ALLMedicine™ Complex Partial Seizures Center

Oct 8th, 2021 - An attractive target to interfere with epileptic brain hyperexcitability is the enhancement of γ-aminobutyric acidergic (GABAergic) inhibition by inactivation of the GABA-metabolizing enzyme GABA aminotransferase (GABA-AT). GABA-AT inactivators we...

Aug 2nd, 2021 - History Severity varies based on an individual's enzyme activity level. Symptoms typically present in childhood, including exercise intolerance (premature fatigability), weakness and stiffness with exercise, and painful muscle cramps. Most symptom...

Jul 26th, 2021 - History The predominant symptoms occurring during a seizure event determine the seizure type. These can be assessed from direct observation or from video recordings (see the video below), but this is relatively rare because most patients with epil...

Jul 26th, 2021 - Practice Essentials A complex partial seizure, now known as a focal impaired awareness seizure according to the updated classification system from the International League Against Epilepsy (ILAE), [1] starts focally within the brain and causes imp...

Jul 26th, 2021 - Practice Essentials A complex partial seizure, now known as a focal impaired awareness seizure according to the updated classification system from the International League Against Epilepsy (ILAE), [1] starts focally within the brain and causes imp...

Jul 12th, 2017 - This is an open-label, phase 4 study to examine the safety and efficacy of vigabatrin (Sabril) in Tuberous Sclerosis patients, a subset of the larger refractory complex partial epilepsy population for which the drug is approved. While enrolled on ...

Jul 2nd, 2017 - Objectives. This is an initial pilot study to acquire information upon which a more specific, statistically rigorous follow-on investigation will be based. The objectives of the overall project are: (1) to compare the absolute levels and rates of ...

Jun 7th, 2016 - Multicenter, prospective open-label study with approximately 25 sites in the US that specialize in caring for adult patients with refractory CPS Sites must have access to Humphrey static perimetry and to Spectralis SD-OCT. All vision test results ...

Jan 16th, 2019 - The US Food and Drug Administration (FDA) has approved the first generic version of the antiseizure medication Sabril (vigabatrin, Lundbeck). Generic vigabatrin (500-mg tablets), made by Teva Pharmaceuticals USA, is indicated as add-on therapy for...

Dec 12th, 2017 - WASHINGTON, DC — A microinfusion device that continuously delivers valproate directly to the brain is safe and effective in patients with refractory focal epilepsy, early research shows. Delivery of valproate through the intracerebroventricular de...

Jul 21st, 2017 - What is Epilepsy? Epilepsy is a condition characterized by recurrent and unpredictable seizures. Seizures are characterized by groups of neurons being activated simultaneously, leading to both outward symptoms like muscle jerking and convulsions, ...

Jun 23rd, 2016 - Gina Kolata shares "a cautionary tale" about a man who received stem cell therapy at a Mexican clinic hoping to improve his recovery from stroke only to end up with an aggressive, vascular mass growing on his spine -- a growth triggered by donor c...

Nov 3rd, 2015 - WASHINGTON, DC — Researchers are reporting further positive results using an investigational product containing pure cannabidiol (Epidiolex, GW Pharmaceuticals) in children with intractable epilepsy. Francis Filloux, MD, chief, Division of Pediatr...