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About 15,230 results

ALLMedicine™ Amyotrophic Lateral Sclerosis Center

Research & Reviews  5,592 results

An Open Label Pilot Study of the Safety and Tolerability of Perampanel in Amyotrophic L...
https://doi.org/10.1002/mus.27385
Muscle & Nerve; Hotait M, Ismail HH et. al.

Jul 30th, 2021 - Perampanel, a selective non-competitive α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) antagonist, is capable of slowing the progression of the amyotrophic lateral sclerosis (ALS) phenotype and increasing the number of anterior horn c...

Challenging the Established Order: Innovating Clinical Trials for Amyotrophic Lateral S...
https://doi.org/10.1212/WNL.0000000000012545
Neurology van Eijk RPA, Nikolakopoulos S et. al.

Jul 29th, 2021 - Development of effective treatment for amyotrophic lateral sclerosis (ALS) has been hampered by disease heterogeneity, a limited understanding of underlying pathophysiology and methodological design challenges. Here we have evaluated two major the...

A model incorporating ultrasound to predict the probability of fast disease progression...
https://doi.org/10.1016/j.clinph.2021.05.034
Clinical Neurophysiology : Official Journal of the Intern... Toh TH, Abdul-Aziz NA et. al.

Jul 28th, 2021 - We aimed to develop a model to predict amyotrophic lateral sclerosis (ALS) disease progression based on clinical and neuromuscular ultrasound (NMUS) parameters. ALS patients were prospectively recruited. Muscle fasciculation (≥2 over 30-seconds, e...

Glutathione S-transferase Omega 2 DD genotype is associated with an increased risk of s...
https://doi.org/10.1177/03000605211033219
The Journal of International Medical Research; Fan Z, Jiang H et. al.

Jul 28th, 2021 - To investigate whether GSTA1, GSTO2, and GSTZ1 are relevant to an increased risk of amyotrophic lateral sclerosis (ALS) in a Chinese population. In this study, 143 sporadic ALS (sALS) patients (83 men, 60 women) and 210 age- and sex-matched health...

Evaluation and categorisation of individual patients based on white matter profiles: Si...
https://doi.org/10.1016/j.jns.2021.117584
Journal of the Neurological Sciences; Tahedl M, Murad A et. al.

Jul 28th, 2021 - The majority of radiology studies in neurodegenerative conditions infer group-level imaging traits from group comparisons. While this strategy is helpful to define phenotype-specific imaging signatures for academic use, the meaningful interpretati...

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Guidelines  4 results

Provisional best practices guidelines for the evaluation of bulbar dysfunction in amyot...
https://doi.org/10.1002/mus.26408
Muscle & Nerve; Pattee GL, Plowman EK et. al.

Jan 9th, 2019 - Universally established comprehensive clinical bulbar scales objectively assessing disease progression in amyotrophic lateral sclerosis (ALS) are currently lacking. The goal of this working group project is to design a best practice set of provisi...

ESPEN guideline clinical nutrition in neurology.
https://doi.org/10.1016/j.clnu.2017.09.003
Clinical Nutrition (Edinburgh, Scotland); Burgos R, Bretón I et. al.

Dec 25th, 2017 - Neurological diseases are frequently associated with swallowing disorders and malnutrition. Moreover, patients with neurological diseases are at increased risk of micronutrient deficiency and dehydration. On the other hand, nutritional factors may...

EFNS guidelines for the molecular diagnosis of neurogenetic disorders: motoneuron, peri...
https://doi.org/10.1111/j.1468-1331.2010.03069.x
European Journal of Neurology; Burgunder JM, Schöls L et. al.

May 27th, 2010 - These EFNS guidelines on the molecular diagnosis of motoneuron disorders, neuropathies and myopathies are designed to summarize the possibilities and limitations of molecular genetic techniques and to provide diagnostic criteria for deciding when ...

Practice parameter update: the care of the patient with amyotrophic lateral sclerosis: ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2764728
Neurology Miller RG, Jackson CE et. al.

Oct 14th, 2009 - To systematically review evidence bearing on the management of patients with amyotrophic lateral sclerosis (ALS). The authors analyzed studies from 1998 to 2007 to update the 1999 practice parameter. Topics covered in this section include breaking...

