rate of AGE in people who are...

Phase 1 Norwalk Vaccine Study
https://clinicaltrials.gov/ct2/show/NCT00806962

May 6th, 2015 - Randomized, double blind, multi-site, study in healthy adults, comparing safety and immunogenicity of two dosage levels of Norwalk VLP Vaccine with adjuvant/excipients and with placebo controls Primary Objective: Safety as determined by occurrence...

New Challenge Pool of Norwalk Virus Inoculum
https://clinicaltrials.gov/ct2/show/NCT00138476

May 9th, 2014 - Noroviruses are the cause of most acute, epidemic, non-bacterial gastroenteritis (24-hour intestinal flu) and Norwalk virus (NV) is the prototype strain of this group of viruses. Although NV was identified some 30 years ago, progress in understand...

Infectivity of Norovirus in Groundwater-Human Challenge Study
https://clinicaltrials.gov/ct2/show/NCT00313404

Nov 19th, 2013 - Norwalk virus and related "Norwalk-like viruses" are the most common cause of outbreaks of stomach sickness (nausea, vomiting, diarrhea) in older children and adults in the United States. These viruses are sometimes found in drinking water, ice, s...

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News  5 results

Investigational Norovirus Vaccine Trims Norwalk Infection Risk
https://www.mdedge.com/familymedicine/article/46639/infectious-diseases/investigational-norovirus-vaccine-trims-norwalk
Internal Medicine News; Mary Ann Moon

Dec 7th, 2011 - An investigational norovirus vaccine was protective against Norwalk virus infection and its associated gastroenteritis in a proof-of-concept study reported in the Dec. 8 issue of the New England Journal of Medicine.

Investigational Norovirus Vaccine Trims Norwalk Infection Risk
https://www.mdedge.com/internalmedicine/article/46639/infectious-diseases/investigational-norovirus-vaccine-trims-norwalk
Mary Ann Moon

Dec 7th, 2011 - An investigational norovirus vaccine was protective against Norwalk virus infection and its associated gastroenteritis in a proof-of-concept study reported in the Dec. 8 issue of the New England Journal of Medicine.

Norwalk Virus Vaccine Promises Smoother Sailing
https://www.medpagetoday.com/infectiousdisease/vaccines/30082

Dec 7th, 2011 - Action Points Explain that it might be possible to use a vaccine to prevent norovirus illness. Point out that the duration of protection from vaccination is unclear, and the vaccine evaluated in the study protected against the Norwalk strain (geno...

Intranasal Vaccine for Noroviral Infections in Pipeline
https://www.mdedge.com/pediatrics/article/41143/infectious-diseases/intranasal-vaccine-noroviral-infections-pipeline
Doug Brunk

Oct 20th, 2011 - CHICAGO – An intranasal vaccine reduces norovirus disease and infection in humans, results from a proof-of-concept study suggest. The findings are important because infections with norovirus, commonly referred to as "cruise ship viruses," cause 96.

MDCT of the Small Bowel
https://www.medscape.com/viewarticle/769704_6

Infection Infectious enteritis is a common cause of acute diarrheal illness in the United States and can be caused by viruses, bacteria, or, less commonly, protozoa. The most common viral causes include norovirus (formerly Norwalk virus) and rotav...

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