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About 8,450 results

ALLMedicine™ Epilepsy Center

Research & Reviews  2,678 results

Two-trajectory laser amygdalohippocampotomy: Anatomic modeling and initial seizure outc...
https://doi.org/10.1111/epi.17019
Epilepsia Liu DD, Lauro PM et. al.

Aug 3rd, 2021 - Laser interstitial thermal therapy (LITT) for mesial temporal lobe epilepsy (mTLE) is typically performed with one trajectory to target the medial temporal lobe (MTL). MTL structures such as piriform and entorhinal cortex are epileptogenic, but du...

Artificial intelligence for classification of temporal lobe epilepsy with ROI-level MRI...
https://doi.org/10.1016/j.nicl.2021.102765
NeuroImage. Clinical; Gleichgerrcht E, Munsell BC et. al.

Aug 3rd, 2021 - Artificial intelligence has recently gained popularity across different medical fields to aid in the detection of diseases based on pathology samples or medical imaging findings. Brain magnetic resonance imaging (MRI) is a key assessment tool for ...

Temporal lobe epilepsy: Evaluation of central and systemic immune-inflammatory features...
https://doi.org/10.1016/j.seizure.2021.07.028
Seizure Toledo A, Orozco-Suárez S et. al.

Aug 3rd, 2021 - Neuroinflammation is probably one of the factors involved in drug resistance in people with epilepsy. Finding peripheral markers reflecting the intensity of neuroinflammation could be of great help to decide for which patients anti-inflammatory tr...

Anterior Nucleus of the Thalamus Deep Brain Stimulation with Concomitant Vagus Nerve St...
https://doi.org/10.1093/neuros/nyab253
Neurosurgery Parisi V, Lundstrom BN et. al.

Aug 2nd, 2021 - The Food and Drug Administration approved the deep brain stimulation of the anterior nucleus of the thalamus (ANT-DBS) as an adjunctive therapy for drug-resistant epilepsy (DRE) in the United States in 2018. The DBS Therapy for Epilepsy Post-Appro...

Oral and manual automatisms elicited by electrical stimulation of the pars opercularis ...
https://doi.org/10.1016/j.clineuro.2021.106784
Clinical Neurology and Neurosurgery; Li H, Meng Q et. al.

Aug 1st, 2021 - Oral automatism (OA) and manual automatism (MA) are common signs during initiation of temporal seizures. However, the precise symptomatogenic zones for OA and MA remains largely unclear. In this study, we presented a case of intractable frontal lo...

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Guidelines  4 results

Practice guideline update summary: Efficacy and tolerability of the new antiepileptic d...
https://doi.org/10.1212/WNL.0000000000005756
Neurology Kanner AM, Ashman E et. al.

Jun 15th, 2018 - To update the 2004 American Academy of Neurology guideline for managing treatment-resistant (TR) epilepsy with second- and third-generation antiepileptic drugs (AEDs). 2004 criteria were used to systemically review literature (January 2003 to Nove...

Practice guideline summary: Sudden unexpected death in epilepsy incidence rates and ris...
https://doi.org/10.1212/WNL.0000000000003685
Neurology Harden C, Tomson T et. al.

Apr 26th, 2017 - To determine the incidence rates of sudden unexpected death in epilepsy (SUDEP) in different epilepsy populations and address the question of whether risk factors for SUDEP have been identified. Systematic review of evidence; modified Grading Reco...

Management issues for women with epilepsy-Focus on pregnancy (an evidence-based review)...
https://doi.org/10.1111/j.1528-1167.2009.02129.x
Epilepsia Harden CL, Meador KJ et. al.

Jun 10th, 2009 - A committee assembled by the American Academy of Neurology (AAN) reassessed the evidence related to the care of women with epilepsy (WWE) during pregnancy, including antiepileptic drug (AED) teratogenicity and adverse perinatal outcomes. It is hig...

Management issues for women with epilepsy--focus on pregnancy (an evidence-based review...
https://doi.org/10.1111/j.1528-1167.2009.02130.x
Epilepsia Harden CL, Pennell PB et. al.

