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About 30,608 results

ALLMedicine™ Amyotrophic Lateral Sclerosis Center

Research & Reviews  15,125 results

Stathmin-2: adding another piece to the puzzle of TDP-43 proteinopathies and neurodegen...
https://doi.org/10.1172/JCI142854
The Journal of Clinical Investigation; Glass JD

Oct 19th, 2020 - Cytoplasmic aggregated proteins are a common neuropathological feature of neurodegenerative diseases. Cytoplasmic mislocalization and aggregation of TAR-DNA binding protein 43 (TDP-43) is found in the majority of patients with amyotrophic lateral ...

Blood metal levels and amyotrophic lateral sclerosis risk: a prospective cohort.
https://doi.org/10.1002/ana.25932
Annals of Neurology; Peters S, Broberg K et. al.

Oct 17th, 2020 - Metals have been suggested as risk factor for amyotrophic lateral sclerosis (ALS), but only retrospective studies are available to date. We compared metal levels in prospectively collected blood samples from ALS patients and controls, to explore w...

Matrix metalloproteinases deregulation in amyotrophic lateral sclerosis.
https://doi.org/10.1016/j.jns.2020.117175
Journal of the Neurological Sciences; Sánchez-Torres JL, Yescas-Gómez P et. al.

Oct 17th, 2020 - Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by the loss of upper and lower motor neurons that results in progressive paralysis and muscular atrophy. There are many molecules and genes involved in neuromuscular ...

TDP-43 and tau oligomers in Alzheimer's disease, amyotrophic lateral sclerosis, and fro...
https://doi.org/10.1016/j.nbd.2020.105130
Neurobiology of Disease; Montalbano M, McAllen S et. al.

Oct 16th, 2020 - Proteinaceous aggregates are major hallmarks of several neurodegenerative diseases. Aggregates of post-translationally modified transactive response (TAR)-DNA binding protein 43 (TDP-43) in cytoplasmic inclusion bodies are characteristic features ...

Cognition and behaviour in frontotemporal dementia with and without amyotrophic lateral...
https://doi.org/10.1136/jnnp-2020-323969
Journal of Neurology, Neurosurgery, and Psychiatry; Saxon JA, Thompson JC et. al.

Oct 15th, 2020 - The precise relationship between frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) is incompletely understood. The association has been described as a continuum, yet data suggest that this may be an oversimplification. Direct c...

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Guidelines  9 results

Aquestive Therapeutics Receives FDA Approval for Exservan (riluzole) Oral Film
http://aquestive.com/aquestive-therapeutics-receives-fda-approval-for-exservan-riluzole-oral-film/

Nov 24th, 2019 - Aquestive Therapeutics, Inc. (NASDAQ: AQST), a specialty pharmaceutical company focused on developing and commercializing differentiated products to solve therapeutic problems, today announced that Exservan™ (riluzole) Oral Film received early-act...

Provisional best practices guidelines for the evaluation of bulbar dysfunction in amyot...
https://doi.org/10.1002/mus.26408
Muscle & Nerve; Pattee GL, Plowman EK et. al.

Jan 8th, 2019 - Universally established comprehensive clinical bulbar scales objectively assessing disease progression in amyotrophic lateral sclerosis (ALS) are currently lacking. The goal of this working group project is to design a best practice set of provisi...

MDA U.S. Neuromuscular Disease Registry
https://www.mda.org/services/neuromuscular-disease-registry
Muscular Dystrophy Association (USA)

Dec 31st, 2015 - In 2013, MDA launched the U. S.

EFNS guidelines on the clinical management of amyotrophic lateral sclerosis (MALS)--rev...
https://doi.org/10.1111/j.1468-1331.2011.03501.x
European Journal of Neurology; , Andersen PM et. al.

Sep 14th, 2011 - The evidence base for the diagnosis and management of amyotrophic lateral sclerosis (ALS) is weak. To provide evidence-based or expert recommendations for the diagnosis and management of ALS based on a literature search and the consensus of an exp...

Practice parameter update: the care of the patient with amyotrophic lateral sclerosis: ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2764728
Neurology Miller RG, Jackson CE et. al.

Oct 13th, 2009 - To systematically review evidence bearing on the management of patients with amyotrophic lateral sclerosis (ALS). The authors analyzed studies from 1998 to 2007 to update the 1999 practice parameter. Topics covered in this section include breaking...