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Drugs  17 results see all →

Clinicaltrials.gov  192 results

Intrathecal Autologous Adipose-derived Mesenchymal Stromal Cells for Amyotrophic Lateral Sclerosis (ALS)
https://clinicaltrials.gov/ct2/show/NCT03268603

May 5th, 2020 - The Goal of the Proposed Study is to perform an open label, 60 subject, Phase II multi-site clinical trial to investigate the safety and efficacy of intrathecal treatment of aaMSCs in ALS. Patients will be treated with 1 x 10^8 aaMSCs every 3 mont...

HERV-K Suppression Using Antiretroviral Therapy in Volunteers With Amyotrophic Lateral Sclerosis (ALS)
https://clinicaltrials.gov/ct2/show/NCT02437110

May 1st, 2020 - Objective: In this Phase I, proof-of-concept study, we aim to determine whether an antiretroviral regimen approved to treat human immunodeficiency virus (HIV) infection would also suppress levels of Human Endogenous Retrovirus-K (HERV-K) found to ...

Efficacy of Cannabinoids in Amyotrophic Lateral Sclerosis or Motor Neurone Disease
https://clinicaltrials.gov/ct2/show/NCT03690791

Apr 22nd, 2020 - This is a randomised, double-blind, placebo controlled study on a cannabis-based medicine extract (MediCabilis CBD Oil), in patients with Amyotrophic Lateral Sclerosis or Motor Neurone Disease. Participants will be randomised in a 1:1 ratio to rec...

Intraspinal Transplantation of Autologous ADRC in ALS Patients
https://clinicaltrials.gov/ct2/show/NCT03296501

Apr 15th, 2020 - Amyotrophic Lateral Sclerosis (ALS) is an incurable disease of unknown etiology that in a short time leads to significant impairment of motor functions and death. The frequency of ALS is 4-8/100 000. Mostly it affects people between 40 and 70 year...

Investigating Complex Neurodegenerative Disorders Related to Amyotrophic Lateral Sclerosis and Frontotemporal Dementia
https://clinicaltrials.gov/ct2/show/NCT03225144

Apr 14th, 2020 - Objectives The primary objective is to evaluate patients referred with a diagnosis of frontotemporal dementia (FTD), amyotrophic lateral sclerosis (ALS), or related adult-onset neurodegenerative disorder to assess patient eligibility for ongoing p...

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News  274 results

A Quick Tour of the New Lyme Disease Guideline
https://www.medscape.com/viewarticle/951589

Jun 14th, 2021 - This transcript has been edited for clarity. Hello. This is Paul Auwaerter for Medscape Infectious Diseases, speaking from Johns Hopkins University School of Medicine. Spring is in full swing and tick season has certainly returned. I thought I wou...

Scientists Discover New Genetic Form of ALS in 11 Children
https://www.medscape.com/viewarticle/952489

Jun 7th, 2021 - (Reuters Health) - Scientists have identified four specific, dominant variants of the SPTLC1 gene in 11 children from seven different families who appear to have a new and unique form of amyotrophic lateral sclerosis (ALS). The findings suggest th...

Twofold Increased ALS Risk in Manual Laborers
https://www.medscape.com/viewarticle/949580

Apr 20th, 2021 - Blue-collar workers, particularly carpenters and construction workers, have a significantly increased risk for amyotrophic lateral sclerosis (ALS) compared with white-collar workers, new research shows. Investigators found manual laborers had a tw...

Theatrics, Hypnosis, and the Roots of Modern Neurology
https://www.medscape.com/viewarticle/947504

Mar 15th, 2021 - "Symptoms, then, are in reality nothing but a cry from suffering organs" – Jean-Martin Charcot Nearly 130 years after his death, Jean-Martin Charcot's name still resonates with modern neurologists. The famed 19th century French physician made myri...

New Compound Promising for ALS, Other Upper Motor Neuron Diseases
https://www.medscape.com/viewarticle/947056

Mar 11th, 2021 - NEW YORK (Reuters Health) - A new compound, NU-9, improved diseased upper motor neurons (UMN) in mice and shows promise for treating amyotrophic lateral sclerosis (ALS) in humans, though more work is needed before a clinical trial can be started, ...

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Patient Education  13 results see all →