Jun 10th, 2009 - A committee assembled by the American Academy of Neurology (AAN) reassessed the evidence related to the care of women with epilepsy (WWE) during pregnancy, including preconceptional folic acid and prenatal vitamin K use and the clinical implicatio...

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Drugs  404 results see all →

Clinicaltrials.gov  129 results

Surgery as a Treatment for Medically Intractable Epilepsy
https://clinicaltrials.gov/ct2/show/NCT01273129

May 8th, 2020 - Objective This protocol is being performed provide standard care therapy for patients with drug resistant epilepsy and to follow the therapeutic course of patients from pre-operative evaluation, through surgery, and post-operatively, and to collec...

Investigation of Blood-Brain-Barrier Breakdown Using Manganese Magnetic Resonance Imaging in Drug-Resistant Epilepsy
https://clinicaltrials.gov/ct2/show/NCT02531880

May 7th, 2020 - Objective: The primary goals of this pilot study is to (1) describe the safety profile of administration of mangafodipir in patients with epilepsy and (2) determine if peri-ictal administration will allow focal entry of mangafodipir through the bl...

Study to Test the Safety and Efficacy of Padsevonil as Adjunctive Treatment of Focal-onset Seizures in Adult Subjects With Drug-resistant Epilepsy
https://clinicaltrials.gov/ct2/show/NCT03370120

May 5th, 2020 - The purpose of the study is to evaluate the long-term safety and tolerability of Padsevonil administered at individualized doses as adjunctive treatment for subjects with drug-resistant epilepsy.

Study to Test the Efficacy and Safety of Padsevonil as Adjunctive Treatment of Focal-onset Seizures in Adults With Drug-resistant Epilepsy
https://clinicaltrials.gov/ct2/show/NCT03373383

May 5th, 2020 - The purpose of the study is to characterize the dose-response relationship with respect to efficacy of Padsevonil administered concomitantly with up to 3 anti-epileptic drugs (AEDs) for treatment of observable focal-onset seizures in subjects with...

Open-label Long-term Study of Adjunctive Brivaracetam in Pediatric Subjects With Epilepsy
https://clinicaltrials.gov/ct2/show/NCT01364597

Apr 24th, 2020 - This is a Phase 3, open-label, single-arm, multicenter, long-term study to evaluate the safety and efficacy of brivaracetam (BRV) in children with epilepsy. This study was initially designed for pediatric subjects who had completed a previous BRV ...

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News  153 results

Epilepsy Linked to Anxiety, Suicidality in Young Adults
https://www.medscape.com/viewarticle/951815

May 25th, 2021 - Young adults with epilepsy experience higher rates of anxiety, depression, and suicidality, compared with their counterparts in the general population, a new study shows. The findings, based on a study of 144 young adults with epilepsy (YAWE), was...

Deeper Sleep, Slower Heart Rate Tied to Sudden Death in Epilepsy
https://www.medscape.com/viewarticle/951137

May 14th, 2021 - Deeper sleep and slower heart rate following seizures may work synergistically to increase the risk for sudden unexpected death in epilepsy (SUDEP), new research suggests. Investigators analyzed data on 100 seizures in 42 patients with epilepsy. T...

Task Force Tackles FDA Lamotrigine Cardiac Risk Warning
https://www.medscape.com/viewarticle/946270

Feb 22nd, 2021 - A joint task force of the American Epilepsy Society (AES) and International League Against Epilepsy (ILAE) has issued an advisory to address concerns arising from a Food and Drug Administration (FDA) warning of cardiac risk in patients taking the ...

COVID-19's Global Impact on Epilepsy
https://www.medscape.com/viewarticle/943001

Dec 21st, 2020 - Editor's note: Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center. Around the globe, the COVID-19 pandemic has placed an enormous strain on patients with epilepsy, new research shows. The pandemic also appears to ...

SUDEP May Explain 3% of All Sudden Deaths in Kids
https://www.medscape.com/viewarticle/942139

Dec 7th, 2020 - Sudden unexpected death in epilepsy (SUDEP) may explain 3% of all sudden deaths in children – a prevalence rate that is at least three times greater than previously reported estimates – new research shows Dr Vicky Whittemore Just a few years ago, ...

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Patient Education  12 results see all →