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Drugs  31 results see all →

Clinicaltrials.gov  15,251 results

Stathmin-2: adding another piece to the puzzle of TDP-43 proteinopathies and neurodegen...
https://doi.org/10.1172/JCI142854
The Journal of Clinical Investigation; Glass JD

Oct 19th, 2020 - Cytoplasmic aggregated proteins are a common neuropathological feature of neurodegenerative diseases. Cytoplasmic mislocalization and aggregation of TAR-DNA binding protein 43 (TDP-43) is found in the majority of patients with amyotrophic lateral ...

Blood metal levels and amyotrophic lateral sclerosis risk: a prospective cohort.
https://doi.org/10.1002/ana.25932
Annals of Neurology; Peters S, Broberg K et. al.

Oct 17th, 2020 - Metals have been suggested as risk factor for amyotrophic lateral sclerosis (ALS), but only retrospective studies are available to date. We compared metal levels in prospectively collected blood samples from ALS patients and controls, to explore w...

Matrix metalloproteinases deregulation in amyotrophic lateral sclerosis.
https://doi.org/10.1016/j.jns.2020.117175
Journal of the Neurological Sciences; Sánchez-Torres JL, Yescas-Gómez P et. al.

Oct 17th, 2020 - Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by the loss of upper and lower motor neurons that results in progressive paralysis and muscular atrophy. There are many molecules and genes involved in neuromuscular ...

TDP-43 and tau oligomers in Alzheimer's disease, amyotrophic lateral sclerosis, and fro...
https://doi.org/10.1016/j.nbd.2020.105130
Neurobiology of Disease; Montalbano M, McAllen S et. al.

Oct 16th, 2020 - Proteinaceous aggregates are major hallmarks of several neurodegenerative diseases. Aggregates of post-translationally modified transactive response (TAR)-DNA binding protein 43 (TDP-43) in cytoplasmic inclusion bodies are characteristic features ...

Cognition and behaviour in frontotemporal dementia with and without amyotrophic lateral...
https://doi.org/10.1136/jnnp-2020-323969
Journal of Neurology, Neurosurgery, and Psychiatry; Saxon JA, Thompson JC et. al.

Oct 15th, 2020 - The precise relationship between frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) is incompletely understood. The association has been described as a continuum, yet data suggest that this may be an oversimplification. Direct c...

see more →

News  165 results

Aquestive Therapeutics Receives FDA Approval for Exservan (riluzole) Oral Film
http://aquestive.com/aquestive-therapeutics-receives-fda-approval-for-exservan-riluzole-oral-film/

Nov 24th, 2019 - Aquestive Therapeutics, Inc. (NASDAQ: AQST), a specialty pharmaceutical company focused on developing and commercializing differentiated products to solve therapeutic problems, today announced that Exservan™ (riluzole) Oral Film received early-act...

FDA approves Aquestive's ALS treatment
https://www.reuters.com/article/us-fda-aquestive/fda-approves-aquestives-als-treatment-idUSKBN1XW2AQ

Nov 22nd, 2019 - (Reuters) - The U.S. Food and Drug Administration on Friday approved bit.ly/2pIFzi5 Aquestive Therapeutics' treatment for neurological disorder amyotrophic lateral sclerosis (ALS). Shares of the company, which developed riluzole oral film (ROF) an...

Researchers identify common reasons for misdiagnosis of ALS
https://www.mdedge.com/jcomjournal/article/210441/neuromuscular-disorders/researchers-identify-common-reasons-misdiagnosis?channel=39313
Erik Greb

Oct 19th, 2019 - AUSTIN – Lack of upper motor neuron signs on examination, presence of sensory symptoms, and absence of tongue fasciculations are common causes of amyotrophic lateral sclerosis (ALS) misdiagnosis, according to an investigation presented at the annu.

Study refines ALS risk among first-degree relatives of patients with disease
https://www.mdedge.com/jcomjournal/article/205169/neuromuscular-disorders/study-refines-als-risk-among-first-degree?channel=285
Kari Oakes

Jul 23rd, 2019 - Having a first-degree relative with amyotrophic lateral sclerosis (ALS) increases the lifetime risk of developing the condition, even in the absence of a known ALS-associated genetic mutation, according to a recent Irish population–based study. de.

Biohaven's treatment for Lou Gehrig's disease fails to win FDA nod
https://www.reuters.com/article/us-biohaven-pharma-fda/biohavens-treatment-for-lou-gehrigs-disease-fails-to-win-fda-nod-idUSKCN1UE2PQ

Jul 19th, 2019 - FILE PHOTO: The logo for Biohaven Pharmaceutical Holding Company is displayed on a screen during the company's IPO on the floor of the New York Stock Exchange (NYSE) in New York, U.S., May 4, 2017. REUTERS/Brendan McDermid (Reuters) - Biohaven Pha...

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Patient Education  27 results see all →